PharmaCoNets of Mafenide (SPCN: 29.45 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Mafenidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Mafenidehsa00220Arginine biosynthesis1.54E-022P05089, P49448ARG1, GLUD2More
Mafenidehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Mafenidehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Mafenidehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Mafenidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Mafenidehsa00910Nitrogen metabolism2.93E-022P22748, P49448CA4, GLUD2More
Mafenidehsa00983Drug metabolism - other enzymes3.20E-023P04183, P32320, P05164TK1, CDA, MPOMore
Mafenidehsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Mafenidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Mafenidehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Mafenidehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Mafenidehsa04060Cytokine-cytokine receptor interaction5.39E-0310P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Mafenidehsa04061Viral protein interaction with cytokine and cytokine receptor4.34E-025P09341, P47992, Q9UBD3, Q13651, P01375CXCL1, XCL1, XCL2, IL10RA, TNFMore
Mafenidehsa04064NF-kappa B signaling pathway1.59E-0413P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1More
Mafenidehsa04071Sphingolipid signaling pathway4.62E-058P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Mafenidehsa04080Neuroactive ligand-receptor interaction4.72E-028P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1More
Mafenidehsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Mafenidehsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Mafenidehsa04145Phagosome1.08E-028O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOBMore
Mafenidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Mafenidehsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Mafenidehsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Mafenidehsa04610Complement and coagulation cascades1.29E-052P00734, P0C0L4F2, C4AMore
Mafenidehsa04612Antigen processing and presentation1.05E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Mafenidehsa04613Neutrophil extracellular trap formation1.86E-0516P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Mafenidehsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Mafenidehsa04640Hematopoietic cell lineage4.96E-026P27930, P25063, P09693, P01732, P13765, P01375IL1R2, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Mafenidehsa04650Natural killer cell mediated cytotoxicity2.94E-038P01375, P06239, O60880, P20963, Q13241, P26718, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Mafenidehsa04657IL-17 signaling pathway2.68E-048O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNFMore
Mafenidehsa04658Th1 and Th2 cell differentiation8.55E-059Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Mafenidehsa04659Th17 cell differentiation3.55E-038Q04759, P06239, P13765, Q9HBE5, Q9UL17, P23771, P09693, P20963PRKCQ, LCK, HLA-DOB, IL21R, TBX21, GATA3, CD3G, CD247More
Mafenidehsa04660T cell receptor signaling pathway3.16E-0512P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Mafenidehsa04666Fc gamma R-mediated phagocytosis3.08E-025O75015, P06396, O14494, P14598, P17252FCGR3B, GSN, PLPP1, NCF1, PRKCAMore
Mafenidehsa04940Type I diabetes mellitus4.18E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Mafenidehsa04964Proximal tubule bicarbonate reclamation2.74E-033P22748, P00918, P49448CA4, CA2, GLUD2More
Mafenidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Mafenidehsa05133Pertussis2.64E-032P0DP23, P0C0L4CALM1, C4AMore
Mafenidehsa05140Leishmaniasis4.75E-049P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4More
Mafenidehsa05143African trypanosomiasis1.74E-032P69905, P68871HBA2, HBBMore
Mafenidehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Mafenidehsa05146Amoebiasis1.39E-038P09341, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Mafenidehsa05150Staphylococcus aureus infection1.65E-026P21730, P21462, O75015, P13765, Q16581, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMPMore
Mafenidehsa05152Tuberculosis8.54E-039O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Mafenidehsa05202Transcriptional misregulation in cancer1.50E-0620Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Mafenidehsa05205Proteoglycans in cancer4.43E-023P63261, P04637, Q06124ACTG1, TP53, PTPN11More
Mafenidehsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Mafenidehsa05212Pancreatic cancer2.60E-022P04637, P24522TP53, GADD45AMore
Mafenidehsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Mafenidehsa05214Glioma2.60E-022P04637, P24522TP53, GADD45AMore
Mafenidehsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Mafenidehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Mafenidehsa05218Melanoma1.14E-022P04637, P24522TP53, GADD45AMore
Mafenidehsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Mafenidehsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Mafenidehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Mafenidehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Mafenidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.34E-025O95267, P20963, P09693, P06239, Q04759RASGRP1, CD247, CD3G, LCK, PRKCQMore
Mafenidehsa05310Asthma2.35E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Mafenidehsa05321Inflammatory bowel disease1.03E-067O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Mafenidehsa05322Systemic lupus erythematosus3.06E-0310O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, Q16778, P12814, P05455FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST2H2BE, ACTN1, SSBMore
Mafenidehsa05332Graft-versus-host disease3.02E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Mafenidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Mafenide (SDC: 3.39)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)