PharmaCoNets of Methadone (SPCN: 140.34 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Methadonehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Methadonehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Methadonehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Methadonehsa00190Oxidative phosphorylation3.92E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Methadonehsa00310Lysine degradation8.26E-042Q96KQ7, P51648EHMT2, ALDH3A2More
Methadonehsa00500Starch and sucrose metabolism1.89E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Methadonehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Methadonehsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Methadonehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Methadonehsa00630Glyoxylate and dicarboxylate metabolism1.13E-022P40925, P15104MDH1, GLULMore
Methadonehsa00730Thiamine metabolism5.65E-052P05186, P24666ALPL, ACP1More
Methadonehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Methadonehsa00830Retinol metabolism1.36E-031P00325ADH1BMore
Methadonehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Methadonehsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Methadonehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Methadonehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Methadonehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Methadonehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Methadonehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Methadonehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Methadonehsa01522Endocrine resistance2.16E-021P04049RAF1More
Methadonehsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Methadonehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Methadonehsa03008Ribosome biogenesis in eukaryotes1.31E-047Q9NYH9, O14980, O60832, P78345, Q9BVP2, O15381, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NVL, NXF2; NXF2BMore
Methadonehsa03013RNA transport1.20E-0714O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FXR1More
Methadonehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Methadonehsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Methadonehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Methadonehsa03030DNA replication5.00E-021P27694RPA1More
Methadonehsa03040Spliceosome8.25E-0915Q14562, O43143, O60508, Q99633, P08579, P26368, Q13595, Q01130, P84103, Q13243, Q9UMS4, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, PRPF18, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, PRPF19, HSPA8, WBP11, PPIH, ASCC3L1More
Methadonehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Methadonehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Methadonehsa04014Ras signaling pathway1.38E-026P04049, P42338, P49767, P0DP23, P63218, P50151RAF1, PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Methadonehsa04015Rap1 signaling pathway4.21E-037P04049, P20827, P49767, P63261, P25116, P0DP23, P17252RAF1, EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Methadonehsa04020Calcium signaling pathway2.42E-0710P27987, P21796, Q16566, P17252, P30679, O15399, P25116, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, PRKCA, GNA15, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Methadonehsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Methadonehsa04024cAMP signaling pathway3.18E-047P42338, P0DP23, P23634, P04049, Q16566, O15399, P25116PIK3CB, CALM1, ATP2B4, RAF1, CAMK4, GRIN2D, F2RMore
Methadonehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Methadonehsa04062Chemokine signaling pathway1.19E-0415P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P04049, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, RAF1, GSK3BMore
Methadonehsa04064NF-kappa B signaling pathway2.99E-0416P10415, P51617, O00463, Q13546, P14778, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643BCL2, IRAK1, TRAF5, RIPK1, IL1R1, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTBMore
Methadonehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Methadonehsa04070Phosphatidylinositol signaling system2.54E-048P0DP23, Q14643, P42338, Q96PE3, O14732, Q13572, P27987, P17252CALM1, ITPR1, PIK3CB, INPP4A, IMPA2, ITPK1, ITPKB, PRKCAMore
Methadonehsa04071Sphingolipid signaling pathway4.85E-0611P04049, P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, GAB2More
Methadonehsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Methadonehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Methadonehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Methadonehsa04120Ubiquitin mediated proteolysis4.81E-034Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Methadonehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Methadonehsa04140Autophagy - animal2.82E-021P04049RAF1More
Methadonehsa04144Endocytosis2.81E-026Q13191, P11142, P25024, P43250, P14784, Q9Y5X3CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5More
Methadonehsa04145Phagosome1.32E-038P63261, Q15080, P14598, Q13509, P68371, Q13488, O60603, P27824ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, CANXMore
Methadonehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Methadonehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Methadonehsa04210Apoptosis3.64E-035O76075, P01375, Q9NR28, Q16548, P04049DFFB, TNF, DIABLO, BCL2A1, RAF1More
Methadonehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Methadonehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Methadonehsa04218Cellular senescence2.49E-021P04049RAF1More
Methadonehsa04261Adrenergic signaling in cardiomyocytes5.00E-0410P07550, P22694, P18848, Q13362, Q14738, Q16537, P0DP23, P17252, P10415, P20020ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Methadonehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Methadonehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Methadonehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Methadonehsa04360Axon guidance2.49E-021P04049RAF1More
Methadonehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Methadonehsa04371Apelin signaling pathway2.41E-036P63218, P50151, P04049, Q13485, Q16566, P0DP23GNG5, GNG10, RAF1, SMAD4, CAMK4, CALM1More
Methadonehsa04390Hippo signaling pathway2.11E-036P63261, Q13485, O15105, Q9UJU2, O43623, Q13489ACTG1, SMAD4, SMAD7, LEF1, SNAI2, BIRC3More
Methadonehsa04510Focal adhesion9.88E-037Q15942, P17252, Q13489, P10415, P04049, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, RAF1, VEGFC, ACTG1More
Methadonehsa04514Cell adhesion molecules1.22E-022P23229, P30511ITGA6, HLA-FMore
Methadonehsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Methadonehsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Methadonehsa04540Gap junction1.00E-024P17252, Q13509, P68371, P04049PRKCA, TUBB3, TUBB2C, RAF1More
Methadonehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Methadonehsa04612Antigen processing and presentation9.45E-059P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Methadonehsa04613Neutrophil extracellular trap formation2.02E-0415P17252, P04049, O60603, P08246, Q92769, P04908, Q6FI13, Q93077, P33778, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, RAF1, TLR2, ELA2, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC3, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Methadonehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Methadonehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Methadonehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Methadonehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Methadonehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Methadonehsa04650Natural killer cell mediated cytotoxicity1.82E-1015P19174, P01375, P78314, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Methadonehsa04657IL-17 signaling pathway3.73E-048O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Methadonehsa04658Th1 and Th2 cell differentiation2.74E-058Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Methadonehsa04659Th17 cell differentiation1.68E-0510Q04759, P19174, P06239, P14784, P14778, Q9UL17, Q13485, P08238, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD4, HSP90AB1, CD3E, CD247More
Methadonehsa04660T cell receptor signaling pathway1.57E-0615P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Methadonehsa04662B cell receptor signaling pathway4.47E-035P42338, P60033, P07948, Q8N149, P04049PIK3CB, CD81, LYN, LILRA2, RAF1More
Methadonehsa04664Fc epsilon RI signaling pathway3.64E-034P42338, P07948, P04049, P09917PIK3CB, LYN, RAF1, ALOX5More
Methadonehsa04666Fc gamma R-mediated phagocytosis1.78E-038P07948, P42338, P04049, P23528, P49006, P06396, P14598, P17252LYN, PIK3CB, RAF1, CFL1, MARCKSL1, GSN, NCF1, PRKCAMore
Methadonehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Methadonehsa04713Circadian entrainment8.43E-034O15399, P0DP23, P63218, P50151GRIN2D, CALM1, GNG5, GNG10More
Methadonehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Methadonehsa04720Long-term potentiation1.22E-056P17252, Q16566, P0DP23, O15399, P04049, Q14643PRKCA, CAMK4, CALM1, GRIN2D, RAF1, ITPR1More
Methadonehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Methadonehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Methadonehsa04724Glutamatergic synapse2.25E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Methadonehsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Methadonehsa04726Serotonergic synapse1.75E-035P63218, P50151, P33260, P09917, P04049GNG5, GNG10, CYP2C18, ALOX5, RAF1More
Methadonehsa04727GABAergic synapse4.42E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Methadonehsa04728Dopaminergic synapse3.76E-0410P14416, P63218, P50151, P49841, Q16539, P49407, Q13362, Q14738, P0DP23, O00327DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, PPP2R5D, CALM1, ARNTLMore
Methadonehsa04730Long-term depression3.01E-032Q14344, P04049GNA13, RAF1More
Methadonehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Methadonehsa04810Regulation of actin cytoskeleton4.09E-033P04049, P23229, Q14344RAF1, ITGA6, GNA13More
Methadonehsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Methadonehsa04912GnRH signaling pathway2.49E-024P17252, Q14643, P0DP23, P04049PRKCA, ITPR1, CALM1, RAF1More
Methadonehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Methadonehsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Methadonehsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Methadonehsa04916Melanogenesis8.11E-034P0DP23, Q9UJU2, P17252, P04049CALM1, LEF1, PRKCA, RAF1More
Methadonehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Methadonehsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Methadonehsa04921Oxytocin signaling pathway1.28E-037P0DP23, P17252, P04049, Q16566, P63261, Q96RR4, Q13469CALM1, PRKCA, RAF1, CAMK4, ACTG1, CAMKK2, NFATC2More
Methadonehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Methadonehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Methadonehsa04925Aldosterone synthesis and secretion2.55E-056Q14643, P0DP23, P17252, Q16566, P20020, P23634ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4More
Methadonehsa04926Relaxin signaling pathway1.17E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, P04049, P30679PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, RAF1, GNA15More
Methadonehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Methadonehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Methadonehsa04929GnRH secretion4.98E-031P04049RAF1More
Methadonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Methadonehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Methadonehsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Methadonehsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Methadonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Methadonehsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Methadonehsa04970Salivary secretion4.63E-058P07550, P22694, Q14643, P20020, P23634, P17252, P0DP23, P49913ADRB2, PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1, CAMPMore
Methadonehsa04971Gastric acid secretion4.76E-023P17252, P63261, P0DP23PRKCA, ACTG1, CALM1More
Methadonehsa04972Pancreatic secretion6.55E-045Q14643, P20020, P17252, Q08828, P62491ITPR1, ATP2B1, PRKCA, ADCY1, RAB11AMore
Methadonehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Methadonehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Methadonehsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Methadonehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Methadonehsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Methadonehsa05017Spinocerebellar ataxia3.88E-045Q92915, Q8TB72, O15399, P42338, P21796FGF14, PUM2, GRIN2D, PIK3CB, VDAC1More
Methadonehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Methadonehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Methadonehsa05031Amphetamine addiction1.61E-037O15399, P0DP23, Q16566, P22694, P18848, P17252, Q13547GRIN2D, CALM1, CAMK4, PRKACB, ATF4, PRKCA, HDAC1More
Methadonehsa05034Alcoholism6.38E-036O15399, Q16566, P0DP23, P63218, P50151, P04049GRIN2D, CAMK4, CALM1, GNG5, GNG10, RAF1More
Methadonehsa05120Epithelial cell signaling in Helicobacter pylori infection1.84E-057Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Methadonehsa05132Salmonella infection1.90E-0414P51617, P04049, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, RAF1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Methadonehsa05133Pertussis2.52E-023P0DP23, P23528, P09871CALM1, CFL1, C1SMore
Methadonehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Methadonehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Methadonehsa05140Leishmaniasis2.39E-0611O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, P51617, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Methadonehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Methadonehsa05144Malaria1.03E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Methadonehsa05146Amoebiasis4.70E-0612P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Methadonehsa05152Tuberculosis3.98E-021P04049RAF1More
Methadonehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Methadonehsa05161Hepatitis B1.99E-021P04049RAF1More
Methadonehsa05163Human cytomegalovirus infection8.72E-0516P42338, P04049, P01375, P30511, P63218, P50151, Q14643, P0DP23, Q14344, P49841, P14778, P25025, Q16539, P04637, O00463, P30101PIK3CB, RAF1, TNF, HLA-F, GNG5, GNG10, ITPR1, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5, PDIA3More
Methadonehsa05164Influenza A3.65E-021P04049RAF1More
Methadonehsa05167Kaposi sarcoma-associated herpesvirus infection1.49E-038P42338, P23458, P63218, P50151, Q13469, P04049, P07948, P0DP23PIK3CB, JAK1, GNG5, GNG10, NFATC2, RAF1, LYN, CALM1More
Methadonehsa05168Herpes simplex virus 1 infection2.31E-0417Q9UKJ0, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6, P10415PILRB, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Methadonehsa05169Epstein-Barr virus infection2.54E-028Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3GMore
Methadonehsa05170Human immunodeficiency virus 1 infection1.43E-0415P42338, P04049, P63218, P50151, P0DP23, P17252, Q13546, P30101, Q14643, P51617, O60603, P23528, P09693, P10415, Q9Y6Q5PIK3CB, RAF1, GNG5, GNG10, CALM1, PRKCA, RIPK1, PDIA3, ITPR1, IRAK1, TLR2, CFL1, CD3G, BCL2, AP1M2More
Methadonehsa05200Pathways in cancer1.51E-0212Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21More
Methadonehsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Methadonehsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Methadonehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Methadonehsa05210Colorectal cancer1.66E-021P04049RAF1More
Methadonehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Methadonehsa05212Pancreatic cancer4.19E-044P04049, Q15311, P23458, P37173RAF1, RALBP1, JAK1, TGFBR2More
Methadonehsa05213Endometrial cancer9.95E-031P04049RAF1More
Methadonehsa05214Glioma8.81E-067P0DP23, Q16566, P17252, P04049, P42338, P04637, P24522CALM1, CAMK4, PRKCA, RAF1, PIK3CB, TP53, GADD45AMore
Methadonehsa05215Prostate cancer1.33E-021P04049RAF1More
Methadonehsa05216Thyroid cancer1.85E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Methadonehsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Methadonehsa05218Melanoma6.63E-031P04049RAF1More
Methadonehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Methadonehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Methadonehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Methadonehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Methadonehsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Methadonehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Methadonehsa05226Gastric cancer8.29E-031P04049RAF1More
Methadonehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Methadonehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Methadonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.06E-0412P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, PRKCQ, MAPK14, CD4More
Methadonehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Methadonehsa05323Rheumatoid arthritis2.00E-023Q13488, P10747, O60603TCIRG1, CD28, TLR2More
Methadonehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Methadonehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Methadonehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Methadonehsa05418Fluid shear stress and atherosclerosis2.06E-0412Q16539, P78417, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Methadone (SDC: 5.92)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DReported00.10350.15650.64481.0095
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P12271RLBP1RetinaldehydeNonebinding protein 1Predicted00.0840.106200.2543
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)