PharmaCoNets

PharmaCoNets of Metergoline (S_PCN: 218.09 )

Metergoline regulated-network (S_DN: 24.10)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Metergoline

hsa00030

Pentose phosphate pathway

9.38E-07

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Metergoline

hsa00052

Galactose metabolism

1.06E-03

P06280, O43451

GLA, MGAM

Metergoline

hsa00071

Fatty acid degradation

3.50E-02

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Metergoline

hsa00072

Synthesis and degradation of ketone bodies

2.78E-02

Q01581

HMGCS1

Metergoline

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Metergoline

hsa00190

Oxidative phosphorylation

5.31E-07

Q16718, Q13488, P36542, O14521

NDUFA5, TCIRG1, ATP5C1, SDHD

Metergoline

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Metergoline

hsa00280

Valine, leucine and isoleucine degradation

3.41E-03

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Metergoline

hsa00310

Lysine degradation

2.89E-03

Q96KQ7, Q02809, P51648

EHMT2, PLOD1, ALDH3A2

Metergoline

hsa00500

Starch and sucrose metabolism

2.32E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Metergoline

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Metergoline

hsa00562

Inositol phosphate metabolism

3.69E-02

P27987, P19174, P42338

ITPKB, PLCG1, PIK3CB

Metergoline

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Metergoline

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Metergoline

hsa00600

Sphingolipid metabolism

2.77E-02

Q9BX95, Q8TCT0, P15289

SGPP1, CERK, ARSA

Metergoline

hsa00630

Glyoxylate and dicarboxylate metabolism

4.35E-07

P40925, P40926, P05166, P15104

MDH1, MDH2, PCCB, GLUL

Metergoline

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Metergoline

hsa00730

Thiamine metabolism

2.53E-04

P05186, P24666

ALPL, ACP1

Metergoline

hsa00760

Nicotinate and nicotinamide metabolism

3.52E-02

P21589

NT5E

Metergoline

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Metergoline

hsa00830

Retinol metabolism

2.27E-03

P00325, P11766, P00352, Q9BPW9, O75911

ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3

Metergoline

hsa00900

Terpenoid backbone biosynthesis

9.84E-04

Q01581, P49354, Q9UHG3

HMGCS1, FNTA, PCYOX1

Metergoline

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Metergoline

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Metergoline

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Metergoline

hsa00983

Drug metabolism - other enzymes

5.10E-06

P04183, P20839, P32320, P05164, Q16772

TK1, IMPDH1, CDA, MPO, GSTA3

Metergoline

hsa01040

Biosynthesis of unsaturated fatty acids

2.92E-02

P22307, Q9H5J4

SCP2, ELOVL6

Metergoline

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Metergoline

hsa01210

2-Oxocarboxylic acid metabolism

1.40E-02

P50213

IDH3A

Metergoline

hsa01230

Biosynthesis of amino acids

2.26E-03

P51854, P60891, P05089, P37837

TKTL1, PRPS1, ARG1, TALDO1

Metergoline

hsa01240

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Metergoline

hsa01521

EGFR tyrosine kinase inhibitor resistance

2.18E-02

P49841, Q9NRA1

GSK3B, PDGFC

Metergoline

hsa01522

Endocrine resistance

5.79E-03

P22694, Q02750, Q9UM47, P46527, P10415, Q13323

PRKACB, MAP2K1, NOTCH3, CDKN1B, BCL2, BIK

Metergoline

hsa01523

Antifolate resistance

1.02E-05

P41440, Q92820, P04818, P01375, P18054

SLC19A1, GGH, TYMS, TNF, ALOX12

Metergoline

hsa01524

Platinum drug resistance

4.67E-02

Q13489, P98170, P78417, P43246

BIRC3, BIRC4, GSTO1, MSH2

Metergoline

hsa02010

ABC transporters

1.98E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Metergoline

hsa03010

Ribosome

1.53E-05

P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396

RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3

Metergoline

hsa03013

RNA transport

3.22E-09

P62826, O14980, Q09161, O14893, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, P47813, Q14152, P55884, O15371, O75822, Q9H777, P20042, Q14240, Q9BZI7, Q06787, P51114

RAN, XPO1, NCBP1, GEMIN2, RNPS1, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF3A, EIF3B, EIF3D, EIF3J, ELAC1, EIF2S2, EIF4A2, UPF3B, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62826	RAN	GTP-binding nuclear protein Ran	0.767
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
P26358	DNMT1	DNA	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.81
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.719
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.701
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P26358	DNMT1	DNA	P35658	NUP214	Nuclear pore complex protein Nup214	-0.717
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P35658	NUP214	Nuclear pore complex protein Nup214	-0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.743
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P68104	EEF1A1	Elongation factor 1-alpha 1	0.797
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
P26358	DNMT1	DNA	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.738
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
P26358	DNMT1	DNA	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.823
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
P26358	DNMT1	DNA	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.7
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q9H777	ELAC1	Zinc phosphodiesterase ELAC protein 1	0.785
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798
P26358	DNMT1	DNA	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.841

Metergoline

hsa03022

Basal transcription factors

2.97E-03

P20226, O00268, Q15544

TBP, TAF4, TAF11

Metergoline

hsa03040

Spliceosome

9.22E-07

Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, P51991, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142

DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, HNRPA3, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.809
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.811
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.702
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.879
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Metergoline

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Metergoline

hsa03060

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Metergoline

hsa03320

PPAR signaling pathway

4.55E-02

O00767, Q02318

SCD, CYP27A1

Metergoline

hsa03410

Base excision repair

7.59E-03

P27695

APEX1

Metergoline

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Metergoline

hsa04010

MAPK signaling pathway

1.53E-02

Q9H2K8, Q12933

TAOK3, TRAF2

Metergoline

hsa04012

ErbB signaling pathway

1.84E-04

P21860, P16333, Q13191, Q13557, P19174, O14944, P42338, P01106

ERBB3, NCK1, CBLB, CAMK2D, PLCG1, EREG, PIK3CB, MYC

Metergoline

hsa04014

Ras signaling pathway

1.23E-03

Q02750, Q15389, Q9NRA1, Q13009, P17252, P21359, P0DP23, P62873, P62879, P63218, P50151, P19174, P22694

MAP2K1, ANGPT1, PDGFC, TIAM1, PRKCA, NF1, CALM1, GNB1, GNB2, GNG5, GNG10, PLCG1, PRKACB

Metergoline

hsa04020

Calcium signaling pathway

3.93E-05

Q96DU7, Q08828, P45880, Q13557, P21860, P0DP24, P05141, P51828, P23634

ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CALM2, SLC25A5, ADCY7, ATP2B4

Metergoline

hsa04022

cGMP-PKG signaling pathway

3.74E-03

Q02153, Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24

GUCY1B3, CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2

Metergoline

hsa04060

Cytokine-cytokine receptor interaction

1.06E-04

P14784, P27930, P14778, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, O75509, P09341, P19875, P01730, Q93038

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, TNFRSF21, CXCL1, CXCL2, CD4, TNFRSF25

Metergoline

hsa04061

Viral protein interaction with cytokine and cytokine receptor

2.01E-04

P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Metergoline

hsa04062

Chemokine signaling pathway

4.30E-07

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43250	GRK6	G protein-coupled receptor kinase 6	0.815
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.771
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818

Metergoline

hsa04064

NF-kappa B signaling pathway

1.68E-08

P10415, Q13489, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9NQC7

BCL2, BIRC3, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q04759	PRKCQ	Protein kinase C theta type	O00463	TRAF5	TNF receptor-associated factor 5	0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q04759	PRKCQ	Protein kinase C theta type	Q16548	BCL2A1	Bcl-2-related protein A1	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q04759	PRKCQ	Protein kinase C theta type	P09341	CXCL1	Growth-regulated alpha protein	-0.885
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Metergoline

hsa04066

HIF-1 signaling pathway

4.48E-02

P17252, Q15389, Q02750, P46527

PRKCA, ANGPT1, MAP2K1, CDKN1B

Metergoline

hsa04070

Phosphatidylinositol signaling system

2.57E-03

P19174, P0DP23, Q14643, P23743, P27987, P17252

PLCG1, CALM1, ITPR1, DGKA, ITPKB, PRKCA

Metergoline

hsa04071

Sphingolipid signaling pathway

9.77E-06

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2, Q12933, Q02156

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2, TRAF2, PRKCE

Metergoline

hsa04072

Phospholipase D signaling pathway

5.17E-03

P42338, Q92529, P43657, P25024, P25025, P19174, Q14344

PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13

Metergoline

hsa04080

Neuroactive ligand-receptor interaction

4.76E-05

P08311, P28472, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21730, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, C5AR1, ADRB2

Metergoline

hsa04110

Cell cycle

2.12E-06

Q9UBD5, P06493, O60566, Q14683, O75293, P30304, P33981, P42773, P01106

ORC3, CDK1, BUB1B, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYC

Metergoline

hsa04120

Ubiquitin mediated proteolysis

1.08E-03

Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669

SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12

Metergoline

hsa04140

Autophagy - animal

1.86E-03

Q9Y4H2, P42338, Q9NQL2, P22694, Q14643, P10415, Q04759

IRS2, PIK3CB, RRAGD, PRKACB, ITPR1, BCL2, PRKCQ

Metergoline

hsa04141

Protein processing in endoplasmic reticulum

6.19E-07

P18848, P30101, Q15437, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, P14625, Q9H173, Q9UNL2

ATF4, PDIA3, SEC23B, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, HSP90B1, SIL1, SSR3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14625	HSP90B1	Endoplasmin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.739
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q15437	SEC23B	Protein transport protein Sec23B	0.768
P14625	HSP90B1	Endoplasmin	Q15436	SEC23A	Protein transport protein Sec23A	0.729
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q15436	SEC23A	Protein transport protein Sec23A	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.775
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.801
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.771
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.763
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.7
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.744
P14625	HSP90B1	Endoplasmin	P14625	HSP90B1	Endoplasmin	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9H173	SIL1	Nucleotide exchange factor SIL1	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9UNL2	SSR3	Translocon-associated protein subunit gamma	-0.706

Metergoline

hsa04145

Phagosome

3.28E-05

P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, O60603, P13765

ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB

Metergoline

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Metergoline

hsa04151

PI3K-Akt signaling pathway

1.45E-05

P62753, P21860, P25116, P27348, P49767, Q13362, P07900, P14625, P62873, P61952, P16144, Q16363, P22105, O60603, P01568, Q99941, P18848, P10415, P17252, O00141

RPS6, ERBB3, F2R, YWHAQ, VEGFC, PPP2R5C, HSP90AA1, HSP90B1, GNB1, GNG11, ITGB4, LAMA4, TNXB, TLR2, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14625	HSP90B1	Endoplasmin	P62753	RPS6	40S ribosomal protein S6	0.738
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62753	RPS6	40S ribosomal protein S6	0.709
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.85
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P27348	YWHAQ	14-3-3 protein theta	0.76
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.763
P14625	HSP90B1	Endoplasmin	P14625	HSP90B1	Endoplasmin	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.789
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	-0.756
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P14625	HSP90B1	Endoplasmin	Q16363	LAMA4	Laminin subunit alpha-4	0.818
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q16363	LAMA4	Laminin subunit alpha-4	0.773
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P22105	TNXB	Tenascin-X	0.777
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P22105	TNXB	Tenascin-X	0.801
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.801
P14625	HSP90B1	Endoplasmin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.739
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709

Metergoline

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Metergoline

hsa04211

Longevity regulating pathway

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Metergoline

hsa04213

Longevity regulating pathway - multiple species

1.63E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Metergoline

hsa04217

Necroptosis

5.35E-08

P01375, P01568, P48023, Q13489, P98170, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q13557, O43633, P21796, Q08752

TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CAMK2D, CHMP2A, VDAC1, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.763
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P15104	GLUL	Glutamine synthetase	0.745
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P15104	GLUL	Glutamine synthetase	0.809
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P05141	SLC25A5	ADP/ATP translocase 2	0.779
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P01584	IL1B	Interleukin-1 beta	0.725
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P0C0S5	H2AFZ	Histone H2A.Z	0.786
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	1
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Metergoline

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Metergoline

hsa04260

Cardiac muscle contraction

4.02E-02

P09493, P14927

TPM1, UQCRB

Metergoline

hsa04261

Adrenergic signaling in cardiomyocytes

1.86E-05

P09493, P07550, P51828, P22694, Q99941, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634

TPM1, ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51828	ADCY7	Adenylate cyclase type 7	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P07550	ADRB2	Beta-2 adrenergic receptor	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	-0.704
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.763
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Metergoline

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Metergoline

hsa04340

Hedgehog signaling pathway

7.27E-04

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Metergoline

hsa04370

VEGF signaling pathway

4.05E-02

P19174, P42338

PLCG1, PIK3CB

Metergoline

hsa04371

Apelin signaling pathway

1.90E-07

P62873, P63218, P50151, P61952, Q08828, Q13370, Q14344, Q13485, P84022, P62753, Q16566, P0DP23, P0DP24

GNB1, GNG5, GNG10, GNG11, ADCY1, PDE3B, GNA13, SMAD4, SMAD3, RPS6, CAMK4, CALM1, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.789
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	-0.756
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62753	RPS6	40S ribosomal protein S6	0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.708
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P0DP24	CALM2	Calmodulin-2	0.786

Metergoline

hsa04380

Osteoclast differentiation

9.58E-05

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Metergoline

hsa04512

ECM-receptor interaction

1.90E-02

P26012, P16070

ITGB8, CD44

Metergoline

hsa04530

Tight junction

2.45E-03

Q8TEU7, P16989, P56750, O00501, Q14247, P24844

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9

Metergoline

hsa04540

Gap junction

2.34E-06

P17252, P22694, Q13509, P68371, Q71U36, Q02750, Q9NRA1, Q14643

PRKCA, PRKACB, TUBB3, TUBB2C, TUBA1A, MAP2K1, PDGFC, ITPR1

Metergoline

hsa04550

Signaling pathways regulating pluripotency of stem cells

2.16E-02

P04628, P40189

WNT1, IL6ST

Metergoline

hsa04610

Complement and coagulation cascades

8.75E-05

P0C0L4

C4A

Metergoline

hsa04612

Antigen processing and presentation

7.49E-07

P13765, P01730, Q14953, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375

HLA-DOB, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
Q04759	PRKCQ	Protein kinase C theta type	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.803
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q04759	PRKCQ	Protein kinase C theta type	P26717	KLRC2	NKG2-C type II integral membrane protein	0.803
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
Q04759	PRKCQ	Protein kinase C theta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.849
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Metergoline

hsa04613

Neutrophil extracellular trap formation

1.09E-04

P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Metergoline

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Metergoline

hsa04621

NOD-like receptor signaling pathway

3.40E-02

Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838

ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4

Metergoline

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Metergoline

hsa04623

Cytosolic DNA-sensing pathway

1.31E-03

P01568, P25963

IFNA21, NFKBIA

Metergoline

hsa04625

C-type lectin receptor signaling pathway

9.91E-04

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Metergoline

hsa04630

JAK-STAT signaling pathway

3.09E-03

O75925, P40189, Q06124

PIAS1, IL6ST, PTPN11

Metergoline

hsa04640

Hematopoietic cell lineage

1.37E-09

P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584

ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q04759	PRKCQ	Protein kinase C theta type	P25063	CD24	Signal transducer CD24	-0.903
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Metergoline

hsa04650

Natural killer cell mediated cytotoxicity

8.47E-13

P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q04759	PRKCQ	Protein kinase C theta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.855
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q04759	PRKCQ	Protein kinase C theta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.849
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q04759	PRKCQ	Protein kinase C theta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.918
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q04759	PRKCQ	Protein kinase C theta type	P26717	KLRC2	NKG2-C type II integral membrane protein	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
Q04759	PRKCQ	Protein kinase C theta type	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Metergoline

hsa04657

IL-17 signaling pathway

1.67E-05

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1B

Metergoline

hsa04658

Th1 and Th2 cell differentiation

3.34E-17

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q04759	PRKCQ	Protein kinase C theta type	Q14765	STAT4	Signal transducer and activator of transcription 4	0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Metergoline

hsa04659

Th17 cell differentiation

4.90E-16

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, P01584, P08238, P07766, P09693, P20963, P23458

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q04759	PRKCQ	Protein kinase C theta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.8
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Metergoline

hsa04660

T cell receptor signaling pathway

9.39E-12

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q04759	PRKCQ	Protein kinase C theta type	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q04759	PRKCQ	Protein kinase C theta type	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q04759	PRKCQ	Protein kinase C theta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.767
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Metergoline

hsa04662

B cell receptor signaling pathway

2.11E-02

P42338, P60033, P21854, Q8N149

PIK3CB, CD81, CD72, LILRA2

Metergoline

hsa04664

Fc epsilon RI signaling pathway

7.09E-04

P01375, P04141, Q16539, Q9UQC2, P07948, P19174, P09917

TNF, CSF2, MAPK14, GAB2, LYN, PLCG1, ALOX5

Metergoline

hsa04668

TNF signaling pathway

1.28E-05

P01375, O00463, Q16539, Q99941, P18848, P19875, P01584, P20749, P14780, P20333, O95429

TNF, TRAF5, MAPK14, CREBL1, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B, BAG4

Metergoline

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Metergoline

hsa04713

Circadian entrainment

2.18E-08

O15399, P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P63218, P50151, P61952, Q14643, Q08828

GRIN2D, CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG5, GNG10, GNG11, ITPR1, ADCY1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.729
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P0DP24	CALM2	Calmodulin-2	0.786
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	1
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q02153	GUCY1B3	Guanylate cyclase soluble subunit beta-1	-0.792
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.789
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	-0.756
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q08828	ADCY1	Adenylate cyclase type 1	0.75

Metergoline

hsa04714

Thermogenesis

6.01E-04

Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521

MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHD

Metergoline

hsa04720

Long-term potentiation

4.71E-06

P17252, Q16566, Q13557, P0DP23, P0DP24, P51812, P18848, O15399, P22694, Q08828, Q02750, Q14643

PRKCA, CAMK4, CAMK2D, CALM1, CALM2, RPS6KA3, ATF4, GRIN2D, PRKACB, ADCY1, MAP2K1, ITPR1

Metergoline

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Metergoline

hsa04722

Neurotrophin signaling pathway

1.98E-03

Q05655, P49841, O43524, P48023, P52566

PRKCD, GSK3B, FOXO3, FASLG, ARHGDIB

Metergoline

hsa04723

Retrograde endocannabinoid signaling

1.69E-03

Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718

ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5

Metergoline

hsa04724

Glutamatergic synapse

4.55E-06

O15399, Q08828, P62873, P63218, P50151, P61952, P15104

GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLUL

Metergoline

hsa04725

Cholinergic synapse

1.03E-08

Q08828, P51828, P22694, Q14643, P17252, P62873, P62879, P63218, P50151, P61952, P18848, Q16566, Q13557, P10415, Q02750

ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNB2, GNG5, GNG10, GNG11, ATF4, CAMK4, CAMK2D, BCL2, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51828	ADCY7	Adenylate cyclase type 7	0.726
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.71
Q13315	ATM	Serine-protein kinase ATM	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.858
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.768
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
Q13315	ATM	Serine-protein kinase ATM	P17252	PRKCA	Protein kinase C alpha type	0.739
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.789
Q13315	ATM	Serine-protein kinase ATM	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	-0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	-0.756
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.708
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.763
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	1
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.723
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q13315	ATM	Serine-protein kinase ATM	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	-0.797

Metergoline

hsa04726

Serotonergic synapse

1.47E-04

P22694, P17252, P62873, P62879, P63218, P50151, P09917, Q02750

PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ALOX5, MAP2K1

Metergoline

hsa04727

GABAergic synapse

1.31E-07

Q08828, P62873, P62879, P63218, P50151, P61952, P15104, P22694, O60296, Q15111, P17252

ADCY1, GNB1, GNB2, GNG5, GNG10, GNG11, GLUL, PRKACB, TRAK2, PLCL1, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.789
Q13315	ATM	Serine-protein kinase ATM	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	-0.716
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	-0.756
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P15104	GLUL	Glutamine synthetase	-0.773
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P15104	GLUL	Glutamine synthetase	0.745
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P15104	GLUL	Glutamine synthetase	0.809
Q13315	ATM	Serine-protein kinase ATM	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.858
Q13315	ATM	Serine-protein kinase ATM	O60296	TRAK2	Trafficking kinesin-binding protein 2	0.74
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q15111	PLCL1	Inactive phospholipase C-like protein 1	0.857
Q13315	ATM	Serine-protein kinase ATM	P17252	PRKCA	Protein kinase C alpha type	0.739

Metergoline

hsa04728

Dopaminergic synapse

3.34E-05

Q14643, P17252, P62873, P61952, Q99941, P18848, Q13557, Q13362, P0DP23, P0DP24, O15516

ITPR1, PRKCA, GNB1, GNG11, CREBL1, ATF4, CAMK2D, PPP2R5C, CALM1, CALM2, CLOCK

Metergoline

hsa04730

Long-term depression

6.53E-03

Q14344, P07948

GNA13, LYN

Metergoline

hsa04740

Olfactory transduction

1.17E-03

P62873, Q9H255, Q13557, P0DP24

GNB1, OR51E2, CAMK2D, CALM2

Metergoline

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Metergoline

hsa04744

Phototransduction

7.96E-08

P62873, P0DP23, P0DP24

GNB1, CALM1, CALM2

Metergoline

hsa04750

Inflammatory mediator regulation of TRP channels

5.20E-08

P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P01584	IL1B	Interleukin-1 beta	0.725
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P51828	ADCY7	Adenylate cyclase type 7	0.718
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.838
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0DP24	CALM2	Calmodulin-2	0.798
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P0DP24	CALM2	Calmodulin-2	0.786

Metergoline

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Metergoline

hsa04911

Insulin secretion

8.91E-07

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Metergoline

hsa04912

GnRH signaling pathway

7.11E-04

P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694

PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB

Metergoline

hsa04913

Ovarian steroidogenesis

1.27E-03

P42330, P22694

AKR1C3, PRKACB

Metergoline

hsa04915

Estrogen signaling pathway

6.27E-05

Q99941, P18848, Q08828, P51828, P07900, P11142, P0DP24

CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA8, CALM2

Metergoline

hsa04916

Melanogenesis

2.18E-02

P49841, Q01726

GSK3B, MC1R

Metergoline

hsa04918

Thyroid hormone synthesis

4.59E-05

Q08828, P51828, Q99941, P18848, P14625, P02768

ADCY1, ADCY7, CREBL1, ATF4, HSP90B1, ALB

Metergoline

hsa04919

Thyroid hormone signaling pathway

6.35E-04

P17252, P49841, Q02750, P22694, O60244, Q9NVC6, Q12778, Q9UM47

PRKCA, GSK3B, MAP2K1, PRKACB, MED14, MED17, FOXO1, NOTCH3

Metergoline

hsa04920

Adipocytokine signaling pathway

4.76E-03

Q06124, Q9Y478

PTPN11, PRKAB1

Metergoline

hsa04922

Glucagon signaling pathway

5.91E-03

P14618, P06737, Q12778, Q13370, P0DP23, Q14643

PKM2, PYGL, FOXO1, PDE3B, CALM1, ITPR1

Metergoline

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Metergoline

hsa04924

Renin secretion

6.00E-06

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Metergoline

hsa04925

Aldosterone synthesis and secretion

7.32E-07

Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634

CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4

Metergoline

hsa04926

Relaxin signaling pathway

1.50E-04

P62873, P61952, Q99941, P18848, P22694, P14780, Q08828, P51828, P30679

GNB1, GNG11, CREBL1, ATF4, PRKACB, MMP9, ADCY1, ADCY7, GNA15

Metergoline

hsa04927

Cortisol synthesis and secretion

2.04E-06

Q14643, Q99941, P18848, Q08828, P51828, P22694

ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB

Metergoline

hsa04928

Parathyroid hormone synthesis, secretion and action

1.09E-04

Q14643, P51828, P22694, P23771, Q02750, P17252, Q99941, P18848, P10415, Q9Y5Q3

ITPR1, ADCY7, PRKACB, GATA3, MAP2K1, PRKCA, CREBL1, ATF4, BCL2, MAFB

Metergoline

hsa04930

Type II diabetes mellitus

9.83E-04

Q05655, Q02156

PRKCD, PRKCE

Metergoline

hsa04931

Insulin resistance

9.16E-04

P01375, P49841, Q06124, P06737, Q9Y478

TNF, GSK3B, PTPN11, PYGL, PRKAB1

Metergoline

hsa04932

Non-alcoholic fatty liver disease

2.94E-04

P01375, P49841, P18848, P48023, P01584, P13073, P12074, O15239, Q16718, O14521

TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, SDHD

Metergoline

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.27E-02

P42224, P10415, Q12778, P49767, P17252

STAT1, BCL2, FOXO1, VEGFC, PRKCA

Metergoline

hsa04934

Cushing syndrome

2.90E-07

Q14643, Q99941, P18848, Q08828, P51828, P22694, O15169, Q13557, P04628

ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1

Metergoline

hsa04935

Growth hormone synthesis, secretion and action

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Metergoline

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Metergoline

hsa04960

Aldosterone-regulated sodium reabsorption

4.38E-02

P48048

KCNJ1

Metergoline

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Metergoline

hsa04966

Collecting duct acid secretion

1.95E-03

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Metergoline

hsa04970

Salivary secretion

1.60E-05

P07550, Q08828, P22694, Q14643, P17252, P0DP24, Q02153, P49913

ADRB2, ADCY1, PRKACB, ITPR1, PRKCA, CALM2, GUCY1B3, CAMP

Metergoline

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Metergoline

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Metergoline

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Metergoline

hsa04976

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Metergoline

hsa05010

Alzheimer disease

3.24E-03

Q92542, Q16718, O14521, P05496, P12074, Q14643, O75460, P0DP23, P01584, Q13509, P68371, O15169, P45880, Q08752

NCSTN, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, ERN1, CALM1, IL1B, TUBB3, TUBB2C, AXIN1, VDAC2, PPID

Metergoline

hsa05012

Parkinson disease

1.33E-04

O15239, Q16718, O14521, P13073, P12074, P05496, P05141, P60604, P18848, Q14643, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371

NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, UBE2G2, ATF4, ITPR1, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.885
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.712
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.763
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.818
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.775
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P0DP24	CALM2	Calmodulin-2	0.786
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741

Metergoline

hsa05014

Amyotrophic lateral sclerosis

2.72E-02

P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Metergoline

hsa05020

Prion disease

3.68E-06

P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P45880, Q13509, P68371, P49841, Q99941, P14598, Q15080, Q16539

IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, VDAC2, TUBB3, TUBB2C, GSK3B, CREBL1, NCF1, NCF4, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P01584	IL1B	Interleukin-1 beta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.745
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.885
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.818
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.712
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.763
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.801
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Metergoline

hsa05022

Pathways of neurodegeneration - multiple diseases

2.00E-04

Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23

ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1

Metergoline

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Metergoline

hsa05031

Amphetamine addiction

3.49E-05

P0DP24, Q13557, P22694, Q99941, P18848, Q13547

CALM2, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1

Metergoline

hsa05032

Morphine addiction

7.62E-04

P62873, P63218, P50151, Q13370, P43250

GNB1, GNG5, GNG10, PDE3B, GRK6

Metergoline

hsa05034

Alcoholism

2.51E-06

O15399, Q99941, P18848, Q16566, P0DP23, P0DP24, P62873, P63218, P50151, P61952, P0C0S5, Q93077, P62807, Q93079, O60814, P68431

GRIN2D, CREBL1, ATF4, CAMK4, CALM1, CALM2, GNB1, GNG5, GNG10, GNG11, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	0.729
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.801
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.708
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P0DP24	CALM2	Calmodulin-2	0.786
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.789
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	-0.756
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P0C0S5	H2AFZ	Histone H2A.Z	0.786
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q93079	H2BC9	Histone H2B type 1-H	-0.807
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Metergoline

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.22E-05

P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948

NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Metergoline

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Metergoline

hsa05131

Shigellosis

4.98E-04

Q12933, P68431, Q05655, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737

TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1

Metergoline

hsa05132

Salmonella infection

7.05E-04

P25963, P08238, Q9UJU2, P84095, Q13489, P10415, O75369, P07737, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

NFKBIA, HSP90AB1, LEF1, RHOG, BIRC3, BCL2, FLNB, PFN1, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Metergoline

hsa05133

Pertussis

3.51E-02

P0C0L4

C4A

Metergoline

hsa05134

Legionellosis

1.63E-06

P01584, P25963, Q9NR31, P11215, P68104, P11142, P09341, P19875

IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2

Metergoline

hsa05135

Yersinia infection

4.39E-02

P06239, P19174, P42338, P01732

LCK, PLCG1, PIK3CB, CD8A

Metergoline

hsa05140

Leishmaniasis

2.39E-06

P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, Q16539, Q15080

ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758

Metergoline

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Metergoline

hsa05144

Malaria

1.74E-03

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Metergoline

hsa05145

Toxoplasmosis

1.11E-02

P10415, Q13489, P42224, P13765, O60603, P29965

BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Metergoline

hsa05146

Amoebiasis

3.87E-12

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q04759	PRKCQ	Protein kinase C theta type	P09341	CXCL1	Growth-regulated alpha protein	-0.885
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q04759	PRKCQ	Protein kinase C theta type	P05089	ARG1	Arginase-1	-0.899
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
Q04759	PRKCQ	Protein kinase C theta type	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q04759	PRKCQ	Protein kinase C theta type	P12814	ACTN1	Alpha-actinin-1	-0.821
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
Q04759	PRKCQ	Protein kinase C theta type	P08311	CTSG	Cathepsin G	-0.913
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816

Metergoline

hsa05150

Staphylococcus aureus infection

3.10E-05

P0C0L4, P21462, O75015, P13646, Q14532, P59665, P59666, P12838

C4A, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4

Metergoline

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Metergoline

hsa05160

Hepatitis C

1.52E-03

P60033, O00501, P29728, P49841, P01375, P48023, P01106

CD81, CLDN5, OAS2, GSK3B, TNF, FASLG, MYC

Metergoline

hsa05161

Hepatitis B

3.34E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Metergoline

hsa05163

Human cytomegalovirus infection

1.49E-06

P01375, P25963, P62873, P63218, P50151, P61952, P0DP23, P0DP24, Q14344, Q08828, P49841, P14778, P01584, P25025, Q16539, Q99941, P18848, O00463, P30101, P61769, P01568

TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, CALM1, CALM2, GNA13, ADCY1, GSK3B, IL1R1, IL1B, CXCR2, MAPK14, CREBL1, ATF4, TRAF5, PDIA3, B2M, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.789
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	-0.756
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P0DP24	CALM2	Calmodulin-2	0.786
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P01584	IL1B	Interleukin-1 beta	0.725
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.801
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61769	B2M	Beta-2-microglobulin	0.753
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703

Metergoline

hsa05165

Human papillomavirus infection

5.80E-04

P46527, Q02750, P16144, P35443, Q92796, Q05086, Q9UM47, P01568, P42224, Q13488, P22694, Q13362, Q12778, Q13315

CDKN1B, MAP2K1, ITGB4, THBS4, DLG3, UBE3A, NOTCH3, IFNA21, STAT1, TCIRG1, PRKACB, PPP2R5C, FOXO1, ATM

Metergoline

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.28E-06

P01568, P42224, P25963, P62873, P63218, P50151, P19174, Q14643, P07948, P04141, P0DP23, Q9UJU2

IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, ITPR1, LYN, CSF2, CALM1, LEF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881

Metergoline

hsa05168

Herpes simplex virus 1 infection

7.71E-05

P25963, P01568, Q05823, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, Q13398, Q9HCX3, P52738, O75820, Q9NZL3, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF224, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13398	ZNF211	Zinc finger protein 211	-0.886
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q9NZL3	ZNF224	Zinc finger protein 224	-0.762
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824

Metergoline

hsa05169

Epstein-Barr virus infection

5.59E-04

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P01375, P29728, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, TNF, OAS2, CD3E, CD3G, CD247

Metergoline

hsa05170

Human immunodeficiency virus 1 infection

1.21E-05

P62873, P63218, P50151, P0DP23, P17252, P30101, Q14643, P01568, P25963, O60603, Q13315, P19174, P23528, P10415, Q9Y6Q5

GNB1, GNG5, GNG10, CALM1, PRKCA, PDIA3, ITPR1, IFNA21, NFKBIA, TLR2, ATM, PLCG1, CFL1, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P23528	CFL1	Cofilin-1	0.738
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829

Metergoline

hsa05171

Coronavirus disease - COVID-19

4.36E-05

P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513

RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37A

Metergoline

hsa05200

Pathways in cancer

1.32E-06

Q13751, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P14923, P10415, Q13489, P98170, P49767, Q12778, P25116, P62873, P63218, P50151, Q14344, P78417, O75293, P0DP23, P01568, P14784, P01042

LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, JUP, BCL2, BIRC3, BIRC4, VEGFC, FOXO1, F2R, GNB1, GNG5, GNG10, GNA13, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Metergoline

hsa05202

Transcriptional misregulation in cancer

1.08E-04

Q12778, Q13315, P17844, P14780, P27930, Q15744, Q16548, Q13077, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13315	ATM	Serine-protein kinase ATM	Q12778	FOXO1	Forkhead box protein O1	0.821
Q13315	ATM	Serine-protein kinase ATM	Q13315	ATM	Serine-protein kinase ATM	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
Q04759	PRKCQ	Protein kinase C theta type	P14780	MMP9	Matrix metalloproteinase-9	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q04759	PRKCQ	Protein kinase C theta type	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.745
Q13315	ATM	Serine-protein kinase ATM	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.709
Q04759	PRKCQ	Protein kinase C theta type	Q16548	BCL2A1	Bcl-2-related protein A1	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q13315	ATM	Serine-protein kinase ATM	P46527	CDKN1B	Cyclin-dependent kinase inhibitor 1B	0.708
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q04759	PRKCQ	Protein kinase C theta type	P05164	MPO	Myeloperoxidase	-0.88
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q13315	ATM	Serine-protein kinase ATM	P05164	MPO	Myeloperoxidase	-0.725
Q04759	PRKCQ	Protein kinase C theta type	P12838	DEFA4	Neutrophil defensin 4	-0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
Q04759	PRKCQ	Protein kinase C theta type	P08246	ELA2	Neutrophil elastase	-0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q13315	ATM	Serine-protein kinase ATM	P08246	ELA2	Neutrophil elastase	-0.742
Q04759	PRKCQ	Protein kinase C theta type	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
Q13315	ATM	Serine-protein kinase ATM	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
Q04759	PRKCQ	Protein kinase C theta type	Q13547	HDAC1	Histone deacetylase 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Metergoline

hsa05203

Viral carcinogenesis

2.63E-03

Q99941, P18848, P27348, Q15283, P61978, P62807, O60814

CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12

Metergoline

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Metergoline

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Metergoline

hsa05206

MicroRNAs in cancer

5.33E-04

P46527, P15311, P21860, P61978, P46531, Q9UM47, P16070, P63279, Q13315, P22105, P17252, Q02750

CDKN1B, VIL2, ERBB3, HNRPK, NOTCH1, NOTCH3, CD44, UBE2I, ATM, TNXB, PRKCA, MAP2K1

Metergoline

hsa05210

Colorectal cancer

4.67E-02

P84022, Q13485, P43246, O75293

SMAD3, SMAD4, MSH2, GADD45B

Metergoline

hsa05212

Pancreatic cancer

3.62E-03

P42224, P84022, Q13485, O75293

STAT1, SMAD3, SMAD4, GADD45B

Metergoline

hsa05214

Glioma

3.62E-03

P0DP23, Q16566, P19174, O75293

CALM1, CAMK4, PLCG1, GADD45B

Metergoline

hsa05215

Prostate cancer

4.48E-02

P18848, P14625

ATF4, HSP90B1

Metergoline

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Metergoline

hsa05217

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Metergoline

hsa05221

Acute myeloid leukemia

4.95E-02

P42338, Q15744, P11215

PIK3CB, CEBPE, ITGAM

Metergoline

hsa05222

Small cell lung cancer

3.80E-02

Q13751, Q13489, P98170, O75293

LAMB3, BIRC3, BIRC4, GADD45B

Metergoline

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Metergoline

hsa05225

Hepatocellular carcinoma

1.85E-02

Q92529, P51531

SHC3, SMARCA2

Metergoline

hsa05226

Gastric cancer

2.94E-02

P04628, P10826

WNT1, RARB

Metergoline

hsa05231

Choline metabolism in cancer

2.60E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Metergoline

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.83E-09

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, Q9HC35, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q04759	PRKCQ	Protein kinase C theta type	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719

Metergoline

hsa05310

Asthma

8.13E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Metergoline

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Metergoline

hsa05321

Inflammatory bowel disease

1.63E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Metergoline

hsa05322

Systemic lupus erythematosus

4.80E-06

P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Metergoline

hsa05323

Rheumatoid arthritis

1.59E-03

Q06643, P13765, Q13488, P10747, P09341, P19875, O60603

LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2

Metergoline

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Metergoline

hsa05332

Graft-versus-host disease

2.11E-06

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Metergoline

hsa05340

Primary immunodeficiency

2.02E-05

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Metergoline

hsa05410

Hypertrophic cardiomyopathy

1.73E-02

P26012, P09493

ITGB8, TPM1

Metergoline

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.98E-04

P54284, P15924, P26012

CACNB3, DSP, ITGB8

Metergoline

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Metergoline

hsa05415

Diabetic cardiomyopathy

5.60E-05

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Metergoline

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Metergoline

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Metergoline (S_DC: 9.05)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P21453

S1PR1

Sphingosine 1Nonephosphate receptor 1

Predicted

0.1434

0.3847

0.221

1.0621

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

Q05655

PRKCD

Protein kinase C delta type

Predicted

0.0816

0.4194

0.6544

1.5339

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

P24723

PRKCH

Protein kinase C eta type

Predicted

0.1955

0.3294

0.2048

0.9614

Q04759

PRKCQ

Protein kinase C theta type

Predicted

0.0405

0.4244

0.6173

1.4864

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

Q96EB6

SIRT1

NADNonedependent protein deacetylase sirtuinNone1

Predicted

0.2865

0.4571

0.5784

1.6358

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

Q13557

CAMK2D

Calcium/calmodulinNonedependent protein kinase type II subunit delta

Predicted

0.4778

0.306

0.8095

1.6604

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

P27695

APEX1

DNANone(apurinic or apyrimidinic site) endonuclease

Predicted

0.402

0.221

0.1217

0.7647

O00767

SCD

StearoylNoneCoA desaturase

Predicted

0.1686

0.187

0.1997

0.6581

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

P26358

DNMT1

DNA

Predicted

0.3404

0.2809

0.2659

0.998

Q9Y478

PRKAB1

5'NoneAMPNoneactivated protein kinase subunit betaNone1

Predicted

0.1478

0.1088

0.5564

0.8479

Q13315

ATM

SerineNoneprotein kinase ATM

Predicted

0.7747

0.2014

0.9391

1.7293

P48048

KCNJ1

ATPNonesensitive inward rectifier potassium channel 1

Predicted

0.0042

0.282

0.1274

0.6935

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P14625

HSP90B1

Endoplasmin

Predicted

0.2336

0.1497

0.5384

0.9546

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

P41968

MC3R

Melanocortin receptor 3

Predicted

0.2235

0.2637

0.6392

Q01726

MC1R

MelanocyteNonestimulating hormone receptor

Predicted

0.047

0.2375

0.011

0.5095

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P07947

YES1

TyrosineNoneprotein kinase Yes

Predicted

0.1212

0.4345

0.165

1.0947

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

O75381

PEX14

Peroxisomal membrane protein PEX14

Predicted

0.1907

0.0995

0.1097

0.4039

PharmaCoNets of Metergoline (SPCN: 218.09 )

Metergoline regulated-network (SDN: 24.10)

Community members of Metergoline (SDC: 9.05)

PharmaCoNets of Metergoline (S_PCN: 218.09 )

Metergoline regulated-network (S_DN: 24.10)

Community members of Metergoline (S_DC: 9.05)