PharmaCoNets

PharmaCoNets of Mesoridazine (S_PCN: 75.49 )

Mesoridazine regulated-network (S_DN: 14.03)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Mesoridazine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Mesoridazine

hsa00040

Pentose and glucuronate interconversions

4.00E-02

P15121

AKR1B1

Mesoridazine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Mesoridazine

hsa00500

Starch and sucrose metabolism

2.21E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Mesoridazine

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Mesoridazine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Mesoridazine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Mesoridazine

hsa00600

Sphingolipid metabolism

4.77E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Mesoridazine

hsa00620

Pyruvate metabolism

3.90E-02

P07195, P11766

LDHB, ADH5

Mesoridazine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Mesoridazine

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Mesoridazine

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Mesoridazine

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.38E-04

P78417, P09211, P11712

GSTO1, GSTP1, CYP2C9

Mesoridazine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Mesoridazine

hsa00983

Drug metabolism - other enzymes

3.48E-03

P04183, P32320, P05164

TK1, CDA, MPO

Mesoridazine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Mesoridazine

hsa01230

Biosynthesis of amino acids

2.92E-03

P51854, P60891, P05089, P15104, P37837

TKTL1, PRPS1, ARG1, GLUL, TALDO1

Mesoridazine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Mesoridazine

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Mesoridazine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Mesoridazine

hsa03010

Ribosome

2.25E-04

P40429, Q07020, P27635, P05386, P62249

RPL13A, RPL18, RPL10, RPLP1, RPS16

Mesoridazine

hsa03013

RNA transport

2.12E-02

P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Mesoridazine

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Mesoridazine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Mesoridazine

hsa03060

Protein export

4.46E-03

Q15070, O76094

OXA1L, SRP72

Mesoridazine

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Mesoridazine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Mesoridazine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Mesoridazine

hsa04060

Cytokine-cytokine receptor interaction

2.05E-02

P27930, P14778, P26842, Q13651, P25024, P25025, Q9UBD3, P47992, P09341, P18510, P01730

IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCR2, XCL2, XCL1, CXCL1, IL1RN, CD4

Mesoridazine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.68E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Mesoridazine

hsa04062

Chemokine signaling pathway

4.11E-04

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.843
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.892
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P47992	XCL1	Lymphotactin	-0.796
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.796
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.709
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798

Mesoridazine

hsa04064

NF-kappa B signaling pathway

7.48E-05

P10415, O00463, P14778, P19174, Q04759, Q9UDY8, Q16548, P07948, P06239, Q13315, P24522, P09341, P19875, Q06643

BCL2, TRAF5, IL1R1, PLCG1, PRKCQ, MALT1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16548	BCL2A1	Bcl-2-related protein A1	0.82
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.793
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09341	CXCL1	Growth-regulated alpha protein	0.788
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Mesoridazine

hsa04071

Sphingolipid signaling pathway

1.82E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Mesoridazine

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Mesoridazine

hsa04080

Neuroactive ligand-receptor interaction

2.16E-03

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2

Mesoridazine

hsa04114

Oocyte meiosis

6.23E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Mesoridazine

hsa04115

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Mesoridazine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Mesoridazine

hsa04145

Phagosome

3.82E-03

Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4

Mesoridazine

hsa04210

Apoptosis

3.77E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Mesoridazine

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Mesoridazine

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Mesoridazine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Mesoridazine

hsa04370

VEGF signaling pathway

3.06E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Mesoridazine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Mesoridazine

hsa04610

Complement and coagulation cascades

1.47E-05

P00734, P0C0L4

F2, C4A

Mesoridazine

hsa04612

Antigen processing and presentation

2.09E-04

P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Mesoridazine

hsa04613

Neutrophil extracellular trap formation

2.18E-03

P04908, Q93077, P62807, O60814, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Mesoridazine

hsa04640

Hematopoietic cell lineage

1.48E-04

P13612, P14778, P27930, P11215, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, IL1R1, IL1R2, ITGAM, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Mesoridazine

hsa04650

Natural killer cell mediated cytotoxicity

9.30E-08

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.774
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.9
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P78314	SH3BP2	SH3 domain-binding protein 2	0.807
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.799
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.799
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.733
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.888
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.712
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Mesoridazine

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

Mesoridazine

hsa04658

Th1 and Th2 cell differentiation

1.52E-09

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.714
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.867
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.738
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.744
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Mesoridazine

hsa04659

Th17 cell differentiation

1.42E-07

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.738
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.867
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.714
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87

Mesoridazine

hsa04660

T cell receptor signaling pathway

3.47E-07

Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.727
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.709
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.759
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.75
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798

Mesoridazine

hsa04662

B cell receptor signaling pathway

2.57E-02

P49841, P60033, P07948, P21854, Q8N149

GSK3B, CD81, LYN, CD72, LILRA2

Mesoridazine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Mesoridazine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Mesoridazine

hsa04720

Long-term potentiation

2.85E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Mesoridazine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Mesoridazine

hsa04725

Cholinergic synapse

4.83E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Mesoridazine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Mesoridazine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Mesoridazine

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Mesoridazine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Mesoridazine

hsa04914

Progesterone-mediated oocyte maturation

1.00E-02

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Mesoridazine

hsa04915

Estrogen signaling pathway

2.96E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Mesoridazine

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Mesoridazine

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Mesoridazine

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Mesoridazine

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Mesoridazine

hsa04927

Cortisol synthesis and secretion

4.44E-04

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Mesoridazine

hsa04928

Parathyroid hormone synthesis, secretion and action

2.13E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Mesoridazine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Mesoridazine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Mesoridazine

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.68E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Mesoridazine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Mesoridazine

hsa04972

Pancreatic secretion

2.68E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Mesoridazine

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Mesoridazine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Mesoridazine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Mesoridazine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Mesoridazine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Mesoridazine

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Mesoridazine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

5.40E-05

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Mesoridazine

hsa05132

Salmonella infection

4.62E-03

P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Mesoridazine

hsa05133

Pertussis

2.95E-03

P0DP23, P0C0L4

CALM1, C4A

Mesoridazine

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Mesoridazine

hsa05135

Yersinia infection

2.59E-03

Q05397, P51812, P13612, P06239, Q16539, Q02750, P49841, Q96JJ3, P01730, P01732

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, GSK3B, ELMO2, CD4, CD8A

Mesoridazine

hsa05143

African trypanosomiasis

3.01E-03

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Mesoridazine

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Mesoridazine

hsa05146

Amoebiasis

2.05E-05

P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814

CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1

Mesoridazine

hsa05152

Tuberculosis

1.08E-02

Q13488, P48382, P25208, O60603, P10415, P01568, Q9UDY8, P51617

TCIRG1, RFX5, NFYB, TLR2, BCL2, IFNA21, MALT1, IRAK1

Mesoridazine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Mesoridazine

hsa05163

Human cytomegalovirus infection

8.17E-03

P63218, P50151, P49841, P14778, Q13651, P25025, Q16539, O00463, P30101

GNG5, GNG10, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3

Mesoridazine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.96E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Mesoridazine

hsa05169

Epstein-Barr virus infection

1.68E-03

P13765, Q13547, O00463, Q16539, P07948, P30101, Q13761, P24522, P29728, P07766, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, LYN, PDIA3, RUNX3, GADD45A, OAS2, CD3E, CD3G, CD247

Mesoridazine

hsa05170

Human immunodeficiency virus 1 infection

2.65E-03

P62873, P63218, P50151, P17252, Q13546, O00463, P30101, Q14643, P01568, P01730, Q16539, P51617, O60603, Q13315, P07766, P09693, P20963, P10415, Q9Y6Q5

GNB1, GNG5, GNG10, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, CD4, MAPK14, IRAK1, TLR2, ATM, CD3E, CD3G, CD247, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.701
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P30101	PDIA3	Protein disulfide-isomerase A3	-0.721
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.946

Mesoridazine

hsa05171

Coronavirus disease - COVID-19

3.87E-04

P62249, P40429, P27635, Q07020, P05386

RPS16, RPL13A, RPL10, RPL18, RPLP1

Mesoridazine

hsa05202

Transcriptional misregulation in cancer

9.36E-04

Q12778, Q15532, Q13315, P14780, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
P05164	MPO	Myeloperoxidase	Q15532	SS18	Protein SSXT	-0.719
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P05164	MPO	Myeloperoxidase	P14780	MMP9	Matrix metalloproteinase-9	0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P05164	MPO	Myeloperoxidase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.799
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
P05164	MPO	Myeloperoxidase	O15550	UTX	Lysine-specific demethylase 6A	0.763
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P05164	MPO	Myeloperoxidase	P05164	MPO	Myeloperoxidase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P05164	MPO	Myeloperoxidase	P12838	DEFA4	Neutrophil defensin 4	0.733
P05164	MPO	Myeloperoxidase	P08246	ELA2	Neutrophil elastase	0.903
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
P05164	MPO	Myeloperoxidase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.854
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812

Mesoridazine

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Mesoridazine

hsa05204

Chemical carcinogenesis

1.09E-03

P09211, P78417, P11712

GSTP1, GSTO1, CYP2C9

Mesoridazine

hsa05205

Proteoglycans in cancer

2.02E-03

Q13009, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962

TIAM1, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63

Mesoridazine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.65E-05

P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4

Mesoridazine

hsa05321

Inflammatory bowel disease

1.19E-03

P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Mesoridazine

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Mesoridazine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Mesoridazine

hsa05332

Graft-versus-host disease

1.91E-05

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Mesoridazine

hsa05340

Primary immunodeficiency

3.99E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Mesoridazine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Community members of Mesoridazine (S_DC: 5.38)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Reported

0.0604

0.4779

2.5081

P11169

SLC2A3

Solute carrier family 2, facilitated glucose transporter member 3

Predicted

0.1357

0.0658

0.1995

P09211

GSTP1

Glutathione SNonetransferase P

Predicted

0.3204

0.3523

0.4566

1.3213

P05164

MPO

Myeloperoxidase

Predicted

0.2035

0.5368

0.5502

1.7255

Q9UDY8

MALT1

MucosaNoneassociated lymphoid tissue lymphoma translocation protein 1

Predicted

0.0516

0.147

0.5592

0.8789

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P37840

SNCA

AlphaNonesynuclein

Predicted

0.0853

0.1324

0.3321

0.6395

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

Q6PCB7

SLC27A1

LongNonechain fatty acid transport protein 1

Predicted

0.2915

0.0768

0.0992

0.3985

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

PharmaCoNets of Mesoridazine (SPCN: 75.49 )

Mesoridazine regulated-network (SDN: 14.03)

Community members of Mesoridazine (SDC: 5.38)

PharmaCoNets of Mesoridazine (S_PCN: 75.49 )

Mesoridazine regulated-network (S_DN: 14.03)

Community members of Mesoridazine (S_DC: 5.38)