PharmaCoNets of Methysergide (SPCN: 94.49 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Methysergidehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Methysergidehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Methysergidehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Methysergidehsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Methysergidehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Methysergidehsa00630Glyoxylate and dicarboxylate metabolism8.89E-043P40926, P05166, P15104MDH2, PCCB, GLULMore
Methysergidehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Methysergidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Methysergidehsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Methysergidehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Methysergidehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Methysergidehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Methysergidehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Methysergidehsa03013RNA transport5.66E-038P62826, Q15287, Q9UBU9, P35658, P63279, P68104, P55884, Q9H777RAN, RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, ELAC1More
Methysergidehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Methysergidehsa03410Base excision repair7.59E-031P27695APEX1More
Methysergidehsa03430Mismatch repair4.38E-021P20585MSH3More
Methysergidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Methysergidehsa04015Rap1 signaling pathway9.14E-032P06213, O00522INSR, KRIT1More
Methysergidehsa04020Calcium signaling pathway1.24E-026Q96DU7, Q08828, Q13557, P21860, P0DP24, P05141ITPKC, ADCY1, CAMK2D, ERBB3, CALM2, SLC25A5More
Methysergidehsa04022cGMP-PKG signaling pathway2.84E-026Q02153, Q99941, P18848, Q08828, P05141, P0DP24GUCY1B3, CREBL1, ATF4, ADCY1, SLC25A5, CALM2More
Methysergidehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Methysergidehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Methysergidehsa04064NF-kappa B signaling pathway1.98E-0415P10415, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643BCL2, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Methysergidehsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Methysergidehsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Methysergidehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Methysergidehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Methysergidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Methysergidehsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Methysergidehsa04141Protein processing in endoplasmic reticulum5.27E-048P18848, Q15437, Q15436, Q99941, P11142, Q9H3Z4, P07900, Q9NR31ATF4, SEC23B, SEC23A, CREBL1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Methysergidehsa04145Phagosome3.69E-027O75015, Q15080, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Methysergidehsa04151PI3K-Akt signaling pathway4.86E-0411P62753, P21860, P27348, P07900, P62873, P61952, Q16363, P22105, Q99941, P18848, O00141RPS6, ERBB3, YWHAQ, HSP90AA1, GNB1, GNG11, LAMA4, TNXB, CREBL1, ATF4, SGKMore
Methysergidehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Methysergidehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Methysergidehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Methysergidehsa04217Necroptosis2.92E-0310P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2DMore
Methysergidehsa04261Adrenergic signaling in cardiomyocytes1.33E-037P07550, P51828, P22694, Q99941, P18848, Q13362, Q13557ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CAMK2DMore
Methysergidehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Methysergidehsa04371Apelin signaling pathway3.80E-025P62873, P61952, Q08828, P62753, P0DP24GNB1, GNG11, ADCY1, RPS6, CALM2More
Methysergidehsa04612Antigen processing and presentation3.33E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Methysergidehsa04640Hematopoietic cell lineage2.27E-0312P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNFMore
Methysergidehsa04650Natural killer cell mediated cytotoxicity4.87E-0713P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Methysergidehsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Methysergidehsa04658Th1 and Th2 cell differentiation4.98E-0612Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Methysergidehsa04659Th17 cell differentiation1.24E-0412Q04759, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Methysergidehsa04660T cell receptor signaling pathway5.90E-0513P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Methysergidehsa04668TNF signaling pathway1.48E-038P01375, Q99941, P18848, P19875, P01584, P14780, P20333, O95429TNF, CREBL1, ATF4, CXCL2, IL1B, MMP9, TNFRSF1B, BAG4More
Methysergidehsa04713Circadian entrainment4.35E-046P0DP24, Q13557, Q02153, P62873, P61952, Q08828CALM2, CAMK2D, GUCY1B3, GNB1, GNG11, ADCY1More
Methysergidehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Methysergidehsa04720Long-term potentiation2.60E-024Q13557, P0DP24, P18848, Q08828CAMK2D, CALM2, ATF4, ADCY1More
Methysergidehsa04722Neurotrophin signaling pathway1.98E-035Q05655, P49841, O43524, P48023, P52566PRKCD, GSK3B, FOXO3, FASLG, ARHGDIBMore
Methysergidehsa04723Retrograde endocannabinoid signaling3.71E-024P62873, P61952, Q08828, O15239GNB1, GNG11, ADCY1, NDUFA1More
Methysergidehsa04724Glutamatergic synapse2.60E-024Q08828, P62873, P61952, P15104ADCY1, GNB1, GNG11, GLULMore
Methysergidehsa04725Cholinergic synapse6.66E-046Q08828, P51828, P62873, P61952, P18848, Q13557ADCY1, ADCY7, GNB1, GNG11, ATF4, CAMK2DMore
Methysergidehsa04727GABAergic synapse1.52E-025Q08828, P62873, P61952, P15104, Q15111ADCY1, GNB1, GNG11, GLUL, PLCL1More
Methysergidehsa04728Dopaminergic synapse2.50E-047P62873, P61952, Q99941, P18848, Q13557, P0DP24, O15516GNB1, GNG11, CREBL1, ATF4, CAMK2D, CALM2, CLOCKMore
Methysergidehsa04740Olfactory transduction1.17E-034P62873, Q9H255, Q13557, P0DP24GNB1, OR51E2, CAMK2D, CALM2More
Methysergidehsa04742Taste transduction1.01E-021P30939HTR1FMore
Methysergidehsa04744Phototransduction4.22E-022P62873, P0DP24GNB1, CALM2More
Methysergidehsa04750Inflammatory mediator regulation of TRP channels7.19E-049P14778, P01584, Q08828, Q13557, P19174, P42338, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY1, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2More
Methysergidehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Methysergidehsa04911Insulin secretion2.15E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Methysergidehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Methysergidehsa04913Ovarian steroidogenesis2.45E-033P42330, P22694, P06213AKR1C3, PRKACB, INSRMore
Methysergidehsa04915Estrogen signaling pathway4.25E-047Q99941, P18848, Q08828, P51828, P07900, P11142, P0DP24CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA8, CALM2More
Methysergidehsa04918Thyroid hormone synthesis3.37E-045Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Methysergidehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Methysergidehsa04923Regulation of lipolysis in adipocytes4.24E-034P07550, P06213, P42338, Q9Y4H2ADRB2, INSR, PIK3CB, IRS2More
Methysergidehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Methysergidehsa04925Aldosterone synthesis and secretion4.69E-056Q99941, P18848, Q08828, P51828, P0DP24, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2DMore
Methysergidehsa04926Relaxin signaling pathway1.50E-049P62873, P61952, Q99941, P18848, P22694, P14780, Q08828, P51828, P30679GNB1, GNG11, CREBL1, ATF4, PRKACB, MMP9, ADCY1, ADCY7, GNA15More
Methysergidehsa04927Cortisol synthesis and secretion3.49E-055Q99941, P18848, Q08828, P51828, P22694CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Methysergidehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Methysergidehsa04930Type II diabetes mellitus1.48E-032P06213, Q05655INSR, PRKCDMore
Methysergidehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Methysergidehsa04932Non-alcoholic fatty liver disease3.08E-038P01375, P49841, P18848, P48023, P01584, P13073, P12074, O15239TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, COX6A1, NDUFA1More
Methysergidehsa04934Cushing syndrome1.55E-045Q99941, P18848, Q08828, P51828, Q13557CREBL1, ATF4, ADCY1, ADCY7, CAMK2DMore
Methysergidehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Methysergidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Methysergidehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Methysergidehsa04970Salivary secretion2.25E-036P07550, Q08828, P22694, P0DP24, Q02153, P49913ADRB2, ADCY1, PRKACB, CALM2, GUCY1B3, CAMPMore
Methysergidehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Methysergidehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Methysergidehsa05012Parkinson disease4.13E-028O15239, P13073, P12074, P05496, P05141, P18848, P0DP24, Q13557NDUFA1, COX4I1, COX6A1, ATP5G1, SLC25A5, ATF4, CALM2, CAMK2DMore
Methysergidehsa05020Prion disease1.86E-0210P01584, P46531, P11142, O15239, P05496, P13073, P12074, P18848, P05141, Q99941IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, CREBL1More
Methysergidehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Methysergidehsa05031Amphetamine addiction3.49E-056P0DP24, Q13557, P22694, Q99941, P18848, Q13547CALM2, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Methysergidehsa05034Alcoholism6.15E-036Q99941, P18848, P0DP24, P62873, P61952, P0C0S5CREBL1, ATF4, CALM2, GNB1, GNG11, H2AFZMore
Methysergidehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Methysergidehsa05131Shigellosis2.57E-022Q05655, P07737PRKCD, PFN1More
Methysergidehsa05132Salmonella infection4.88E-022P84095, P07737RHOG, PFN1More
Methysergidehsa05134Legionellosis8.12E-047P01584, Q9NR31, P11215, P68104, P11142, P09341, P19875IL1B, SAR1A, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Methysergidehsa05140Leishmaniasis3.53E-026P13612, O75015, P13765, O60603, P01375, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, NCF4More
Methysergidehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Methysergidehsa05144Malaria6.75E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Methysergidehsa05146Amoebiasis2.46E-0613P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Methysergidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Methysergidehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Methysergidehsa05163Human cytomegalovirus infection2.89E-028P62873, P61952, P0DP24, Q08828, P01584, Q99941, P18848, P61769GNB1, GNG11, CALM2, ADCY1, IL1B, CREBL1, ATF4, B2MMore
Methysergidehsa05202Transcriptional misregulation in cancer2.35E-0212Q13315, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Methysergidehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Methysergidehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Methysergidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Methysergidehsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Methysergidehsa05321Inflammatory bowel disease1.17E-057O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Methysergidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Methysergidehsa05332Graft-versus-host disease7.00E-055P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More

Community members of Methysergide (SDC: 6.32)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30939HTR1F5Nonehydroxytryptamine receptor 1FReported00.000910.01982.0202
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)