PharmaCoNets

PharmaCoNets of Mebendazole (S_PCN: 129.93 )

Mebendazole regulated-network (S_DN: 18.51)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Mebendazole

hsa00010

Glycolysis / Gluconeogenesis

1.18E-02

P60174, P06744

TPI1, GPI

Mebendazole

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Mebendazole

hsa00053

Ascorbate and aldarate metabolism

1.20E-03

P51648, P14550, Q9UEF7

ALDH3A2, AKR1A1, KL

Mebendazole

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Mebendazole

hsa00220

Arginine biosynthesis

3.21E-04

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Mebendazole

hsa00250

Alanine, aspartate and glutamate metabolism

2.42E-02

P15104

GLUL

Mebendazole

hsa00310

Lysine degradation

4.27E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Mebendazole

hsa00500

Starch and sucrose metabolism

6.17E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Mebendazole

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Mebendazole

hsa00561

Glycerolipid metabolism

4.36E-03

O14494, P51648, P23743

PLPP1, ALDH3A2, DGKA

Mebendazole

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Mebendazole

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Mebendazole

hsa00630

Glyoxylate and dicarboxylate metabolism

6.25E-04

P40925, P15104

MDH1, GLUL

Mebendazole

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Mebendazole

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Mebendazole

hsa00970

Aminoacyl-tRNA biosynthesis

2.24E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Mebendazole

hsa01200

Carbon metabolism

1.99E-02

P06744, P60174

GPI, TPI1

Mebendazole

hsa01230

Biosynthesis of amino acids

5.53E-03

P15104, P37837

GLUL, TALDO1

Mebendazole

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.14E-02

P17252, P08069, P10415, Q9NRA1

PRKCA, IGF1R, BCL2, PDGFC

Mebendazole

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Mebendazole

hsa01524

Platinum drug resistance

4.79E-03

Q13315, P10415, Q13489, P98170, P78417, P43246

ATM, BCL2, BIRC3, BIRC4, GSTO1, MSH2

Mebendazole

hsa02010

ABC transporters

2.17E-03

Q8IZY2

ABCA7

Mebendazole

hsa03013

RNA transport

5.22E-03

P52298, Q09161, O14893, P38919, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, EIF4A3, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, RPP38, TACC3

Mebendazole

hsa03040

Spliceosome

2.18E-10

Q14562, O43143, O60508, P08579, P26368, P52298, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, U2AF2, NCBP2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13509	TUBB3	Tubulin beta-3 chain	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.922
Q71U36	TUBA1A	Tubulin alpha-1A chain	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.717
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.809
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
Q13509	TUBB3	Tubulin beta-3 chain	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.878
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
Q13509	TUBB3	Tubulin beta-3 chain	O60508	CDC40	Pre-mRNA-processing factor 17	0.784
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
Q71U36	TUBA1A	Tubulin alpha-1A chain	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.766
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
Q13509	TUBB3	Tubulin beta-3 chain	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.818
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.814
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.879
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
Q13509	TUBB3	Tubulin beta-3 chain	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.799
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
Q13509	TUBB3	Tubulin beta-3 chain	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.87
Q71U36	TUBA1A	Tubulin alpha-1A chain	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.823
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
Q13509	TUBB3	Tubulin beta-3 chain	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.749
Q71U36	TUBA1A	Tubulin alpha-1A chain	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
Q13509	TUBB3	Tubulin beta-3 chain	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.724
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Mebendazole

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Mebendazole

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Mebendazole

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Mebendazole

hsa04014

Ras signaling pathway

1.13E-02

P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Mebendazole

hsa04015

Rap1 signaling pathway

7.59E-04

P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174

EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1

Mebendazole

hsa04020

Calcium signaling pathway

2.09E-02

Q16566, P17252, P25116, P0DP23, Q9NRA1

CAMK4, PRKCA, F2R, CALM1, PDGFC

Mebendazole

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Mebendazole

hsa04062

Chemokine signaling pathway

7.15E-05

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43250	GRK6	G protein-coupled receptor kinase 6	0.815
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.771
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Mebendazole

hsa04064

NF-kappa B signaling pathway

2.53E-07

P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, O75293, P09341, P19875, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, GADD45B, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P68371	TUBB2C	Tubulin beta-4B chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.892
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q13509	TUBB3	Tubulin beta-3 chain	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.757
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P68371	TUBB2C	Tubulin beta-4B chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.748
Q13509	TUBB3	Tubulin beta-3 chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.735
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P68371	TUBB2C	Tubulin beta-4B chain	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.783
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q13509	TUBB3	Tubulin beta-3 chain	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.846
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P68371	TUBB2C	Tubulin beta-4B chain	Q13315	ATM	Serine-protein kinase ATM	-0.772
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
Q13509	TUBB3	Tubulin beta-3 chain	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.826
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Mebendazole

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Mebendazole

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Mebendazole

hsa04071

Sphingolipid signaling pathway

5.66E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, P01042

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, KNG1

Mebendazole

hsa04072

Phospholipase D signaling pathway

1.54E-03

P42338, P43657, P25116, P25024, P25025, P19174, P17252, O14494, P23743, Q9NRA1

PIK3CB, P2RY5, F2R, CXCR1, CXCR2, PLCG1, PRKCA, PLPP1, DGKA, PDGFC

Mebendazole

hsa04080

Neuroactive ligand-receptor interaction

1.18E-02

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1

Mebendazole

hsa04114

Oocyte meiosis

3.19E-03

P51812, Q02750, P16298, Q17RY0, P08069

RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Mebendazole

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Mebendazole

hsa04140

Autophagy - animal

2.82E-02

P08069

IGF1R

Mebendazole

hsa04141

Protein processing in endoplasmic reticulum

2.77E-02

P27824, P30101, P60604, P11142, P08238

CANX, PDIA3, UBE2G2, HSPA8, HSP90AB1

Mebendazole

hsa04142

Lysosome

2.64E-02

Q99437, P25774

ATP6V0B, CTSS

Mebendazole

hsa04145

Phagosome

1.22E-04

Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, O60603, P35443, P27824, P13765, P25774

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, CANX, HLA-DOB, CTSS

Mebendazole

hsa04150

mTOR signaling pathway

7.74E-03

P08069, Q02750, Q9NQL2, P51812

IGF1R, MAP2K1, RRAGD, RPS6KA3

Mebendazole

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Mebendazole

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Mebendazole

hsa04210

Apoptosis

1.52E-02

Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643

ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1

Mebendazole

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Mebendazole

hsa04213

Longevity regulating pathway - multiple species

1.17E-02

P42338, P08069, Q9Y4H2, P11142, Q13547

PIK3CB, IGF1R, IRS2, HSPA8, HDAC1

Mebendazole

hsa04217

Necroptosis

1.82E-06

P01568, Q13489, P98170, Q13546, P42224, P08238, P15104, Q6FI13, P10415, O43633, P21796

IFNA21, BIRC3, BIRC4, RIPK1, STAT1, HSP90AB1, GLUL, H2AC18; H2AC19, BCL2, CHMP2A, VDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P68371	TUBB2C	Tubulin beta-4B chain	P01568	IFNA21	Interferon alpha-21	-0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
P68371	TUBB2C	Tubulin beta-4B chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.892
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
P68371	TUBB2C	Tubulin beta-4B chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.748
Q13509	TUBB3	Tubulin beta-3 chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.735
Q13509	TUBB3	Tubulin beta-3 chain	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.733
P68371	TUBB2C	Tubulin beta-4B chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.741
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
Q13509	TUBB3	Tubulin beta-3 chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.789
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P15104	GLUL	Glutamine synthetase	0.745
P68371	TUBB2C	Tubulin beta-4B chain	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.791
Q13509	TUBB3	Tubulin beta-3 chain	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.908
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P68371	TUBB2C	Tubulin beta-4B chain	O43633	CHMP2A	Charged multivesicular body protein 2a	0.718
Q13509	TUBB3	Tubulin beta-3 chain	O43633	CHMP2A	Charged multivesicular body protein 2a	0.869
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	-0.844

Mebendazole

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Mebendazole

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Mebendazole

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Mebendazole

hsa04371

Apelin signaling pathway

9.81E-08

P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P68371	TUBB2C	Tubulin beta-4B chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q71U36	TUBA1A	Tubulin alpha-1A chain	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.818
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q71U36	TUBA1A	Tubulin alpha-1A chain	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.827
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P68371	TUBB2C	Tubulin beta-4B chain	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14814	MEF2D	Myocyte-specific enhancer factor 2D	0.767
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.879
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.777
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
Q71U36	TUBA1A	Tubulin alpha-1A chain	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.819
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P68371	TUBB2C	Tubulin beta-4B chain	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	-0.74
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.708
P68371	TUBB2C	Tubulin beta-4B chain	P0DP23	CALM1	Calmodulin-1	0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724

Mebendazole

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Mebendazole

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Mebendazole

hsa04520

Adherens junction

7.00E-04

Q13485, P84022, O95863, P08069, Q15223

SMAD4, SMAD3, SNAI1, IGF1R, PVRL1

Mebendazole

hsa04540

Gap junction

5.44E-03

P17252, Q13509, P68371, Q9NRA1

PRKCA, TUBB3, TUBB2C, PDGFC

Mebendazole

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Mebendazole

hsa04610

Complement and coagulation cascades

4.27E-06

P0C0L4

C4A

Mebendazole

hsa04612

Antigen processing and presentation

8.21E-03

P26715, P26717, Q07444, Q13241, P01732

KLRC1, KLRC2, KLRC3, KLRD1, CD8A

Mebendazole

hsa04613

Neutrophil extracellular trap formation

1.30E-03

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1

Mebendazole

hsa04620

Toll-like receptor signaling pathway

7.24E-03

P51617, Q13546, P01568, P42224, P25963

IRAK1, RIPK1, IFNA21, STAT1, NFKBIA

Mebendazole

hsa04621

NOD-like receptor signaling pathway

4.64E-04

P08238, Q14643, P42224, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P12838

HSP90AB1, ITPR1, STAT1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA4

Mebendazole

hsa04623

Cytosolic DNA-sensing pathway

4.52E-05

P01568, Q13546, P25963

IFNA21, RIPK1, NFKBIA

Mebendazole

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Mebendazole

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Mebendazole

hsa04650

Natural killer cell mediated cytotoxicity

6.36E-08

P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, Q07444, P26715

PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1

Mebendazole

hsa04657

IL-17 signaling pathway

1.36E-02

O00463, Q16539, P49841, P14780, P01375

TRAF5, MAPK14, GSK3B, MMP9, TNF

Mebendazole

hsa04658

Th1 and Th2 cell differentiation

6.40E-08

Q04759, P07766, P20963, P09693, P19174, P06239, P23771, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, GATA3, TBX21, IL2RB, RUNX3

Mebendazole

hsa04659

Th17 cell differentiation

7.23E-08

Q04759, P19174, P06239, P14784, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
Q71U36	TUBA1A	Tubulin alpha-1A chain	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.7
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q9UL17	TBX21	T-box transcription factor TBX21	0.705
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.849
Q71U36	TUBA1A	Tubulin alpha-1A chain	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.819
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
Q71U36	TUBA1A	Tubulin alpha-1A chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.866
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q71U36	TUBA1A	Tubulin alpha-1A chain	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.707
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797

Mebendazole

hsa04660

T cell receptor signaling pathway

3.97E-06

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771

Mebendazole

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Mebendazole

hsa04664

Fc epsilon RI signaling pathway

1.78E-04

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Mebendazole

hsa04666

Fc gamma R-mediated phagocytosis

2.81E-02

P23528, O14494, P14598, P17252

CFL1, PLPP1, NCF1, PRKCA

Mebendazole

hsa04668

TNF signaling pathway

1.83E-03

P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9

Mebendazole

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Mebendazole

hsa04710

Circadian rhythm

1.79E-02

O15516

CLOCK

Mebendazole

hsa04713

Circadian entrainment

1.78E-03

O15399, P0DP23, P62873, P63218, P50151

GRIN2D, CALM1, GNB1, GNG5, GNG10

Mebendazole

hsa04720

Long-term potentiation

5.53E-05

P17252, Q16566, P16298, P0DP23, P51812, O15399, Q02750

PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1

Mebendazole

hsa04724

Glutamatergic synapse

2.00E-04

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Mebendazole

hsa04725

Cholinergic synapse

1.97E-04

P17252, P62873, P63218, P50151, Q16566, P10415

PRKCA, GNB1, GNG5, GNG10, CAMK4, BCL2

Mebendazole

hsa04726

Serotonergic synapse

2.38E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Mebendazole

hsa04727

GABAergic synapse

6.18E-04

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Mebendazole

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Mebendazole

hsa04744

Phototransduction

5.98E-07

P62873, P0DP23

GNB1, CALM1

Mebendazole

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Mebendazole

hsa04913

Ovarian steroidogenesis

8.40E-04

P06213, P08069

INSR, IGF1R

Mebendazole

hsa04914

Progesterone-mediated oocyte maturation

5.89E-03

P08069, Q17RY0, P51812, Q02750

IGF1R, CPEB4, RPS6KA3, MAP2K1

Mebendazole

hsa04916

Melanogenesis

2.90E-02

P0DP23, Q9UJU2, P17252

CALM1, LEF1, PRKCA

Mebendazole

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Mebendazole

hsa04923

Regulation of lipolysis in adipocytes

4.24E-03

P07550, P06213, P42338, Q9Y4H2

ADRB2, INSR, PIK3CB, IRS2

Mebendazole

hsa04925

Aldosterone synthesis and secretion

3.91E-02

P0DP23, P17252, Q16566

CALM1, PRKCA, CAMK4

Mebendazole

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Mebendazole

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Mebendazole

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Mebendazole

hsa04961

Endocrine and other factor-regulated calcium reabsorption

1.22E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Mebendazole

hsa04964

Proximal tubule bicarbonate reclamation

2.17E-03

P00918

CA2

Mebendazole

hsa04966

Collecting duct acid secretion

2.17E-03

P00918

CA2

Mebendazole

hsa04970

Salivary secretion

4.49E-02

P22694, Q14643, P17252, P49913

PRKACB, ITPR1, PRKCA, CAMP

Mebendazole

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Mebendazole

hsa05032

Morphine addiction

1.51E-03

P62873, P63218, P50151, P43250

GNB1, GNG5, GNG10, GRK6

Mebendazole

hsa05034

Alcoholism

3.87E-03

O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93079

GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, H2BC9

Mebendazole

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Mebendazole

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Mebendazole

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Mebendazole

hsa05132

Salmonella infection

4.49E-06

P51617, P25963, P01375, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q13509	TUBB3	Tubulin beta-3 chain	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.757
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P68371	TUBB2C	Tubulin beta-4B chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.741
Q13509	TUBB3	Tubulin beta-3 chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.789
P68371	TUBB2C	Tubulin beta-4B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P08246	ELA2	Neutrophil elastase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.771
P68371	TUBB2C	Tubulin beta-4B chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.748
Q13509	TUBB3	Tubulin beta-3 chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.735
P68371	TUBB2C	Tubulin beta-4B chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.892
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
Q13509	TUBB3	Tubulin beta-3 chain	O75369	FLNB	Filamin-B	0.914
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	-0.949
P68371	TUBB2C	Tubulin beta-4B chain	Q13561	DCTN2	Dynactin subunit 2	0.715
P08246	ELA2	Neutrophil elastase	Q13561	DCTN2	Dynactin subunit 2	0.78
Q13509	TUBB3	Tubulin beta-3 chain	Q13561	DCTN2	Dynactin subunit 2	0.74
P68371	TUBB2C	Tubulin beta-4B chain	Q13509	TUBB3	Tubulin beta-3 chain	0.78
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
Q13509	TUBB3	Tubulin beta-3 chain	Q13509	TUBB3	Tubulin beta-3 chain	1
P68371	TUBB2C	Tubulin beta-4B chain	P68371	TUBB2C	Tubulin beta-4B chain	1
Q13509	TUBB3	Tubulin beta-3 chain	P68371	TUBB2C	Tubulin beta-4B chain	0.78

Mebendazole

hsa05133

Pertussis

3.02E-03

P0C0L4

C4A

Mebendazole

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Mebendazole

hsa05140

Leishmaniasis

1.80E-04

P14598, P42224, P13765, O60603, P25963, P01375, P29350, P51617, Q15080

NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, IRAK1, NCF4

Mebendazole

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Mebendazole

hsa05144

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Mebendazole

hsa05145

Toxoplasmosis

1.84E-03

P51617, P25963, P01375, P10415, Q13489, P42224, P13765, P11142, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, HSPA8, TLR2

Mebendazole

hsa05146

Amoebiasis

2.37E-05

P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSG

Mebendazole

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Mebendazole

hsa05152

Tuberculosis

3.89E-05

Q13488, Q99437, P0DP23, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P25774, P01568, P49913, Q9UDY8, P51617

TCIRG1, ATP6V0B, CALM1, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P68371	TUBB2C	Tubulin beta-4B chain	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.729
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P25774	CTSS	Cathepsin S	Q99437	ATP6V0B	V-type proton ATPase 21 kDa proteolipid subunit c''	0.722
P68371	TUBB2C	Tubulin beta-4B chain	P0DP23	CALM1	Calmodulin-1	0.742
Q13509	TUBB3	Tubulin beta-3 chain	P0DP23	CALM1	Calmodulin-1	0.892
Q13509	TUBB3	Tubulin beta-3 chain	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.733
P08246	ELA2	Neutrophil elastase	P48382	RFX5	DNA-binding protein RFX5	-0.895
Q13509	TUBB3	Tubulin beta-3 chain	P25208	NFYB	Nuclear transcription factor Y subunit beta	-0.709
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P25774	CTSS	Cathepsin S	P25774	CTSS	Cathepsin S	1
P68371	TUBB2C	Tubulin beta-4B chain	P01568	IFNA21	Interferon alpha-21	-0.783
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P68371	TUBB2C	Tubulin beta-4B chain	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.783
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q13509	TUBB3	Tubulin beta-3 chain	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.846
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q13509	TUBB3	Tubulin beta-3 chain	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.757

Mebendazole

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Mebendazole

hsa05162

Measles

4.50E-03

P51617, P01568, P25963, P42224, P14784, P10747, P11142, P10415

IRAK1, IFNA21, NFKBIA, STAT1, IL2RB, CD28, HSPA8, BCL2

Mebendazole

hsa05163

Human cytomegalovirus infection

1.64E-03

P01375, P62873, P63218, P50151, P0DP23, P49841, P14778, P25025, Q16539, O00463, P30101, P01568

TNF, GNB1, GNG5, GNG10, CALM1, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21

Mebendazole

hsa05166

Human T-cell leukemia virus 1 infection

1.77E-02

P27824, P30279, P21796, P84022, Q13485, P07766, Q92830, P06746

CANX, CCND2, VDAC1, SMAD3, SMAD4, CD3E, KAT2A, POLB

Mebendazole

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.12E-03

P01568, P62873, P62879, P63218, P50151, P16298, Q02750, P07948, P0DP23, P0CG47

IFNA21, GNB1, GNB2, GNG5, GNG10, PPP3CB, MAP2K1, LYN, CALM1, UBB

Mebendazole

hsa05168

Herpes simplex virus 1 infection

1.15E-04

P25963, P01568, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P51617, P30101, Q13398, Q9NR11, P17097, P17038, Q03923, Q9NZL3, P10415

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, IRAK1, PDIA3, ZNF211, ZNF302, ZNF7, ZNF43, ZNF85, ZNF224, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
Q13509	TUBB3	Tubulin beta-3 chain	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.733
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
Q13509	TUBB3	Tubulin beta-3 chain	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.799
Q13509	TUBB3	Tubulin beta-3 chain	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.87
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
Q13509	TUBB3	Tubulin beta-3 chain	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.749
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
Q13509	TUBB3	Tubulin beta-3 chain	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.757
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13398	ZNF211	Zinc finger protein 211	-0.886
Q13509	TUBB3	Tubulin beta-3 chain	Q13398	ZNF211	Zinc finger protein 211	0.738
Q13509	TUBB3	Tubulin beta-3 chain	Q9NR11	ZNF302	Zinc finger protein 302	-0.82
Q13509	TUBB3	Tubulin beta-3 chain	P17097	ZNF7	Zinc finger protein 7	-0.811
Q13509	TUBB3	Tubulin beta-3 chain	P17038	ZNF43	Zinc finger protein 43	-0.722
Q13509	TUBB3	Tubulin beta-3 chain	Q03923	ZNF85	Zinc finger protein 85	-0.842
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q9NZL3	ZNF224	Zinc finger protein 224	-0.762
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809

Mebendazole

hsa05170

Human immunodeficiency virus 1 infection

3.38E-10

Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, Q13546, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P68371	TUBB2C	Tubulin beta-4B chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13509	TUBB3	Tubulin beta-3 chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.816
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P68371	TUBB2C	Tubulin beta-4B chain	P0DP23	CALM1	Calmodulin-1	0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q13509	TUBB3	Tubulin beta-3 chain	P0DP23	CALM1	Calmodulin-1	0.892
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P68371	TUBB2C	Tubulin beta-4B chain	P17252	PRKCA	Protein kinase C alpha type	-0.842
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
Q13509	TUBB3	Tubulin beta-3 chain	P17252	PRKCA	Protein kinase C alpha type	-0.756
P68371	TUBB2C	Tubulin beta-4B chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.748
Q13509	TUBB3	Tubulin beta-3 chain	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.735
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P68371	TUBB2C	Tubulin beta-4B chain	P01568	IFNA21	Interferon alpha-21	-0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q13509	TUBB3	Tubulin beta-3 chain	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.757
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P68371	TUBB2C	Tubulin beta-4B chain	Q13315	ATM	Serine-protein kinase ATM	-0.772
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P23528	CFL1	Cofilin-1	0.738
Q13509	TUBB3	Tubulin beta-3 chain	P23528	CFL1	Cofilin-1	-0.726
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P68371	TUBB2C	Tubulin beta-4B chain	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.753
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811
Q13509	TUBB3	Tubulin beta-3 chain	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.886
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Mebendazole

hsa05200

Pathways in cancer

3.43E-09

P04628, Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30279, P30281, P10415, Q13489, P98170, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P01042

WNT1, LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND2, CCND3, BCL2, BIRC3, BIRC4, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13509	TUBB3	Tubulin beta-3 chain	P04628	WNT1	Proto-oncogene Wnt-1	-0.709
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13751	LAMB3	Laminin subunit beta-3	0.748
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q71U36	TUBA1A	Tubulin alpha-1A chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.866
P68371	TUBB2C	Tubulin beta-4B chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.741
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q13509	TUBB3	Tubulin beta-3 chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.789
Q13509	TUBB3	Tubulin beta-3 chain	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.733
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
Q71U36	TUBA1A	Tubulin alpha-1A chain	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P68371	TUBB2C	Tubulin beta-4B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P68371	TUBB2C	Tubulin beta-4B chain	P17252	PRKCA	Protein kinase C alpha type	-0.842
Q13509	TUBB3	Tubulin beta-3 chain	P17252	PRKCA	Protein kinase C alpha type	-0.756
P68371	TUBB2C	Tubulin beta-4B chain	P43246	MSH2	DNA mismatch repair protein Msh2	0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
Q13509	TUBB3	Tubulin beta-3 chain	P43246	MSH2	DNA mismatch repair protein Msh2	0.872
Q71U36	TUBA1A	Tubulin alpha-1A chain	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.819
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.777
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
Q71U36	TUBA1A	Tubulin alpha-1A chain	P20585	MSH3	DNA mismatch repair protein Msh3	-0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P68371	TUBB2C	Tubulin beta-4B chain	P14923	JUP	Junction plakoglobin	-0.781
Q13509	TUBB3	Tubulin beta-3 chain	P14923	JUP	Junction plakoglobin	-0.937
Q71U36	TUBA1A	Tubulin alpha-1A chain	P30279	CCND2	G1/S-specific cyclin-D2	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P68371	TUBB2C	Tubulin beta-4B chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.892
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P68371	TUBB2C	Tubulin beta-4B chain	Q12778	FOXO1	Forkhead box protein O1	-0.895
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P68371	TUBB2C	Tubulin beta-4B chain	P25116	F2R	Proteinase-activated receptor 1	-0.799
P68371	TUBB2C	Tubulin beta-4B chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13509	TUBB3	Tubulin beta-3 chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.816
Q71U36	TUBA1A	Tubulin alpha-1A chain	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.818
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q71U36	TUBA1A	Tubulin alpha-1A chain	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.827
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.879
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
Q13509	TUBB3	Tubulin beta-3 chain	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.826
P68371	TUBB2C	Tubulin beta-4B chain	P0DP23	CALM1	Calmodulin-1	0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q13509	TUBB3	Tubulin beta-3 chain	P0DP23	CALM1	Calmodulin-1	0.892
P68371	TUBB2C	Tubulin beta-4B chain	P01568	IFNA21	Interferon alpha-21	-0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q13509	TUBB3	Tubulin beta-3 chain	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.709
P68371	TUBB2C	Tubulin beta-4B chain	P01042	KNG1	Kininogen-1	-0.7
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Mebendazole

hsa05202

Transcriptional misregulation in cancer

1.51E-05

Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Mebendazole

hsa05203

Viral carcinogenesis

1.90E-02

P06746, Q92830, P07948, P30279, P29083, Q93079

POLB, KAT2A, LYN, CCND2, GTF2E1, H2BC9

Mebendazole

hsa05205

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Mebendazole

hsa05210

Colorectal cancer

4.67E-02

P84022, Q13485, P43246, O75293

SMAD3, SMAD4, MSH2, GADD45B

Mebendazole

hsa05212

Pancreatic cancer

3.46E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Mebendazole

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Mebendazole

hsa05214

Glioma

3.39E-04

P08069, P0DP23, Q16566, P17252, O75293

IGF1R, CALM1, CAMK4, PRKCA, GADD45B

Mebendazole

hsa05215

Prostate cancer

5.28E-04

P10415, Q9UJU2, Q12778, P08069, Q9NRA1, P08238

BCL2, LEF1, FOXO1, IGF1R, PDGFC, HSP90AB1

Mebendazole

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Mebendazole

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Mebendazole

hsa05222

Small cell lung cancer

3.10E-03

Q13751, Q13489, P98170, P10415, P25963, Q13077, O00463, P24522, O75293

LAMB3, BIRC3, BIRC4, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45B

Mebendazole

hsa05224

Breast cancer

1.49E-02

P08069

IGF1R

Mebendazole

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Mebendazole

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Mebendazole

hsa05231

Choline metabolism in cancer

5.44E-03

Q9NRA1, P23743, O14494, P17252

PDGFC, DGKA, PLPP1, PRKCA

Mebendazole

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.32E-04

P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ

Mebendazole

hsa05310

Asthma

3.88E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Mebendazole

hsa05321

Inflammatory bowel disease

1.28E-02

O60603, P01375, P13765, Q14765, P23771

TLR2, TNF, HLA-DOB, STAT4, GATA3

Mebendazole

hsa05322

Systemic lupus erythematosus

2.70E-03

P08246, P08311, P01375, P10747, P13765, Q6FI13, P62807, Q16778, P12814, P05455

ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, ACTN1, SSB

Mebendazole

hsa05332

Graft-versus-host disease

9.30E-03

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Mebendazole

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.17E-03

P54284

CACNB3

Mebendazole

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Mebendazole

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Mebendazole (S_DC: 7.02)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

TUBA1A

Tubulin alphaNone1A chain

Reported

0.5888

0.0701

0.7094

1.1439

P68371

TUBB2C

Tubulin betaNone4B chain

Reported

0.2866

0.097

0.6484

0.9857

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P06213

INSR

Insulin receptor

Predicted

0.2794

0.7813

0.7209

2.4232

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

P00352

ALDH1A1

Aldehyde dehydrogenase 1A1

Predicted

0.3208

0.2925

0.1543

0.8998

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

Q13885

TUBB2A

Tubulin betaNone2A chain

Predicted

0.0398

0.0963

0.6484

0.8609

Q13509

TUBB3

Tubulin betaNone3 chain

Predicted

0.0904

0.0961

0.6484

0.8858

PharmaCoNets of Mebendazole (SPCN: 129.93 )

Mebendazole regulated-network (SDN: 18.51)

Community members of Mebendazole (SDC: 7.02)

PharmaCoNets of Mebendazole (S_PCN: 129.93 )

Mebendazole regulated-network (S_DN: 18.51)

Community members of Mebendazole (S_DC: 7.02)