| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Methyltestosterone | hsa00020 | Citrate cycle (TCA cycle) | 3.41E-02 | 2 | P50213, O14521 | IDH3A, SDHD | More | | | Methyltestosterone | hsa00030 | Pentose phosphate pathway | 3.67E-03 | 3 | P60891, P11413, P37837 | PRPS1, G6PD, TALDO1 | More | | | Methyltestosterone | hsa00052 | Galactose metabolism | 1.03E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Methyltestosterone | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Methyltestosterone | hsa00071 | Fatty acid degradation | 3.77E-02 | 3 | O75521, P11766, P33121 | ECI2, ADH5, ACSL1 | More | | | Methyltestosterone | hsa00190 | Oxidative phosphorylation | 9.21E-05 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Methyltestosterone | hsa00220 | Arginine biosynthesis | 4.88E-02 | 1 | P49448 | GLUD2 | More | | | Methyltestosterone | hsa00250 | Alanine, aspartate and glutamate metabolism | 4.88E-02 | 1 | P49448 | GLUD2 | More | | | Methyltestosterone | hsa00471 | D-Glutamine and D-glutamate metabolism | 1.65E-02 | 1 | P49448 | GLUD2 | More | | | Methyltestosterone | hsa00480 | Glutathione metabolism | 1.35E-02 | 1 | P11413 | G6PD | More | | | Methyltestosterone | hsa00500 | Starch and sucrose metabolism | 1.00E-03 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Methyltestosterone | hsa00512 | Mucin type O-glycan biosynthesis | 3.78E-02 | 2 | O95395, Q8N4A0 | GCNT3, GALNT4 | More | | | Methyltestosterone | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 3.43E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Methyltestosterone | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Methyltestosterone | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Methyltestosterone | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Methyltestosterone | hsa00600 | Sphingolipid metabolism | 3.76E-02 | 1 | P15289 | ARSA | More | | | Methyltestosterone | hsa00630 | Glyoxylate and dicarboxylate metabolism | 1.88E-05 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Methyltestosterone | hsa00730 | Thiamine metabolism | 5.29E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Methyltestosterone | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Methyltestosterone | hsa00860 | Porphyrin and chlorophyll metabolism | 1.69E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Methyltestosterone | hsa00910 | Nitrogen metabolism | 4.88E-02 | 1 | P49448 | GLUD2 | More | | | Methyltestosterone | hsa00920 | Sulfur metabolism | 3.18E-02 | 1 | Q16762 | TST | More | | | Methyltestosterone | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.35E-05 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | | Methyltestosterone | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Methyltestosterone | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Methyltestosterone | hsa00983 | Drug metabolism - other enzymes | 2.44E-02 | 2 | P32320, P05164 | CDA, MPO | More | | | Methyltestosterone | hsa01200 | Carbon metabolism | 2.91E-02 | 1 | P11413 | G6PD | More | | | Methyltestosterone | hsa01210 | 2-Oxocarboxylic acid metabolism | 3.43E-02 | 1 | P50213 | IDH3A | More | | | Methyltestosterone | hsa01230 | Biosynthesis of amino acids | 3.27E-03 | 5 | P51854, P60891, Q99707, P50213, P37837 | TKTL1, PRPS1, MTR, IDH3A, TALDO1 | More | | | Methyltestosterone | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa01522 | Endocrine resistance | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa01523 | Antifolate resistance | 1.43E-03 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Methyltestosterone | hsa02010 | ABC transporters | 4.93E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Methyltestosterone | hsa03008 | Ribosome biogenesis in eukaryotes | 2.40E-03 | 5 | P19784, P67870, O14980, O60832, Q9BVP2 | CSNK2A2, CSNK2B, XPO1, DKC1, GNL3 | More | | | Methyltestosterone | hsa03013 | RNA transport | 7.80E-06 | 15 | P62826, O14980, P52298, O14893, P61326, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, Q14240, P23588, Q9Y6A5, Q14232 | RAN, XPO1, NCBP2, GEMIN2, MAGOH, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF4A2, EIF4B, TACC3, EIF2B1 | More | | | Methyltestosterone | hsa03020 | RNA polymerase | 6.21E-04 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | | | Methyltestosterone | hsa03040 | Spliceosome | 4.48E-08 | 14 | Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.76 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.787 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.712 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.822 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| | Methyltestosterone | hsa03060 | Protein export | 3.28E-02 | 1 | Q15070 | OXA1L | More | | | Methyltestosterone | hsa03430 | Mismatch repair | 4.38E-02 | 1 | P20585 | MSH3 | More | | | Methyltestosterone | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | | Methyltestosterone | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa04014 | Ras signaling pathway | 9.55E-04 | 9 | P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174 | PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1 | More | | | Methyltestosterone | hsa04015 | Rap1 signaling pathway | 9.79E-05 | 14 | P20827, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P08514, P19174 | EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, ITGA2B, PLCG1 | More | | | Methyltestosterone | hsa04020 | Calcium signaling pathway | 4.83E-02 | 4 | Q08828, P0DP23, P05141, P51828 | ADCY1, CALM1, SLC25A5, ADCY7 | More | | | Methyltestosterone | hsa04022 | cGMP-PKG signaling pathway | 4.38E-03 | 6 | P18848, P31751, Q08828, P51828, P05141, P0DP23 | ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1 | More | | | Methyltestosterone | hsa04024 | cAMP signaling pathway | 5.36E-04 | 10 | P63092, Q08828, P51828, P42338, P31751, P26678, P0DP23, P61586, Q13370, Q13009 | GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM1, RHOA, PDE3B, TIAM1 | More | | | Methyltestosterone | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.79E-03 | 7 | Q8NHW4, P09341, P19875, P25024, P25025, Q13651, P14784 | CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RB | More | | | Methyltestosterone | hsa04062 | Chemokine signaling pathway | 5.65E-04 | 14 | P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1 | CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5 | More | | | Methyltestosterone | hsa04064 | NF-kappa B signaling pathway | 1.60E-05 | 15 | Q13489, Q13546, P14778, P01584, P19174, Q04759, Q9UDY8, P06239, P63279, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7 | BIRC3, RIPK1, IL1R1, IL1B, PLCG1, PRKCQ, MALT1, LCK, UBE2I, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLD | More | | | Methyltestosterone | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa04070 | Phosphatidylinositol signaling system | 1.28E-03 | 6 | P0DP23, P42338, O14986, Q16760, P48426, P27987 | CALM1, PIK3CB, PIP5K1B, DGKD, PIP4K2A, ITPKB | More | | | Methyltestosterone | hsa04071 | Sphingolipid signaling pathway | 1.94E-02 | 3 | Q9H228, P01375, Q9UQC2 | EDG8, TNF, GAB2 | More | | | Methyltestosterone | hsa04072 | Phospholipase D signaling pathway | 5.40E-05 | 13 | P31751, P42338, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760 | AKT2, PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKD | More | | | Methyltestosterone | hsa04080 | Neuroactive ligand-receptor interaction | 3.70E-02 | 7 | P08311, P48058, Q15722, Q9H228, P43657, P21730, P35318 | CTSG, GRIA4, LTB4R, EDG8, P2RY5, C5AR1, ADM | More | | | Methyltestosterone | hsa04110 | Cell cycle | 1.97E-05 | 7 | P06493, O60566, O75293, P30304, P33981, P42773, P01106 | CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC | More | | | Methyltestosterone | hsa04114 | Oocyte meiosis | 1.78E-04 | 10 | P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069 | RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1R | More | | | Methyltestosterone | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Methyltestosterone | hsa04122 | Sulfur relay system | 3.18E-02 | 1 | Q16762 | TST | More | | | Methyltestosterone | hsa04136 | Autophagy - other | 5.92E-03 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | | Methyltestosterone | hsa04137 | Mitophagy - animal | 2.52E-02 | 2 | P19784, P67870 | CSNK2A2, CSNK2B | More | | | Methyltestosterone | hsa04140 | Autophagy - animal | 4.41E-03 | 6 | P08069, P31751, Q7L523, O75460, Q96GC9, Q8TEV9 | IGF1R, AKT2, RRAGA, ERN1, TMEM49, SMCR8 | More | | | Methyltestosterone | hsa04141 | Protein processing in endoplasmic reticulum | 2.78E-02 | 3 | P07384, O95487, O95816 | CAPN1, SEC24B, BAG2 | More | | | Methyltestosterone | hsa04150 | mTOR signaling pathway | 7.74E-03 | 4 | P08069, Q02750, Q9NQL2, P51812 | IGF1R, MAP2K1, RRAGD, RPS6KA3 | More | | | Methyltestosterone | hsa04151 | PI3K-Akt signaling pathway | 1.89E-03 | 12 | P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281 | PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3 | More | | | Methyltestosterone | hsa04152 | AMPK signaling pathway | 2.07E-03 | 3 | P08069, Q96EB6, P36956 | IGF1R, SIRT1, SREBF1 | More | | | Methyltestosterone | hsa04210 | Apoptosis | 3.58E-02 | 4 | O76075, P01375, Q9NR28, Q16548 | DFFB, TNF, DIABLO, BCL2A1 | More | | | Methyltestosterone | hsa04211 | Longevity regulating pathway | 1.96E-04 | 8 | Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96KQ7 | FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, EHMT2 | More | | | Methyltestosterone | hsa04213 | Longevity regulating pathway - multiple species | 1.50E-04 | 8 | P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P11142, Q13547 | AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA8, HDAC1 | More | | | Methyltestosterone | hsa04215 | Apoptosis - multiple species | 1.56E-02 | 2 | Q13489, P10415 | BIRC3, BCL2 | More | | | Methyltestosterone | hsa04217 | Necroptosis | 2.34E-05 | 13 | P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID | More | | | Methyltestosterone | hsa04218 | Cellular senescence | 4.79E-02 | 4 | P01106, O75293, P30304, P06493 | MYC, GADD45B, CDC25A, CDK1 | More | | | Methyltestosterone | hsa04261 | Adrenergic signaling in cardiomyocytes | 4.98E-04 | 7 | Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23 | ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1 | More | | | Methyltestosterone | hsa04310 | Wnt signaling pathway | 4.17E-03 | 3 | P61586, P19784, P67870 | RHOA, CSNK2A2, CSNK2B | More | | | Methyltestosterone | hsa04340 | Hedgehog signaling pathway | 3.32E-02 | 2 | P49841, P22694 | GSK3B, PRKACB | More | | | Methyltestosterone | hsa04360 | Axon guidance | 1.58E-04 | 8 | P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124 | NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11 | More | | | Methyltestosterone | hsa04370 | VEGF signaling pathway | 2.68E-03 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | | Methyltestosterone | hsa04371 | Apelin signaling pathway | 1.11E-03 | 11 | P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23 | GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1 | More | | | Methyltestosterone | hsa04380 | Osteoclast differentiation | 1.88E-02 | 4 | Q9NQC7, P23458, P31751, P01584 | CYLD, JAK1, AKT2, IL1B | More | | | Methyltestosterone | hsa04390 | Hippo signaling pathway | 2.08E-02 | 3 | P84022, Q13485, Q13489 | SMAD3, SMAD4, BIRC3 | More | | | Methyltestosterone | hsa04510 | Focal adhesion | 8.84E-03 | 4 | O14986, P61586, Q16363, P08069 | PIP5K1B, RHOA, LAMA4, IGF1R | More | | | Methyltestosterone | hsa04512 | ECM-receptor interaction | 3.73E-02 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | | | Methyltestosterone | hsa04514 | Cell adhesion molecules | 8.19E-03 | 3 | P16109, P56750, O00501 | SELP, CLDN17, CLDN5 | More | | | Methyltestosterone | hsa04520 | Adherens junction | 1.65E-05 | 4 | P08069, P19784, P67870, P61586 | IGF1R, CSNK2A2, CSNK2B, RHOA | More | | | Methyltestosterone | hsa04530 | Tight junction | 1.64E-06 | 8 | Q8TEU7, P63261, P16989, P56750, O00501, Q9Y478, Q92974, Q14247 | RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, PRKAB1, ARHGEF2, CTTN | More | | | Methyltestosterone | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa04610 | Complement and coagulation cascades | 1.03E-03 | 3 | P25116, P09871, P0C0L4 | F2R, C1S, C4A | More | | | Methyltestosterone | hsa04611 | Platelet activation | 5.18E-05 | 5 | P25116, P08514, Q15746, Q8WYR1, P07359 | F2R, ITGA2B, MYLK, PIK3R5, GP1BA | More | | | Methyltestosterone | hsa04613 | Neutrophil extracellular trap formation | 1.07E-05 | 11 | P16109, P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, P08514, P07359 | SELP, ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ITGA2B, GP1BA | More | | | Methyltestosterone | hsa04620 | Toll-like receptor signaling pathway | 4.30E-04 | 5 | Q13546, P01568, P01584, P31751, Q8NHW4 | RIPK1, IFNA21, IL1B, AKT2, CCL4L2 | More | | | Methyltestosterone | hsa04621 | NOD-like receptor signaling pathway | 4.72E-02 | 3 | P01568, Q13489, Q13546 | IFNA21, BIRC3, RIPK1 | More | | | Methyltestosterone | hsa04622 | RIG-I-like receptor signaling pathway | 2.39E-02 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | | | Methyltestosterone | hsa04623 | Cytosolic DNA-sensing pathway | 8.89E-08 | 6 | P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4 | IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2 | More | | | Methyltestosterone | hsa04625 | C-type lectin receptor signaling pathway | 9.86E-03 | 4 | P01584, Q9NQC7, P31751, P0DP23 | IL1B, CYLD, AKT2, CALM1 | More | | | Methyltestosterone | hsa04630 | JAK-STAT signaling pathway | 4.54E-02 | 3 | P31751, P23458, Q13651 | AKT2, JAK1, IL10RA | More | | | Methyltestosterone | hsa04640 | Hematopoietic cell lineage | 1.15E-05 | 13 | P13612, P21926, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P06127, P09564 | ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7 | More | | | Methyltestosterone | hsa04650 | Natural killer cell mediated cytotoxicity | 8.24E-07 | 15 | P16298, P50591, P19174, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715 | PPP3CB, TNFSF10, PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | | Methyltestosterone | hsa04657 | IL-17 signaling pathway | 3.31E-02 | 3 | P49841, P14780, P01375 | GSK3B, MMP9, TNF | More | | | Methyltestosterone | hsa04658 | Th1 and Th2 cell differentiation | 9.26E-08 | 12 | Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P23771, Q9UL17, P14784, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, RUNX3 | More | | | Methyltestosterone | hsa04659 | Th17 cell differentiation | 1.89E-09 | 18 | P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963 | NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.728 | | O43451 | MGAM | Maltase-glucoamylase | Q04759 | PRKCQ | Protein kinase C theta type | -0.777 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | O43451 | MGAM | Maltase-glucoamylase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.871 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | O43451 | MGAM | Maltase-glucoamylase | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.724 | | O43451 | MGAM | Maltase-glucoamylase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.748 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | O43451 | MGAM | Maltase-glucoamylase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.924 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | | O43451 | MGAM | Maltase-glucoamylase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.799 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | O43451 | MGAM | Maltase-glucoamylase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.771 | | O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.769 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.721 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | O43451 | MGAM | Maltase-glucoamylase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.73 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | | O43451 | MGAM | Maltase-glucoamylase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.755 | | O43451 | MGAM | Maltase-glucoamylase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.79 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 |
| | Methyltestosterone | hsa04660 | T cell receptor signaling pathway | 7.40E-06 | 12 | Q04759, P42338, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | | Methyltestosterone | hsa04662 | B cell receptor signaling pathway | 9.03E-05 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Methyltestosterone | hsa04664 | Fc epsilon RI signaling pathway | 1.29E-03 | 4 | P42338, P07948, P19174, P09917 | PIK3CB, LYN, PLCG1, ALOX5 | More | | | Methyltestosterone | hsa04666 | Fc gamma R-mediated phagocytosis | 3.08E-02 | 3 | P42338, P23528, P14598 | PIK3CB, CFL1, NCF1 | More | | | Methyltestosterone | hsa04713 | Circadian entrainment | 5.44E-03 | 5 | P0DP23, P62873, Q08828, P51828, P63092 | CALM1, GNB1, ADCY1, ADCY7, GNAS | More | | | Methyltestosterone | hsa04714 | Thermogenesis | 1.25E-02 | 3 | P15336, P63261, Q9Y478 | ATF2, ACTG1, PRKAB1 | More | | | Methyltestosterone | hsa04720 | Long-term potentiation | 1.71E-03 | 6 | P16298, P0DP23, P51812, P18848, Q08828, Q02750 | PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1 | More | | | Methyltestosterone | hsa04721 | Synaptic vesicle cycle | 9.45E-04 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Methyltestosterone | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Methyltestosterone | hsa04723 | Retrograde endocannabinoid signaling | 4.94E-02 | 2 | P48169, P62873 | GABRA4, GNB1 | More | | | Methyltestosterone | hsa04724 | Glutamatergic synapse | 2.85E-03 | 5 | P43003, P63092, P62873, P50151, P15104 | SLC1A3, GNAS, GNB1, GNG10, GLUL | More | | | Methyltestosterone | hsa04725 | Cholinergic synapse | 1.39E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | | Methyltestosterone | hsa04726 | Serotonergic synapse | 2.52E-02 | 2 | P63092, P62873 | GNAS, GNB1 | More | | | Methyltestosterone | hsa04728 | Dopaminergic synapse | 7.83E-03 | 5 | P31751, P18848, Q13362, Q14738, P0DP23 | AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1 | More | | | Methyltestosterone | hsa04730 | Long-term depression | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa04750 | Inflammatory mediator regulation of TRP channels | 2.03E-04 | 9 | P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1 | More | | | Methyltestosterone | hsa04810 | Regulation of actin cytoskeleton | 2.58E-02 | 3 | Q15746, P08514, P25116 | MYLK, ITGA2B, F2R | More | | | Methyltestosterone | hsa04910 | Insulin signaling pathway | 2.35E-02 | 3 | P22694, P06737, P49841 | PRKACB, PYGL, GSK3B | More | | | Methyltestosterone | hsa04911 | Insulin secretion | 2.40E-02 | 3 | Q08828, P51828, P18848 | ADCY1, ADCY7, ATF4 | More | | | Methyltestosterone | hsa04912 | GnRH signaling pathway | 1.39E-02 | 4 | Q08828, P51828, P18848, P0DP23 | ADCY1, ADCY7, ATF4, CALM1 | More | | | Methyltestosterone | hsa04913 | Ovarian steroidogenesis | 8.40E-04 | 2 | P06213, P08069 | INSR, IGF1R | More | | | Methyltestosterone | hsa04914 | Progesterone-mediated oocyte maturation | 9.67E-04 | 7 | P08069, Q17RY0, P42338, Q13370, P08238, P51812, Q02750 | IGF1R, CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1 | More | | | Methyltestosterone | hsa04915 | Estrogen signaling pathway | 2.13E-02 | 5 | P18848, Q08828, P51828, P31751, P0DP23 | ATF4, ADCY1, ADCY7, AKT2, CALM1 | More | | | Methyltestosterone | hsa04916 | Melanogenesis | 2.40E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | | Methyltestosterone | hsa04919 | Thyroid hormone signaling pathway | 7.11E-03 | 4 | P49841, P22694, O60244, Q9NVC6 | GSK3B, PRKACB, MED14, MED17 | More | | | Methyltestosterone | hsa04920 | Adipocytokine signaling pathway | 2.80E-02 | 2 | Q06124, Q9Y478 | PTPN11, PRKAB1 | More | | | Methyltestosterone | hsa04923 | Regulation of lipolysis in adipocytes | 6.16E-05 | 7 | Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751 | ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2 | More | | | Methyltestosterone | hsa04924 | Renin secretion | 3.77E-02 | 2 | Q13370, P0DP23 | PDE3B, CALM1 | More | | | Methyltestosterone | hsa04925 | Aldosterone synthesis and secretion | 9.86E-03 | 4 | P18848, Q08828, P51828, P0DP23 | ATF4, ADCY1, ADCY7, CALM1 | More | | | Methyltestosterone | hsa04926 | Relaxin signaling pathway | 2.46E-02 | 4 | P31751, P18848, Q08828, P51828 | AKT2, ATF4, ADCY1, ADCY7 | More | | | Methyltestosterone | hsa04927 | Cortisol synthesis and secretion | 1.59E-02 | 3 | P18848, Q08828, P51828 | ATF4, ADCY1, ADCY7 | More | | | Methyltestosterone | hsa04930 | Type II diabetes mellitus | 3.14E-02 | 1 | P06213 | INSR | More | | | Methyltestosterone | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | | Methyltestosterone | hsa04932 | Non-alcoholic fatty liver disease | 5.87E-04 | 8 | P31751, P01375, P49841, P18848, P48023, O75460, P01584, O95298 | AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFC2 | More | | | Methyltestosterone | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.11E-03 | 6 | P84022, Q13485, P10415, P42338, P49767, P19174 | SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1 | More | | | Methyltestosterone | hsa04934 | Cushing syndrome | 4.54E-02 | 3 | P18848, Q08828, P51828 | ATF4, ADCY1, ADCY7 | More | | | Methyltestosterone | hsa04935 | Growth hormone synthesis, secretion and action | 1.88E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | | Methyltestosterone | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Methyltestosterone | hsa04960 | Aldosterone-regulated sodium reabsorption | 3.14E-02 | 1 | P06213 | INSR | More | | | Methyltestosterone | hsa04964 | Proximal tubule bicarbonate reclamation | 4.53E-03 | 2 | P00918, P49448 | CA2, GLUD2 | More | | | Methyltestosterone | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | | Methyltestosterone | hsa04970 | Salivary secretion | 1.59E-02 | 3 | Q08828, P51828, P0DP23 | ADCY1, ADCY7, CALM1 | More | | | Methyltestosterone | hsa04971 | Gastric acid secretion | 2.54E-03 | 4 | Q08828, P51828, P15311, P0DP23 | ADCY1, ADCY7, VIL2, CALM1 | More | | | Methyltestosterone | hsa04972 | Pancreatic secretion | 3.65E-02 | 2 | P63092, P61586 | GNAS, RHOA | More | | | Methyltestosterone | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Methyltestosterone | hsa04975 | Fat digestion and absorption | 9.50E-04 | 1 | O14494 | PLPP1 | More | | | Methyltestosterone | hsa04976 | Bile secretion | 7.23E-04 | 5 | Q08828, P51828, P22694, P08183, Q14032 | ADCY1, ADCY7, PRKACB, ABCB1, BAAT | More | | | Methyltestosterone | hsa05010 | Alzheimer disease | 4.94E-03 | 9 | O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070 | NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4 | More | | | Methyltestosterone | hsa05016 | Huntington disease | 2.24E-02 | 7 | O95298, P24928, P30876, P62487, P05141, O75460, P28070 | NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4 | More | | | Methyltestosterone | hsa05017 | Spinocerebellar ataxia | 3.94E-02 | 4 | O75460, P31751, P28070, P05141 | ERN1, AKT2, PSMB4, SLC25A5 | More | | | Methyltestosterone | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.67E-02 | 9 | O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070 | NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4 | More | | | Methyltestosterone | hsa05032 | Morphine addiction | 2.47E-03 | 3 | P62873, P48169, P63092 | GNB1, GABRA4, GNAS | More | | | Methyltestosterone | hsa05034 | Alcoholism | 2.05E-05 | 7 | Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431 | HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Methyltestosterone | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 3.32E-04 | 6 | Q16539, P09341, P19875, P19174, P25024, P25025 | MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | | Methyltestosterone | hsa05130 | Pathogenic Escherichia coli infection | 2.02E-04 | 8 | Q14247, P56750, O00501, Q92974, P63261, P25116, Q06124, O95487 | CTTN, CLDN17, CLDN5, ARHGEF2, ACTG1, F2R, PTPN11, SEC24B | More | | | Methyltestosterone | hsa05132 | Salmonella infection | 5.76E-04 | 7 | P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371 | NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2C | More | | | Methyltestosterone | hsa05133 | Pertussis | 1.86E-03 | 3 | P09871, P0C0L4, Q02556 | C1S, C4A, IRF8 | More | | | Methyltestosterone | hsa05134 | Legionellosis | 1.29E-02 | 4 | P11215, P11142, P09341, P19875 | ITGAM, HSPA8, CXCL1, CXCL2 | More | | | Methyltestosterone | hsa05135 | Yersinia infection | 1.52E-02 | 6 | P13612, P06239, Q16539, P49841, P01730, P01732 | ITGA4, LCK, MAPK14, GSK3B, CD4, CD8A | More | | | Methyltestosterone | hsa05140 | Leishmaniasis | 2.18E-04 | 6 | P14598, P42224, O60603, P25963, P29350, Q15080 | NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4 | More | | | Methyltestosterone | hsa05143 | African trypanosomiasis | 7.50E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Methyltestosterone | hsa05144 | Malaria | 3.09E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | | Methyltestosterone | hsa05145 | Toxoplasmosis | 2.78E-02 | 3 | P25963, P10415, Q13489 | NFKBIA, BCL2, BIRC3 | More | | | Methyltestosterone | hsa05146 | Amoebiasis | 2.36E-05 | 9 | P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSG | More | | | Methyltestosterone | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Methyltestosterone | hsa05161 | Hepatitis B | 8.49E-03 | 4 | P25963, Q13485, P10415, P84022 | NFKBIA, SMAD4, BCL2, SMAD3 | More | | | Methyltestosterone | hsa05163 | Human cytomegalovirus infection | 6.70E-06 | 13 | P31751, P62873, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651, P18848, P63092, P61769 | AKT2, GNB1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA, ATF4, GNAS, B2M | More | | | Methyltestosterone | hsa05164 | Influenza A | 4.49E-02 | 5 | P31751, P01584, P23458, P05141, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, NXF1 | More | | | Methyltestosterone | hsa05166 | Human T-cell leukemia virus 1 infection | 3.90E-02 | 7 | P23458, P05141, P62826, Q08828, P51828, P18848, P31751 | JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2 | More | | | Methyltestosterone | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.94E-02 | 4 | P62879, P16298, Q02750, P0CG47 | GNB2, PPP3CB, MAP2K1, UBB | More | | | Methyltestosterone | hsa05168 | Herpes simplex virus 1 infection | 1.38E-04 | 15 | P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212 | More | | | Methyltestosterone | hsa05170 | Human immunodeficiency virus 1 infection | 6.02E-03 | 5 | Q02750, P62879, P16298, Q05397, P20333 | MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B | More | | | Methyltestosterone | hsa05200 | Pathways in cancer | 1.31E-03 | 21 | Q13751, P42338, P08238, P42224, P19174, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 |
| | Methyltestosterone | hsa05202 | Transcriptional misregulation in cancer | 8.55E-04 | 5 | P27930, P11215, P08069, Q13547, P12980 | IL1R2, ITGAM, IGF1R, HDAC1, LYL1 | More | | | Methyltestosterone | hsa05203 | Viral carcinogenesis | 1.22E-03 | 6 | Q13547, Q15283, P58876, P62807, Q16778, O60814 | HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12 | More | | | Methyltestosterone | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Methyltestosterone | hsa05205 | Proteoglycans in cancer | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa05210 | Colorectal cancer | 1.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Methyltestosterone | hsa05211 | Renal cell carcinoma | 1.06E-02 | 2 | Q06124, Q99814 | PTPN11, EPAS1 | More | | | Methyltestosterone | hsa05212 | Pancreatic cancer | 1.59E-05 | 8 | P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293 | PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45B | More | | | Methyltestosterone | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | | Methyltestosterone | hsa05214 | Glioma | 1.88E-03 | 4 | P08069, P0DP23, P42338, O75293 | IGF1R, CALM1, PIK3CB, GADD45B | More | | | Methyltestosterone | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa05216 | Thyroid cancer | 3.80E-02 | 2 | P01106, O75293 | MYC, GADD45B | More | | | Methyltestosterone | hsa05218 | Melanoma | 6.63E-03 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa05220 | Chronic myeloid leukemia | 1.44E-03 | 6 | Q13547, Q13485, P25963, P84022, P42338, O75293 | HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B | More | | | Methyltestosterone | hsa05222 | Small cell lung cancer | 1.50E-02 | 3 | Q13489, P10415, P25963 | BIRC3, BCL2, NFKBIA | More | | | Methyltestosterone | hsa05223 | Non-small cell lung cancer | 1.39E-02 | 3 | P10826, Q9HC35, O75293 | RARB, EML4, GADD45B | More | | | Methyltestosterone | hsa05224 | Breast cancer | 1.49E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa05225 | Hepatocellular carcinoma | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Methyltestosterone | hsa05226 | Gastric cancer | 4.33E-03 | 5 | Q02750, O15169, P84022, Q13485, P10415 | MAP2K1, AXIN1, SMAD3, SMAD4, BCL2 | More | | | Methyltestosterone | hsa05230 | Central carbon metabolism in cancer | 1.12E-02 | 1 | P11413 | G6PD | More | | | Methyltestosterone | hsa05231 | Choline metabolism in cancer | 3.38E-02 | 3 | P31751, Q16760, O14986 | AKT2, DGKD, PIP5K1B | More | | | Methyltestosterone | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 5.28E-06 | 10 | P42338, P19174, P07766, P20963, P09693, P06239, Q04759, Q16539, Q9HC35, P01730 | PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, EML4, CD4 | More | | | Methyltestosterone | hsa05322 | Systemic lupus erythematosus | 4.80E-06 | 7 | P09871, Q93077, P58876, P62807, Q16778, O60814, P68431 | C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Methyltestosterone | hsa05330 | Allograft rejection | 2.72E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Methyltestosterone | hsa05332 | Graft-versus-host disease | 3.70E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Methyltestosterone | hsa05340 | Primary immunodeficiency | 2.90E-04 | 5 | P01730, P01732, P11912, P07766, P06239 | CD4, CD8A, CD79A, CD3E, LCK | More | | | Methyltestosterone | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | | | Methyltestosterone | hsa05415 | Diabetic cardiomyopathy | 7.96E-03 | 7 | P17252, P14598, Q15080, Q16718, O14521, P04406, P11413 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH, G6PD | More | | | Methyltestosterone | hsa05418 | Fluid shear stress and atherosclerosis | 3.73E-02 | 4 | P42338, P14598, P0DP23, P08238 | PIK3CB, NCF1, CALM1, HSP90AB1 | More | |
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