PharmaCoNets of Metipranolol (SPCN: 60.24 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Metipranololhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Metipranololhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Metipranololhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Metipranololhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Metipranololhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Metipranololhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Metipranololhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Metipranololhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Metipranololhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Metipranololhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Metipranololhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Metipranololhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Metipranololhsa01522Endocrine resistance2.16E-021P04049RAF1More
Metipranololhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Metipranololhsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Metipranololhsa04014Ras signaling pathway3.65E-021P04049RAF1More
Metipranololhsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Metipranololhsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Metipranololhsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Metipranololhsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Metipranololhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Metipranololhsa04071Sphingolipid signaling pathway1.79E-046P04049, P21453, Q9H228, P01375, Q13362, Q9UQC2RAF1, S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Metipranololhsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Metipranololhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Metipranololhsa04140Autophagy - animal2.82E-021P04049RAF1More
Metipranololhsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Metipranololhsa04210Apoptosis3.64E-035O76075, P01375, Q9NR28, Q16548, P04049DFFB, TNF, DIABLO, BCL2A1, RAF1More
Metipranololhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Metipranololhsa04218Cellular senescence2.49E-021P04049RAF1More
Metipranololhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Metipranololhsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Metipranololhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Metipranololhsa04360Axon guidance2.49E-021P04049RAF1More
Metipranololhsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Metipranololhsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Metipranololhsa04510Focal adhesion3.48E-021P04049RAF1More
Metipranololhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Metipranololhsa04540Gap junction1.33E-021P04049RAF1More
Metipranololhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Metipranololhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Metipranololhsa04613Neutrophil extracellular trap formation6.16E-069P04049, P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431RAF1, ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Metipranololhsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Metipranololhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Metipranololhsa04650Natural killer cell mediated cytotoxicity2.93E-058P01375, P20963, P04049, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Metipranololhsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Metipranololhsa04660T cell receptor signaling pathway1.66E-021P04049RAF1More
Metipranololhsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Metipranololhsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Metipranololhsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Metipranololhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Metipranololhsa04720Long-term potentiation1.66E-021P04049RAF1More
Metipranololhsa04722Neurotrophin signaling pathway2.32E-021P04049RAF1More
Metipranololhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Metipranololhsa04730Long-term depression1.16E-021P04049RAF1More
Metipranololhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Metipranololhsa04742Taste transduction1.01E-021P30939HTR1FMore
Metipranololhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Metipranololhsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Metipranololhsa04912GnRH signaling pathway1.82E-021P04049RAF1More
Metipranololhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Metipranololhsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Metipranololhsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Metipranololhsa04916Melanogenesis1.33E-021P04049RAF1More
Metipranololhsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Metipranololhsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Metipranololhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Metipranololhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Metipranololhsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Metipranololhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Metipranololhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Metipranololhsa04929GnRH secretion4.98E-031P04049RAF1More
Metipranololhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Metipranololhsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Metipranololhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Metipranololhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Metipranololhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Metipranololhsa05034Alcoholism1.81E-068Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Metipranololhsa05132Salmonella infection4.98E-021P04049RAF1More
Metipranololhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Metipranololhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Metipranololhsa05152Tuberculosis3.98E-021P04049RAF1More
Metipranololhsa05160Hepatitis C1.99E-021P04049RAF1More
Metipranololhsa05161Hepatitis B1.99E-021P04049RAF1More
Metipranololhsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Metipranololhsa05164Influenza A3.65E-021P04049RAF1More
Metipranololhsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Metipranololhsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Metipranololhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Metipranololhsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Metipranololhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Metipranololhsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Metipranololhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Metipranololhsa05210Colorectal cancer1.66E-021P04049RAF1More
Metipranololhsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Metipranololhsa05212Pancreatic cancer1.16E-021P04049RAF1More
Metipranololhsa05213Endometrial cancer9.95E-031P04049RAF1More
Metipranololhsa05214Glioma9.95E-031P04049RAF1More
Metipranololhsa05215Prostate cancer1.33E-021P04049RAF1More
Metipranololhsa05218Melanoma6.63E-031P04049RAF1More
Metipranololhsa05219Bladder cancer4.98E-031P04049RAF1More
Metipranololhsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Metipranololhsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Metipranololhsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Metipranololhsa05224Breast cancer1.49E-021P04049RAF1More
Metipranololhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Metipranololhsa05226Gastric cancer8.29E-031P04049RAF1More
Metipranololhsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Metipranololhsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Metipranololhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More
Metipranololhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Metipranololhsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Metipranololhsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More

Community members of Metipranolol (SDC: 4.45)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)