PharmaCoNets of Menthyl-salicylate (SPCN: 76.98 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Menthyl-salicylatehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Menthyl-salicylatehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Menthyl-salicylatehsa00190Oxidative phosphorylation1.29E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Menthyl-salicylatehsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Menthyl-salicylatehsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Menthyl-salicylatehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Menthyl-salicylatehsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Menthyl-salicylatehsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.01E-021Q14442PIGHMore
Menthyl-salicylatehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Menthyl-salicylatehsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Menthyl-salicylatehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Menthyl-salicylatehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Menthyl-salicylatehsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Menthyl-salicylatehsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Menthyl-salicylatehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Menthyl-salicylatehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Menthyl-salicylatehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Menthyl-salicylatehsa01524Platinum drug resistance3.80E-034O15392, Q16772, P09211, P11388BIRC5, GSTA3, GSTP1, TOP2AMore
Menthyl-salicylatehsa02010ABC transporters1.20E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Menthyl-salicylatehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Menthyl-salicylatehsa03013RNA transport6.80E-0613O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3More
Menthyl-salicylatehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Menthyl-salicylatehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Menthyl-salicylatehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Menthyl-salicylatehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Menthyl-salicylatehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Menthyl-salicylatehsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Menthyl-salicylatehsa04064NF-kappa B signaling pathway2.75E-0613P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1More
Menthyl-salicylatehsa04071Sphingolipid signaling pathway4.48E-068P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Menthyl-salicylatehsa04080Neuroactive ligand-receptor interaction3.44E-048P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2More
Menthyl-salicylatehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Menthyl-salicylatehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Menthyl-salicylatehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Menthyl-salicylatehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Menthyl-salicylatehsa04145Phagosome3.44E-0410P60709, Q15075, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Menthyl-salicylatehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Menthyl-salicylatehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Menthyl-salicylatehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Menthyl-salicylatehsa04210Apoptosis1.54E-0311Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1More
Menthyl-salicylatehsa04340Hedgehog signaling pathway1.47E-045P49841, P22694, Q13635, Q9Y496, P10415GSK3B, PRKACB, PTCH1, KIF3A, BCL2More
Menthyl-salicylatehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Menthyl-salicylatehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Menthyl-salicylatehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Menthyl-salicylatehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Menthyl-salicylatehsa04612Antigen processing and presentation3.22E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Menthyl-salicylatehsa04613Neutrophil extracellular trap formation2.07E-0719P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Menthyl-salicylatehsa04621NOD-like receptor signaling pathway2.68E-0414Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Menthyl-salicylatehsa04650Natural killer cell mediated cytotoxicity2.02E-039P16298, P50591, O60880, P20963, Q02750, Q13241, P26718, P26717, P26715PPP3CB, TNFSF10, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KLRC1More
Menthyl-salicylatehsa04657IL-17 signaling pathway5.21E-038O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNFMore
Menthyl-salicylatehsa04658Th1 and Th2 cell differentiation5.80E-058Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Menthyl-salicylatehsa04659Th17 cell differentiation9.58E-0413Q04759, P19174, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, PLCG1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Menthyl-salicylatehsa04660T cell receptor signaling pathway1.84E-0513P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Menthyl-salicylatehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Menthyl-salicylatehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Menthyl-salicylatehsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Menthyl-salicylatehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Menthyl-salicylatehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Menthyl-salicylatehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Menthyl-salicylatehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Menthyl-salicylatehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Menthyl-salicylatehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Menthyl-salicylatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Menthyl-salicylatehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Menthyl-salicylatehsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Menthyl-salicylatehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Menthyl-salicylatehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Menthyl-salicylatehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Menthyl-salicylatehsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Menthyl-salicylatehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Menthyl-salicylatehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Menthyl-salicylatehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Menthyl-salicylatehsa05110Vibrio cholerae infection4.50E-034Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Menthyl-salicylatehsa05120Epithelial cell signaling in Helicobacter pylori infection6.89E-032Q99437, P41240ATP6V0B, CSKMore
Menthyl-salicylatehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Menthyl-salicylatehsa05132Salmonella infection2.98E-0211P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Menthyl-salicylatehsa05133Pertussis4.20E-021P0C0L4C4AMore
Menthyl-salicylatehsa05140Leishmaniasis1.14E-0412P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, IRAK1, NCF4More
Menthyl-salicylatehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Menthyl-salicylatehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Menthyl-salicylatehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Menthyl-salicylatehsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Menthyl-salicylatehsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Menthyl-salicylatehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Menthyl-salicylatehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Menthyl-salicylatehsa05170Human immunodeficiency virus 1 infection2.58E-0518Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Menthyl-salicylatehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Menthyl-salicylatehsa05202Transcriptional misregulation in cancer1.50E-0720Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Menthyl-salicylatehsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Menthyl-salicylatehsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Menthyl-salicylatehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Menthyl-salicylatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Menthyl-salicylatehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Menthyl-salicylatehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Menthyl-salicylatehsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Menthyl-salicylatehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Menthyl-salicylatehsa05231Choline metabolism in cancer3.99E-024P19174, P23743, O14494, P17252PLCG1, DGKA, PLPP1, PRKCAMore
Menthyl-salicylatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Menthyl-salicylatehsa05310Asthma3.11E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Menthyl-salicylatehsa05321Inflammatory bowel disease7.75E-076O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Menthyl-salicylatehsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Menthyl-salicylatehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Menthyl-salicylatehsa05332Graft-versus-host disease1.60E-055P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Menthyl-salicylatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Menthyl-salicylatehsa05415Diabetic cardiomyopathy2.18E-038P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Menthyl-salicylate (SDC: 5.99)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)