PharmaCoNets of Methylprednisolone (SPCN: 69.49 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Methylprednisolonehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Methylprednisolonehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Methylprednisolonehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Methylprednisolonehsa00190Oxidative phosphorylation8.71E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Methylprednisolonehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Methylprednisolonehsa00500Starch and sucrose metabolism2.00E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Methylprednisolonehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Methylprednisolonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Methylprednisolonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Methylprednisolonehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Methylprednisolonehsa00970Aminoacyl-tRNA biosynthesis1.21E-021P14868DARSMore
Methylprednisolonehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Methylprednisolonehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Methylprednisolonehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Methylprednisolonehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Methylprednisolonehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Methylprednisolonehsa03013RNA transport3.11E-022P68104, Q14232EEF1A1, EIF2B1More
Methylprednisolonehsa04061Viral protein interaction with cytokine and cytokine receptor2.00E-027P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNFMore
Methylprednisolonehsa04064NF-kappa B signaling pathway1.34E-038P10415, Q13489, Q13546, P29965, Q9UDY8, Q8WV28, Q13315, Q9UNE0BCL2, BIRC3, RIPK1, CD40LG, MALT1, BLNK, ATM, EDARMore
Methylprednisolonehsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Methylprednisolonehsa04071Sphingolipid signaling pathway2.87E-037P17252, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2PRKCA, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Methylprednisolonehsa04140Autophagy - animal3.61E-025Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759RRAGD, PRKACB, ITPR1, ATG5, PRKCQMore
Methylprednisolonehsa04141Protein processing in endoplasmic reticulum3.89E-022P17861, Q9NR31XBP1, SAR1AMore
Methylprednisolonehsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Methylprednisolonehsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Methylprednisolonehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Methylprednisolonehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Methylprednisolonehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Methylprednisolonehsa04217Necroptosis9.70E-048P01568, Q13489, Q13546, P42224, Q6FI13, P10415, O43633, Q08752IFNA21, BIRC3, RIPK1, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPIDMore
Methylprednisolonehsa04261Adrenergic signaling in cardiomyocytes2.84E-025P09493, Q13362, P0DP23, P17252, P10415TPM1, PPP2R5C, CALM1, PRKCA, BCL2More
Methylprednisolonehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Methylprednisolonehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Methylprednisolonehsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Methylprednisolonehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Methylprednisolonehsa04612Antigen processing and presentation3.60E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Methylprednisolonehsa04613Neutrophil extracellular trap formation7.05E-0623P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Methylprednisolonehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Methylprednisolonehsa04621NOD-like receptor signaling pathway3.13E-0417Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Methylprednisolonehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Methylprednisolonehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Methylprednisolonehsa04640Hematopoietic cell lineage1.10E-029P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Methylprednisolonehsa04650Natural killer cell mediated cytotoxicity3.11E-049P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Methylprednisolonehsa04657IL-17 signaling pathway1.80E-037O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Methylprednisolonehsa04658Th1 and Th2 cell differentiation5.94E-049Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Methylprednisolonehsa04659Th17 cell differentiation3.91E-039Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247More
Methylprednisolonehsa04660T cell receptor signaling pathway6.95E-0411P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Methylprednisolonehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Methylprednisolonehsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Methylprednisolonehsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Methylprednisolonehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Methylprednisolonehsa04725Cholinergic synapse1.88E-024Q14643, P17252, P62873, P10415ITPR1, PRKCA, GNB1, BCL2More
Methylprednisolonehsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Methylprednisolonehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Methylprednisolonehsa04750Inflammatory mediator regulation of TRP channels3.61E-025P14778, P22694, Q16539, Q14643, Q04759IL1R1, PRKACB, MAPK14, ITPR1, PRKCQMore
Methylprednisolonehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Methylprednisolonehsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Methylprednisolonehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Methylprednisolonehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Methylprednisolonehsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Methylprednisolonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Methylprednisolonehsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Methylprednisolonehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Methylprednisolonehsa04966Collecting duct acid secretion2.07E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Methylprednisolonehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Methylprednisolonehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Methylprednisolonehsa05010Alzheimer disease1.07E-0210Q16718, O14521, Q06055, Q14643, P0DP23, Q13509, P68371, Q08752, P17861, P62195NDUFA5, SDHD, ATP5G2, ITPR1, CALM1, TUBB3, TUBB2C, PPID, XBP1, PSMC5More
Methylprednisolonehsa05012Parkinson disease5.36E-039Q16718, O14521, Q06055, P17861, P62195, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ATP5G2, XBP1, PSMC5, ITPR1, CALM1, TUBB3, TUBB2CMore
Methylprednisolonehsa05014Amyotrophic lateral sclerosis1.01E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Methylprednisolonehsa05017Spinocerebellar ataxia1.42E-022P17861, P62195XBP1, PSMC5More
Methylprednisolonehsa05020Prion disease1.15E-027Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Methylprednisolonehsa05022Pathways of neurodegeneration - multiple diseases1.98E-0313Q14643, Q13509, P68371, P10415, Q16718, O14521, Q06055, P17861, Q13561, P17252, Q08752, P0DP23, P62195ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, ATP5G2, XBP1, DCTN2, PRKCA, PPID, CALM1, PSMC5More
Methylprednisolonehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Methylprednisolonehsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Methylprednisolonehsa05132Salmonella infection5.51E-0410Q9UJU2, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371LEF1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Methylprednisolonehsa05133Pertussis4.20E-021P0C0L4C4AMore
Methylprednisolonehsa05134Legionellosis5.53E-032Q9NR31, P68104SAR1A, EEF1A1More
Methylprednisolonehsa05135Yersinia infection3.72E-026P13612, P06239, Q16539, P01375, P49841, P01732ITGA4, LCK, MAPK14, TNF, GSK3B, CD8AMore
Methylprednisolonehsa05140Leishmaniasis2.45E-0410P13612, O75015, P14598, P42224, P13765, O60603, P01375, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, TNF, PTPN6, MAPK14, NCF4More
Methylprednisolonehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Methylprednisolonehsa05144Malaria9.96E-057P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Methylprednisolonehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Methylprednisolonehsa05146Amoebiasis5.94E-049P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Methylprednisolonehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Methylprednisolonehsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Methylprednisolonehsa05163Human cytomegalovirus infection2.51E-029P01375, Q14643, P22694, P49841, P14778, Q13651, P25025, Q16539, O00463TNF, ITPR1, PRKACB, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5More
Methylprednisolonehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Methylprednisolonehsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Methylprednisolonehsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Methylprednisolonehsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Methylprednisolonehsa05202Transcriptional misregulation in cancer4.29E-0313P14780, P27930, Q15744, Q16548, P11215, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Methylprednisolonehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Methylprednisolonehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Methylprednisolonehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Methylprednisolonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.42E-027O95267, P20963, P09693, P06239, O60603, Q04759, Q16539RASGRP1, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14More
Methylprednisolonehsa05310Asthma1.62E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Methylprednisolonehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Methylprednisolonehsa05321Inflammatory bowel disease1.09E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Methylprednisolonehsa05322Systemic lupus erythematosus2.33E-0712P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Methylprednisolonehsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Methylprednisolonehsa05330Allograft rejection1.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Methylprednisolonehsa05332Graft-versus-host disease1.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Methylprednisolonehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Methylprednisolonehsa05415Diabetic cardiomyopathy2.33E-026P17252, P14598, Q15080, Q16718, O14521, P11413PRKCA, NCF1, NCF4, NDUFA5, SDHD, G6PDMore
Methylprednisolonehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Methylprednisolone (SDC: 4.72)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P12429ANXA3Annexin A3Predicted00.44920.06300.3507
P08758ANXA5Annexin A5Predicted10.21280.054300.215
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)