PharmaCoNets

PharmaCoNets of Maraviroc (S_PCN: 132.05 )

Maraviroc regulated-network (S_DN: 21.44)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Maraviroc

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Maraviroc

hsa00071

Fatty acid degradation

3.65E-03

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Maraviroc

hsa00072

Synthesis and degradation of ketone bodies

2.78E-02

Q01581

HMGCS1

Maraviroc

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Maraviroc

hsa00220

Arginine biosynthesis

1.21E-02

P15104

GLUL

Maraviroc

hsa00250

Alanine, aspartate and glutamate metabolism

2.42E-02

P15104

GLUL

Maraviroc

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Maraviroc

hsa00500

Starch and sucrose metabolism

5.22E-07

O43451, P46976, P06737

MGAM, GYG1, PYGL

Maraviroc

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Maraviroc

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Maraviroc

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Maraviroc

hsa00630

Glyoxylate and dicarboxylate metabolism

3.26E-04

P40925, P40926, P05166, P15104

MDH1, MDH2, PCCB, GLUL

Maraviroc

hsa00730

Thiamine metabolism

1.32E-04

P05186, P24666

ALPL, ACP1

Maraviroc

hsa00760

Nicotinate and nicotinamide metabolism

3.52E-02

P21589

NT5E

Maraviroc

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Maraviroc

hsa00830

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Maraviroc

hsa00900

Terpenoid backbone biosynthesis

9.84E-04

Q01581, P49354, Q9UHG3

HMGCS1, FNTA, PCYOX1

Maraviroc

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Maraviroc

hsa00970

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Maraviroc

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Maraviroc

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Maraviroc

hsa00983

Drug metabolism - other enzymes

1.73E-02

P20839, Q16772

IMPDH1, GSTA3

Maraviroc

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Maraviroc

hsa01230

Biosynthesis of amino acids

5.53E-03

P15104, P37837

GLUL, TALDO1

Maraviroc

hsa01521

EGFR tyrosine kinase inhibitor resistance

2.18E-02

P49841, Q9NRA1

GSK3B, PDGFC

Maraviroc

hsa02010

ABC transporters

1.98E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Maraviroc

hsa03008

Ribosome biogenesis in eukaryotes

4.42E-02

Q9NYH9, P78345, Q9BVP2

UTP6, RPP38, GNL3

Maraviroc

hsa03013

RNA transport

3.43E-05

P62826, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, O75822, P78345, Q9H777, Q9Y6A5

RAN, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF3J, RPP38, ELAC1, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62826	RAN	GTP-binding nuclear protein Ran	0.767
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.719
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.701
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P35658	NUP214	Nuclear pore complex protein Nup214	-0.769
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.743
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P68104	EEF1A1	Elongation factor 1-alpha 1	0.797
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.823
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q9H777	ELAC1	Zinc phosphodiesterase ELAC protein 1	0.785
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732

Maraviroc

hsa03020

RNA polymerase

3.03E-03

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Maraviroc

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Maraviroc

hsa03040

Spliceosome

2.10E-04

O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643

CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1

Maraviroc

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Maraviroc

hsa04020

Calcium signaling pathway

1.24E-02

Q96DU7, Q08828, Q13557, P21860, P0DP24, P05141

ITPKC, ADCY1, CAMK2D, ERBB3, CALM2, SLC25A5

Maraviroc

hsa04022

cGMP-PKG signaling pathway

2.30E-03

Q02153, Q99941, P18848, Q8WYR1, Q08828, P05141, P0DP24

GUCY1B3, CREBL1, ATF4, PIK3R5, ADCY1, SLC25A5, CALM2

Maraviroc

hsa04060

Cytokine-cytokine receptor interaction

3.41E-03

Q9UHF4, P16871, P78552, Q9UBD3, P47992, P02775, O75509, P32248, P51684

IL20RA, IL7R, IL13RA1, XCL2, XCL1, PPBP, TNFRSF21, CCR7, CCR6

Maraviroc

hsa04061

Viral protein interaction with cytokine and cytokine receptor

7.74E-04

P51684, P32248, P02775, P47992, Q9UBD3, Q9UHF4

CCR6, CCR7, PPBP, XCL1, XCL2, IL20RA

Maraviroc

hsa04062

Chemokine signaling pathway

3.93E-03

P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3B

Maraviroc

hsa04064

NF-kappa B signaling pathway

2.55E-10

P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9NQC7

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P51684	CCR6	C-C chemokine receptor type 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P51684	CCR6	C-C chemokine receptor type 6	Q13077	TRAF1	TNF receptor-associated factor 1	0.768
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Maraviroc

hsa04066

HIF-1 signaling pathway

3.40E-02

Q09472, P07195, P10415

EP300, LDHB, BCL2

Maraviroc

hsa04068

FoxO signaling pathway

3.52E-02

Q96BR1

SGK3

Maraviroc

hsa04070

Phosphatidylinositol signaling system

3.39E-03

P19174, P0DP23, Q14643, P49619, O14732, P27987, P17252

PLCG1, CALM1, ITPR1, DGKG, IMPA2, ITPKB, PRKCA

Maraviroc

hsa04071

Sphingolipid signaling pathway

3.39E-04

P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2

Maraviroc

hsa04072

Phospholipase D signaling pathway

9.70E-03

Q92529, Q14344

SHC3, GNA13

Maraviroc

hsa04080

Neuroactive ligand-receptor interaction

5.67E-03

P08311, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730

CTSG, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1

Maraviroc

hsa04110

Cell cycle

1.72E-03

Q9UJX4, P06493, O60566, Q09472, P24522, P04637, P49918, P30304, P33981, P01106, Q13547

ANAPC5, CDK1, BUB1B, EP300, GADD45A, TP53, CDKN1C, CDC25A, TTK, MYC, HDAC1

Maraviroc

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Maraviroc

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Maraviroc

hsa04140

Autophagy - animal

4.55E-02

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Maraviroc

hsa04141

Protein processing in endoplasmic reticulum

3.96E-02

P18848, Q15436, Q99941, P11142, Q9H3Z4, P07900, Q9NR31

ATF4, SEC23A, CREBL1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Maraviroc

hsa04142

Lysosome

2.45E-03

Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Maraviroc

hsa04144

Endocytosis

4.54E-04

Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3

CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5

Maraviroc

hsa04145

Phagosome

1.65E-03

O75015, Q15080, P14598, Q13509, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774

FCGR3B, NCF4, NCF1, TUBB3, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSS

Maraviroc

hsa04151

PI3K-Akt signaling pathway

7.33E-04

P62753, P21860, O43521, P27348, P07900, Q8WYR1, P62873, P61952, Q16363, P22105, Q99941, P18848, O00141, Q6ZUJ8

RPS6, ERBB3, BCL2L11, YWHAQ, HSP90AA1, PIK3R5, GNB1, GNG11, LAMA4, TNXB, CREBL1, ATF4, SGK, PIK3AP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62753	RPS6	40S ribosomal protein S6	0.709
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.85
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P27348	YWHAQ	14-3-3 protein theta	0.76
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.763
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.789
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	-0.756
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q16363	LAMA4	Laminin subunit alpha-4	0.773
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P22105	TNXB	Tenascin-X	0.801
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.801
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728

Maraviroc

hsa04210

Apoptosis

2.32E-05

Q13315, P04637, P10415, Q13489, P25963, P01375, O75460, P24522, Q16548, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643

ATM, TP53, BCL2, BIRC3, NFKBIA, TNF, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1

Maraviroc

hsa04213

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Maraviroc

hsa04217

Necroptosis

7.22E-05

P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557, Q9H444

TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2D, CHMP4B

Maraviroc

hsa04260

Cardiac muscle contraction

4.02E-02

P09493, P14927

TPM1, UQCRB

Maraviroc

hsa04261

Adrenergic signaling in cardiomyocytes

3.44E-02

Q16537, P0DP23, P17252, P10415, P20020

PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1

Maraviroc

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Maraviroc

hsa04371

Apelin signaling pathway

3.80E-02

P62873, P61952, Q08828, P62753, P0DP24

GNB1, GNG11, ADCY1, RPS6, CALM2

Maraviroc

hsa04380

Osteoclast differentiation

9.58E-05

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Maraviroc

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Maraviroc

hsa04610

Complement and coagulation cascades

8.75E-05

P0C0L4

C4A

Maraviroc

hsa04612

Antigen processing and presentation

1.66E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Maraviroc

hsa04613

Neutrophil extracellular trap formation

4.11E-08

P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, P33778, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Maraviroc

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Maraviroc

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Maraviroc

hsa04623

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Maraviroc

hsa04625

C-type lectin receptor signaling pathway

9.91E-04

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Maraviroc

hsa04630

JAK-STAT signaling pathway

3.20E-02

P01106, P42224, P14784, Q13651

MYC, STAT1, IL2RB, IL10RA

Maraviroc

hsa04640

Hematopoietic cell lineage

5.76E-03

P13612, P14778, P27930, P15144, P11836, P25063, P09693, P01732, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3G, CD8A, HLA-DOB, TNF, IL1B

Maraviroc

hsa04650

Natural killer cell mediated cytotoxicity

5.61E-07

P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Maraviroc

hsa04657

IL-17 signaling pathway

1.41E-04

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Maraviroc

hsa04658

Th1 and Th2 cell differentiation

8.91E-08

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13761	RUNX3	Runt-related transcription factor 3	-0.713
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855

Maraviroc

hsa04659

Th17 cell differentiation

7.34E-07

Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P01584, P08238, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P51955	NEK2	Serine/threonine-protein kinase Nek2	P06239	LCK	Tyrosine-protein kinase Lck	-0.827
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51955	NEK2	Serine/threonine-protein kinase Nek2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.723
P51955	NEK2	Serine/threonine-protein kinase Nek2	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.788
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P51955	NEK2	Serine/threonine-protein kinase Nek2	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.779
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Maraviroc

hsa04660

T cell receptor signaling pathway

1.64E-07

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	1
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.811
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Maraviroc

hsa04662

B cell receptor signaling pathway

4.07E-02

P42338, P60033, P07948, Q8N149

PIK3CB, CD81, LYN, LILRA2

Maraviroc

hsa04664

Fc epsilon RI signaling pathway

3.98E-02

P01375, Q16539, Q9UQC2

TNF, MAPK14, GAB2

Maraviroc

hsa04666

Fc gamma R-mediated phagocytosis

2.22E-02

P49006, P06396, P14598, P17252

MARCKSL1, GSN, NCF1, PRKCA

Maraviroc

hsa04668

TNF signaling pathway

7.92E-06

P01375, O00463, Q13489, Q16539, P25963, Q99941, P18848, P01584, P20749, Q13077, P14780, P20333, O95429

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, ATF4, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B, BAG4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.801
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P01584	IL1B	Interleukin-1 beta	0.725
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P49841	GSK3B	Glycogen synthase kinase-3 beta	P20749	BCL3	B-cell lymphoma 3 protein	0.745
P08246	ELA2	Neutrophil elastase	P20749	BCL3	B-cell lymphoma 3 protein	0.712
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.725
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	O95429	BAG4	BAG family molecular chaperone regulator 4	0.71

Maraviroc

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Maraviroc

hsa04713

Circadian entrainment

4.35E-04

P0DP24, Q13557, Q02153, P62873, P61952, Q08828

CALM2, CAMK2D, GUCY1B3, GNB1, GNG11, ADCY1

Maraviroc

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Maraviroc

hsa04720

Long-term potentiation

2.46E-03

P17252, Q13557, P0DP24, P0DP23, P18848, Q08828, Q14643

PRKCA, CAMK2D, CALM2, CALM1, ATF4, ADCY1, ITPR1

Maraviroc

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Maraviroc

hsa04723

Retrograde endocannabinoid signaling

3.71E-02

P62873, P61952, Q08828, O15239

GNB1, GNG11, ADCY1, NDUFA1

Maraviroc

hsa04724

Glutamatergic synapse

1.40E-03

O15399, Q08828, P62873, P63218, P50151, P61952, P15104

GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLUL

Maraviroc

hsa04725

Cholinergic synapse

1.03E-02

Q08828, P62873, P61952, P18848, Q13557

ADCY1, GNB1, GNG11, ATF4, CAMK2D

Maraviroc

hsa04727

GABAergic synapse

1.40E-03

Q08828, P62873, P63218, P50151, P61952, P15104, Q15111

ADCY1, GNB1, GNG5, GNG10, GNG11, GLUL, PLCL1

Maraviroc

hsa04728

Dopaminergic synapse

1.85E-04

P14416, P62873, P63218, P50151, P61952, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP24, O15516

DRD2, GNB1, GNG5, GNG10, GNG11, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM2, CLOCK

Maraviroc

hsa04730

Long-term depression

3.52E-02

Q14344

GNA13

Maraviroc

hsa04740

Olfactory transduction

6.79E-03

P62873, Q13557, P0DP24

GNB1, CAMK2D, CALM2

Maraviroc

hsa04744

Phototransduction

4.22E-02

P62873, P0DP24

GNB1, CALM2

Maraviroc

hsa04750

Inflammatory mediator regulation of TRP channels

1.45E-04

P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2, CALM1

Maraviroc

hsa04911

Insulin secretion

1.06E-02

Q08828, Q99941, P18848, Q13557

ADCY1, CREBL1, ATF4, CAMK2D

Maraviroc

hsa04912

GnRH signaling pathway

5.11E-03

P17252, P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694

PRKCA, ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB

Maraviroc

hsa04915

Estrogen signaling pathway

2.49E-03

Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788

CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1

Maraviroc

hsa04916

Melanogenesis

2.18E-02

P49841, Q01726

GSK3B, MC1R

Maraviroc

hsa04918

Thyroid hormone synthesis

3.71E-02

Q08828, Q99941, P18848, P02768

ADCY1, CREBL1, ATF4, ALB

Maraviroc

hsa04919

Thyroid hormone signaling pathway

1.64E-02

P19174, P42224, Q13547, P01106

PLCG1, STAT1, HDAC1, MYC

Maraviroc

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Maraviroc

hsa04925

Aldosterone synthesis and secretion

2.43E-04

Q14643, Q99941, P18848, Q08828, P0DP24, P0DP23, P17252, Q13557, P20020

ITPR1, CREBL1, ATF4, ADCY1, CALM2, CALM1, PRKCA, CAMK2D, ATP2B1

Maraviroc

hsa04926

Relaxin signaling pathway

2.13E-02

P62873, P61952, Q99941, P18848, Q08828

GNB1, GNG11, CREBL1, ATF4, ADCY1

Maraviroc

hsa04927

Cortisol synthesis and secretion

4.49E-02

Q99941, P18848, Q08828

CREBL1, ATF4, ADCY1

Maraviroc

hsa04932

Non-alcoholic fatty liver disease

1.33E-07

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P01584	IL1B	Interleukin-1 beta	0.725
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.712
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.763
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.885
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Maraviroc

hsa04934

Cushing syndrome

2.60E-02

Q99941, P18848, Q08828, Q13557

CREBL1, ATF4, ADCY1, CAMK2D

Maraviroc

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Maraviroc

hsa04960

Aldosterone-regulated sodium reabsorption

4.38E-02

P48048

KCNJ1

Maraviroc

hsa04962

Vasopressin-regulated water reabsorption

1.80E-02

P62491, P46459

RAB11A, NSF

Maraviroc

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Maraviroc

hsa04966

Collecting duct acid secretion

2.19E-03

P02730, P00918, Q9Y666

SLC4A1, CA2, SLC12A7

Maraviroc

hsa04970

Salivary secretion

2.10E-05

Q08828, P51828, P22694, Q14643, P20020, P17252, P0DP23, P0DP24, Q02153, P49913

ADCY1, ADCY7, PRKACB, ITPR1, ATP2B1, PRKCA, CALM1, CALM2, GUCY1B3, CAMP

Maraviroc

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Maraviroc

hsa04976

Bile secretion

3.14E-03

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Maraviroc

hsa05010

Alzheimer disease

2.78E-02

P13073, O75460, P0DP24, P01584, P18848, P05141

COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5

Maraviroc

hsa05012

Parkinson disease

5.18E-03

O15239, P13073, P12074, P05496, P05141, O75460, P18848, P0DP24, Q13557

NDUFA1, COX4I1, COX6A1, ATP5G1, SLC25A5, ERN1, ATF4, CALM2, CAMK2D

Maraviroc

hsa05016

Huntington disease

3.74E-03

O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12

Maraviroc

hsa05017

Spinocerebellar ataxia

2.22E-02

Q92915, O15399, P42338, P21796

FGF14, GRIN2D, PIK3CB, VDAC1

Maraviroc

hsa05020

Prion disease

7.71E-04

P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P12074, P18848, P05141, P49841, Q99941, Q16539

IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, GSK3B, CREBL1, MAPK14

Maraviroc

hsa05022

Pathways of neurodegeneration - multiple diseases

6.94E-04

P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24

GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2

Maraviroc

hsa05031

Amphetamine addiction

1.06E-02

P0DP24, Q13557, Q99941, P18848

CALM2, CAMK2D, CREBL1, ATF4

Maraviroc

hsa05034

Alcoholism

3.65E-05

Q99941, P18848, Q13547, P0DP24, P62873, P61952, P0C0S5, Q93077, P62807, Q16778, O60814, P68431

CREBL1, ATF4, HDAC1, CALM2, GNB1, GNG11, H2AFZ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Maraviroc

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Maraviroc

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.85E-03

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Maraviroc

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Maraviroc

hsa05132

Salmonella infection

2.30E-04

P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, P51808, Q13561, Q13509

IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3

Maraviroc

hsa05133

Pertussis

3.51E-02

P0C0L4

C4A

Maraviroc

hsa05134

Legionellosis

1.77E-03

P01584, Q9NR31, P68104, P0DMV8, P11142

IL1B, SAR1A, EEF1A1, HSPA1A, HSPA8

Maraviroc

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Maraviroc

hsa05140

Leishmaniasis

6.15E-07

P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P51684	CCR6	C-C chemokine receptor type 6	P49006	MARCKSL1	MARCKS-related protein	0.727
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15080	NCF4	Neutrophil cytosol factor 4	-0.74
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803

Maraviroc

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Maraviroc

hsa05144

Malaria

5.01E-06

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Maraviroc

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Maraviroc

hsa05146

Amoebiasis

4.20E-04

P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311

IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Maraviroc

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Maraviroc

hsa05152

Tuberculosis

9.13E-03

Q13488, Q99437, P48382, O60603, P01375, P10415, P13765, P25774, P49913, Q9UDY8, P51617

TCIRG1, ATP6V0B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, CAMP, MALT1, IRAK1

Maraviroc

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Maraviroc

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Maraviroc

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Maraviroc

hsa05163

Human cytomegalovirus infection

1.88E-06

P01375, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P61769

TNF, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, B2M

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.789
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	-0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P0DP24	CALM2	Calmodulin-2	0.786
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P01584	IL1B	Interleukin-1 beta	0.725
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.801
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.844
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	P61769	B2M	Beta-2-microglobulin	0.753

Maraviroc

hsa05169

Epstein-Barr virus infection

2.62E-04

P13765, P01106, Q13547, Q92769, P04637, Q13546, P10415, Q13761, P24522, P42224, O60603, P29728, P51617, P07766, P09693

HLA-DOB, MYC, HDAC1, HDAC2, TP53, RIPK1, BCL2, RUNX3, GADD45A, STAT1, TLR2, OAS2, IRAK1, CD3E, CD3G

Maraviroc

hsa05170

Human immunodeficiency virus 1 infection

2.45E-05

P0DP23, P01375, P17252, Q13546, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P09693, P10415, Q13619, Q93034, Q9Y6Q5

CALM1, TNF, PRKCA, RIPK1, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, CD3G, BCL2, CUL4A, CUL5, AP1M2

Maraviroc

hsa05200

Pathways in cancer

4.87E-02

P04637, Q9UJU2, Q09472, P14923, P10415, Q13077, O95267, P24522, P16871

TP53, LEF1, EP300, JUP, BCL2, TRAF1, RASGRP1, GADD45A, IL7R

Maraviroc

hsa05202

Transcriptional misregulation in cancer

8.60E-08

Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P32248	CCR7	C-C chemokine receptor type 7	Q15532	SS18	Protein SSXT	0.804
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P14780	MMP9	Matrix metalloproteinase-9	-0.855
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P32248	CCR7	C-C chemokine receptor type 7	P14923	JUP	Junction plakoglobin	0.711
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P32248	CCR7	C-C chemokine receptor type 7	Q13077	TRAF1	TNF receptor-associated factor 1	0.748
P32248	CCR7	C-C chemokine receptor type 7	O15550	UTX	Lysine-specific demethylase 6A	-0.715
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P12838	DEFA4	Neutrophil defensin 4	-0.86
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08246	ELA2	Neutrophil elastase	-0.782
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.9
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P32248	CCR7	C-C chemokine receptor type 7	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862

Maraviroc

hsa05203

Viral carcinogenesis

1.29E-03

Q13547, Q15283, P12814, P06493, P62807, Q16778, O60814

HDAC1, RASA2, ACTN1, CDK1, HIST1H2BC, HIST2H2BE, H2BC12

Maraviroc

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Maraviroc

hsa05210

Colorectal cancer

2.41E-02

P10415, P04637, Q9UJU2, P24522

BCL2, TP53, LEF1, GADD45A

Maraviroc

hsa05213

Endometrial cancer

1.91E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Maraviroc

hsa05214

Glioma

1.00E-02

P0DP23, P17252, P04637, P24522

CALM1, PRKCA, TP53, GADD45A

Maraviroc

hsa05215

Prostate cancer

1.94E-02

P10415, Q9UJU2, Q09472, P04637

BCL2, LEF1, EP300, TP53

Maraviroc

hsa05216

Thyroid cancer

2.42E-04

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Maraviroc

hsa05217

Basal cell carcinoma

2.82E-04

Q13635, P49841, Q9UJU2, P04637, P24522

PTCH1, GSK3B, LEF1, TP53, GADD45A

Maraviroc

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Maraviroc

hsa05222

Small cell lung cancer

1.93E-03

Q13489, P10415, P25963, Q13077, O00463, P04637, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, TP53, GADD45A

Maraviroc

hsa05224

Breast cancer

5.34E-03

Q9UJU2, P49841, Q92837, P04637, P24522

LEF1, GSK3B, FRAT1, TP53, GADD45A

Maraviroc

hsa05225

Hepatocellular carcinoma

1.85E-02

Q92529, P51531

SHC3, SMARCA2

Maraviroc

hsa05226

Gastric cancer

8.86E-03

Q9UJU2, P04637, P24522, P14923, P10415

LEF1, TP53, GADD45A, JUP, BCL2

Maraviroc

hsa05230

Central carbon metabolism in cancer

4.04E-02

P07195, P04637

LDHB, TP53

Maraviroc

hsa05231

Choline metabolism in cancer

1.39E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Maraviroc

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.34E-04

O95267, P19174, P07766, P20963, P09693, P06239, P23458, P42224, O60603, Q04759, Q16539, Q9HC35, P01730

RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4

Maraviroc

hsa05310

Asthma

2.14E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Maraviroc

hsa05321

Inflammatory bowel disease

7.20E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Maraviroc

hsa05322

Systemic lupus erythematosus

1.96E-05

P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB

Maraviroc

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Maraviroc

hsa05332

Graft-versus-host disease

7.11E-05

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Maraviroc

hsa05410

Hypertrophic cardiomyopathy

1.73E-02

P26012, P09493

ITGB8, TPM1

Maraviroc

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.98E-04

P54284, P15924, P26012

CACNB3, DSP, ITGB8

Maraviroc

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Maraviroc

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Maraviroc

hsa05418

Fluid shear stress and atherosclerosis

1.79E-05

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Maraviroc (S_DC: 6.16)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CXCR5

CNoneXNoneC chemokine receptor type 5

Predicted

0.2455

0.0459

0.3304

0.545

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

Q08881

ITK

TyrosineNoneprotein kinase ITK/TSK

Predicted

0.1635

0.5545

0.422

1.6127

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

Q9GZT9

EGLN1

Egl nine homolog 1

Predicted

0.5804

0.6061

0.2556

1.7581

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P41968

MC3R

Melanocortin receptor 3

Predicted

0.2235

0.2637

0.6392

Q01726

MC1R

MelanocyteNonestimulating hormone receptor

Predicted

0.047

0.2375

0.011

0.5095

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P07948

LYN

TyrosineNoneprotein kinase Lyn

Predicted

0.091

0.5319

0.606

1.7154

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P48048

KCNJ1

ATPNonesensitive inward rectifier potassium channel 1

Predicted

0.0042

0.282

0.1274

0.6935

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

Q13557

CAMK2D

Calcium/calmodulinNonedependent protein kinase type II subunit delta

Predicted

0.4778

0.306

0.8095

1.6604

P51955

NEK2

Serine/threonineNoneprotein kinase Nek2

Predicted

0.6599

0.3692

1.0684

O75381

PEX14

Peroxisomal membrane protein PEX14

Predicted

0.1907

0.0995

0.1097

0.4039

P32248

CCR7

CNoneC chemokine receptor type 7

Predicted

0.1391

0.0461

0.3304

0.4922

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P32302

CXCR5

CNoneXNoneC chemokine receptor type 5

Predicted

0.2455

0.0459

0.3304

0.545

PharmaCoNets of Maraviroc (SPCN: 132.05 )

Maraviroc regulated-network (SDN: 21.44)

Community members of Maraviroc (SDC: 6.16)

PharmaCoNets of Maraviroc (S_PCN: 132.05 )

Maraviroc regulated-network (S_DN: 21.44)

Community members of Maraviroc (S_DC: 6.16)