PharmaCoNets of Lumacaftor (SPCN: 162.15 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lumacaftorhsa00030Pentose phosphate pathway7.65E-043P06744, P60891, P37837GPI, PRPS1, TALDO1More
Lumacaftorhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Lumacaftorhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Lumacaftorhsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Lumacaftorhsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Lumacaftorhsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Lumacaftorhsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lumacaftorhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Lumacaftorhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Lumacaftorhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Lumacaftorhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Lumacaftorhsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Lumacaftorhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Lumacaftorhsa00670One carbon pool by folate9.14E-043P00374, P04818, Q99707DHFR, TYMS, MTRMore
Lumacaftorhsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Lumacaftorhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Lumacaftorhsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Lumacaftorhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Lumacaftorhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Lumacaftorhsa00920Sulfur metabolism1.78E-021Q16762TSTMore
Lumacaftorhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Lumacaftorhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Lumacaftorhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Lumacaftorhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Lumacaftorhsa01200Carbon metabolism7.69E-033P06744, P37837, P40926GPI, TALDO1, MDH2More
Lumacaftorhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Lumacaftorhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Lumacaftorhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Lumacaftorhsa01522Endocrine resistance4.63E-038P14780, P22694, P04049, Q16539, Q9UM47, P04637, P10415, Q13323MMP9, PRKACB, RAF1, MAPK14, NOTCH3, TP53, BCL2, BIKMore
Lumacaftorhsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Lumacaftorhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Lumacaftorhsa03008Ribosome biogenesis in eukaryotes6.72E-046Q9NYH9, O14980, O60832, P78345, Q9BVP2, O15381UTP6, XPO1, DKC1, RPP38, GNL3, NVLMore
Lumacaftorhsa03013RNA transport1.20E-0718O14980, P52298, Q09161, O14893, P61326, P38919, P37198, Q7Z3B4, P35658, P47813, Q14152, P55884, O75822, P78345, Q14240, P23588, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NUP62, NUP54, NUP214, EIF1AX, EIF3A, EIF3B, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FXR1More
Lumacaftorhsa03030DNA replication5.00E-021P27694RPA1More
Lumacaftorhsa03050Proteasome4.83E-021P55036PSMD4More
Lumacaftorhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Lumacaftorhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Lumacaftorhsa04012ErbB signaling pathway6.63E-034P16333, P19174, P01106, P04049NCK1, PLCG1, MYC, RAF1More
Lumacaftorhsa04014Ras signaling pathway2.60E-034P04049, Q15283, P61586, P62873RAF1, RASA2, RHOA, GNB1More
Lumacaftorhsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Lumacaftorhsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Lumacaftorhsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Lumacaftorhsa04061Viral protein interaction with cytokine and cytokine receptor1.12E-0310P51684, P32248, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, P14784CCR6, CCR7, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL2RBMore
Lumacaftorhsa04062Chemokine signaling pathway7.67E-039P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151, P04049CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10, RAF1More
Lumacaftorhsa04064NF-kappa B signaling pathway8.49E-1121P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Lumacaftorhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Lumacaftorhsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Lumacaftorhsa04071Sphingolipid signaling pathway7.81E-089P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Lumacaftorhsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Lumacaftorhsa04080Neuroactive ligand-receptor interaction4.77E-059P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2More
Lumacaftorhsa04110Cell cycle8.56E-047Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P01106ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, MYCMore
Lumacaftorhsa04115p53 signaling pathway5.07E-037P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2More
Lumacaftorhsa04120Ubiquitin mediated proteolysis4.61E-022Q13042, Q15751CDC16, HERC1More
Lumacaftorhsa04122Sulfur relay system1.78E-021Q16762TSTMore
Lumacaftorhsa04136Autophagy - other4.02E-042O94817, Q9H1Y0ATG12, ATG5More
Lumacaftorhsa04140Autophagy - animal7.34E-036P04049, P22694, Q14643, P10415, Q9H1Y0, Q04759RAF1, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Lumacaftorhsa04145Phagosome1.21E-049O75015, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Lumacaftorhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Lumacaftorhsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Lumacaftorhsa04210Apoptosis1.53E-0513Q13315, P04637, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643, P04049ATM, TP53, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1, RAF1More
Lumacaftorhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Lumacaftorhsa04217Necroptosis1.93E-024P01568, Q13489, Q13546, Q6FI13IFNA21, BIRC3, RIPK1, H2AC18; H2AC19More
Lumacaftorhsa04218Cellular senescence2.49E-021P04049RAF1More
Lumacaftorhsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Lumacaftorhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Lumacaftorhsa04340Hedgehog signaling pathway2.62E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Lumacaftorhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Lumacaftorhsa04360Axon guidance2.49E-021P04049RAF1More
Lumacaftorhsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Lumacaftorhsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Lumacaftorhsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Lumacaftorhsa04390Hippo signaling pathway6.38E-046P63261, O15105, P04628, Q9UJU2, O43623, Q13489ACTG1, SMAD7, WNT1, LEF1, SNAI2, BIRC3More
Lumacaftorhsa04510Focal adhesion3.48E-021P04049RAF1More
Lumacaftorhsa04514Cell adhesion molecules6.68E-044P23229, P16109, P30511, O00501ITGA6, SELP, HLA-F, CLDN5More
Lumacaftorhsa04530Tight junction3.70E-047P63261, P16989, P56750, O00501, Q92974, Q14247, P24844ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9More
Lumacaftorhsa04540Gap junction1.33E-021P04049RAF1More
Lumacaftorhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Lumacaftorhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Lumacaftorhsa04612Antigen processing and presentation3.22E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Lumacaftorhsa04613Neutrophil extracellular trap formation2.53E-1124P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Lumacaftorhsa04614Renin-angiotensin system7.48E-034P50052, P15144, P08311, O75787AGTR2, ANPEP, CTSG, ATP6AP2More
Lumacaftorhsa04621NOD-like receptor signaling pathway2.68E-0414Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Lumacaftorhsa04623Cytosolic DNA-sensing pathway5.29E-032P01568, Q13546IFNA21, RIPK1More
Lumacaftorhsa04625C-type lectin receptor signaling pathway1.88E-0310Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Lumacaftorhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Lumacaftorhsa04640Hematopoietic cell lineage2.62E-0314P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1BMore
Lumacaftorhsa04650Natural killer cell mediated cytotoxicity7.52E-0614P19174, P01375, P78314, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Lumacaftorhsa04657IL-17 signaling pathway3.73E-059O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Lumacaftorhsa04658Th1 and Th2 cell differentiation8.66E-1014Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Lumacaftorhsa04659Th17 cell differentiation7.74E-0614Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Lumacaftorhsa04660T cell receptor signaling pathway1.78E-0918P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Lumacaftorhsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Lumacaftorhsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Lumacaftorhsa04666Fc gamma R-mediated phagocytosis3.41E-026O75015, P04049, P06396, O14494, P14598, P17252FCGR3B, RAF1, GSN, PLPP1, NCF1, PRKCAMore
Lumacaftorhsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Lumacaftorhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Lumacaftorhsa04710Circadian rhythm2.43E-021O15516CLOCKMore
Lumacaftorhsa04720Long-term potentiation1.66E-021P04049RAF1More
Lumacaftorhsa04722Neurotrophin signaling pathway6.79E-035P04049, Q16566, P04637, Q16539, P10415RAF1, CAMK4, TP53, MAPK14, BCL2More
Lumacaftorhsa04723Retrograde endocannabinoid signaling2.68E-022P48169, P62873GABRA4, GNB1More
Lumacaftorhsa04725Cholinergic synapse3.92E-023Q14643, Q16566, P10415ITPR1, CAMK4, BCL2More
Lumacaftorhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Lumacaftorhsa04727GABAergic synapse3.69E-022P62873, P48169GNB1, GABRA4More
Lumacaftorhsa04730Long-term depression3.01E-032Q14344, P04049GNA13, RAF1More
Lumacaftorhsa04742Taste transduction4.80E-021P48169GABRA4More
Lumacaftorhsa04750Inflammatory mediator regulation of TRP channels3.14E-0411P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Lumacaftorhsa04810Regulation of actin cytoskeleton4.09E-033P04049, P23229, Q14344RAF1, ITGA6, GNA13More
Lumacaftorhsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Lumacaftorhsa04912GnRH signaling pathway2.74E-027P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694, P04049ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB, RAF1More
Lumacaftorhsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Lumacaftorhsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Lumacaftorhsa04916Melanogenesis1.33E-021P04049RAF1More
Lumacaftorhsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Lumacaftorhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Lumacaftorhsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Lumacaftorhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Lumacaftorhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Lumacaftorhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Lumacaftorhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Lumacaftorhsa04926Relaxin signaling pathway2.32E-021P04049RAF1More
Lumacaftorhsa04928Parathyroid hormone synthesis, secretion and action1.60E-025Q14643, P22694, P23771, P04049, P10415ITPR1, PRKACB, GATA3, RAF1, BCL2More
Lumacaftorhsa04929GnRH secretion4.98E-031P04049RAF1More
Lumacaftorhsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Lumacaftorhsa04940Type I diabetes mellitus4.18E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Lumacaftorhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Lumacaftorhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Lumacaftorhsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Lumacaftorhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Lumacaftorhsa05032Morphine addiction1.42E-022P62873, P48169GNB1, GABRA4More
Lumacaftorhsa05033Nicotine addiction2.43E-021P48169GABRA4More
Lumacaftorhsa05034Alcoholism1.89E-057P62879, P04049, Q9BTM1, Q93077, P62807, O60814, P68431GNB2, RAF1, H2AFJ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lumacaftorhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Lumacaftorhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Lumacaftorhsa05132Salmonella infection3.43E-0414P51617, P25963, P01375, P04049, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, NFKBIA, TNF, RAF1, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Lumacaftorhsa05133Pertussis4.20E-021P0C0L4C4AMore
Lumacaftorhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Lumacaftorhsa05140Leishmaniasis2.31E-0713P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4More
Lumacaftorhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Lumacaftorhsa05144Malaria3.81E-038P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Lumacaftorhsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Lumacaftorhsa05146Amoebiasis3.39E-0613P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Lumacaftorhsa05150Staphylococcus aureus infection1.19E-039P21730, P21462, O75015, P13765, Q16581, Q14532, P59665, P59666, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Lumacaftorhsa05152Tuberculosis9.38E-0411P04049, Q13488, O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617RAF1, TCIRG1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Lumacaftorhsa05160Hepatitis C1.99E-021P04049RAF1More
Lumacaftorhsa05161Hepatitis B4.82E-039P17252, P04049, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, RAF1, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Lumacaftorhsa05163Human cytomegalovirus infection6.95E-0310P04049, P30511, Q14643, Q14344, P49841, P14778, P25025, Q16539, P04637, O00463RAF1, HLA-F, ITPR1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Lumacaftorhsa05164Influenza A3.65E-021P04049RAF1More
Lumacaftorhsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Lumacaftorhsa05169Epstein-Barr virus infection3.45E-026P13765, P04637, P10415, Q16539, P24522, P09693HLA-DOB, TP53, BCL2, MAPK14, GADD45A, CD3GMore
Lumacaftorhsa05170Human immunodeficiency virus 1 infection2.93E-0414P04049, P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5RAF1, TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Lumacaftorhsa05200Pathways in cancer4.70E-023P17301, P20585, P62879ITGA2, MSH3, GNB2More
Lumacaftorhsa05202Transcriptional misregulation in cancer8.08E-1124Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Lumacaftorhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Lumacaftorhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Lumacaftorhsa05205Proteoglycans in cancer3.48E-021P04049RAF1More
Lumacaftorhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Lumacaftorhsa05210Colorectal cancer4.24E-035P04049, P10415, P04637, Q9UJU2, P24522RAF1, BCL2, TP53, LEF1, GADD45AMore
Lumacaftorhsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Lumacaftorhsa05212Pancreatic cancer7.36E-042P04049, P37173RAF1, TGFBR2More
Lumacaftorhsa05213Endometrial cancer2.64E-034Q9UJU2, P04049, P04637, P24522LEF1, RAF1, TP53, GADD45AMore
Lumacaftorhsa05214Glioma2.64E-034Q16566, P04049, P04637, P24522CAMK4, RAF1, TP53, GADD45AMore
Lumacaftorhsa05215Prostate cancer1.33E-021P04049RAF1More
Lumacaftorhsa05216Thyroid cancer6.17E-033Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Lumacaftorhsa05217Basal cell carcinoma4.73E-046Q13635, P04628, P49841, Q9UJU2, P04637, P24522PTCH1, WNT1, GSK3B, LEF1, TP53, GADD45AMore
Lumacaftorhsa05218Melanoma6.63E-031P04049RAF1More
Lumacaftorhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Lumacaftorhsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Lumacaftorhsa05221Acute myeloid leukemia2.64E-034P14923, Q9UJU2, P04049, P05164JUP, LEF1, RAF1, MPOMore
Lumacaftorhsa05222Small cell lung cancer2.18E-037Q13489, P10415, P25963, Q13077, O00463, P04637, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, TP53, GADD45AMore
Lumacaftorhsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Lumacaftorhsa05224Breast cancer1.58E-036P04049, Q9UJU2, P49841, Q92837, P04637, P24522RAF1, LEF1, GSK3B, FRAT1, TP53, GADD45AMore
Lumacaftorhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Lumacaftorhsa05226Gastric cancer3.89E-046P04049, Q9UJU2, P04637, P24522, P14923, P10415RAF1, LEF1, TP53, GADD45A, JUP, BCL2More
Lumacaftorhsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Lumacaftorhsa05231Choline metabolism in cancer4.44E-034P04049, Q9Y259, P19174, P49619RAF1, CHKB, PLCG1, DGKGMore
Lumacaftorhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer5.08E-0614P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, P10747, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4More
Lumacaftorhsa05310Asthma1.53E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Lumacaftorhsa05321Inflammatory bowel disease1.77E-097O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Lumacaftorhsa05322Systemic lupus erythematosus2.54E-0513O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Lumacaftorhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Lumacaftorhsa05332Graft-versus-host disease1.04E-065P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Lumacaftorhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Lumacaftorhsa05414Dilated cardiomyopathy2.68E-022P09493, P26678TPM1, PLNMore
Lumacaftorhsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Lumacaftor (SDC: 7.68)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P10619CTSALysosomal protective proteinPredicted00.12260.15310.19010.5575
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P23025XPADNA repair protein complementing XPNoneA cellsPredicted00.00510.02320.20320.2521
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P26358DNMT1DNAPredicted00.34040.28090.26590.998
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P61586RHOATransforming protein RhoAPredicted00.35410.068911.3149
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)