PharmaCoNets of Manidipine (SPCN: 5.71 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Manidipinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Manidipinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Manidipinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Manidipinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Manidipinehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Manidipinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Manidipinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Manidipinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Manidipinehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Manidipinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Manidipinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Manidipinehsa04610Complement and coagulation cascades1.12E-051P0C0L4C4AMore
Manidipinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Manidipinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Manidipinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Manidipinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Manidipinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Manidipinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Manidipinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Manidipinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Manidipinehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Manidipinehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Manidipinehsa05150Staphylococcus aureus infection4.36E-022P0C0L4, P13646C4A, KRT13More
Manidipinehsa05214Glioma4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Manidipinehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Manidipinehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Manidipinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Manidipine (SDC: 2.64)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Reported00.10260.15390.32910.6881
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)