PharmaCoNets of Methsuximide (SPCN: 24.62 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Methsuximidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Methsuximidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Methsuximidehsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Methsuximidehsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Methsuximidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Methsuximidehsa03013RNA transport4.09E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Methsuximidehsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Methsuximidehsa04064NF-kappa B signaling pathway1.91E-0412P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45AMore
Methsuximidehsa04071Sphingolipid signaling pathway9.39E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Methsuximidehsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Methsuximidehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Methsuximidehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Methsuximidehsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Methsuximidehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Methsuximidehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Methsuximidehsa04217Necroptosis1.93E-024P01568, Q13489, Q13546, Q6FI13IFNA21, BIRC3, RIPK1, H2AC18; H2AC19More
Methsuximidehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Methsuximidehsa04390Hippo signaling pathway5.79E-034P04628, Q9UJU2, O43623, Q13489WNT1, LEF1, SNAI2, BIRC3More
Methsuximidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Methsuximidehsa04613Neutrophil extracellular trap formation1.30E-0313P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Methsuximidehsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Methsuximidehsa04623Cytosolic DNA-sensing pathway5.29E-032P01568, Q13546IFNA21, RIPK1More
Methsuximidehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Methsuximidehsa04660T cell receptor signaling pathway4.20E-027P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITKMore
Methsuximidehsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Methsuximidehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Methsuximidehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Methsuximidehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Methsuximidehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Methsuximidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Methsuximidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Methsuximidehsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Methsuximidehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Methsuximidehsa05132Salmonella infection5.54E-0413P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Methsuximidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Methsuximidehsa05140Leishmaniasis1.18E-027P14598, P13765, O60603, P25963, P01375, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4More
Methsuximidehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Methsuximidehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Methsuximidehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Methsuximidehsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Methsuximidehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Methsuximidehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Methsuximidehsa05170Human immunodeficiency virus 1 infection2.58E-0518Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Methsuximidehsa05202Transcriptional misregulation in cancer1.51E-0414Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Methsuximidehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Methsuximidehsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Methsuximidehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Methsuximidehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Methsuximidehsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Methsuximidehsa05321Inflammatory bowel disease1.28E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Methsuximidehsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Methsuximidehsa05332Graft-versus-host disease9.30E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Methsuximidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Methsuximide (SDC: 3.76)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)