PharmaCoNets of Metamfetamine (SPCN: 21.76 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Metamfetaminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Metamfetaminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Metamfetaminehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Metamfetaminehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Metamfetaminehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Metamfetaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Metamfetaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Metamfetaminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Metamfetaminehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Metamfetaminehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Metamfetaminehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Metamfetaminehsa03015mRNA surveillance pathway2.95E-023O94913, Q9H307, Q13148PCF11, PNN, TARDBPMore
Metamfetaminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Metamfetaminehsa03050Proteasome1.21E-021P28074PSMB5More
Metamfetaminehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Metamfetaminehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Metamfetaminehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Metamfetaminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Metamfetaminehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Metamfetaminehsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Metamfetaminehsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Metamfetaminehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Metamfetaminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Metamfetaminehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Metamfetaminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Metamfetaminehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Metamfetaminehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Metamfetaminehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Metamfetaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Metamfetaminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Metamfetaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Metamfetaminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Metamfetaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Metamfetaminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Metamfetaminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Metamfetaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Metamfetaminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Metamfetaminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Metamfetaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Metamfetaminehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Metamfetaminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Metamfetaminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Metamfetaminehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Metamfetaminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Metamfetaminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Metamfetaminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Metamfetaminehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Metamfetaminehsa05133Pertussis4.94E-021P0C0L4C4AMore
Metamfetaminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Metamfetaminehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Metamfetaminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Metamfetaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Metamfetaminehsa05205Proteoglycans in cancer4.79E-038P63261, P04637, P14780, P01375, P23588, Q06124, Q13635, P22694ACTG1, TP53, MMP9, TNF, EIF4B, PTPN11, PTCH1, PRKACBMore
Metamfetaminehsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Metamfetaminehsa05212Pancreatic cancer2.60E-022P04637, P24522TP53, GADD45AMore
Metamfetaminehsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Metamfetaminehsa05214Glioma2.60E-022P04637, P24522TP53, GADD45AMore
Metamfetaminehsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Metamfetaminehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Metamfetaminehsa05218Melanoma3.41E-045P09619, Q9GZP0, P04637, Q02750, P24522PDGFRB, PDGFD, TP53, MAP2K1, GADD45AMore
Metamfetaminehsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Metamfetaminehsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Metamfetaminehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Metamfetaminehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Metamfetaminehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Metamfetaminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Metamfetaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Metamfetaminehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Metamfetaminehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Metamfetaminehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Metamfetaminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Metamfetamine (SDC: 2.73)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P30679GNA15Guanine nucleotideNonebinding protein subunit alphaNone15Predicted00.03730.11460.28910.5369
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)