PharmaCoNets of Melatonin (SPCN: 156.12 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Melatoninhsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Melatoninhsa00230Purine metabolism4.60E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Melatoninhsa00240Pyrimidine metabolism4.50E-022P32320, P27707CDA, DCKMore
Melatoninhsa00500Starch and sucrose metabolism3.88E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Melatoninhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Melatoninhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Melatoninhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Melatoninhsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Melatoninhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Melatoninhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Melatoninhsa00670One carbon pool by folate3.99E-022O95954, Q99707FTCD, MTRMore
Melatoninhsa00730Thiamine metabolism3.79E-022P05186, P24666ALPL, ACP1More
Melatoninhsa00770Pantothenate and CoA biosynthesis4.29E-042O95498, Q9NRN7VNN2, AASDHPPTMore
Melatoninhsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Melatoninhsa00920Sulfur metabolism3.88E-042Q16762, O95571TST, ETHE1More
Melatoninhsa00970Aminoacyl-tRNA biosynthesis2.24E-033O95363, P14868, Q15046FARS2, DARS, KARSMore
Melatoninhsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Melatoninhsa01100Metabolic pathways3.95E-0223Q9Y234, Q99707, P29218, P11310, P27707, Q13370, P36959, Q13956, P30043, Q02252, O60701, O14772, O95954, Q02318, P04406, O15466, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, MTR, IMPA1, ACADM, DCK, PDE3B, GMPR, PDE6H, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, CYP27A1, GAPDH, ST8SIA5, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Melatoninhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Melatoninhsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Melatoninhsa02010ABC transporters4.89E-021Q99758ABCA3More
Melatoninhsa03010Ribosome3.22E-032Q9UHA3, P50914RSL24D1, RPL14More
Melatoninhsa03013RNA transport1.87E-0417P62826, P52298, Q09161, O14893, P38919, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, O75822, P78345, Q9Y6A5, Q14232RAN, NCBP2, NCBP1, GEMIN2, EIF4A3, NXF1, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF3J, RPP38, TACC3, EIF2B1More
Melatoninhsa03015mRNA surveillance pathway3.62E-023O43148, P61326, P52298RNMT, MAGOH, NCBP2More
Melatoninhsa03020RNA polymerase2.51E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Melatoninhsa03022Basal transcription factors3.52E-033O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Melatoninhsa03040Spliceosome3.19E-1223Q14562, O43143, O60508, P17844, O14776, P08579, P26368, O75940, P52298, P09651, Q15365, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O95777, O43447, O75643, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, U2AF2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, LSM8, PPIH, ASCC3L1, MAGOHMore
Melatoninhsa03050Proteasome2.51E-033P55036, P43686, P28070PSMD4, PSMC4, PSMB4More
Melatoninhsa03320PPAR signaling pathway2.18E-022O00767, Q02318SCD, CYP27A1More
Melatoninhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Melatoninhsa03460Fanconi anemia pathway3.70E-033Q9NPI8, O60673, Q9UNA4FANCF, REV3L, POLIMore
Melatoninhsa04014Ras signaling pathway2.19E-0413P31751, P42338, P20827, P49767, Q13009, P17252, Q15311, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, RALBP1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Melatoninhsa04015Rap1 signaling pathway3.54E-0413P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, Q08828, P51828, P42338, P31751, P0DP23, P17252, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Melatoninhsa04020Calcium signaling pathway1.59E-0712P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P05141, P51828, P23634, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Melatoninhsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Melatoninhsa04024cAMP signaling pathway4.17E-049Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1More
Melatoninhsa04061Viral protein interaction with cytokine and cytokine receptor4.79E-037Q8NHW4, P09341, P19875, P25024, P25025, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RBMore
Melatoninhsa04062Chemokine signaling pathway4.72E-0522P51684, P25024, P25025, P09341, P19875, Q8NHW4, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08828, P51828, Q7LDG7, Q13009, P14598, P42224, P31751, Q8WYR1CCR6, CXCR1, CXCR2, CXCL1, CXCL2, CCL4L2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ADCY1, ADCY7, RASGRP2, TIAM1, NCF1, STAT1, AKT2, PIK3R5More
Melatoninhsa04064NF-kappa B signaling pathway1.15E-1325P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, O75293, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, GADD45B, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Melatoninhsa04070Phosphatidylinositol signaling system2.11E-058P19174, P0DP23, O14986, P23743, Q16760, P48426, P27987, P17252PLCG1, CALM1, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKB, PRKCAMore
Melatoninhsa04071Sphingolipid signaling pathway3.45E-0711P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, P01042PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, KNG1More
Melatoninhsa04072Phospholipase D signaling pathway4.56E-0514P31751, P42338, P43657, P25024, P25025, P19174, P17252, O14986, Q15438, Q08828, P51828, P23743, Q16760, P00734AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PRKCA, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKA, DGKD, F2More
Melatoninhsa04080Neuroactive ligand-receptor interaction3.27E-0610P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADMMore
Melatoninhsa04114Oocyte meiosis5.20E-049P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Melatoninhsa04115p53 signaling pathway3.32E-035P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Melatoninhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Melatoninhsa04122Sulfur relay system8.89E-031Q16762TSTMore
Melatoninhsa04140Autophagy - animal1.88E-0410P31751, Q7L523, Q96RR4, O75460, P22694, Q14643, P10415, Q04759, Q96GC9, Q8TEV9AKT2, RRAGA, CAMKK2, ERN1, PRKACB, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8More
Melatoninhsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Melatoninhsa04145Phagosome6.16E-0511P60709, P63261, Q15075, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Melatoninhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Melatoninhsa04151PI3K-Akt signaling pathway6.34E-0426P42338, P43657, O43521, P27348, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8, P30281PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1, CCND3More
Melatoninhsa04210Apoptosis1.18E-0515Q13315, P10415, Q13489, O76075, P25963, P07384, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643, P60709, P63261ATM, BCL2, BIRC3, DFFB, NFKBIA, CAPN1, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1, ACTB, ACTG1More
Melatoninhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Melatoninhsa04213Longevity regulating pathway - multiple species4.29E-037P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Melatoninhsa04217Necroptosis2.92E-0919P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P08238, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4BMore
Melatoninhsa04261Adrenergic signaling in cardiomyocytes1.90E-0812P09493, Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Melatoninhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Melatoninhsa04340Hedgehog signaling pathway1.05E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Melatoninhsa04360Axon guidance1.15E-0410P61073, P16333, P20827, O95631, P17252, Q13557, P42338, P07332, P23528, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, PIK3CB, FES, CFL1, PLCG1More
Melatoninhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Melatoninhsa04371Apelin signaling pathway1.34E-0413P62873, P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Melatoninhsa04380Osteoclast differentiation3.11E-038Q9NQC7, Q9UQC2, P23458, P42224, P31751, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, AKT2, IL1B, NCF4, NCF1More
Melatoninhsa04390Hippo signaling pathway2.63E-033P60709, P63261, O15105ACTB, ACTG1, SMAD7More
Melatoninhsa04510Focal adhesion3.76E-027P16144, O75369, Q15942, P17252, Q13489, P10415, P49767ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFCMore
Melatoninhsa04520Adherens junction1.58E-022P60709, P63261ACTB, ACTG1More
Melatoninhsa04530Tight junction4.99E-044P60709, P63261, Q92974, P60660ACTB, ACTG1, ARHGEF2, MYL6More
Melatoninhsa04540Gap junction4.08E-025P17252, Q13509, P68371, Q08828, P51828PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7More
Melatoninhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Melatoninhsa04611Platelet activation2.61E-022P60709, P63261ACTB, ACTG1More
Melatoninhsa04612Antigen processing and presentation1.42E-047P13765, P48382, P26715, P26717, Q07444, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, CD8AMore
Melatoninhsa04613Neutrophil extracellular trap formation1.49E-0516P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Melatoninhsa04614Renin-angiotensin system3.52E-021P10619CTSAMore
Melatoninhsa04620Toll-like receptor signaling pathway1.82E-046P51617, P01568, P01584, P31751, P42224, Q8NHW4IRAK1, IFNA21, IL1B, AKT2, STAT1, CCL4L2More
Melatoninhsa04621NOD-like receptor signaling pathway3.98E-0520P01584, P08238, Q16539, Q14643, P23458, P42224, P01568, P25963, Q9H3M7, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838IL1B, HSP90AB1, MAPK14, ITPR1, JAK1, STAT1, IFNA21, NFKBIA, TXNIP, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Melatoninhsa04623Cytosolic DNA-sensing pathway8.22E-054P01584, P01568, Q9Y535, Q8NHW4IL1B, IFNA21, POLR3H, CCL4L2More
Melatoninhsa04625C-type lectin receptor signaling pathway9.86E-034P01584, Q9NQC7, P31751, P0DP23IL1B, CYLD, AKT2, CALM1More
Melatoninhsa04630JAK-STAT signaling pathway1.40E-038P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21More
Melatoninhsa04640Hematopoietic cell lineage3.20E-049P08514, P21926, P14778, P27930, P11215, P25063, P07766, P01732, P09564ITGA2B, CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Melatoninhsa04650Natural killer cell mediated cytotoxicity1.17E-0814P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1More
Melatoninhsa04657IL-17 signaling pathway1.28E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Melatoninhsa04658Th1 and Th2 cell differentiation1.04E-1114Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Melatoninhsa04659Th17 cell differentiation1.53E-0816Q04759, Q16539, P19174, P06239, P42226, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Melatoninhsa04660T cell receptor signaling pathway7.84E-0917P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Melatoninhsa04662B cell receptor signaling pathway1.72E-057P25963, P42338, P20023, P60033, P07948, P21854, Q8N149NFKBIA, PIK3CB, CR2, CD81, LYN, CD72, LILRA2More
Melatoninhsa04664Fc epsilon RI signaling pathway1.55E-034P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Melatoninhsa04666Fc gamma R-mediated phagocytosis2.78E-026P08575, P19174, P23528, Q9UQC2, P14598, P17252PTPRC, PLCG1, CFL1, GAB2, NCF1, PRKCAMore
Melatoninhsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Melatoninhsa04670Leukocyte transendothelial migration9.64E-039P14780, P60709, P63261, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, ACTB, ACTG1, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Melatoninhsa04713Circadian entrainment7.67E-067O15399, P0DP23, Q13557, P17252, P62873, Q08828, P51828GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, ADCY1, ADCY7More
Melatoninhsa04714Thermogenesis3.64E-044P15336, P60709, P63261, P36542ATF2, ACTB, ACTG1, ATP5C1More
Melatoninhsa04720Long-term potentiation2.30E-059P17252, Q13557, P16298, P0DP23, P51812, P18848, O15399, Q08828, Q02750PRKCA, CAMK2D, PPP3CB, CALM1, RPS6KA3, ATF4, GRIN2D, ADCY1, MAP2K1More
Melatoninhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Melatoninhsa04724Glutamatergic synapse1.47E-049P48058, O15399, Q08828, P51828, P17252, P62873, P63218, P50151, P15104GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, GLULMore
Melatoninhsa04725Cholinergic synapse4.52E-0713Q08828, P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Melatoninhsa04727GABAergic synapse2.34E-038Q08828, P51828, P62873, P63218, P50151, P15104, P46459, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GLUL, NSF, PRKCAMore
Melatoninhsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Melatoninhsa04740Olfactory transduction2.61E-023P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Melatoninhsa04744Phototransduction1.30E-052P62873, P0DP23GNB1, CALM1More
Melatoninhsa04750Inflammatory mediator regulation of TRP channels5.49E-0812P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P17252, P24723, Q04759, P0DP23, P01042IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCA, PRKCH, PRKCQ, CALM1, KNG1More
Melatoninhsa04911Insulin secretion2.41E-035Q08828, P51828, P17252, P18848, Q13557ADCY1, ADCY7, PRKCA, ATF4, CAMK2DMore
Melatoninhsa04912GnRH signaling pathway1.36E-036P17252, Q08828, P51828, P18848, Q13557, P0DP23PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, CALM1More
Melatoninhsa04914Progesterone-mediated oocyte maturation3.78E-039Q17RY0, Q08828, P51828, P31751, Q13370, Q9UJX4, P08238, P51812, Q02750CPEB4, ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1, RPS6KA3, MAP2K1More
Melatoninhsa04915Estrogen signaling pathway3.97E-0512P14780, P22694, P18848, Q08828, P51828, P31751, P08238, P11142, Q14643, P0DP23, Q15788, P10415MMP9, PRKACB, ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, ITPR1, CALM1, NCOA1, BCL2More
Melatoninhsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Melatoninhsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Melatoninhsa04919Thyroid hormone signaling pathway3.20E-022P60709, P63261ACTB, ACTG1More
Melatoninhsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Melatoninhsa04921Oxytocin signaling pathway1.77E-033P60660, P60709, P63261MYL6, ACTB, ACTG1More
Melatoninhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Melatoninhsa04923Regulation of lipolysis in adipocytes2.38E-057Q08828, P51828, P07550, Q13370, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PDE3B, PIK3CB, IRS2, AKT2More
Melatoninhsa04924Renin secretion1.75E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Melatoninhsa04925Aldosterone synthesis and secretion2.60E-057P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4More
Melatoninhsa04926Relaxin signaling pathway3.95E-049P31751, P42338, P63218, P50151, P18848, P49767, Q08828, P51828, P49407AKT2, PIK3CB, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, ARRB1More
Melatoninhsa04927Cortisol synthesis and secretion5.17E-045Q14643, P18848, Q08828, P51828, P22694ITPR1, ATF4, ADCY1, ADCY7, PRKACBMore
Melatoninhsa04928Parathyroid hormone synthesis, secretion and action2.33E-035Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Melatoninhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Melatoninhsa04932Non-alcoholic fatty liver disease5.87E-048P31751, P01375, P49841, P18848, P48023, O75460, P01584, O95298AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFC2More
Melatoninhsa04933AGE-RAGE signaling pathway in diabetic complications2.38E-0710P84022, Q13485, P01584, P42224, P10415, P31751, P42338, P49767, P17252, P19174SMAD3, SMAD4, IL1B, STAT1, BCL2, AKT2, PIK3CB, VEGFC, PRKCA, PLCG1More
Melatoninhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Melatoninhsa04935Growth hormone synthesis, secretion and action2.71E-037P19174, Q08828, P51828, P17252, P18848, P31751, P42224PLCG1, ADCY1, ADCY7, PRKCA, ATF4, AKT2, STAT1More
Melatoninhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Melatoninhsa04970Salivary secretion1.13E-058Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP23, P49913ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM1, CAMPMore
Melatoninhsa04971Gastric acid secretion1.24E-046Q08828, P51828, P15311, P60709, P63261, P0DP23ADCY1, ADCY7, VIL2, ACTB, ACTG1, CALM1More
Melatoninhsa04972Pancreatic secretion1.75E-045P23634, P17252, Q08828, P51828, P62491ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Melatoninhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Melatoninhsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Melatoninhsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Melatoninhsa05014Amyotrophic lateral sclerosis2.98E-023P36542, P60709, P63261ATP5C1, ACTB, ACTG1More
Melatoninhsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Melatoninhsa05017Spinocerebellar ataxia4.28E-049P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232, P05141PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12, SLC25A5More
Melatoninhsa05022Pathways of neurodegeneration - multiple diseases1.67E-029O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4More
Melatoninhsa05031Amphetamine addiction2.85E-025O15399, P0DP23, Q13557, P18848, P17252GRIN2D, CALM1, CAMK2D, ATF4, PRKCAMore
Melatoninhsa05032Morphine addiction2.92E-049Q08828, P51828, P62873, Q13370, Q07343, P78334, P17252, P32298, P43250ADCY1, ADCY7, GNB1, PDE3B, PDE4B, GABRE, PRKCA, GRK4, GRK6More
Melatoninhsa05100Bacterial invasion of epithelial cells1.02E-022P60709, P63261ACTB, ACTG1More
Melatoninhsa05110Vibrio cholerae infection3.95E-032P60709, P63261ACTB, ACTG1More
Melatoninhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Melatoninhsa05131Shigellosis5.73E-0314P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, P60709, P63261, Q14643, Q12778, P07384, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ACTB, ACTG1, ITPR1, FOXO1, CAPN1, ATM, BCL2, MYLPFMore
Melatoninhsa05132Salmonella infection4.93E-0519P51617, P01584, P25963, P01375, P08238, Q9UJU2, Q96RF0, Q13489, P10415, P08575, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, NFKBIA, TNF, HSP90AB1, LEF1, SNAG1, BIRC3, BCL2, PTPRC, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Melatoninhsa05133Pertussis2.51E-056P0DP23, P01584, P23528, P09871, P0C0L4, P51617CALM1, IL1B, CFL1, C1S, C4A, IRAK1More
Melatoninhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Melatoninhsa05135Yersinia infection3.88E-033P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Melatoninhsa05140Leishmaniasis8.96E-048P14598, P13765, O60603, P25963, P01375, P29350, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, IRAK1, NCF4More
Melatoninhsa05143African trypanosomiasis3.88E-047P01375, P01584, P69905, P68871, P48023, P17252, P01042TNF, IL1B, HBA2, HBB, FASLG, PRKCA, KNG1More
Melatoninhsa05145Toxoplasmosis5.97E-0613P51617, P25963, P01375, P10415, Q13489, P23458, P42224, P13765, P31751, P11142, O60603, P29965, Q13651IRAK1, NFKBIA, TNF, BCL2, BIRC3, JAK1, STAT1, HLA-DOB, AKT2, HSPA8, TLR2, CD40LG, IL10RAMore
Melatoninhsa05146Amoebiasis2.37E-059P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSGMore
Melatoninhsa05150Staphylococcus aureus infection4.37E-026P21730, P21462, O75015, P13765, Q16581, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4More
Melatoninhsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Melatoninhsa05160Hepatitis C1.16E-036P52630, P60033, Q9NZJ5, P49841, P01375, P48023STAT2, CD81, EIF2AK3, GSK3B, TNF, FASLGMore
Melatoninhsa05161Hepatitis B1.13E-0515P17252, P14780, P18848, P23458, P25963, Q13485, P01375, P31751, P10415, P27348, P01568, P42224, P51617, O60603, Q14765PRKCA, MMP9, ATF4, JAK1, NFKBIA, SMAD4, TNF, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1, TLR2, STAT4More
Melatoninhsa05162Measles1.74E-0410P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Melatoninhsa05163Human cytomegalovirus infection8.60E-0614P31751, P62873, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, P17252, Q13651, P18848, P61769, P01568AKT2, GNB1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, PRKCA, IL10RA, ATF4, B2M, IFNA21More
Melatoninhsa05164Influenza A1.74E-038P31751, P01584, P48551, P23458, P05141, P60709, P63261, Q9UBU9AKT2, IL1B, IFNAR2, JAK1, SLC25A5, ACTB, ACTG1, NXF1More
Melatoninhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Melatoninhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Melatoninhsa05168Herpes simplex virus 1 infection2.45E-0518P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1More
Melatoninhsa05169Epstein-Barr virus infection6.15E-0317P13765, Q13547, O00463, P16070, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, Q8WV28, P01375, O60603, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, BLNK, TNF, TLR2, CD3E, CD3G, CD247More
Melatoninhsa05170Human immunodeficiency virus 1 infection9.56E-0926P31751, Q02750, P62873, P62879, P16298, P0DP23, P01375, P61073, Q05397, P17252, O00463, P61769, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333AKT2, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, TNF, CXCR4, PTK2, PRKCA, TRAF5, B2M, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Melatoninhsa05200Pathways in cancer2.30E-1038Q13751, P42338, P23458, P08238, P42224, P19174, Q15311, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, P31751, P43657, Q08828, P51828, P62873, P63218, P50151, Q14344, Q7LDG7, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042LAMB3, PIK3CB, JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, AKT2, P2RY5, ADCY1, ADCY7, GNB1, GNG5, GNG10, GNA13, RASGRP2, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Melatoninhsa05202Transcriptional misregulation in cancer5.69E-0919Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Melatoninhsa05204Chemical carcinogenesis3.70E-033P00325, P78417, P33260ADH1B, GSTO1, CYP2C18More
Melatoninhsa05206MicroRNAs in cancer4.07E-022P15311, P63279VIL2, UBE2IMore
Melatoninhsa05212Pancreatic cancer4.74E-058P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Melatoninhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Melatoninhsa05214Glioma1.87E-056P0DP23, Q13557, P17252, P31751, P19174, O75293CALM1, CAMK2D, PRKCA, AKT2, PLCG1, GADD45BMore
Melatoninhsa05217Basal cell carcinoma1.43E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Melatoninhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Melatoninhsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Melatoninhsa05225Hepatocellular carcinoma4.07E-022P60709, P63261ACTB, ACTG1More
Melatoninhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Melatoninhsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Melatoninhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.33E-0510P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQMore
Melatoninhsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Melatoninhsa05321Inflammatory bowel disease1.16E-088O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL21RMore
Melatoninhsa05322Systemic lupus erythematosus2.70E-0310P08246, P08311, P01375, P10747, P13765, Q6FI13, P62807, Q16778, P12814, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, ACTN1, SSBMore
Melatoninhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Melatoninhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Melatoninhsa05332Graft-versus-host disease2.87E-076P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Melatoninhsa05340Primary immunodeficiency2.68E-022P11912, P07766CD79A, CD3EMore
Melatoninhsa05410Hypertrophic cardiomyopathy1.02E-022P60709, P63261ACTB, ACTG1More
Melatoninhsa05412Arrhythmogenic right ventricular cardiomyopathy8.96E-032P60709, P63261ACTB, ACTG1More
Melatoninhsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Melatoninhsa05416Viral myocarditis8.96E-032P60709, P63261ACTB, ACTG1More
Melatoninhsa05418Fluid shear stress and atherosclerosis3.64E-038P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2More

Community members of Melatonin (SDC: 6.26)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P0DP23CALM1CalmodulinNone1Reported00.45520.147911.5235
P05164MPOMyeloperoxidaseReported10.20350.53680.55021.7255
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Reported00.29580.313400.7747
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q16762TSTThiosulfate sulfurtransferasePredicted00.19330.14580.16810.5563
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q16613AANATSerotonin NNoneacetyltransferasePredicted10.01660.01230.15410.1869
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
P60660MYL6Myosin light polypeptide 6Predicted00.55950.06870.21750.6346
P24844MYL9Myosin regulatory light polypeptide 9Predicted00.00640.0630.60260.7318
P14649MYL6BMyosin light chain 6BPredicted00.04770.06530.21750.3719
P05976MYL1Myosin light chain 1/3, skeletal muscle isoformPredicted00.25810.061900.2528
O15182CETN3CentrinNone3Predicted00.18720.059400.2123
Q96A32MYLPFMyosin regulatory light chain 2, skeletal muscle isoformPredicted00.01350.04730.54120.6425
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
NQO2P16083IC5064.57
NQO2P16083IC5065
NQO2P16083IC506600
NQO2P16083Ki28
NQO2P16083Ki57