PharmaCoNets of Methyldopa (SPCN: 5.51 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Methyldopahsa00500Starch and sucrose metabolism4.43E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Methyldopahsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Methyldopahsa03060Protein export3.28E-022Q15070, O76094OXA1L, SRP72More
Methyldopahsa03410Base excision repair7.59E-031P27695APEX1More
Methyldopahsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Methyldopahsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Methyldopahsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Methyldopahsa04621NOD-like receptor signaling pathway3.15E-0210Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Methyldopahsa04650Natural killer cell mediated cytotoxicity1.37E-029P01375, P78314, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Methyldopahsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Methyldopahsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Methyldopahsa04742Taste transduction1.01E-021P30939HTR1FMore
Methyldopahsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Methyldopahsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Methyldopahsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Methyldopahsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Methyldopahsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Methyldopahsa05163Human cytomegalovirus infection4.07E-029P01375, P63218, P50151, Q14643, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Methyldopahsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Methyldopahsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Methyldopa (SDC: 2.21)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
O75475PSIP1PC4 and SFRS1Noneinteracting proteinPredicted00.33320.063800.2943
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)