PharmaCoNets

PharmaCoNets of Methdilazine (S_PCN: 147.25 )

Methdilazine regulated-network (S_DN: 20.57)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Methdilazine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Methdilazine

hsa00040

Pentose and glucuronate interconversions

4.00E-02

P15121

AKR1B1

Methdilazine

hsa00190

Oxidative phosphorylation

1.03E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Methdilazine

hsa00220

Arginine biosynthesis

1.97E-02

P15104, P49448

GLUL, GLUD2

Methdilazine

hsa00250

Alanine, aspartate and glutamate metabolism

1.97E-02

P49448, P15104

GLUD2, GLUL

Methdilazine

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Methdilazine

hsa00500

Starch and sucrose metabolism

2.21E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Methdilazine

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Methdilazine

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Methdilazine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Methdilazine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Methdilazine

hsa00600

Sphingolipid metabolism

4.77E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Methdilazine

hsa00620

Pyruvate metabolism

3.90E-02

P07195, P11766

LDHB, ADH5

Methdilazine

hsa00630

Glyoxylate and dicarboxylate metabolism

4.19E-05

P40925, P15104

MDH1, GLUL

Methdilazine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Methdilazine

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Methdilazine

hsa00910

Nitrogen metabolism

1.97E-02

P15104, P49448

GLUL, GLUD2

Methdilazine

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Methdilazine

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.38E-04

P78417, P09211, P11712

GSTO1, GSTP1, CYP2C9

Methdilazine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Methdilazine

hsa00983

Drug metabolism - other enzymes

3.48E-03

P04183, P32320, P05164

TK1, CDA, MPO

Methdilazine

hsa01100

Metabolic pathways

4.11E-02

P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6

PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHE

Methdilazine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Methdilazine

hsa01230

Biosynthesis of amino acids

2.92E-03

P51854, P60891, P05089, P15104, P37837

TKTL1, PRPS1, ARG1, GLUL, TALDO1

Methdilazine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Methdilazine

hsa03010

Ribosome

2.25E-04

P40429, Q07020, P27635, P05386, P62249

RPL13A, RPL18, RPL10, RPLP1, RPS16

Methdilazine

hsa03013

RNA transport

3.85E-04

P52298, Q09161, O14893, P61326, P38919, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, RPP38, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.956
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O14893	GEMIN2	Gem-associated protein 2	0.925
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P61326	MAGOH	Protein mago nashi homolog	0.761
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q7Z3B4	NUP54	Nucleoporin p54	0.854
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.79
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.715
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.793
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P78345	RPP38	Ribonuclease P protein subunit p38	0.819
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.891
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849

Methdilazine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Methdilazine

hsa03040

Spliceosome

2.29E-04

Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142

DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8

Methdilazine

hsa03060

Protein export

4.46E-03

Q15070, O76094

OXA1L, SRP72

Methdilazine

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Methdilazine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Methdilazine

hsa04010

MAPK signaling pathway

1.53E-02

Q9H2K8, Q12933

TAOK3, TRAF2

Methdilazine

hsa04014

Ras signaling pathway

8.66E-03

Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174

PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Methdilazine

hsa04024

cAMP signaling pathway

4.38E-02

P42338, P0DP23, Q13370, Q13009

PIK3CB, CALM1, PDE3B, TIAM1

Methdilazine

hsa04060

Cytokine-cytokine receptor interaction

2.05E-02

P27930, P14778, P26842, Q13651, P25024, P25025, Q9UBD3, P47992, P09341, P18510, P01730

IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCR2, XCL2, XCL1, CXCL1, IL1RN, CD4

Methdilazine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.68E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Methdilazine

hsa04062

Chemokine signaling pathway

3.23E-06

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, Q08881, Q13009, P14598, P42224, P25963, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, ITK, TIAM1, NCF1, STAT1, NFKBIA, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.843
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.892
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P47992	XCL1	Lymphotactin	-0.796
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.796
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798

Methdilazine

hsa04064

NF-kappa B signaling pathway

1.25E-08

P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16548	BCL2A1	Bcl-2-related protein A1	0.82
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.793
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Methdilazine

hsa04070

Phosphatidylinositol signaling system

3.50E-04

P19174, P0DP23, Q14643, P42338, P23743, P27987, P17252

PLCG1, CALM1, ITPR1, PIK3CB, DGKA, ITPKB, PRKCA

Methdilazine

hsa04071

Sphingolipid signaling pathway

1.53E-07

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q12933, Q02156

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P05164	MPO	Myeloperoxidase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.773
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P05164	MPO	Myeloperoxidase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.876
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P05164	MPO	Myeloperoxidase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.75
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.799
P08246	ELA2	Neutrophil elastase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.865
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P05164	MPO	Myeloperoxidase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.714
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.917
P08246	ELA2	Neutrophil elastase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.847
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q02156	PRKCE	Protein kinase C epsilon type	Q12933	TRAF2	TNF receptor-associated factor 2	-0.78
Q02156	PRKCE	Protein kinase C epsilon type	Q02156	PRKCE	Protein kinase C epsilon type	1

Methdilazine

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Methdilazine

hsa04080

Neuroactive ligand-receptor interaction

8.77E-05

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2

Methdilazine

hsa04114

Oocyte meiosis

6.23E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Methdilazine

hsa04115

p53 signaling pathway

3.32E-03

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Methdilazine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Methdilazine

hsa04141

Protein processing in endoplasmic reticulum

8.60E-03

P30101, P60604, P11142, P08238, Q9H173, Q9UNL2

PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3

Methdilazine

hsa04145

Phagosome

7.35E-08

P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15080	NCF4	Neutrophil cytosol factor 4	-0.919
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14598	NCF1	Neutrophil cytosol factor 1	-0.857
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.716
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.759
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35443	THBS4	Thrombospondin-4	-0.755
P08246	ELA2	Neutrophil elastase	P35443	THBS4	Thrombospondin-4	0.871
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729

Methdilazine

hsa04151

PI3K-Akt signaling pathway

5.38E-03

P43657, P25116, P09603, P49767, Q9GZP0, Q13362, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, O60603, P01568, P10415, P17252

P2RY5, F2R, CSF1, VEGFC, PDGFD, PPP2R5C, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TLR2, IFNA21, BCL2, PRKCA

Methdilazine

hsa04210

Apoptosis

1.53E-03

Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1

Methdilazine

hsa04213

Longevity regulating pathway - multiple species

4.41E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Methdilazine

hsa04217

Necroptosis

7.46E-06

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPID

Methdilazine

hsa04261

Adrenergic signaling in cardiomyocytes

2.31E-03

P09493, P07550, P22694, P18848, Q13362, P0DP23, P17252, P10415

TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, CALM1, PRKCA, BCL2

Methdilazine

hsa04330

Notch signaling pathway

4.84E-04

Q92542, P49768

NCSTN, PSEN1

Methdilazine

hsa04360

Axon guidance

1.71E-02

P20827, O95631, P42338, P23528

EFNA1, NTN1, PIK3CB, CFL1

Methdilazine

hsa04370

VEGF signaling pathway

3.06E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Methdilazine

hsa04371

Apelin signaling pathway

7.95E-04

P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1

Methdilazine

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Methdilazine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Methdilazine

hsa04540

Gap junction

3.48E-04

P17252, Q13509, P68371, Q71U36, Q9NRA1, Q14643

PRKCA, TUBB3, TUBB2C, TUBA1A, PDGFC, ITPR1

Methdilazine

hsa04610

Complement and coagulation cascades

3.16E-03

P00734, P0C0L4

F2, C4A

Methdilazine

hsa04612

Antigen processing and presentation

2.09E-04

P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Methdilazine

hsa04613

Neutrophil extracellular trap formation

9.02E-08

P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, P21730, P21462, O43315, Q16539

PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Methdilazine

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Methdilazine

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Methdilazine

hsa04623

Cytosolic DNA-sensing pathway

1.31E-03

P01568, P25963

IFNA21, NFKBIA

Methdilazine

hsa04640

Hematopoietic cell lineage

1.48E-04

P13612, P14778, P27930, P11215, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, IL1R1, IL1R2, ITGAM, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Methdilazine

hsa04650

Natural killer cell mediated cytotoxicity

9.30E-08

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.774
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.9
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P78314	SH3BP2	SH3 domain-binding protein 2	0.807
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.799
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.799
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.733
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.888
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.712
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Methdilazine

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

Methdilazine

hsa04658

Th1 and Th2 cell differentiation

1.52E-09

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.714
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.867
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.738
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.744
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Methdilazine

hsa04659

Th17 cell differentiation

1.54E-09

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.738
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.867
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.714
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87

Methdilazine

hsa04660

T cell receptor signaling pathway

1.21E-07

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.727
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.709
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.759
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.75
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798

Methdilazine

hsa04662

B cell receptor signaling pathway

2.57E-02

P49841, P60033, P07948, P21854, Q8N149

GSK3B, CD81, LYN, CD72, LILRA2

Methdilazine

hsa04664

Fc epsilon RI signaling pathway

6.97E-03

P04141, P07948, P19174, P09917

CSF2, LYN, PLCG1, ALOX5

Methdilazine

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

P42338, P23528, P14598

PIK3CB, CFL1, NCF1

Methdilazine

hsa04668

TNF signaling pathway

2.93E-03

P01375, O00463, Q13489, P25963, P18848, P19875, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, NFKBIA, ATF4, CXCL2, BCL3, TRAF1, MMP9

Methdilazine

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Methdilazine

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Methdilazine

hsa04713

Circadian entrainment

1.44E-03

P0DP23, P17252, P62873, P63218, P50151, Q14643

CALM1, PRKCA, GNB1, GNG5, GNG10, ITPR1

Methdilazine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Methdilazine

hsa04720

Long-term potentiation

3.25E-03

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Methdilazine

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Methdilazine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Methdilazine

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Methdilazine

hsa04724

Glutamatergic synapse

3.88E-04

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Methdilazine

hsa04725

Cholinergic synapse

2.42E-03

P22694, Q14643, P17252, P62873, P18848, P10415

PRKACB, ITPR1, PRKCA, GNB1, ATF4, BCL2

Methdilazine

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Methdilazine

hsa04727

GABAergic synapse

2.40E-04

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Methdilazine

hsa04728

Dopaminergic synapse

3.55E-02

Q14643, P17252, P62873, Q13362, P0DP23

ITPR1, PRKCA, GNB1, PPP2R5C, CALM1

Methdilazine

hsa04730

Long-term depression

3.34E-03

Q14344, P07948

GNA13, LYN

Methdilazine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Methdilazine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Methdilazine

hsa04744

Phototransduction

9.32E-05

P62873, P0DP23

GNB1, CALM1

Methdilazine

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Methdilazine

hsa04912

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Methdilazine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Methdilazine

hsa04914

Progesterone-mediated oocyte maturation

9.70E-04

Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1

Methdilazine

hsa04915

Estrogen signaling pathway

2.96E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Methdilazine

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Methdilazine

hsa04919

Thyroid hormone signaling pathway

3.71E-02

P26678, P08237

PLN, PFKM

Methdilazine

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Methdilazine

hsa04922

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Methdilazine

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Methdilazine

hsa04924

Renin secretion

6.30E-05

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Methdilazine

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Methdilazine

hsa04927

Cortisol synthesis and secretion

4.44E-04

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Methdilazine

hsa04928

Parathyroid hormone synthesis, secretion and action

2.13E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Methdilazine

hsa04930

Type II diabetes mellitus

2.47E-02

Q02156

PRKCE

Methdilazine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Methdilazine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.27E-02

P42224, P10415, Q12778, P49767, P17252

STAT1, BCL2, FOXO1, VEGFC, PRKCA

Methdilazine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Methdilazine

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.68E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Methdilazine

hsa04966

Collecting duct acid secretion

2.86E-02

Q13488, Q9Y666

TCIRG1, SLC12A7

Methdilazine

hsa04970

Salivary secretion

2.82E-03

P07550, P22694, Q14643, P17252, P49913

ADRB2, PRKACB, ITPR1, PRKCA, CAMP

Methdilazine

hsa04972

Pancreatic secretion

2.68E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Methdilazine

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Methdilazine

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Methdilazine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Methdilazine

hsa05010

Alzheimer disease

4.45E-03

Q16718, O14521, Q14643, O15399, Q9NZJ5, P0DP23, Q13564, Q71U36, Q13509, P68371, P09603, P21796, Q08752

NDUFA5, SDHD, ITPR1, GRIN2D, EIF2AK3, CALM1, APPBP1, TUBA1A, TUBB3, TUBB2C, CSF1, VDAC1, PPID

Methdilazine

hsa05012

Parkinson disease

1.15E-03

Q16718, O14521, P60604, Q14643, P19174, P0DP23, Q71U36, Q13509, P68371

NDUFA5, SDHD, UBE2G2, ITPR1, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Methdilazine

hsa05020

Prion disease

1.31E-03

Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14

Methdilazine

hsa05022

Pathways of neurodegeneration - multiple diseases

2.00E-04

Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23

ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1

Methdilazine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Methdilazine

hsa05032

Morphine addiction

7.62E-04

P62873, P63218, P50151, Q13370, Q07343, P43250

GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6

Methdilazine

hsa05034

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Methdilazine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.73E-06

Q16539, P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Methdilazine

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Methdilazine

hsa05131

Shigellosis

5.38E-04

P01375, P25963, Q12933, O00463, P68431, Q02156, Q04759, Q9UDY8, Q9H1Y0, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32

TNF, NFKBIA, TRAF2, TRAF5, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, PRKCQ, MALT1, ATG5, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF

Methdilazine

hsa05132

Salmonella infection

3.06E-06

P51617, P25963, P01375, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.825
P08246	ELA2	Neutrophil elastase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.771
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75369	FLNB	Filamin-B	0.706
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.924
P08246	ELA2	Neutrophil elastase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	-0.949
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13561	DCTN2	Dynactin subunit 2	-0.809
P08246	ELA2	Neutrophil elastase	Q13561	DCTN2	Dynactin subunit 2	0.78
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.728

Methdilazine

hsa05133

Pertussis

2.24E-02

P0DP23, P0C0L4

CALM1, C4A

Methdilazine

hsa05134

Legionellosis

1.49E-03

P25963, P11215, P11142, P09341, P19875

NFKBIA, ITGAM, HSPA8, CXCL1, CXCL2

Methdilazine

hsa05135

Yersinia infection

2.59E-03

Q05397, P51812, P13612, P06239, Q16539, Q02750, P49841, Q96JJ3, P01730, P01732

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, GSK3B, ELMO2, CD4, CD8A

Methdilazine

hsa05140

Leishmaniasis

8.63E-07

P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P51617, Q15080

NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945

Methdilazine

hsa05143

African trypanosomiasis

3.01E-03

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Methdilazine

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Methdilazine

hsa05145

Toxoplasmosis

1.19E-03

P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965

IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Methdilazine

hsa05146

Amoebiasis

2.05E-05

P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814

CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1

Methdilazine

hsa05152

Tuberculosis

5.66E-06

Q13488, P0DP23, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, P51617

TCIRG1, CALM1, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P48382	RFX5	DNA-binding protein RFX5	0.797
P08246	ELA2	Neutrophil elastase	P48382	RFX5	DNA-binding protein RFX5	-0.895
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P25208	NFYB	Nuclear transcription factor Y subunit beta	0.742
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	1
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734

Methdilazine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Methdilazine

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Methdilazine

hsa05163

Human cytomegalovirus infection

7.99E-05

P25963, P62873, P63218, P50151, P0DP23, Q14344, P49841, P14778, Q13651, P25025, Q16539, O00463, P30101, P01568

NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.713
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.892
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P30101	PDIA3	Protein disulfide-isomerase A3	-0.721
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733

Methdilazine

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Methdilazine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.60E-06

P01568, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, Q14643, Q02750, P07948, P04141, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, ITPR1, MAP2K1, LYN, CSF2, CALM1, UBB, LEF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.872
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.774
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P0CG47	UBB	Polyubiquitin-B	-0.731
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881

Methdilazine

hsa05168

Herpes simplex virus 1 infection

2.24E-05

P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776

Methdilazine

hsa05169

Epstein-Barr virus infection

1.68E-03

P13765, Q13547, O00463, Q16539, P07948, P30101, Q13761, P24522, P29728, P07766, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, LYN, PDIA3, RUNX3, GADD45A, OAS2, CD3E, CD3G, CD247

Methdilazine

hsa05170

Human immunodeficiency virus 1 infection

1.47E-08

P62873, P63218, P50151, P0DP23, P01375, P17252, Q13546, O00463, P30101, Q14643, P01568, P01730, Q16539, P51617, P25963, O60603, Q13315, O95067, P19174, P07766, P09693, P20963, P10415, Q13619, Q93034, Q9Y6Q5

GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, CD4, MAPK14, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CD3E, CD3G, CD247, BCL2, CUL4A, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P30101	PDIA3	Protein disulfide-isomerase A3	-0.721
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.946
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811

Methdilazine

hsa05171

Coronavirus disease - COVID-19

3.87E-04

P62249, P40429, P27635, Q07020, P05386

RPS16, RPL13A, RPL10, RPL18, RPLP1

Methdilazine

hsa05200

Pathways in cancer

6.83E-05

P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, P20585, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P40189

PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, MSH3, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83

Methdilazine

hsa05202

Transcriptional misregulation in cancer

1.20E-07

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7

Methdilazine

hsa05203

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Methdilazine

hsa05204

Chemical carcinogenesis

1.09E-03

P09211, P78417, P11712

GSTP1, GSTO1, CYP2C9

Methdilazine

hsa05205

Proteoglycans in cancer

2.02E-03

Q13009, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962

TIAM1, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63

Methdilazine

hsa05212

Pancreatic cancer

2.11E-03

P42338, P42224, P84022, O75293

PIK3CB, STAT1, SMAD3, GADD45B

Methdilazine

hsa05214

Glioma

2.11E-03

P0DP23, P42338, P19174, O75293

CALM1, PIK3CB, PLCG1, GADD45B

Methdilazine

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Methdilazine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.65E-05

P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4

Methdilazine

hsa05310

Asthma

3.88E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Methdilazine

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Methdilazine

hsa05321

Inflammatory bowel disease

4.75E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Methdilazine

hsa05322

Systemic lupus erythematosus

2.36E-07

P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717

Methdilazine

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Methdilazine

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Methdilazine

hsa05332

Graft-versus-host disease

6.57E-07

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Methdilazine

hsa05340

Primary immunodeficiency

3.99E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Methdilazine

hsa05415

Diabetic cardiomyopathy

5.60E-05

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Methdilazine

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Methdilazine

hsa05418

Fluid shear stress and atherosclerosis

3.73E-02

P42338, P14598, P0DP23, P08238

PIK3CB, NCF1, CALM1, HSP90AB1

Community members of Methdilazine (S_DC: 7.16)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

GSTP1

Glutathione SNonetransferase P

Predicted

0.3204

0.3523

0.4566

1.3213

Q9UDY8

MALT1

MucosaNoneassociated lymphoid tissue lymphoma translocation protein 1

Predicted

0.0516

0.147

0.5592

0.8789

P37840

SNCA

AlphaNonesynuclein

Predicted

0.0853

0.1324

0.3321

0.6395

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P05164

MPO

Myeloperoxidase

Predicted

0.2035

0.5368

0.5502

1.7255

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P61088

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

P11169

SLC2A3

Solute carrier family 2, facilitated glucose transporter member 3

Predicted

0.1357

0.0658

0.1995

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

O95931

CBX7

Chromobox protein homolog 7

Predicted

0.4186

0.1816

0.5726

P29375

JARID1A

LysineNonespecific demethylase 5A

Predicted

0.3605

0.7052

1.5906

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

Q6PCB7

SLC27A1

LongNonechain fatty acid transport protein 1

Predicted

0.2915

0.0768

0.0992

0.3985

PharmaCoNets of Methdilazine (SPCN: 147.25 )

Methdilazine regulated-network (SDN: 20.57)

Community members of Methdilazine (SDC: 7.16)

PharmaCoNets of Methdilazine (S_PCN: 147.25 )

Methdilazine regulated-network (S_DN: 20.57)

Community members of Methdilazine (S_DC: 7.16)