| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Megestrol-acetate | hsa00030 | Pentose phosphate pathway | 8.97E-03 | 1 | P11413 | G6PD | More | | | Megestrol-acetate | hsa00052 | Galactose metabolism | 1.03E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Megestrol-acetate | hsa00220 | Arginine biosynthesis | 5.12E-03 | 2 | P05089, P49448 | ARG1, GLUD2 | More | | | Megestrol-acetate | hsa00250 | Alanine, aspartate and glutamate metabolism | 4.88E-02 | 1 | P49448 | GLUD2 | More | | | Megestrol-acetate | hsa00471 | D-Glutamine and D-glutamate metabolism | 1.65E-02 | 1 | P49448 | GLUD2 | More | | | Megestrol-acetate | hsa00480 | Glutathione metabolism | 1.35E-02 | 1 | P11413 | G6PD | More | | | Megestrol-acetate | hsa00500 | Starch and sucrose metabolism | 1.67E-02 | 2 | O43451, P06737 | MGAM, PYGL | More | | | Megestrol-acetate | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 3.43E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Megestrol-acetate | hsa00561 | Glycerolipid metabolism | 2.51E-02 | 2 | P51648, P23743 | ALDH3A2, DGKA | More | | | Megestrol-acetate | hsa00562 | Inositol phosphate metabolism | 7.30E-04 | 4 | P27987, Q96PE3, P19174, P42338 | ITPKB, INPP4A, PLCG1, PIK3CB | More | | | Megestrol-acetate | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Megestrol-acetate | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Megestrol-acetate | hsa00620 | Pyruvate metabolism | 2.51E-02 | 2 | P40925, P51648 | MDH1, ALDH3A2 | More | | | Megestrol-acetate | hsa00630 | Glyoxylate and dicarboxylate metabolism | 1.25E-05 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Megestrol-acetate | hsa00730 | Thiamine metabolism | 5.29E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Megestrol-acetate | hsa00830 | Retinol metabolism | 3.93E-02 | 3 | P00352, Q9BPW9, O75911 | ALDH1A1, DHRS9, DHRS3 | More | | | Megestrol-acetate | hsa00910 | Nitrogen metabolism | 4.88E-02 | 1 | P49448 | GLUD2 | More | | | Megestrol-acetate | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Megestrol-acetate | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Megestrol-acetate | hsa00983 | Drug metabolism - other enzymes | 2.44E-02 | 2 | P32320, P05164 | CDA, MPO | More | | | Megestrol-acetate | hsa01100 | Metabolic pathways | 4.12E-02 | 12 | P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P23743, P43034, P09917, Q53FZ2 | GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, DGKA, PAFAH1B1, ALOX5, ACSM3 | More | | | Megestrol-acetate | hsa01200 | Carbon metabolism | 2.91E-02 | 1 | P11413 | G6PD | More | | | Megestrol-acetate | hsa01210 | 2-Oxocarboxylic acid metabolism | 3.43E-02 | 1 | P50213 | IDH3A | More | | | Megestrol-acetate | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 7.30E-04 | 4 | Q92529, P19174, P42338, Q9NRA1 | SHC3, PLCG1, PIK3CB, PDGFC | More | | | Megestrol-acetate | hsa03013 | RNA transport | 8.18E-05 | 9 | P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P55884, O15371, P20042 | EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2 | More | | | Megestrol-acetate | hsa03040 | Spliceosome | 3.23E-03 | 9 | O60508, P08579, Q15427, P38159, P61978, Q07955, Q01130, P11142, Q9Y2W2 | CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS1, SFRS2, HSPA8, WBP11 | More | | | Megestrol-acetate | hsa03060 | Protein export | 6.41E-04 | 3 | Q15070, P37108, Q15005 | OXA1L, SRP14, SPCS2 | More | | | Megestrol-acetate | hsa04012 | ErbB signaling pathway | 8.84E-04 | 6 | P21860, Q92529, Q13557, P19174, O14944, P42338 | ERBB3, SHC3, CAMK2D, PLCG1, EREG, PIK3CB | More | | | Megestrol-acetate | hsa04014 | Ras signaling pathway | 3.23E-05 | 9 | P42338, Q92529, P20827, Q9NRA1, P49767, Q13009, P63218, P50151, P19174 | PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, TIAM1, GNG5, GNG10, PLCG1 | More | | | Megestrol-acetate | hsa04015 | Rap1 signaling pathway | 3.91E-02 | 4 | Q9NRA1, P49767, P42338, P19174 | PDGFC, VEGFC, PIK3CB, PLCG1 | More | | | Megestrol-acetate | hsa04020 | Calcium signaling pathway | 5.34E-05 | 10 | P27987, Q96DU7, P45880, Q13557, P21860, P19174, P51828, P23634, Q9NRA1, P49767 | ITPKB, ITPKC, VDAC2, CAMK2D, ERBB3, PLCG1, ADCY7, ATP2B4, PDGFC, VEGFC | More | | | Megestrol-acetate | hsa04022 | cGMP-PKG signaling pathway | 4.72E-02 | 4 | Q99941, P23634, P51828, P45880 | CREBL1, ATP2B4, ADCY7, VDAC2 | More | | | Megestrol-acetate | hsa04060 | Cytokine-cytokine receptor interaction | 5.34E-03 | 11 | P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730 | IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4 | More | | | Megestrol-acetate | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.32E-02 | 6 | P09341, P25024, P47992, Q9UBD3, Q13651, P14784 | CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB | More | | | Megestrol-acetate | hsa04062 | Chemokine signaling pathway | 1.29E-04 | 12 | P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, Q92529, P63218, P50151, P43250, Q08881 | CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, GRK6, ITK | More | | | Megestrol-acetate | hsa04064 | NF-kappa B signaling pathway | 3.44E-06 | 15 | P10415, Q13489, O00463, Q13546, P14778, Q04759, Q9UDY8, Q16548, P07948, P06239, Q13315, P24522, P09341, Q06643, Q9UNE0 | BCL2, BIRC3, TRAF5, RIPK1, IL1R1, PRKCQ, MALT1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, LTB, EDAR | More | | | Megestrol-acetate | hsa04070 | Phosphatidylinositol signaling system | 3.19E-04 | 5 | P19174, P42338, P23743, Q96PE3, P27987 | PLCG1, PIK3CB, DGKA, INPP4A, ITPKB | More | | | Megestrol-acetate | hsa04071 | Sphingolipid signaling pathway | 7.26E-04 | 7 | P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2 | S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2 | More | | | Megestrol-acetate | hsa04072 | Phospholipase D signaling pathway | 1.85E-04 | 6 | P42338, Q92529, P19174, Q14344, P23743, Q9NRA1 | PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFC | More | | | Megestrol-acetate | hsa04080 | Neuroactive ligand-receptor interaction | 1.00E-02 | 7 | P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2 | More | | | Megestrol-acetate | hsa04114 | Oocyte meiosis | 1.33E-02 | 4 | P51812, Q02750, P16298, Q17RY0 | RPS6KA3, MAP2K1, PPP3CB, CPEB4 | More | | | Megestrol-acetate | hsa04140 | Autophagy - animal | 3.19E-02 | 4 | P22694, Q14643, P10415, Q04759 | PRKACB, ITPR1, BCL2, PRKCQ | More | | | Megestrol-acetate | hsa04141 | Protein processing in endoplasmic reticulum | 2.01E-03 | 8 | P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816 | CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2 | More | | | Megestrol-acetate | hsa04145 | Phagosome | 4.48E-02 | 5 | Q15080, P05164, O60603, P35443, P13765 | NCF4, MPO, TLR2, THBS4, HLA-DOB | More | | | Megestrol-acetate | hsa04150 | mTOR signaling pathway | 3.60E-02 | 3 | Q02750, Q9NQL2, P51812 | MAP2K1, RRAGD, RPS6KA3 | More | | | Megestrol-acetate | hsa04151 | PI3K-Akt signaling pathway | 1.09E-04 | 11 | P42338, P43657, P20827, Q9NRA1, P49767, P08238, P63218, P50151, O15335, Q13751, P14784 | PIK3CB, P2RY5, EFNA1, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, LAMB3, IL2RB | More | | | Megestrol-acetate | hsa04152 | AMPK signaling pathway | 2.34E-02 | 2 | Q96EB6, P36956 | SIRT1, SREBF1 | More | | | Megestrol-acetate | hsa04210 | Apoptosis | 4.11E-03 | 9 | Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643 | ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1 | More | | | Megestrol-acetate | hsa04211 | Longevity regulating pathway | 1.18E-02 | 3 | Q12778, Q9UEF7, Q96KQ7 | FOXO1, KL, EHMT2 | More | | | Megestrol-acetate | hsa04213 | Longevity regulating pathway - multiple species | 2.85E-02 | 2 | Q9Y4H2, Q13547 | IRS2, HDAC1 | More | | | Megestrol-acetate | hsa04215 | Apoptosis - multiple species | 1.56E-02 | 2 | Q13489, P10415 | BIRC3, BCL2 | More | | | Megestrol-acetate | hsa04217 | Necroptosis | 2.93E-02 | 3 | P01568, Q13489, Q13546 | IFNA21, BIRC3, RIPK1 | More | | | Megestrol-acetate | hsa04261 | Adrenergic signaling in cardiomyocytes | 3.98E-02 | 4 | P51828, Q99941, Q13557, P23634 | ADCY7, CREBL1, CAMK2D, ATP2B4 | More | | | Megestrol-acetate | hsa04330 | Notch signaling pathway | 2.46E-03 | 3 | Q92542, P49768, P46531 | NCSTN, PSEN1, NOTCH1 | More | | | Megestrol-acetate | hsa04340 | Hedgehog signaling pathway | 2.61E-03 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Megestrol-acetate | hsa04360 | Axon guidance | 1.50E-02 | 3 | P20827, P23528, Q06124 | EFNA1, CFL1, PTPN11 | More | | | Megestrol-acetate | hsa04370 | VEGF signaling pathway | 8.20E-05 | 5 | P19174, P16298, P42338, Q05397, Q02750 | PLCG1, PPP3CB, PIK3CB, PTK2, MAP2K1 | More | | | Megestrol-acetate | hsa04371 | Apelin signaling pathway | 1.24E-02 | 4 | P63218, P50151, Q13370, Q14344 | GNG5, GNG10, PDE3B, GNA13 | More | | | Megestrol-acetate | hsa04390 | Hippo signaling pathway | 2.08E-02 | 3 | P84022, Q13485, Q13489 | SMAD3, SMAD4, BIRC3 | More | | | Megestrol-acetate | hsa04510 | Focal adhesion | 1.55E-02 | 5 | P42338, O15335, Q9NRA1, P49767, Q92529 | PIK3CB, CHAD, PDGFC, VEGFC, SHC3 | More | | | Megestrol-acetate | hsa04530 | Tight junction | 1.74E-03 | 6 | P63261, P16989, P56750, Q9Y478, Q92974, Q14247 | ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTN | More | | | Megestrol-acetate | hsa04611 | Platelet activation | 4.11E-02 | 3 | P42338, Q14344, P07948 | PIK3CB, GNA13, LYN | More | | | Megestrol-acetate | hsa04612 | Antigen processing and presentation | 2.20E-03 | 6 | P13765, P01730, P26715, P26717, Q13241, P01732 | HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8A | More | | | Megestrol-acetate | hsa04613 | Neutrophil extracellular trap formation | 7.20E-05 | 16 | P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P21730 | ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1 | More | | | Megestrol-acetate | hsa04620 | Toll-like receptor signaling pathway | 4.16E-02 | 2 | Q13546, P01568 | RIPK1, IFNA21 | More | | | Megestrol-acetate | hsa04621 | NOD-like receptor signaling pathway | 4.72E-02 | 3 | P01568, Q13489, Q13546 | IFNA21, BIRC3, RIPK1 | More | | | Megestrol-acetate | hsa04622 | RIG-I-like receptor signaling pathway | 2.39E-02 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | | | Megestrol-acetate | hsa04623 | Cytosolic DNA-sensing pathway | 2.20E-03 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | | | Megestrol-acetate | hsa04640 | Hematopoietic cell lineage | 1.60E-04 | 10 | P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765 | ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB | More | | | Megestrol-acetate | hsa04650 | Natural killer cell mediated cytotoxicity | 1.86E-05 | 11 | P16298, P50591, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, P26717, P26715 | PPP3CB, TNFSF10, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1 | More | | | Megestrol-acetate | hsa04657 | IL-17 signaling pathway | 3.31E-02 | 3 | P49841, P14780, P01375 | GSK3B, MMP9, TNF | More | | | Megestrol-acetate | hsa04658 | Th1 and Th2 cell differentiation | 1.05E-10 | 13 | Q04759, P07766, P20963, P09693, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | | Megestrol-acetate | hsa04659 | Th17 cell differentiation | 9.05E-09 | 16 | P25963, Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963 | NFKBIA, PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.728 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | P06746 | POLB | DNA polymerase beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P06746 | POLB | DNA polymerase beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.766 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.735 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.85 | | O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.769 | | O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.721 | | P06746 | POLB | DNA polymerase beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.834 | | P06746 | POLB | DNA polymerase beta | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.736 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 |
| | Megestrol-acetate | hsa04660 | T cell receptor signaling pathway | 3.19E-05 | 11 | Q9UDY8, Q04759, P10747, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239 | MALT1, PRKCQ, CD28, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK | More | | | Megestrol-acetate | hsa04662 | B cell receptor signaling pathway | 8.32E-05 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Megestrol-acetate | hsa04664 | Fc epsilon RI signaling pathway | 4.31E-05 | 4 | P42338, P07948, P19174, P09917 | PIK3CB, LYN, PLCG1, ALOX5 | More | | | Megestrol-acetate | hsa04666 | Fc gamma R-mediated phagocytosis | 1.73E-02 | 3 | P07948, P42338, P19174 | LYN, PIK3CB, PLCG1 | More | | | Megestrol-acetate | hsa04668 | TNF signaling pathway | 4.74E-02 | 3 | Q99941, P01584, O95429 | CREBL1, IL1B, BAG4 | More | | | Megestrol-acetate | hsa04714 | Thermogenesis | 1.25E-02 | 3 | P15336, P63261, Q9Y478 | ATF2, ACTG1, PRKAB1 | More | | | Megestrol-acetate | hsa04720 | Long-term potentiation | 1.38E-02 | 3 | P16298, P51812, Q02750 | PPP3CB, RPS6KA3, MAP2K1 | More | | | Megestrol-acetate | hsa04722 | Neurotrophin signaling pathway | 4.87E-02 | 3 | P42338, P19174, Q92529 | PIK3CB, PLCG1, SHC3 | More | | | Megestrol-acetate | hsa04724 | Glutamatergic synapse | 1.40E-03 | 4 | P43003, P63218, P50151, P15104 | SLC1A3, GNG5, GNG10, GLUL | More | | | Megestrol-acetate | hsa04725 | Cholinergic synapse | 1.73E-02 | 3 | P63218, P50151, P42338 | GNG5, GNG10, PIK3CB | More | | | Megestrol-acetate | hsa04726 | Serotonergic synapse | 3.41E-02 | 3 | P63218, P50151, P09917 | GNG5, GNG10, ALOX5 | More | | | Megestrol-acetate | hsa04727 | GABAergic synapse | 6.57E-03 | 3 | P63218, P50151, P15104 | GNG5, GNG10, GLUL | More | | | Megestrol-acetate | hsa04730 | Long-term depression | 1.56E-02 | 2 | Q14344, P07948 | GNA13, LYN | More | | | Megestrol-acetate | hsa04750 | Inflammatory mediator regulation of TRP channels | 3.74E-02 | 3 | P01584, P51828, Q13557 | IL1B, ADCY7, CAMK2D | More | | | Megestrol-acetate | hsa04910 | Insulin signaling pathway | 2.44E-03 | 6 | P22694, P06737, Q92529, Q13370, P42338, P49841 | PRKACB, PYGL, SHC3, PDE3B, PIK3CB, GSK3B | More | | | Megestrol-acetate | hsa04911 | Insulin secretion | 1.48E-02 | 3 | P51828, Q99941, Q13557 | ADCY7, CREBL1, CAMK2D | More | | | Megestrol-acetate | hsa04914 | Progesterone-mediated oocyte maturation | 1.58E-03 | 6 | Q17RY0, P42338, Q13370, P08238, P51812, Q02750 | CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1 | More | | | Megestrol-acetate | hsa04915 | Estrogen signaling pathway | 7.27E-04 | 7 | Q99941, P51828, P42338, Q92529, P07900, P08238, P11142 | CREBL1, ADCY7, PIK3CB, SHC3, HSP90AA1, HSP90AB1, HSPA8 | More | | | Megestrol-acetate | hsa04919 | Thyroid hormone signaling pathway | 7.11E-03 | 4 | P49841, P22694, O60244, Q9NVC6 | GSK3B, PRKACB, MED14, MED17 | More | | | Megestrol-acetate | hsa04920 | Adipocytokine signaling pathway | 2.80E-02 | 2 | Q06124, Q9Y478 | PTPN11, PRKAB1 | More | | | Megestrol-acetate | hsa04922 | Glucagon signaling pathway | 4.23E-02 | 4 | P22694, P06737, Q12778, Q14643 | PRKACB, PYGL, FOXO1, ITPR1 | More | | | Megestrol-acetate | hsa04923 | Regulation of lipolysis in adipocytes | 3.64E-02 | 2 | Q13370, P42338 | PDE3B, PIK3CB | More | | | Megestrol-acetate | hsa04924 | Renin secretion | 1.04E-02 | 3 | P22694, P07550, Q14643 | PRKACB, ADRB2, ITPR1 | More | | | Megestrol-acetate | hsa04925 | Aldosterone synthesis and secretion | 5.19E-03 | 4 | Q99941, P51828, Q13557, P23634 | CREBL1, ADCY7, CAMK2D, ATP2B4 | More | | | Megestrol-acetate | hsa04926 | Relaxin signaling pathway | 1.31E-03 | 5 | P42338, P63218, P50151, P49767, Q92529 | PIK3CB, GNG5, GNG10, VEGFC, SHC3 | More | | | Megestrol-acetate | hsa04928 | Parathyroid hormone synthesis, secretion and action | 4.23E-02 | 4 | Q14643, P22694, P23771, P10415 | ITPR1, PRKACB, GATA3, BCL2 | More | | | Megestrol-acetate | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | | Megestrol-acetate | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.47E-03 | 6 | P84022, Q13485, P10415, P42338, P49767, P19174 | SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1 | More | | | Megestrol-acetate | hsa04934 | Cushing syndrome | 3.48E-03 | 4 | Q99941, P51828, O15169, Q13557 | CREBL1, ADCY7, AXIN1, CAMK2D | More | | | Megestrol-acetate | hsa04935 | Growth hormone synthesis, secretion and action | 2.78E-02 | 3 | P19174, P42338, Q92529 | PLCG1, PIK3CB, SHC3 | More | | | Megestrol-acetate | hsa04964 | Proximal tubule bicarbonate reclamation | 4.88E-02 | 1 | P49448 | GLUD2 | More | | | Megestrol-acetate | hsa04971 | Gastric acid secretion | 1.48E-02 | 3 | P51828, P15311, Q13557 | ADCY7, VIL2, CAMK2D | More | | | Megestrol-acetate | hsa04975 | Fat digestion and absorption | 9.50E-04 | 1 | O14494 | PLPP1 | More | | | Megestrol-acetate | hsa04976 | Bile secretion | 2.44E-02 | 2 | P22694, P08183 | PRKACB, ABCB1 | More | | | Megestrol-acetate | hsa05010 | Alzheimer disease | 2.07E-02 | 7 | Q92542, P05496, P12074, O75460, P01584, O15169, P45880 | NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2 | More | | | Megestrol-acetate | hsa05020 | Prion disease | 1.81E-02 | 7 | P01584, P46531, P11142, P05496, P12074, P45880, Q99941 | IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1 | More | | | Megestrol-acetate | hsa05032 | Morphine addiction | 2.22E-02 | 3 | P63218, P50151, Q13370 | GNG5, GNG10, PDE3B | More | | | Megestrol-acetate | hsa05034 | Alcoholism | 2.05E-05 | 7 | Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431 | HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Megestrol-acetate | hsa05100 | Bacterial invasion of epithelial cells | 3.64E-02 | 2 | P42338, Q92529 | PIK3CB, SHC3 | More | | | Megestrol-acetate | hsa05130 | Pathogenic Escherichia coli infection | 9.80E-03 | 4 | Q92974, P63261, Q06124, O95487 | ARHGEF2, ACTG1, PTPN11, SEC24B | More | | | Megestrol-acetate | hsa05132 | Salmonella infection | 5.76E-04 | 7 | P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371 | NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2C | More | | | Megestrol-acetate | hsa05145 | Toxoplasmosis | 2.78E-02 | 3 | P25963, P10415, Q13489 | NFKBIA, BCL2, BIRC3 | More | | | Megestrol-acetate | hsa05146 | Amoebiasis | 9.73E-03 | 6 | P09341, P14778, P27930, P05089, P12814, P08311 | CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSG | More | | | Megestrol-acetate | hsa05161 | Hepatitis B | 8.49E-03 | 4 | P25963, Q13485, P10415, P84022 | NFKBIA, SMAD4, BCL2, SMAD3 | More | | | Megestrol-acetate | hsa05162 | Measles | 3.91E-02 | 4 | P14784, P07766, P42338, P11142 | IL2RB, CD3E, PIK3CB, HSPA8 | More | | | Megestrol-acetate | hsa05163 | Human cytomegalovirus infection | 1.14E-02 | 5 | P42338, P63218, P50151, Q14344, P30101 | PIK3CB, GNG5, GNG10, GNA13, PDIA3 | More | | | Megestrol-acetate | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 6.22E-04 | 9 | P42338, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P0CG47 | PIK3CB, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, UBB | More | | | Megestrol-acetate | hsa05169 | Epstein-Barr virus infection | 5.44E-04 | 12 | P13765, P01106, Q13547, O00463, P42338, P07948, P30101, Q13761, P24522, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, CD3E, CD3G, CD247 | More | | | Megestrol-acetate | hsa05170 | Human immunodeficiency virus 1 infection | 1.36E-04 | 11 | P42338, Q02750, P62879, P63218, P50151, P16298, Q05397, P30101, P19174, P07766, P20333 | PIK3CB, MAP2K1, GNB2, GNG5, GNG10, PPP3CB, PTK2, PDIA3, PLCG1, CD3E, TNFRSF1B | More | | | Megestrol-acetate | hsa05200 | Pathways in cancer | 3.05E-02 | 8 | P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784 | PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RB | More | | | Megestrol-acetate | hsa05202 | Transcriptional misregulation in cancer | 2.34E-03 | 13 | Q12778, Q13315, P14780, P27930, Q16548, P11215, O15550, P05164, P08246, Q9C0K0, Q13547, P12980, P24522 | FOXO1, ATM, MMP9, IL1R2, BCL2A1, ITGAM, UTX, MPO, ELA2, BCL11B, HDAC1, LYL1, GADD45A | More | | | Megestrol-acetate | hsa05203 | Viral carcinogenesis | 1.22E-03 | 6 | Q13547, Q15283, P58876, P62807, Q16778, O60814 | HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12 | More | | | Megestrol-acetate | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Megestrol-acetate | hsa05206 | MicroRNAs in cancer | 2.97E-03 | 6 | P15311, P21860, P61978, P46531, P63279, P22105 | VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB | More | | | Megestrol-acetate | hsa05210 | Colorectal cancer | 1.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Megestrol-acetate | hsa05211 | Renal cell carcinoma | 1.06E-02 | 2 | Q06124, Q99814 | PTPN11, EPAS1 | More | | | Megestrol-acetate | hsa05212 | Pancreatic cancer | 3.52E-02 | 2 | P84022, Q13485 | SMAD3, SMAD4 | More | | | Megestrol-acetate | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | | Megestrol-acetate | hsa05214 | Glioma | 9.49E-03 | 3 | Q92529, P42338, P19174 | SHC3, PIK3CB, PLCG1 | More | | | Megestrol-acetate | hsa05215 | Prostate cancer | 4.87E-02 | 3 | Q9NRA1, P08238, P42338 | PDGFC, HSP90AB1, PIK3CB | More | | | Megestrol-acetate | hsa05218 | Melanoma | 3.64E-02 | 2 | Q9NRA1, P42338 | PDGFC, PIK3CB | More | | | Megestrol-acetate | hsa05220 | Chronic myeloid leukemia | 1.25E-02 | 3 | Q13485, P25963, P84022 | SMAD4, NFKBIA, SMAD3 | More | | | Megestrol-acetate | hsa05222 | Small cell lung cancer | 1.50E-02 | 3 | Q13489, P10415, P25963 | BIRC3, BCL2, NFKBIA | More | | | Megestrol-acetate | hsa05226 | Gastric cancer | 4.33E-03 | 5 | Q02750, O15169, P84022, Q13485, P10415 | MAP2K1, AXIN1, SMAD3, SMAD4, BCL2 | More | | | Megestrol-acetate | hsa05230 | Central carbon metabolism in cancer | 1.12E-02 | 1 | P11413 | G6PD | More | | | Megestrol-acetate | hsa05231 | Choline metabolism in cancer | 1.17E-03 | 4 | P42338, Q9NRA1, P19174, P23743 | PIK3CB, PDGFC, PLCG1, DGKA | More | | | Megestrol-acetate | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 7.87E-04 | 8 | P07766, P20963, P09693, P06239, O60603, P10747, Q04759, P01730 | CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, CD4 | More | | | Megestrol-acetate | hsa05321 | Inflammatory bowel disease | 1.17E-03 | 5 | O60603, P13765, Q14765, Q9UL17, P23771 | TLR2, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Megestrol-acetate | hsa05322 | Systemic lupus erythematosus | 4.80E-06 | 7 | P09871, Q93077, P58876, P62807, Q16778, O60814, P68431 | C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Megestrol-acetate | hsa05323 | Rheumatoid arthritis | 1.60E-02 | 4 | P13765, P10747, P09341, O60603 | HLA-DOB, CD28, CXCL1, TLR2 | More | | | Megestrol-acetate | hsa05332 | Graft-versus-host disease | 3.63E-04 | 4 | P13765, P10747, P26715, Q13241 | HLA-DOB, CD28, KLRC1, KLRD1 | More | | | Megestrol-acetate | hsa05340 | Primary immunodeficiency | 2.19E-02 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Megestrol-acetate | hsa05415 | Diabetic cardiomyopathy | 3.59E-02 | 1 | P11413 | G6PD | More | |
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