PharmaCoNets of Lypressin (SPCN: 49.08 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lypressinhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Lypressinhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Lypressinhsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Lypressinhsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Lypressinhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lypressinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Lypressinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Lypressinhsa00630Glyoxylate and dicarboxylate metabolism1.13E-022P40925, P15104MDH1, GLULMore
Lypressinhsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Lypressinhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Lypressinhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Lypressinhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Lypressinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Lypressinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Lypressinhsa03040Spliceosome2.10E-0410O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1More
Lypressinhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Lypressinhsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Lypressinhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Lypressinhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Lypressinhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Lypressinhsa04061Viral protein interaction with cytokine and cytokine receptor1.70E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Lypressinhsa04062Chemokine signaling pathway4.01E-0413P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITKMore
Lypressinhsa04064NF-kappa B signaling pathway4.92E-0410O00463, P14778, P19174, Q04759, P07948, P06239, P24522, P09341, P19875, Q06643TRAF5, IL1R1, PLCG1, PRKCQ, LYN, LCK, GADD45A, CXCL1, CXCL2, LTBMore
Lypressinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Lypressinhsa04080Neuroactive ligand-receptor interaction4.15E-022Q01726, P41968MC1R, MC3RMore
Lypressinhsa04144Endocytosis2.81E-026Q13191, P11142, P25024, P43250, P14784, Q9Y5X3CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5More
Lypressinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Lypressinhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Lypressinhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Lypressinhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Lypressinhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Lypressinhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Lypressinhsa04530Tight junction1.14E-046Q8TEU7, P16989, P56750, O00501, Q14247, P24844RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9More
Lypressinhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Lypressinhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Lypressinhsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Lypressinhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lypressinhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Lypressinhsa04640Hematopoietic cell lineage1.03E-0511P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Lypressinhsa04650Natural killer cell mediated cytotoxicity2.48E-0510P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Lypressinhsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Lypressinhsa04658Th1 and Th2 cell differentiation9.87E-1112Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Lypressinhsa04659Th17 cell differentiation5.83E-1014Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Lypressinhsa04660T cell receptor signaling pathway1.03E-0511Q04759, P42338, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, PIK3CB, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Lypressinhsa04662B cell receptor signaling pathway4.07E-024P42338, P60033, P07948, Q8N149PIK3CB, CD81, LYN, LILRA2More
Lypressinhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Lypressinhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Lypressinhsa04724Glutamatergic synapse2.25E-036P48058, O15399, P63218, P50151, P15104, Q9NSB8GRIA4, GRIN2D, GNG5, GNG10, GLUL, HOMER2More
Lypressinhsa04727GABAergic synapse4.42E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Lypressinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Lypressinhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Lypressinhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Lypressinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Lypressinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Lypressinhsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Lypressinhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lypressinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Lypressinhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Lypressinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Lypressinhsa05146Amoebiasis8.66E-069P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSGMore
Lypressinhsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Lypressinhsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Lypressinhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Lypressinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Lypressinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.33E-048P42338, P19174, P07766, P20963, P09693, P06239, Q04759, P01730PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Lypressinhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lypressinhsa05332Graft-versus-host disease3.93E-023P13765, P26715, Q13241HLA-DOB, KLRC1, KLRD1More
Lypressinhsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Lypressinhsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Lypressin (SDC: 5.21)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)