PharmaCoNets of Methoxyflurane (SPCN: 10.62 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Methoxyfluranehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Methoxyfluranehsa00190Oxidative phosphorylation3.50E-022Q16718, Q13488NDUFA5, TCIRG1More
Methoxyfluranehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Methoxyfluranehsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Methoxyfluranehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Methoxyfluranehsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Methoxyfluranehsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Methoxyfluranehsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Methoxyfluranehsa01100Metabolic pathways4.56E-0211P15144, P32320, P06280, P24666, P33121, P42330, Q13093, Q9NY28, Q9BX95, P09960, Q16718ANPEP, CDA, GLA, ACP1, ACSL1, AKR1C3, PLA2G7, GALNT8, SGPP1, LTA4H, NDUFA5More
Methoxyfluranehsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Methoxyfluranehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Methoxyfluranehsa03010Ribosome3.56E-0614P62753, P42677, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62910, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL32, RPL6, RPL4, RPLP1, RPS16, RPS3More
Methoxyfluranehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Methoxyfluranehsa03050Proteasome1.40E-021P55036PSMD4More
Methoxyfluranehsa04024cAMP signaling pathway1.27E-037P49019, P63092, P22694, P26678, P20020, P61586, P48058HCAR3, GNAS, PRKACB, PLN, ATP2B1, RHOA, GRIA4More
Methoxyfluranehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Methoxyfluranehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Methoxyfluranehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Methoxyfluranehsa04145Phagosome2.75E-024Q15080, P14598, P68371, Q13488NCF4, NCF1, TUBB2C, TCIRG1More
Methoxyfluranehsa04217Necroptosis1.70E-025P01568, Q13489, P08238, O43633, Q08752IFNA21, BIRC3, HSP90AB1, CHMP2A, PPIDMore
Methoxyfluranehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Methoxyfluranehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Methoxyfluranehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Methoxyfluranehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Methoxyfluranehsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Methoxyfluranehsa04650Natural killer cell mediated cytotoxicity2.11E-024P17252, O60880, P26717, P26715PRKCA, SH2D1A, KLRC2, KLRC1More
Methoxyfluranehsa04659Th17 cell differentiation2.73E-024Q16539, P01730, P13765, P14778MAPK14, CD4, HLA-DOB, IL1R1More
Methoxyfluranehsa04713Circadian entrainment1.84E-035P17252, P62873, P48058, P22694, P63092PRKCA, GNB1, GRIA4, PRKACB, GNASMore
Methoxyfluranehsa04714Thermogenesis3.16E-023P22694, P33121, Q16718PRKACB, ACSL1, NDUFA5More
Methoxyfluranehsa04721Synaptic vesicle cycle1.14E-022Q13488, P31645TCIRG1, SLC6A4More
Methoxyfluranehsa04723Retrograde endocannabinoid signaling1.47E-046P17252, P48169, P62873, P48058, P22694, Q16718PRKCA, GABRA4, GNB1, GRIA4, PRKACB, NDUFA5More
Methoxyfluranehsa04724Glutamatergic synapse1.06E-035P48058, P63092, P22694, P17252, P62873GRIA4, GNAS, PRKACB, PRKCA, GNB1More
Methoxyfluranehsa04726Serotonergic synapse1.84E-035P63092, P22694, P17252, P31645, P62873GNAS, PRKACB, PRKCA, SLC6A4, GNB1More
Methoxyfluranehsa04911Insulin secretion3.01E-022P22694, P17252PRKACB, PRKCAMore
Methoxyfluranehsa04913Ovarian steroidogenesis1.28E-022P42330, P22694AKR1C3, PRKACBMore
Methoxyfluranehsa04918Thyroid hormone synthesis3.01E-022P22694, P17252PRKACB, PRKCAMore
Methoxyfluranehsa04925Aldosterone synthesis and secretion9.86E-033P17252, P22694, P20020PRKCA, PRKACB, ATP2B1More
Methoxyfluranehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Methoxyfluranehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Methoxyfluranehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Methoxyfluranehsa04970Salivary secretion7.14E-033P22694, P20020, P17252PRKACB, ATP2B1, PRKCAMore
Methoxyfluranehsa04972Pancreatic secretion1.29E-044P20020, P17252, P63092, P61586ATP2B1, PRKCA, GNAS, RHOAMore
Methoxyfluranehsa04976Bile secretion3.01E-022P22694, P08183PRKACB, ABCB1More
Methoxyfluranehsa05010Alzheimer disease7.11E-039O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Methoxyfluranehsa05012Parkinson disease2.14E-027O15239, P13073, P05141, P12236, P18848, P28070, P43686NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4More
Methoxyfluranehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Methoxyfluranehsa05017Spinocerebellar ataxia4.66E-024P28070, P43686, P05141, P12236PSMB4, PSMC4, SLC25A5, SLC25A6More
Methoxyfluranehsa05020Prion disease1.55E-0310P46531, O15239, P13073, P18848, P05141, P12236, P28070, P43686, P67870, P51636NOTCH1, NDUFA1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CAV2More
Methoxyfluranehsa05022Pathways of neurodegeneration - multiple diseases5.20E-0415P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, Q08752, P28070, P43686CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, PPID, PSMB4, PSMC4More
Methoxyfluranehsa05031Amphetamine addiction1.69E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Methoxyfluranehsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Methoxyfluranehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Methoxyfluranehsa05110Vibrio cholerae infection3.01E-022P17252, P22694PRKCA, PRKACBMore
Methoxyfluranehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Methoxyfluranehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Methoxyfluranehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Methoxyfluranehsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Methoxyfluranehsa05171Coronavirus disease - COVID-196.74E-0715P23396, P62753, P62249, P42677, P40429, Q9UHA3, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386, O14786RPS3, RPS6, RPS16, RPS27, RPL13A, RSL24D1, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1, NRP1More
Methoxyfluranehsa05224Breast cancer3.88E-023P46531, Q9UM47, O15169NOTCH1, NOTCH3, AXIN1More
Methoxyfluranehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Methoxyfluranehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Methoxyfluranehsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore
Methoxyfluranehsa05415Diabetic cardiomyopathy2.75E-024P17252, P14598, Q15080, Q16718PRKCA, NCF1, NCF4, NDUFA5More

Community members of Methoxyflurane (SDC: 1.61)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)