PharmaCoNets of Methionine (SPCN: 16.46 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
D-Methioninehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
D-Methioninehsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
D-Methioninehsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
D-Methioninehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
D-Methioninehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
D-Methioninehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
D-Methioninehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
D-Methioninehsa04071Sphingolipid signaling pathway4.27E-021Q02156PRKCEMore
D-Methioninehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
D-Methioninehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
D-Methioninehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
D-Methioninehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
D-Methioninehsa04270Vascular smooth muscle contraction4.59E-021Q02156PRKCEMore
D-Methioninehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
D-Methioninehsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
D-Methioninehsa04650Natural killer cell mediated cytotoxicity4.40E-026P78314, P06239, O60880, P20963, P26718, O75015SH3BP2, LCK, SH2D1A, CD247, KLRK1, FCGR3BMore
D-Methioninehsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
D-Methioninehsa04659Th17 cell differentiation7.42E-037Q16539, P06239, P13765, P14778, Q9UL17, P09693, P20963MAPK14, LCK, HLA-DOB, IL1R1, TBX21, CD3G, CD247More
D-Methioninehsa04666Fc gamma R-mediated phagocytosis4.59E-021Q02156PRKCEMore
D-Methioninehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
D-Methioninehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
D-Methioninehsa04750Inflammatory mediator regulation of TRP channels3.29E-021Q02156PRKCEMore
D-Methioninehsa04925Aldosterone synthesis and secretion3.62E-021Q02156PRKCEMore
D-Methioninehsa04930Type II diabetes mellitus9.93E-031Q02156PRKCEMore
D-Methioninehsa04931Insulin resistance2.64E-021Q02156PRKCEMore
D-Methioninehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
D-Methioninehsa04933AGE-RAGE signaling pathway in diabetic complications2.31E-021Q02156PRKCEMore
D-Methioninehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
D-Methioninehsa04974Protein digestion and absorption9.93E-031Q7Z2H8SLC36A1More
D-Methioninehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
D-Methioninehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
D-Methioninehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
D-Methioninehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
D-Methioninehsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
D-Methioninehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
D-Methioninehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
D-Methioninehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
D-Methioninehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
D-Methioninehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-038P07766, P20963, P09693, P06239, O60603, Q16539, Q9HC35, P01730CD3E, CD247, CD3G, LCK, TLR2, MAPK14, EML4, CD4More
D-Methioninehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
D-Methioninehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
D-Methioninehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
D-Methioninehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Methioninehsa00190Oxidative phosphorylation2.11E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Methioninehsa00280Valine, leucine and isoleucine degradation2.75E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Methioninehsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Methioninehsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Methioninehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Methioninehsa01100Metabolic pathways1.66E-0231Q9Y234, O14521, P15144, Q99707, P11310, P27707, Q13370, P36959, Q13956, P22748, P55809, P06280, P30043, Q02252, O60701, O14772, O95954, Q9HCC0, P33121, P04406, Q96EB6, O15466, P36551, Q9BX95, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, SDHD, ANPEP, MTR, ACADM, DCK, PDE3B, GMPR, PDE6H, CA4, OXCT1, GLA, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, MCCC2, ACSL1, GAPDH, SIRT1, ST8SIA5, CPOX, SGPP1, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Methioninehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Methioninehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Methioninehsa03013RNA transport3.46E-0311O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3More
Methioninehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Methioninehsa04071Sphingolipid signaling pathway4.27E-021Q02156PRKCEMore
Methioninehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Methioninehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Methioninehsa04145Phagosome2.33E-027O75015, Q15075, Q15080, P14598, Q13509, Q13488, O60603FCGR3B, EEA1, NCF4, NCF1, TUBB3, TCIRG1, TLR2More
Methioninehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Methioninehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Methioninehsa04270Vascular smooth muscle contraction4.59E-021Q02156PRKCEMore
Methioninehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Methioninehsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Methioninehsa04650Natural killer cell mediated cytotoxicity4.40E-026P78314, P06239, O60880, P20963, P26718, O75015SH3BP2, LCK, SH2D1A, CD247, KLRK1, FCGR3BMore
Methioninehsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Methioninehsa04659Th17 cell differentiation7.42E-037Q16539, P06239, P13765, P14778, Q9UL17, P09693, P20963MAPK14, LCK, HLA-DOB, IL1R1, TBX21, CD3G, CD247More
Methioninehsa04666Fc gamma R-mediated phagocytosis4.59E-021Q02156PRKCEMore
Methioninehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Methioninehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Methioninehsa04750Inflammatory mediator regulation of TRP channels3.29E-021Q02156PRKCEMore
Methioninehsa04925Aldosterone synthesis and secretion3.62E-021Q02156PRKCEMore
Methioninehsa04930Type II diabetes mellitus9.93E-031Q02156PRKCEMore
Methioninehsa04931Insulin resistance2.64E-021Q02156PRKCEMore
Methioninehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Methioninehsa04933AGE-RAGE signaling pathway in diabetic complications2.31E-021Q02156PRKCEMore
Methioninehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Methioninehsa04974Protein digestion and absorption9.93E-031Q7Z2H8SLC36A1More
Methioninehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Methioninehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Methioninehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Methioninehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Methioninehsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Methioninehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Methioninehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Methioninehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Methioninehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Methioninehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-038P07766, P20963, P09693, P06239, O60603, Q16539, Q9HC35, P01730CD3E, CD247, CD3G, LCK, TLR2, MAPK14, EML4, CD4More
Methioninehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Methioninehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Methioninehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Methioninehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Methionine (SDC: 2.74)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q99707MTRMethionine synthaseReported00.16120.05620.1950.3881
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q7Z2H8SLC36A1ProtonNonecoupled amino acid transporter 1Predicted00.20740.034800.1732
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)