PharmaCoNets of Mazindol (SPCN: 65.23 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Mazindolhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Mazindolhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Mazindolhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Mazindolhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Mazindolhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Mazindolhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Mazindolhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Mazindolhsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Mazindolhsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Mazindolhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Mazindolhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Mazindolhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Mazindolhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Mazindolhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Mazindolhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Mazindolhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Mazindolhsa03013RNA transport4.49E-025P62826, Q9UBU9, P63279, P68104, Q14232RAN, NXF1, UBE2I, EEF1A1, EIF2B1More
Mazindolhsa03020RNA polymerase6.21E-044P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Mazindolhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Mazindolhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Mazindolhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Mazindolhsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Mazindolhsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Mazindolhsa04024cAMP signaling pathway3.94E-024Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Mazindolhsa04061Viral protein interaction with cytokine and cytokine receptor4.54E-022Q8NHW4, Q13651CCL4L2, IL10RAMore
Mazindolhsa04064NF-kappa B signaling pathway4.10E-034P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Mazindolhsa04070Phosphatidylinositol signaling system5.86E-046P0DP23, O14986, Q86XP1, Q16760, P48426, Q96DU7CALM1, PIP5K1B, DGKH, DGKD, PIP4K2A, ITPKCMore
Mazindolhsa04072Phospholipase D signaling pathway2.40E-036P31751, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Mazindolhsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Mazindolhsa04114Oocyte meiosis1.35E-025P0DP23, Q08828, P51828, Q13362, Q14738CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Mazindolhsa04140Autophagy - animal1.71E-025P31751, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Mazindolhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Mazindolhsa04213Longevity regulating pathway - multiple species4.54E-023P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Mazindolhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Mazindolhsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Mazindolhsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Mazindolhsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Mazindolhsa04390Hippo signaling pathway2.17E-035P63261, P84022, Q13485, O15105, Q13489ACTG1, SMAD3, SMAD4, SMAD7, BIRC3More
Mazindolhsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Mazindolhsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Mazindolhsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Mazindolhsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Mazindolhsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Mazindolhsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Mazindolhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Mazindolhsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Mazindolhsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Mazindolhsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Mazindolhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Mazindolhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Mazindolhsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Mazindolhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Mazindolhsa04720Long-term potentiation4.54E-023P0DP23, P18848, Q08828CALM1, ATF4, ADCY1More
Mazindolhsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Mazindolhsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Mazindolhsa04750Inflammatory mediator regulation of TRP channels9.86E-034P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Mazindolhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Mazindolhsa04912GnRH signaling pathway1.39E-024Q08828, P51828, P18848, P0DP23ADCY1, ADCY7, ATF4, CALM1More
Mazindolhsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Mazindolhsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Mazindolhsa04923Regulation of lipolysis in adipocytes5.15E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Mazindolhsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Mazindolhsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Mazindolhsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Mazindolhsa04932Non-alcoholic fatty liver disease7.86E-048P31751, P49841, P18848, O75460, P01584, Q16718, O95298, O14521AKT2, GSK3B, ATF4, ERN1, IL1B, NDUFA5, NDUFC2, SDHDMore
Mazindolhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Mazindolhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Mazindolhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Mazindolhsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Mazindolhsa04970Salivary secretion1.59E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Mazindolhsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Mazindolhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Mazindolhsa04976Bile secretion9.77E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Mazindolhsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Mazindolhsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Mazindolhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Mazindolhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Mazindolhsa05022Pathways of neurodegeneration - multiple diseases4.63E-0415P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, P28070GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4More
Mazindolhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Mazindolhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Mazindolhsa05133Pertussis4.94E-021P0C0L4C4AMore
Mazindolhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Mazindolhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Mazindolhsa05163Human cytomegalovirus infection1.64E-0515P31751, P01375, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, O00463AKT2, TNF, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TRAF5More
Mazindolhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Mazindolhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Mazindolhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Mazindolhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Mazindolhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Mazindolhsa05212Pancreatic cancer1.98E-035P31751, Q15311, P23458, P84022, Q13485AKT2, RALBP1, JAK1, SMAD3, SMAD4More
Mazindolhsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Mazindolhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Mazindolhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Mazindolhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Mazindolhsa05231Choline metabolism in cancer8.11E-047Q02750, P31751, P09619, Q9GZP0, O15245, Q16760, O14986MAP2K1, AKT2, PDGFRB, PDGFD, SLC22A1, DGKD, PIP5K1BMore
Mazindolhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Mazindolhsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Mazindolhsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Mazindolhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Mazindolhsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Mazindol (SDC: 5.36)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC6A4P31645IC5054
SLC6A4P31645IC5094
SLC6A4P31645Ki45
SLC6A4P31645Ki50
SLC6A4P31645Ki136