PharmaCoNets of Metformin (SPCN: 3.11 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Metforminhsa00310Lysine degradation4.14E-021Q02809PLOD1More
Metforminhsa012102-Oxocarboxylic acid metabolism1.40E-021P50213IDH3AMore
Metforminhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Metforminhsa04550Signaling pathways regulating pluripotency of stem cells2.16E-022P04628, P40189WNT1, IL6STMore
Metforminhsa04613Neutrophil extracellular trap formation1.23E-035P11215, Q13547, P58876, Q16778, O60814ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Metforminhsa04630JAK-STAT signaling pathway3.09E-033O75925, P40189, Q06124PIAS1, IL6ST, PTPN11More
Metforminhsa04920Adipocytokine signaling pathway4.76E-032Q06124, Q9Y478PTPN11, PRKAB1More
Metforminhsa04931Insulin resistance1.48E-022Q06124, Q9Y478PTPN11, PRKAB1More
Metforminhsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Metforminhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Metforminhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Metforminhsa05226Gastric cancer2.94E-022P04628, P10826WNT1, RARBMore
Metforminhsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More

Community members of Metformin (SDC: 1.95)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9Y478PRKAB15'NoneAMPNoneactivated protein kinase subunit betaNone1Reported10.14780.10880.55640.8479
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)