PharmaCoNets of Medroxyprogesterone-acetate (SPCN: 143.76 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Medroxyprogesterone-acetatehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Medroxyprogesterone-acetatehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Medroxyprogesterone-acetatehsa00220Arginine biosynthesis4.88E-021P49448GLUD2More
Medroxyprogesterone-acetatehsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Medroxyprogesterone-acetatehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Medroxyprogesterone-acetatehsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Medroxyprogesterone-acetatehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Medroxyprogesterone-acetatehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Medroxyprogesterone-acetatehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Medroxyprogesterone-acetatehsa00561Glycerolipid metabolism2.51E-022P51648, P23743ALDH3A2, DGKAMore
Medroxyprogesterone-acetatehsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Medroxyprogesterone-acetatehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Medroxyprogesterone-acetatehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Medroxyprogesterone-acetatehsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Medroxyprogesterone-acetatehsa00630Glyoxylate and dicarboxylate metabolism1.25E-052P40925, P15104MDH1, GLULMore
Medroxyprogesterone-acetatehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Medroxyprogesterone-acetatehsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Medroxyprogesterone-acetatehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Medroxyprogesterone-acetatehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Medroxyprogesterone-acetatehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Medroxyprogesterone-acetatehsa01100Metabolic pathways4.12E-0212P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P23743, P43034, P09917, Q53FZ2GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, DGKA, PAFAH1B1, ALOX5, ACSM3More
Medroxyprogesterone-acetatehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Medroxyprogesterone-acetatehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Medroxyprogesterone-acetatehsa01521EGFR tyrosine kinase inhibitor resistance7.30E-044Q92529, P19174, P42338, Q9NRA1SHC3, PLCG1, PIK3CB, PDGFCMore
Medroxyprogesterone-acetatehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Medroxyprogesterone-acetatehsa03013RNA transport8.18E-059P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P55884, O15371, P20042EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Medroxyprogesterone-acetatehsa03040Spliceosome3.23E-039O60508, P08579, Q15427, P38159, P61978, Q07955, Q01130, P11142, Q9Y2W2CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS1, SFRS2, HSPA8, WBP11More
Medroxyprogesterone-acetatehsa03050Proteasome1.40E-021P55036PSMD4More
Medroxyprogesterone-acetatehsa03060Protein export4.83E-053Q15070, P37108, Q15005OXA1L, SRP14, SPCS2More
Medroxyprogesterone-acetatehsa04012ErbB signaling pathway8.84E-046P21860, Q92529, Q13557, P19174, O14944, P42338ERBB3, SHC3, CAMK2D, PLCG1, EREG, PIK3CBMore
Medroxyprogesterone-acetatehsa04014Ras signaling pathway3.23E-059P42338, Q92529, P20827, Q9NRA1, P49767, Q13009, P63218, P50151, P19174PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, TIAM1, GNG5, GNG10, PLCG1More
Medroxyprogesterone-acetatehsa04015Rap1 signaling pathway3.91E-024Q9NRA1, P49767, P42338, P19174PDGFC, VEGFC, PIK3CB, PLCG1More
Medroxyprogesterone-acetatehsa04020Calcium signaling pathway1.83E-0614P27987, Q96DU7, Q08828, P45880, Q13557, P21860, P19174, P61073, P0DP24, P05141, P51828, P23634, Q9NRA1, P49767ITPKB, ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, PLCG1, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4, PDGFC, VEGFCMore
Medroxyprogesterone-acetatehsa04022cGMP-PKG signaling pathway2.45E-038Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2More
Medroxyprogesterone-acetatehsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Medroxyprogesterone-acetatehsa04061Viral protein interaction with cytokine and cytokine receptor1.91E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Medroxyprogesterone-acetatehsa04062Chemokine signaling pathway4.35E-036P07948, P42338, P19174, Q92529, P63218, P50151LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10More
Medroxyprogesterone-acetatehsa04064NF-kappa B signaling pathway1.06E-0515P10415, Q13489, O00463, Q13546, P01584, Q04759, Q9UDY8, Q16548, Q13315, P63279, P24522, Q8NHW4, P09341, Q9UNE0, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1B, PRKCQ, MALT1, BCL2A1, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, EDAR, CYLDMore
Medroxyprogesterone-acetatehsa04070Phosphatidylinositol signaling system3.19E-045P19174, P42338, P23743, Q96PE3, P27987PLCG1, PIK3CB, DGKA, INPP4A, ITPKBMore
Medroxyprogesterone-acetatehsa04071Sphingolipid signaling pathway7.26E-047P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Medroxyprogesterone-acetatehsa04072Phospholipase D signaling pathway1.65E-059P42338, Q92529, P61586, P19174, O14986, Q14344, P63092, P23743, Q9NRA1PIK3CB, SHC3, RHOA, PLCG1, PIP5K1B, GNA13, GNAS, DGKA, PDGFCMore
Medroxyprogesterone-acetatehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Medroxyprogesterone-acetatehsa04114Oocyte meiosis2.09E-039P51812, Q02750, Q13557, P0DP24, P16298, Q17RY0, Q08828, P51828, P27348RPS6KA3, MAP2K1, CAMK2D, CALM2, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQMore
Medroxyprogesterone-acetatehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Medroxyprogesterone-acetatehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Medroxyprogesterone-acetatehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Medroxyprogesterone-acetatehsa04141Protein processing in endoplasmic reticulum2.01E-038P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2More
Medroxyprogesterone-acetatehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Medroxyprogesterone-acetatehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Medroxyprogesterone-acetatehsa04151PI3K-Akt signaling pathway1.09E-0411P42338, P43657, P20827, Q9NRA1, P49767, P08238, P63218, P50151, O15335, Q13751, P14784PIK3CB, P2RY5, EFNA1, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, LAMB3, IL2RBMore
Medroxyprogesterone-acetatehsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Medroxyprogesterone-acetatehsa04210Apoptosis4.11E-039Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1More
Medroxyprogesterone-acetatehsa04211Longevity regulating pathway3.41E-037Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2More
Medroxyprogesterone-acetatehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Medroxyprogesterone-acetatehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Medroxyprogesterone-acetatehsa04217Necroptosis6.23E-0410P01568, P23458, Q13489, Q9NQC7, Q13546, P05141, P01584, P0C0S5, Q13557, Q9H444IFNA21, JAK1, BIRC3, CYLD, RIPK1, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Medroxyprogesterone-acetatehsa04261Adrenergic signaling in cardiomyocytes1.60E-037Q08828, P51828, Q99941, P18848, P0DP24, Q13557, P23634ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2D, ATP2B4More
Medroxyprogesterone-acetatehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Medroxyprogesterone-acetatehsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Medroxyprogesterone-acetatehsa04340Hedgehog signaling pathway2.61E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Medroxyprogesterone-acetatehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Medroxyprogesterone-acetatehsa04370VEGF signaling pathway8.20E-055P19174, P16298, P42338, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PTK2, MAP2K1More
Medroxyprogesterone-acetatehsa04371Apelin signaling pathway1.24E-024P63218, P50151, Q13370, Q14344GNG5, GNG10, PDE3B, GNA13More
Medroxyprogesterone-acetatehsa04380Osteoclast differentiation4.98E-024Q9NQC7, Q9UQC2, P23458, P01584CYLD, GAB2, JAK1, IL1BMore
Medroxyprogesterone-acetatehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Medroxyprogesterone-acetatehsa04510Focal adhesion1.67E-038P42338, O14986, P61586, O15335, Q16363, Q9NRA1, P49767, Q92529PIK3CB, PIP5K1B, RHOA, CHAD, LAMA4, PDGFC, VEGFC, SHC3More
Medroxyprogesterone-acetatehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Medroxyprogesterone-acetatehsa04530Tight junction1.74E-036P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Medroxyprogesterone-acetatehsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Medroxyprogesterone-acetatehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Medroxyprogesterone-acetatehsa04613Neutrophil extracellular trap formation7.20E-0516P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P21730ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1More
Medroxyprogesterone-acetatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Medroxyprogesterone-acetatehsa04621NOD-like receptor signaling pathway5.35E-037P01568, Q13489, Q13546, P01375, P59665, P59666, P12838IFNA21, BIRC3, RIPK1, TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Medroxyprogesterone-acetatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Medroxyprogesterone-acetatehsa04623Cytosolic DNA-sensing pathway5.86E-054P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Medroxyprogesterone-acetatehsa04650Natural killer cell mediated cytotoxicity2.02E-039P16298, P50591, O60880, P20963, Q02750, Q13241, P26718, P26717, P26715PPP3CB, TNFSF10, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KLRC1More
Medroxyprogesterone-acetatehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Medroxyprogesterone-acetatehsa04658Th1 and Th2 cell differentiation3.54E-0511Q04759, P07766, P20963, P09693, P19174, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Medroxyprogesterone-acetatehsa04659Th17 cell differentiation1.41E-0413P25963, Q04759, P19174, P14784, P13765, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, IL2RB, HLA-DOB, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Medroxyprogesterone-acetatehsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Medroxyprogesterone-acetatehsa04662B cell receptor signaling pathway8.32E-055P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Medroxyprogesterone-acetatehsa04664Fc epsilon RI signaling pathway4.31E-054P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Medroxyprogesterone-acetatehsa04666Fc gamma R-mediated phagocytosis1.73E-023P07948, P42338, P19174LYN, PIK3CB, PLCG1More
Medroxyprogesterone-acetatehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Medroxyprogesterone-acetatehsa04713Circadian entrainment2.44E-036P0DP24, Q13557, P62873, Q08828, P51828, P63092CALM2, CAMK2D, GNB1, ADCY1, ADCY7, GNASMore
Medroxyprogesterone-acetatehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Medroxyprogesterone-acetatehsa04720Long-term potentiation7.69E-047Q13557, P16298, P0DP24, P51812, P18848, Q08828, Q02750CAMK2D, PPP3CB, CALM2, RPS6KA3, ATF4, ADCY1, MAP2K1More
Medroxyprogesterone-acetatehsa04722Neurotrophin signaling pathway4.87E-023P42338, P19174, Q92529PIK3CB, PLCG1, SHC3More
Medroxyprogesterone-acetatehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Medroxyprogesterone-acetatehsa04724Glutamatergic synapse1.32E-046P43003, P63092, P62873, P63218, P50151, P15104SLC1A3, GNAS, GNB1, GNG5, GNG10, GLULMore
Medroxyprogesterone-acetatehsa04725Cholinergic synapse1.56E-037Q08828, P51828, P63218, P50151, P18848, Q13557, P42338ADCY1, ADCY7, GNG5, GNG10, ATF4, CAMK2D, PIK3CBMore
Medroxyprogesterone-acetatehsa04726Serotonergic synapse2.45E-035P63092, P62873, P63218, P50151, P09917GNAS, GNB1, GNG5, GNG10, ALOX5More
Medroxyprogesterone-acetatehsa04727GABAergic synapse6.57E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Medroxyprogesterone-acetatehsa04728Dopaminergic synapse2.67E-025Q99941, P18848, Q13557, P0DP24, O15516CREBL1, ATF4, CAMK2D, CALM2, CLOCKMore
Medroxyprogesterone-acetatehsa04730Long-term depression1.56E-022Q14344, P07948GNA13, LYNMore
Medroxyprogesterone-acetatehsa04750Inflammatory mediator regulation of TRP channels4.53E-045P01584, Q08828, P51828, Q13557, P0DP24IL1B, ADCY1, ADCY7, CAMK2D, CALM2More
Medroxyprogesterone-acetatehsa04910Insulin signaling pathway2.44E-036P22694, P06737, Q92529, Q13370, P42338, P49841PRKACB, PYGL, SHC3, PDE3B, PIK3CB, GSK3BMore
Medroxyprogesterone-acetatehsa04911Insulin secretion2.95E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Medroxyprogesterone-acetatehsa04912GnRH signaling pathway6.99E-035Q08828, P51828, P18848, Q13557, P0DP24ADCY1, ADCY7, ATF4, CAMK2D, CALM2More
Medroxyprogesterone-acetatehsa04914Progesterone-mediated oocyte maturation1.58E-036Q17RY0, P42338, Q13370, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Medroxyprogesterone-acetatehsa04915Estrogen signaling pathway7.27E-047Q99941, P51828, P42338, Q92529, P07900, P08238, P11142CREBL1, ADCY7, PIK3CB, SHC3, HSP90AA1, HSP90AB1, HSPA8More
Medroxyprogesterone-acetatehsa04916Melanogenesis7.61E-034Q13557, P0DP24, Q08828, P51828CAMK2D, CALM2, ADCY1, ADCY7More
Medroxyprogesterone-acetatehsa04918Thyroid hormone synthesis4.47E-035Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Medroxyprogesterone-acetatehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Medroxyprogesterone-acetatehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Medroxyprogesterone-acetatehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Medroxyprogesterone-acetatehsa04923Regulation of lipolysis in adipocytes3.64E-022Q13370, P42338PDE3B, PIK3CBMore
Medroxyprogesterone-acetatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Medroxyprogesterone-acetatehsa04925Aldosterone synthesis and secretion8.00E-067Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4More
Medroxyprogesterone-acetatehsa04926Relaxin signaling pathway1.31E-035P42338, P63218, P50151, P49767, Q92529PIK3CB, GNG5, GNG10, VEGFC, SHC3More
Medroxyprogesterone-acetatehsa04927Cortisol synthesis and secretion4.16E-034Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Medroxyprogesterone-acetatehsa04928Parathyroid hormone synthesis, secretion and action3.92E-038Q14643, Q08828, P51828, P22694, P23771, Q99941, P18848, P10415ITPR1, ADCY1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2More
Medroxyprogesterone-acetatehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Medroxyprogesterone-acetatehsa04932Non-alcoholic fatty liver disease3.45E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Medroxyprogesterone-acetatehsa04933AGE-RAGE signaling pathway in diabetic complications1.47E-036P84022, Q13485, P10415, P42338, P49767, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1More
Medroxyprogesterone-acetatehsa04934Cushing syndrome2.69E-066Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Medroxyprogesterone-acetatehsa04935Growth hormone synthesis, secretion and action3.41E-037P19174, Q08828, P51828, Q99941, P18848, P42338, Q92529PLCG1, ADCY1, ADCY7, CREBL1, ATF4, PIK3CB, SHC3More
Medroxyprogesterone-acetatehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Medroxyprogesterone-acetatehsa04964Proximal tubule bicarbonate reclamation4.88E-021P49448GLUD2More
Medroxyprogesterone-acetatehsa04970Salivary secretion3.54E-023Q08828, P51828, P0DP24ADCY1, ADCY7, CALM2More
Medroxyprogesterone-acetatehsa04971Gastric acid secretion2.95E-055Q08828, P51828, P15311, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM2, CAMK2DMore
Medroxyprogesterone-acetatehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Medroxyprogesterone-acetatehsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Medroxyprogesterone-acetatehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Medroxyprogesterone-acetatehsa05010Alzheimer disease2.62E-0414Q92542, O15239, P05496, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880, P28070, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2, PSMB4, PSMC4More
Medroxyprogesterone-acetatehsa05012Parkinson disease7.90E-039O15239, P12074, P05141, O75460, P18848, P28070, P43686, P0DP24, Q13557NDUFA1, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, PSMC4, CALM2, CAMK2DMore
Medroxyprogesterone-acetatehsa05016Huntington disease3.54E-028O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4More
Medroxyprogesterone-acetatehsa05020Prion disease1.76E-0312P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P45880, P28070, P43686, Q99941IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, CREBL1More
Medroxyprogesterone-acetatehsa05022Pathways of neurodegeneration - multiple diseases1.74E-0313O15239, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686NDUFA1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4More
Medroxyprogesterone-acetatehsa05030Cocaine addiction3.54E-023Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Medroxyprogesterone-acetatehsa05031Amphetamine addiction7.61E-034P0DP24, Q13557, Q99941, P18848CALM2, CAMK2D, CREBL1, ATF4More
Medroxyprogesterone-acetatehsa05032Morphine addiction9.19E-068P62873, P63218, P50151, Q13370, P48169, P78334, P63092, P32298GNB1, GNG5, GNG10, PDE3B, GABRA4, GABRE, GNAS, GRK4More
Medroxyprogesterone-acetatehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Medroxyprogesterone-acetatehsa05100Bacterial invasion of epithelial cells3.64E-022P42338, Q92529PIK3CB, SHC3More
Medroxyprogesterone-acetatehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Medroxyprogesterone-acetatehsa05132Salmonella infection5.76E-047P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2CMore
Medroxyprogesterone-acetatehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Medroxyprogesterone-acetatehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Medroxyprogesterone-acetatehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Medroxyprogesterone-acetatehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Medroxyprogesterone-acetatehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Medroxyprogesterone-acetatehsa05162Measles3.91E-024P14784, P07766, P42338, P11142IL2RB, CD3E, PIK3CB, HSPA8More
Medroxyprogesterone-acetatehsa05163Human cytomegalovirus infection4.51E-0719P42338, P62873, P63218, P50151, P0DP24, Q14344, P61586, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, Q13651, Q99941, P18848, P63092, P30101, P61769PIK3CB, GNB1, GNG5, GNG10, CALM2, GNA13, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4, GNAS, PDIA3, B2MMore
Medroxyprogesterone-acetatehsa05167Kaposi sarcoma-associated herpesvirus infection6.22E-049P42338, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P0CG47PIK3CB, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, UBBMore
Medroxyprogesterone-acetatehsa05169Epstein-Barr virus infection3.34E-025P42338, P07948, P30101, Q13761, P07766PIK3CB, LYN, PDIA3, RUNX3, CD3EMore
Medroxyprogesterone-acetatehsa05170Human immunodeficiency virus 1 infection1.36E-0411P42338, Q02750, P62879, P63218, P50151, P16298, Q05397, P30101, P19174, P07766, P20333PIK3CB, MAP2K1, GNB2, GNG5, GNG10, PPP3CB, PTK2, PDIA3, PLCG1, CD3E, TNFRSF1BMore
Medroxyprogesterone-acetatehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Medroxyprogesterone-acetatehsa05200Pathways in cancer3.05E-028P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RBMore
Medroxyprogesterone-acetatehsa05202Transcriptional misregulation in cancer2.34E-0313Q12778, Q13315, P14780, P27930, Q16548, P11215, O15550, P05164, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, ATM, MMP9, IL1R2, BCL2A1, ITGAM, UTX, MPO, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Medroxyprogesterone-acetatehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Medroxyprogesterone-acetatehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Medroxyprogesterone-acetatehsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Medroxyprogesterone-acetatehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Medroxyprogesterone-acetatehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Medroxyprogesterone-acetatehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Medroxyprogesterone-acetatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Medroxyprogesterone-acetatehsa05214Glioma9.49E-033Q92529, P42338, P19174SHC3, PIK3CB, PLCG1More
Medroxyprogesterone-acetatehsa05215Prostate cancer4.87E-023Q9NRA1, P08238, P42338PDGFC, HSP90AB1, PIK3CBMore
Medroxyprogesterone-acetatehsa05218Melanoma3.64E-022Q9NRA1, P42338PDGFC, PIK3CBMore
Medroxyprogesterone-acetatehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Medroxyprogesterone-acetatehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Medroxyprogesterone-acetatehsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Medroxyprogesterone-acetatehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Medroxyprogesterone-acetatehsa05231Choline metabolism in cancer1.17E-034P42338, Q9NRA1, P19174, P23743PIK3CB, PDGFC, PLCG1, DGKAMore
Medroxyprogesterone-acetatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Medroxyprogesterone-acetatehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Medroxyprogesterone-acetatehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Medroxyprogesterone-acetatehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Medroxyprogesterone-acetatehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Medroxyprogesterone-acetatehsa05332Graft-versus-host disease3.29E-046P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Medroxyprogesterone-acetatehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore

Community members of Medroxyprogesterone-acetate (SDC: 6.14)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)