PharmaCoNets

PharmaCoNets of Menadione (S_PCN: 55.60 )

Menadione regulated-network (S_DN: 17.43)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Menadione

hsa00051

Fructose and mannose metabolism

4.17E-02

P15121, P60174

AKR1B1, TPI1

Menadione

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Menadione

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Menadione

hsa00230

Purine metabolism

1.56E-02

Q7LG56, P51828, Q9Y227

RRM2B, ADCY7, ENTPD4

Menadione

hsa00240

Pyrimidine metabolism

1.45E-02

Q7LG56, Q9Y227

RRM2B, ENTPD4

Menadione

hsa00280

Valine, leucine and isoleucine degradation

3.41E-03

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Menadione

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Menadione

hsa00520

Amino sugar and nucleotide sugar metabolism

1.04E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Menadione

hsa00562

Inositol phosphate metabolism

1.28E-02

Q14642, P29218

INPP5A, IMPA1

Menadione

hsa00600

Sphingolipid metabolism

4.77E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Menadione

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

8.72E-03

P06865, O75752

HEXA, B3GALNT1

Menadione

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.46E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Menadione

hsa00630

Glyoxylate and dicarboxylate metabolism

4.50E-07

P40925, P15104

MDH1, GLUL

Menadione

hsa00830

Retinol metabolism

3.15E-02

P00325

ADH1B

Menadione

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Menadione

hsa00970

Aminoacyl-tRNA biosynthesis

3.36E-04

O95363, P54136, Q15046

FARS2, RARS1, KARS

Menadione

hsa00983

Drug metabolism - other enzymes

2.58E-04

P04183, P32320, P05164

TK1, CDA, MPO

Menadione

hsa01100

Metabolic pathways

4.12E-02

Q14642, P29218, Q14376, P07101, Q9UHK6, P12074

INPP5A, IMPA1, GALE, TH, AMACR, COX6A1

Menadione

hsa01524

Platinum drug resistance

4.67E-02

Q13489, P98170, P78417, P43246

BIRC3, BIRC4, GSTO1, MSH2

Menadione

hsa03010

Ribosome

4.92E-05

P42677, P30050, P40429, P46776, Q9H0U6, Q07020, P62910, P36578, P05386, P62249, P23396

RPS27, RPL12, RPL13A, RPL27A, MRPL18, RPL18, RPL32, RPL4, RPLP1, RPS16, RPS3

Menadione

hsa03013

RNA transport

2.68E-03

P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q9Y6A5, P51114

NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, TACC3, FXR1

Menadione

hsa03020

RNA polymerase

1.31E-02

P24928, P62487

POLR2A, POLR2G

Menadione

hsa03040

Spliceosome

2.01E-09

O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q15365, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, PCBP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.809
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P22891	PROZ	Vitamin K-dependent protein Z	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.893
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P22891	PROZ	Vitamin K-dependent protein Z	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.7
P22891	PROZ	Vitamin K-dependent protein Z	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.759
P22891	PROZ	Vitamin K-dependent protein Z	Q15365	PCBP1	Poly(rC)-binding protein 1	0.829
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.879
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P22891	PROZ	Vitamin K-dependent protein Z	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P22891	PROZ	Vitamin K-dependent protein Z	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.706
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Menadione

hsa03060

Protein export

3.37E-02

P37108, Q15005

SRP14, SPCS2

Menadione

hsa03410

Base excision repair

4.17E-02

P49005, P29372

POLD2, MPG

Menadione

hsa04012

ErbB signaling pathway

3.15E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Menadione

hsa04014

Ras signaling pathway

1.98E-03

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Menadione

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Menadione

hsa04060

Cytokine-cytokine receptor interaction

1.74E-04

P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P19875, P18510, P01730, Q93038

IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, CXCL2, IL1RN, CD4, TNFRSF25

Menadione

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.81E-03

P09341, P19875, P25024, P47992, Q9UBD3, Q13651, P14784, P01375

CXCL1, CXCL2, CXCR1, XCL1, XCL2, IL10RA, IL2RB, TNF

Menadione

hsa04062

Chemokine signaling pathway

2.41E-05

P25024, P09341, P19875, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51124	GZMM	Granzyme M	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.737
P51124	GZMM	Granzyme M	P09341	CXCL1	Growth-regulated alpha protein	-0.733
P51124	GZMM	Granzyme M	P19875	CXCL2	C-X-C motif chemokine 2	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P51124	GZMM	Granzyme M	P07948	LYN	Tyrosine-protein kinase Lyn	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P51124	GZMM	Granzyme M	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.845
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P51124	GZMM	Granzyme M	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43250	GRK6	G protein-coupled receptor kinase 6	0.815
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P51124	GZMM	Granzyme M	P43250	GRK6	G protein-coupled receptor kinase 6	-0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.771
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Menadione

hsa04064

NF-kappa B signaling pathway

3.72E-06

P10415, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q16548, P07948, P06239, Q13315, P24522, O75293, P09341, P19875, Q06643

BCL2, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, BCL2A1, LYN, LCK, ATM, GADD45A, GADD45B, CXCL1, CXCL2, LTB

Menadione

hsa04070

Phosphatidylinositol signaling system

2.65E-02

P29218, Q14642

IMPA1, INPP5A

Menadione

hsa04071

Sphingolipid signaling pathway

2.84E-03

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Menadione

hsa04080

Neuroactive ligand-receptor interaction

6.23E-03

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Menadione

hsa04110

Cell cycle

1.44E-02

P06493, O75293, P30304, P33981, P42773, P01106, Q13547

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1

Menadione

hsa04114

Oocyte meiosis

2.05E-02

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Menadione

hsa04141

Protein processing in endoplasmic reticulum

6.04E-03

P18848, Q15437, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31

ATF4, SEC23B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Menadione

hsa04142

Lysosome

2.23E-02

P22304, Q13510, Q04900, Q9Y227

IDS, ASAH1, CD164, ENTPD4

Menadione

hsa04144

Endocytosis

2.25E-02

O75351, P42566, Q15438, Q14161, Q9UNH7

VPS4B, EPS15, PSCD1, GIT2, SNX6

Menadione

hsa04145

Phagosome

2.82E-04

Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB

Menadione

hsa04151

PI3K-Akt signaling pathway

7.70E-05

P42338, P43657, O43521, P27348, P20827, P49767, Q13362, P07900, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P22105, P14784, P23458, Q99941, P18848, O00141, Q6ZUJ8, P30281

PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, JAK1, CREBL1, ATF4, SGK, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P22891	PROZ	Vitamin K-dependent protein Z	O43521	BCL2L11	Bcl-2-like protein 11	0.774
P22891	PROZ	Vitamin K-dependent protein Z	P27348	YWHAQ	14-3-3 protein theta	0.797
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P22891	PROZ	Vitamin K-dependent protein Z	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.783
P22891	PROZ	Vitamin K-dependent protein Z	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.81
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P22891	PROZ	Vitamin K-dependent protein Z	P22105	TNXB	Tenascin-X	0.712
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P22891	PROZ	Vitamin K-dependent protein Z	P23458	JAK1	Tyrosine-protein kinase JAK1	0.771
P22891	PROZ	Vitamin K-dependent protein Z	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.712
P22891	PROZ	Vitamin K-dependent protein Z	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
P22891	PROZ	Vitamin K-dependent protein Z	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.719
P22891	PROZ	Vitamin K-dependent protein Z	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.786
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Menadione

hsa04210

Apoptosis

2.59E-02

P10415, O76075, P01375, P24522, Q16548, P43234, P18848, Q14643

BCL2, DFFB, TNF, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Menadione

hsa04211

Longevity regulating pathway

4.57E-02

P51828, Q99941, P18848, Q96RR4

ADCY7, CREBL1, ATF4, CAMKK2

Menadione

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Menadione

hsa04217

Necroptosis

2.16E-04

P01568, P23458, Q13489, P98170, Q9NQC7, P07900, P08238, P15104, P05141, P01584, Q9H444, O75351, P21796

IFNA21, JAK1, BIRC3, BIRC4, CYLD, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, CHMP4B, VPS4B, VDAC1

Menadione

hsa04261

Adrenergic signaling in cardiomyocytes

1.26E-02

P67936, P51828, Q99941, P18848, Q13362, P23634

TPM4, ADCY7, CREBL1, ATF4, PPP2R5C, ATP2B4

Menadione

hsa04340

Hedgehog signaling pathway

4.63E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Menadione

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Menadione

hsa04370

VEGF signaling pathway

1.29E-02

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Menadione

hsa04371

Apelin signaling pathway

2.03E-05

P62873, P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Menadione

hsa04610

Complement and coagulation cascades

3.16E-03

P00734, P0C0L4

F2, C4A

Menadione

hsa04612

Antigen processing and presentation

1.76E-05

P04233, P13765, P48382, P26715, P26717, Q13241, P01732, P01889, P10321, Q06323, P01375

CD74, HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, HLA-B, HLA-C, PSME1, TNF

Menadione

hsa04613

Neutrophil extracellular trap formation

1.72E-02

O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P21730, P21462

TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, C5AR1, FPR1

Menadione

hsa04621

NOD-like receptor signaling pathway

2.39E-02

P01584, P07900, P23458, Q9H3M7, P43490

IL1B, HSP90AA1, JAK1, TXNIP, PBEF1

Menadione

hsa04640

Hematopoietic cell lineage

5.95E-03

P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Menadione

hsa04650

Natural killer cell mediated cytotoxicity

2.06E-05

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, P26717, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, KLRC2, KLRC1

Menadione

hsa04657

IL-17 signaling pathway

2.29E-02

O00463, P09341, P14780, P80188, P01375

TRAF5, CXCL1, MMP9, LCN2, TNF

Menadione

hsa04658

Th1 and Th2 cell differentiation

1.28E-09

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
P51124	GZMM	Granzyme M	Q13761	RUNX3	Runt-related transcription factor 3	0.849

Menadione

hsa04659

Th17 cell differentiation

2.65E-08

Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888

Menadione

hsa04660

T cell receptor signaling pathway

5.72E-05

P01375, Q04759, P42338, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, P06239

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, LCK

Menadione

hsa04662

B cell receptor signaling pathway

2.98E-06

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Menadione

hsa04664

Fc epsilon RI signaling pathway

4.74E-05

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Menadione

hsa04710

Circadian rhythm

3.74E-03

O00327, O15055

ARNTL, PER2

Menadione

hsa04713

Circadian entrainment

1.78E-03

O15399, P0DP23, P62873, P63218, P50151

GRIN2D, CALM1, GNB1, GNG5, GNG10

Menadione

hsa04720

Long-term potentiation

2.33E-02

Q16566, P0DP23, O15399

CAMK4, CALM1, GRIN2D

Menadione

hsa04724

Glutamatergic synapse

1.13E-05

O15399, P43003, P62873, P63218, P50151, P15104

GRIN2D, SLC1A3, GNB1, GNG5, GNG10, GLUL

Menadione

hsa04725

Cholinergic synapse

1.09E-03

P22694, Q14643, P62873, P63218, P50151, P18848, Q16566, P10415

PRKACB, ITPR1, GNB1, GNG5, GNG10, ATF4, CAMK4, BCL2

Menadione

hsa04726

Serotonergic synapse

2.38E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Menadione

hsa04727

GABAergic synapse

2.45E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Menadione

hsa04744

Phototransduction

6.94E-03

P62873, P0DP23

GNB1, CALM1

Menadione

hsa04750

Inflammatory mediator regulation of TRP channels

3.85E-02

P14778, P19174, P42338, P24723

IL1R1, PLCG1, PIK3CB, PRKCH

Menadione

hsa04911

Insulin secretion

4.85E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Menadione

hsa04912

GnRH signaling pathway

2.01E-02

P51828, P0DP24, P45985

ADCY7, CALM2, MAP2K4

Menadione

hsa04914

Progesterone-mediated oocyte maturation

2.66E-02

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Menadione

hsa04915

Estrogen signaling pathway

1.20E-03

P14780, P22694, Q99941, P18848, P51828, P07900, P11142, Q14643, Q15788, P10415

MMP9, PRKACB, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, ITPR1, NCOA1, BCL2

Menadione

hsa04918

Thyroid hormone synthesis

2.05E-03

P22694, P51828, Q99941, P18848, Q14643, P05543

PRKACB, ADCY7, CREBL1, ATF4, ITPR1, SERPINA7

Menadione

hsa04925

Aldosterone synthesis and secretion

2.50E-02

Q99941, P18848, P51828, P23634

CREBL1, ATF4, ADCY7, ATP2B4

Menadione

hsa04927

Cortisol synthesis and secretion

7.21E-04

Q14643, Q99941, P18848, P51828, P22694

ITPR1, CREBL1, ATF4, ADCY7, PRKACB

Menadione

hsa04928

Parathyroid hormone synthesis, secretion and action

1.60E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Menadione

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Menadione

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.68E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Menadione

hsa04964

Proximal tubule bicarbonate reclamation

2.93E-02

P22748, P49448

CA4, GLUD2

Menadione

hsa04970

Salivary secretion

4.61E-02

P51828, P0DP24

ADCY7, CALM2

Menadione

hsa04972

Pancreatic secretion

2.54E-03

Q14643, P20020, P17252, Q08828, P62491

ITPR1, ATP2B1, PRKCA, ADCY1, RAB11A

Menadione

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Menadione

hsa05032

Morphine addiction

1.34E-02

P62873, P63218, P50151, P43250

GNB1, GNG5, GNG10, GRK6

Menadione

hsa05034

Alcoholism

3.87E-03

O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93079

GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, H2BC9

Menadione

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P07948

CXCL1, CXCL2, PLCG1, CXCR1, LYN

Menadione

hsa05132

Salmonella infection

4.62E-03

P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Menadione

hsa05133

Pertussis

2.24E-02

P0DP23, P0C0L4

CALM1, C4A

Menadione

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Menadione

hsa05143

African trypanosomiasis

4.81E-02

P69905, P68871

HBA2, HBB

Menadione

hsa05144

Malaria

1.80E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Menadione

hsa05146

Amoebiasis

1.12E-07

Q13751, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Menadione

hsa05150

Staphylococcus aureus infection

2.44E-02

P21462, Q14532, P59665, P59666

FPR1, KRT32, DEFA1; DEFA1B, DEFA3

Menadione

hsa05152

Tuberculosis

1.54E-03

Q13488, P48382, P25208, O60603, P01375, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Menadione

hsa05163

Human cytomegalovirus infection

2.28E-04

P42338, P62873, P63218, P50151, P0DP23, P51828, P23458, P01106, P14778, P01584, P61073, Q13651, Q99941, P18848, P30101, P01568

PIK3CB, GNB1, GNG5, GNG10, CALM1, ADCY7, JAK1, MYC, IL1R1, IL1B, CXCR4, IL10RA, CREBL1, ATF4, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P51124	GZMM	Granzyme M	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.845
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P51124	GZMM	Granzyme M	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P22891	PROZ	Vitamin K-dependent protein Z	P51828	ADCY7	Adenylate cyclase type 7	0.797
P22891	PROZ	Vitamin K-dependent protein Z	P23458	JAK1	Tyrosine-protein kinase JAK1	0.771
P51124	GZMM	Granzyme M	P01106	MYC	Myc proto-oncogene protein	0.774
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P22891	PROZ	Vitamin K-dependent protein Z	P01584	IL1B	Interleukin-1 beta	0.804
P22891	PROZ	Vitamin K-dependent protein Z	P61073	CXCR4	C-X-C chemokine receptor type 4	0.734
P22891	PROZ	Vitamin K-dependent protein Z	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.756
P51124	GZMM	Granzyme M	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.778
P22891	PROZ	Vitamin K-dependent protein Z	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.712
P22891	PROZ	Vitamin K-dependent protein Z	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.732
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P51124	GZMM	Granzyme M	P30101	PDIA3	Protein disulfide-isomerase A3	0.846
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703

Menadione

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.74E-04

P01568, P42338, P62873, P63218, P50151, P09341, P19875, P19174, P07948, P01106, P0DP23

IFNA21, PIK3CB, GNB1, GNG5, GNG10, CXCL1, CXCL2, PLCG1, LYN, MYC, CALM1

Menadione

hsa05168

Herpes simplex virus 1 infection

4.43E-02

P01568, Q07955, P84103, Q13243, Q13489, P30101, Q13398, Q9NZL3

IFNA21, SFRS1, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF224

Menadione

hsa05169

Epstein-Barr virus infection

1.27E-02

P01106, Q13547, P42338, P07948, P30101, Q13761, O75293, P07766, P20963

MYC, HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CD3E, CD247

Menadione

hsa05170

Human immunodeficiency virus 1 infection

1.56E-04

P42338, P62873, P63218, P50151, P0DP23, P17252, Q13546, P30101, Q14643, P01568, P01730, P51617, O60603, Q13315, P19174, P23528, P07766, P20963, P10415, Q9Y6Q5

PIK3CB, GNB1, GNG5, GNG10, CALM1, PRKCA, RIPK1, PDIA3, ITPR1, IFNA21, CD4, IRAK1, TLR2, ATM, PLCG1, CFL1, CD3E, CD247, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.701
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P51124	GZMM	Granzyme M	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.845
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P51124	GZMM	Granzyme M	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P51124	GZMM	Granzyme M	P30101	PDIA3	Protein disulfide-isomerase A3	0.846
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P23528	CFL1	Cofilin-1	0.738
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.946

Menadione

hsa05171

Coronavirus disease - COVID-19

9.07E-04

P23396, P62249, P42677, P40429, P36578, P30050, Q07020, P46776, P62910, P05386

RPS3, RPS16, RPS27, RPL13A, RPL4, RPL12, RPL18, RPL27A, RPL32, RPLP1

Menadione

hsa05200

Pathways in cancer

2.72E-05

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, Q13489, P98170, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P01042

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, BIRC3, BIRC4, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Menadione

hsa05202

Transcriptional misregulation in cancer

2.12E-05

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P24158	PRTN3	Myeloblastin	Q15532	SS18	Protein SSXT	-0.732
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
P24158	PRTN3	Myeloblastin	P14780	MMP9	Matrix metalloproteinase-9	0.837
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P24158	PRTN3	Myeloblastin	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.741
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
P24158	PRTN3	Myeloblastin	O15550	UTX	Lysine-specific demethylase 6A	0.776
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
P24158	PRTN3	Myeloblastin	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.777
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799

Menadione

hsa05203

Viral carcinogenesis

1.32E-03

Q99941, P18848, P23458, P27348, Q7KZF4, Q15283, P06396, P01889, P10321, P61978

CREBL1, ATF4, JAK1, YWHAQ, SND1, RASA2, GSN, HLA-B, HLA-C, HNRPK

Menadione

hsa05205

Proteoglycans in cancer

1.67E-02

Q13009, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962

TIAM1, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63

Menadione

hsa05210

Colorectal cancer

4.67E-02

P84022, Q13485, P43246, O75293

SMAD3, SMAD4, MSH2, GADD45B

Menadione

hsa05212

Pancreatic cancer

3.46E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Menadione

hsa05214

Glioma

3.28E-02

P0DP23, Q16566, O75293

CALM1, CAMK4, GADD45B

Menadione

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Menadione

hsa05222

Small cell lung cancer

3.80E-02

Q13751, Q13489, P98170, O75293

LAMB3, BIRC3, BIRC4, GADD45B

Menadione

hsa05223

Non-small cell lung cancer

4.24E-02

P19174, Q9HC35, O75293

PLCG1, EML4, GADD45B

Menadione

hsa05231

Choline metabolism in cancer

4.24E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Menadione

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

9.00E-06

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, Q04759, Q9HC35, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, PRKCQ, EML4, CD4

Menadione

hsa05310

Asthma

9.49E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Menadione

hsa05321

Inflammatory bowel disease

1.17E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Menadione

hsa05322

Systemic lupus erythematosus

3.90E-02

P08246, P08311, P01375, P13765, Q16778, P12814

ELA2, CTSG, TNF, HLA-DOB, HIST2H2BE, ACTN1

Menadione

hsa05323

Rheumatoid arthritis

2.72E-02

P01375, P13765, P09341, O60603

TNF, HLA-DOB, CXCL1, TLR2

Menadione

hsa05332

Graft-versus-host disease

6.94E-04

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Menadione

hsa05340

Primary immunodeficiency

4.24E-02

P01730, P07766, P06239

CD4, CD3E, LCK

Community members of Menadione (S_DC: 3.19)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

VKORC1

Vitamin K epoxide reductase complex subunit 1

Reported

0.2806

0.04

0.1697

0.39

P00734

Prothrombin

Reported

0.0963

0.707

0.4977

1.9598

P16083

NQO2

Ribosyldihydronicotinamide dehydrogenase [quinone]

Reported

0.2958

0.3134

0.7747

P08575

PTPRC

ReceptorNonetype tyrosineNoneprotein phosphatase C

Predicted

0.2733

0.1358

0.4132

0.8216

Q02750

MAP2K1

Dual specificity mitogenNoneactivated protein kinase kinase 1

Predicted

0.312

0.5129

2.1819

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

P35610

SOAT1

Sterol ONoneacyltransferase 1

Predicted

0.3855

0.2936

0.0165

0.7964

P30304

CDC25A

MNonephase inducer phosphatase 1

Predicted

0.1795

0.2347

0.4274

0.9865

Q09472

EP300

Histone acetyltransferase p300

Predicted

0.4182

0.0672

0.9307

1.2742

Q9UDY8

MALT1

MucosaNoneassociated lymphoid tissue lymphoma translocation protein 1

Predicted

0.0516

0.147

0.5592

0.8789

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P26358

DNMT1

DNA

Predicted

0.3404

0.2809

0.2659

0.998

P22891

PROZ

Vitamin KNonedependent protein Z

Predicted

0.7981

0.0168

0.4327

P24158

PRTN3

Myeloblastin

Predicted

0.0516

0.0511

0.1281

P08311

CTSG

Cathepsin G

Predicted

0.4949

0.1874

0.6478

1.2701

P51124

GZMM

Granzyme M

Predicted

0.0528

0.0301

0.0867

PharmaCoNets of Menadione (SPCN: 55.60 )

Menadione regulated-network (SDN: 17.43)

Community members of Menadione (SDC: 3.19)

PharmaCoNets of Menadione (S_PCN: 55.60 )

Menadione regulated-network (S_DN: 17.43)

Community members of Menadione (S_DC: 3.19)