PharmaCoNets of Loxapine (SPCN: 39.05 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Loxapinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Loxapinehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Loxapinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Loxapinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Loxapinehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Loxapinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Loxapinehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Loxapinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Loxapinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Loxapinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Loxapinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Loxapinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Loxapinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Loxapinehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Loxapinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Loxapinehsa03050Proteasome1.21E-021P28074PSMB5More
Loxapinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Loxapinehsa04061Viral protein interaction with cytokine and cytokine receptor2.43E-024P09341, P02775, P47992, Q9UBD3CXCL1, PPBP, XCL1, XCL2More
Loxapinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Loxapinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Loxapinehsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Loxapinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Loxapinehsa04145Phagosome2.94E-024P05164, P78380, P35443, P13765MPO, OLR1, THBS4, HLA-DOBMore
Loxapinehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Loxapinehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Loxapinehsa04261Adrenergic signaling in cardiomyocytes3.75E-036P07550, P22694, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1More
Loxapinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Loxapinehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Loxapinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Loxapinehsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Loxapinehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Loxapinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Loxapinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Loxapinehsa04658Th1 and Th2 cell differentiation1.99E-024Q04759, P06239, P23771, P13765PRKCQ, LCK, GATA3, HLA-DOBMore
Loxapinehsa04659Th17 cell differentiation4.12E-024Q04759, P06239, P13765, P23771PRKCQ, LCK, HLA-DOB, GATA3More
Loxapinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Loxapinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Loxapinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Loxapinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Loxapinehsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Loxapinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Loxapinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Loxapinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Loxapinehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Loxapinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Loxapinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Loxapinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Loxapinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Loxapinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Loxapinehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Loxapinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Loxapinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Loxapinehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Loxapinehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Loxapinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Loxapinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Loxapinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Loxapinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Loxapinehsa05133Pertussis4.94E-021P0C0L4C4AMore
Loxapinehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Loxapinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Loxapinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Loxapinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Loxapinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Loxapinehsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Loxapinehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Loxapinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Loxapinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Loxapinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Loxapinehsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Loxapinehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Loxapinehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Loxapinehsa05310Asthma2.27E-022P13765, P12724HLA-DOB, RNASE3More
Loxapinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Loxapinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Loxapinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Loxapinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Loxapinehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Loxapinehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Loxapinehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Loxapine (SDC: 4.11)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P07305H1None0Histone H1.0Predicted10.0540.080100.1872
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC5054
DRD2P14416Ki5.2
DRD2P14416Ki9.9
DRD2P14416Ki10.1