PharmaCoNets

PharmaCoNets of Losartan (S_PCN: 164.51 )

Losartan regulated-network (S_DN: 24.05)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Losartan

hsa00030

Pentose phosphate pathway

1.69E-02

P60891, P37837

PRPS1, TALDO1

Losartan

hsa00040

Pentose and glucuronate interconversions

3.53E-02

O60701

UGDH

Losartan

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Losartan

hsa00071

Fatty acid degradation

3.65E-03

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Losartan

hsa00220

Arginine biosynthesis

2.86E-02

P15104, P05089

GLUL, ARG1

Losartan

hsa00280

Valine, leucine and isoleucine degradation

4.31E-02

P26440, Q02252

IVD, ALDH6A1

Losartan

hsa00500

Starch and sucrose metabolism

1.89E-06

O43451, P46976, P06737

MGAM, GYG1, PYGL

Losartan

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Losartan

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Losartan

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Losartan

hsa00591

Linoleic acid metabolism

1.29E-03

P11712

CYP2C9

Losartan

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Losartan

hsa00630

Glyoxylate and dicarboxylate metabolism

4.84E-04

P40925, P40926, P15104

MDH1, MDH2, GLUL

Losartan

hsa00730

Thiamine metabolism

5.65E-05

P05186, P24666

ALPL, ACP1

Losartan

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Losartan

hsa00830

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Losartan

hsa00860

Porphyrin and chlorophyll metabolism

1.70E-04

P36551, P53004, P30043

CPOX, BLVRA, BLVRB

Losartan

hsa00970

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Losartan

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Losartan

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Losartan

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Losartan

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Losartan

hsa01210

2-Oxocarboxylic acid metabolism

1.91E-02

P50213

IDH3A

Losartan

hsa01230

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Losartan

hsa01240

Biosynthesis of cofactors

2.05E-02

P36551, O60701

CPOX, UGDH

Losartan

hsa01523

Antifolate resistance

2.24E-02

P41439, P41440, P01375

FOLR3, SLC19A1, TNF

Losartan

hsa01524

Platinum drug resistance

1.13E-02

P10415, Q13489, P78417, P23025, P43246

BCL2, BIRC3, GSTO1, XPA, MSH2

Losartan

hsa03008

Ribosome biogenesis in eukaryotes

1.31E-04

Q9NYH9, O14980, O60832, P78345, Q9BVP2, O15381, Q9GZY0

UTP6, XPO1, DKC1, RPP38, GNL3, NVL, NXF2; NXF2B

Losartan

hsa03010

Ribosome

1.53E-05

P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396

RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3

Losartan

hsa03013

RNA transport

1.20E-07

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713

Losartan

hsa03020

RNA polymerase

5.61E-04

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Losartan

hsa03040

Spliceosome

3.61E-05

Q14562, O43143, O60508, Q99633, P17844, P08579, P51991, P61978, Q13595, Q01130, Q9UMS4, P11142, O43447

DHX8, DHX15, CDC40, PRPF18, DDX5, SNRPB2, HNRPA3, HNRPK, TRA2A, SFRS2, PRPF19, HSPA8, PPIH

Losartan

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Losartan

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Losartan

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Losartan

hsa03450

Non-homologous end-joining

4.32E-02

Q9NP87

POLM

Losartan

hsa04012

ErbB signaling pathway

3.31E-02

Q13153

PAK1

Losartan

hsa04015

Rap1 signaling pathway

1.58E-02

P20827, P49767, P63261, P25116, P0DP23, P17252

EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCA

Losartan

hsa04020

Calcium signaling pathway

1.16E-03

Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767

CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFC

Losartan

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Losartan

hsa04024

cAMP signaling pathway

7.32E-03

P0DP23, P23634, Q16566, O15399, P25116, Q13153

CALM1, ATP2B4, CAMK4, GRIN2D, F2R, PAK1

Losartan

hsa04060

Cytokine-cytokine receptor interaction

1.52E-04

P27930, P14778, P37173, P26842, Q9UHF4, Q13651, P16871, P78552, P25024, Q9UBD3, P47992, P02775, P09341, P32248, P80075, P51684, P18510, P09603, P01730

IL1R2, IL1R1, TGFBR2, CD27, IL20RA, IL10RA, IL7R, IL13RA1, CXCR1, XCL2, XCL1, PPBP, CXCL1, CCR7, CCL8, CCR6, IL1RN, CSF1, CD4

Losartan

hsa04061

Viral protein interaction with cytokine and cytokine receptor

2.08E-04

P51684, P32248, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, P14784, Q9UHF4

CCR6, CCR7, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL2RB, IL20RA

Losartan

hsa04062

Chemokine signaling pathway

2.43E-04

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3B

Losartan

hsa04064

NF-kappa B signaling pathway

1.36E-06

P10415, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51684	CCR6	C-C chemokine receptor type 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P51684	CCR6	C-C chemokine receptor type 6	Q13077	TRAF1	TNF receptor-associated factor 1	0.768
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Losartan

hsa04066

HIF-1 signaling pathway

3.40E-02

Q09472, P07195, P10415

EP300, LDHB, BCL2

Losartan

hsa04068

FoxO signaling pathway

3.52E-02

Q96BR1

SGK3

Losartan

hsa04070

Phosphatidylinositol signaling system

4.07E-02

P0DP23, Q14643, O14732, P17252

CALM1, ITPR1, IMPA2, PRKCA

Losartan

hsa04071

Sphingolipid signaling pathway

1.82E-06

P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P21462	FPR1	fMet-Leu-Phe receptor	P17252	PRKCA	Protein kinase C alpha type	-0.731
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
Q15722	LTB4R	Leukotriene B4 receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.832
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P21462	FPR1	fMet-Leu-Phe receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.716
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P21462	FPR1	fMet-Leu-Phe receptor	P01375	TNF	Tumor necrosis factor	0.77
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.773
P21462	FPR1	fMet-Leu-Phe receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.878
P51684	CCR6	C-C chemokine receptor type 6	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.819
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.884
P21462	FPR1	fMet-Leu-Phe receptor	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.932
P51684	CCR6	C-C chemokine receptor type 6	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.876
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
Q15722	LTB4R	Leukotriene B4 receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.865
P21462	FPR1	fMet-Leu-Phe receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.855
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Losartan

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Losartan

hsa04110

Cell cycle

2.06E-02

Q9UJX4, O60566, Q09472, P24522, P04637, P49918

ANAPC5, BUB1B, EP300, GADD45A, TP53, CDKN1C

Losartan

hsa04114

Oocyte meiosis

6.23E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Losartan

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Losartan

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Losartan

hsa04141

Protein processing in endoplasmic reticulum

2.82E-04

P18848, Q15437, Q15436, Q99941, P11142, P07900, Q9NR31, P14625

ATF4, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, SAR1A, HSP90B1

Losartan

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Losartan

hsa04144

Endocytosis

2.89E-03

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Losartan

hsa04145

Phagosome

1.06E-03

O75015, P63261, Q15080, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765

FCGR3B, ACTG1, NCF4, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOB

Losartan

hsa04151

PI3K-Akt signaling pathway

1.09E-05

P62753, O43521, P27348, P07900, P14625, Q8WYR1, Q16363, P22105, Q99941, P18848, O00141, Q6ZUJ8

RPS6, BCL2L11, YWHAQ, HSP90AA1, HSP90B1, PIK3R5, LAMA4, TNXB, CREBL1, ATF4, SGK, PIK3AP1

Losartan

hsa04210

Apoptosis

3.78E-05

P04637, P10415, O76075, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643

TP53, BCL2, DFFB, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1

Losartan

hsa04211

Longevity regulating pathway

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Losartan

hsa04213

Longevity regulating pathway - multiple species

2.70E-03

P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Losartan

hsa04217

Necroptosis

3.89E-04

P01375, P48023, Q14765, P15104, P05141, P01584, P0C0S5, Q99878, Q9H444

TNF, FASLG, STAT4, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CHMP4B

Losartan

hsa04261

Adrenergic signaling in cardiomyocytes

2.21E-03

P51828, Q99941, P18848, Q16537, P0DP23, Q13557, P17252, P10415, P20020

ADCY7, CREBL1, ATF4, PPP2R5E, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1

Losartan

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Losartan

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Losartan

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Losartan

hsa04370

VEGF signaling pathway

3.06E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Losartan

hsa04380

Osteoclast differentiation

2.05E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPA

Losartan

hsa04390

Hippo signaling pathway

2.11E-03

P63261, Q13485, O15105, Q9UJU2, O43623, Q13489

ACTG1, SMAD4, SMAD7, LEF1, SNAI2, BIRC3

Losartan

hsa04392

Hippo signaling pathway - multiple species

1.51E-02

Q13153

PAK1

Losartan

hsa04510

Focal adhesion

3.21E-02

Q15942, P17252, Q13489, P10415, P49767, P63261

ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1

Losartan

hsa04520

Adherens junction

3.36E-02

Q13485, Q9UJU2, O43623, P63261

SMAD4, LEF1, SNAI2, ACTG1

Losartan

hsa04530

Tight junction

3.60E-03

P63261, P16989, P56750, Q92974, Q14247

ACTG1, CSDA, CLDN17, ARHGEF2, CTTN

Losartan

hsa04540

Gap junction

4.76E-02

P17252, Q13509, P68371

PRKCA, TUBB3, TUBB2C

Losartan

hsa04550

Signaling pathways regulating pluripotency of stem cells

4.73E-02

Q13873, Q02750, Q86SE9

BMPR2, MAP2K1, PCGF5

Losartan

hsa04610

Complement and coagulation cascades

3.16E-03

P00734, P0C0L4

F2, C4A

Losartan

hsa04612

Antigen processing and presentation

1.51E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Losartan

hsa04613

Neutrophil extracellular trap formation

2.22E-06

P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721

Losartan

hsa04614

Renin-angiotensin system

7.48E-03

P50052, P15144, P08311, O75787

AGTR2, ANPEP, CTSG, ATP6AP2

Losartan

hsa04623

Cytosolic DNA-sensing pathway

1.65E-02

P01584, Q8NHW4

IL1B, CCL4L2

Losartan

hsa04625

C-type lectin receptor signaling pathway

2.53E-03

Q9ULY5, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Losartan

hsa04640

Hematopoietic cell lineage

9.72E-05

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43657	P2RY5	Lysophosphatidic acid receptor 6	P13612	ITGA4	Integrin alpha-4	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09564	CD7	T-cell antigen CD7	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Losartan

hsa04650

Natural killer cell mediated cytotoxicity

3.38E-10

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13153, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P11766	ADH5	Alcohol dehydrogenase class-3	P01375	TNF	Tumor necrosis factor	-0.709
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q13153	PAK1	Serine/threonine-protein kinase PAK 1	Q13153	PAK1	Serine/threonine-protein kinase PAK 1	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P11766	ADH5	Alcohol dehydrogenase class-3	Q13241	KLRD1	Natural killer cells antigen CD94	0.726
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P11766	ADH5	Alcohol dehydrogenase class-3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.71
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P11766	ADH5	Alcohol dehydrogenase class-3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.833
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P11766	ADH5	Alcohol dehydrogenase class-3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.737
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P11766	ADH5	Alcohol dehydrogenase class-3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.737
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Losartan

hsa04657

IL-17 signaling pathway

4.37E-04

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Losartan

hsa04658

Th1 and Th2 cell differentiation

5.15E-07

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43657	P2RY5	Lysophosphatidic acid receptor 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43657	P2RY5	Lysophosphatidic acid receptor 6	P06239	LCK	Tyrosine-protein kinase Lck	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q9UL17	TBX21	T-box transcription factor TBX21	0.731
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13761	RUNX3	Runt-related transcription factor 3	0.712

Losartan

hsa04659

Th17 cell differentiation

6.07E-06

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43657	P2RY5	Lysophosphatidic acid receptor 6	P06239	LCK	Tyrosine-protein kinase Lck	0.788
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q9UL17	TBX21	T-box transcription factor TBX21	0.731
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43657	P2RY5	Lysophosphatidic acid receptor 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Losartan

hsa04660

T cell receptor signaling pathway

1.42E-07

P01375, Q04759, P42338, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13153	PAK1	Serine/threonine-protein kinase PAK 1	Q13153	PAK1	Serine/threonine-protein kinase PAK 1	1
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Losartan

hsa04662

B cell receptor signaling pathway

1.49E-03

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Losartan

hsa04664

Fc epsilon RI signaling pathway

2.32E-02

P42338, P07948, P09917

PIK3CB, LYN, ALOX5

Losartan

hsa04666

Fc gamma R-mediated phagocytosis

2.22E-02

P49006, P06396, P14598, P17252

MARCKSL1, GSN, NCF1, PRKCA

Losartan

hsa04668

TNF signaling pathway

2.91E-02

P18848, P01584, P20333

ATF4, IL1B, TNFRSF1B

Losartan

hsa04714

Thermogenesis

3.31E-02

P51828, P62753, P12074, O15239

ADCY7, RPS6, COX6A1, NDUFA1

Losartan

hsa04720

Long-term potentiation

3.93E-05

P17252, Q16566, P16298, P0DP23, P51812, O15399, Q02750, Q14643

PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1, ITPR1

Losartan

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Losartan

hsa04723

Retrograde endocannabinoid signaling

1.75E-02

Q14643, P17252, P22694, Q16539, Q16718

ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5

Losartan

hsa04724

Glutamatergic synapse

4.39E-05

P48058, O15399, P43003, P63218, P50151, P15104

GRIA4, GRIN2D, SLC1A3, GNG5, GNG10, GLUL

Losartan

hsa04725

Cholinergic synapse

2.49E-03

P51828, P63218, P50151, P18848, Q13557, P42338

ADCY7, GNG5, GNG10, ATF4, CAMK2D, PIK3CB

Losartan

hsa04727

GABAergic synapse

1.56E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Losartan

hsa04728

Dopaminergic synapse

4.12E-03

P14416, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407

DRD2, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1

Losartan

hsa04750

Inflammatory mediator regulation of TRP channels

3.66E-05

P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1

Losartan

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Losartan

hsa04911

Insulin secretion

4.03E-04

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Losartan

hsa04912

GnRH signaling pathway

1.71E-05

P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694

PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB

Losartan

hsa04914

Progesterone-mediated oocyte maturation

1.00E-02

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Losartan

hsa04915

Estrogen signaling pathway

4.95E-04

Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788

CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1

Losartan

hsa04916

Melanogenesis

3.55E-02

P0DP23, Q9UJU2, P17252

CALM1, LEF1, PRKCA

Losartan

hsa04918

Thyroid hormone synthesis

1.98E-04

P51828, Q99941, P18848, P14625, P02768

ADCY7, CREBL1, ATF4, HSP90B1, ALB

Losartan

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Losartan

hsa04921

Oxytocin signaling pathway

4.19E-02

P0DP23, P17252, Q16566, P63261

CALM1, PRKCA, CAMK4, ACTG1

Losartan

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Losartan

hsa04925

Aldosterone synthesis and secretion

2.88E-06

Q14643, Q99941, P18848, P51828, P0DP23, P17252, Q16566, Q13557, P20020, P23634

ITPR1, CREBL1, ATF4, ADCY7, CALM1, PRKCA, CAMK4, CAMK2D, ATP2B1, ATP2B4

Losartan

hsa04926

Relaxin signaling pathway

5.00E-04

P42338, P63218, P50151, Q99941, P18848, P49767, P51828, P49407

PIK3CB, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY7, ARRB1

Losartan

hsa04927

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, P51828

CREBL1, ATF4, ADCY7

Losartan

hsa04928

Parathyroid hormone synthesis, secretion and action

3.47E-03

Q14643, P51828, P22694, P23771, P17252, Q99941, P18848, P10415

ITPR1, ADCY7, PRKACB, GATA3, PRKCA, CREBL1, ATF4, BCL2

Losartan

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Losartan

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Losartan

hsa04932

Non-alcoholic fatty liver disease

7.37E-06

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O95298

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Losartan

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.36E-02

Q13485, P10415, P49767, P17252

SMAD4, BCL2, VEGFC, PRKCA

Losartan

hsa04934

Cushing syndrome

1.12E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Losartan

hsa04935

Growth hormone synthesis, secretion and action

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Losartan

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Losartan

hsa04962

Vasopressin-regulated water reabsorption

1.80E-02

P62491, P46459

RAB11A, NSF

Losartan

hsa04966

Collecting duct acid secretion

3.15E-02

P02730, Q9Y666

SLC4A1, SLC12A7

Losartan

hsa04970

Salivary secretion

1.12E-04

Q08828, P51828, Q14643, P20020, P23634, P17252, P0DP23

ADCY1, ADCY7, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1

Losartan

hsa04971

Gastric acid secretion

4.76E-02

P17252, P63261, P0DP23

PRKCA, ACTG1, CALM1

Losartan

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Losartan

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Losartan

hsa04976

Bile secretion

2.51E-03

Q08828, P51828, P22694, P08183, Q14032

ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Losartan

hsa04978

Mineral absorption

3.94E-02

P23634, Q9BXS9

ATP2B4, SLC26A6

Losartan

hsa05010

Alzheimer disease

2.78E-02

P13073, O75460, P0DP24, P01584, P18848, P05141

COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5

Losartan

hsa05012

Parkinson disease

3.89E-02

P13073, P05141, O75460, P18848, P0DP24

COX4I1, SLC25A5, ERN1, ATF4, CALM2

Losartan

hsa05014

Amyotrophic lateral sclerosis

4.31E-02

O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0

GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B

Losartan

hsa05016

Huntington disease

3.74E-03

O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12

Losartan

hsa05022

Pathways of neurodegeneration - multiple diseases

1.98E-02

P13073, O75460, P18848, P05141, P20333, P01584, P0DP24

COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2

Losartan

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Losartan

hsa05031

Amphetamine addiction

2.72E-04

O15399, P0DP23, Q16566, Q13557, Q99941, P18848, P17252

GRIN2D, CALM1, CAMK4, CAMK2D, CREBL1, ATF4, PRKCA

Losartan

hsa05034

Alcoholism

3.90E-04

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Losartan

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Losartan

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.35E-06

Q16539, Q13153, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, PAK1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Losartan

hsa05132

Salmonella infection

2.12E-04

P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371

IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C

Losartan

hsa05133

Pertussis

1.25E-03

P0DP23, P23528, P09871, P0C0L4

CALM1, CFL1, C1S, C4A

Losartan

hsa05134

Legionellosis

8.80E-04

P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Losartan

hsa05135

Yersinia infection

6.38E-03

Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P49841, Q96JJ3

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, GSK3B, ELMO2

Losartan

hsa05140

Leishmaniasis

1.10E-04

P13612, O75015, P14598, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4

Losartan

hsa05143

African trypanosomiasis

3.01E-03

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Losartan

hsa05144

Malaria

1.35E-04

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Losartan

hsa05146

Amoebiasis

4.45E-07

P01584, Q13751, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13751	LAMB3	Laminin subunit beta-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09341	CXCL1	Growth-regulated alpha protein	-0.839
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P43657	P2RY5	Lysophosphatidic acid receptor 6	P05089	ARG1	Arginase-1	-0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P43657	P2RY5	Lysophosphatidic acid receptor 6	P12814	ACTN1	Alpha-actinin-1	-0.814
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744

Losartan

hsa05152

Tuberculosis

1.26E-02

Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539

TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14

Losartan

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Losartan

hsa05161

Hepatitis B

3.34E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Losartan

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Losartan

hsa05163

Human cytomegalovirus infection

2.09E-04

P01375, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463

TNF, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788

Losartan

hsa05168

Herpes simplex virus 1 infection

1.94E-02

Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415

PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2

Losartan

hsa05169

Epstein-Barr virus infection

2.60E-04

P13765, Q13547, Q92769, P04637, Q13546, P10415, P42338, P07948, Q13761, P24522, O75293, O60603, P29728, P51617, P07766, P09693

HLA-DOB, HDAC1, HDAC2, TP53, RIPK1, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TLR2, OAS2, IRAK1, CD3E, CD3G

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P32248	CCR7	C-C chemokine receptor type 7	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.808
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13547	HDAC1	Histone deacetylase 1	-0.774
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P32248	CCR7	C-C chemokine receptor type 7	P10415	BCL2	Apoptosis regulator Bcl-2	0.748
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13761	RUNX3	Runt-related transcription factor 3	-0.708
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.768
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P32248	CCR7	C-C chemokine receptor type 7	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.738
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.77
P32248	CCR7	C-C chemokine receptor type 7	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.864
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753

Losartan

hsa05170

Human immunodeficiency virus 1 infection

6.54E-03

P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5

CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2

Losartan

hsa05171

Coronavirus disease - COVID-19

4.36E-05

P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513

RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37A

Losartan

hsa05200

Pathways in cancer

2.37E-03

P04637, Q9UJU2, P17252, Q09472, P43246, Q13485, P14923, P10415, Q13489, Q13077, P49767, P25116, O95267, P78417, P24522, P0DP23, P01568, P16871

TP53, LEF1, PRKCA, EP300, MSH2, SMAD4, JUP, BCL2, BIRC3, TRAF1, VEGFC, F2R, RASGRP1, GSTO1, GADD45A, CALM1, IFNA21, IL7R

Losartan

hsa05202

Transcriptional misregulation in cancer

9.78E-06

Q12778, Q15532, P41732, P17844, P14780, P27930, P14923, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, TSPAN7, DDX5, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
P32248	CCR7	C-C chemokine receptor type 7	Q15532	SS18	Protein SSXT	0.804
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
P32248	CCR7	C-C chemokine receptor type 7	P14923	JUP	Junction plakoglobin	0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P32248	CCR7	C-C chemokine receptor type 7	Q13077	TRAF1	TNF receptor-associated factor 1	0.748
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
P32248	CCR7	C-C chemokine receptor type 7	O15550	UTX	Lysine-specific demethylase 6A	-0.715
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
P32248	CCR7	C-C chemokine receptor type 7	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862

Losartan

hsa05203

Viral carcinogenesis

2.01E-04

Q99941, P18848, P27348, Q15283, P61978, P62807, O60814

CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12

Losartan

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Losartan

hsa05210

Colorectal cancer

2.69E-03

Q9UKG1, P10415, P04637, Q9UJU2, P37173, P24522

APPL1, BCL2, TP53, LEF1, TGFBR2, GADD45A

Losartan

hsa05211

Renal cell carcinoma

2.42E-02

Q13153

PAK1

Losartan

hsa05212

Pancreatic cancer

3.40E-02

P37173

TGFBR2

Losartan

hsa05213

Endometrial cancer

1.91E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Losartan

hsa05214

Glioma

8.71E-04

P0DP23, Q16566, P17252, P04637, P24522

CALM1, CAMK4, PRKCA, TP53, GADD45A

Losartan

hsa05215

Prostate cancer

1.97E-03

P10415, Q9UJU2, Q09472, P04637, P18848, P14625

BCL2, LEF1, EP300, TP53, ATF4, HSP90B1

Losartan

hsa05216

Thyroid cancer

2.42E-04

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Losartan

hsa05217

Basal cell carcinoma

2.82E-04

Q13635, P49841, Q9UJU2, P04637, P24522

PTCH1, GSK3B, LEF1, TP53, GADD45A

Losartan

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Losartan

hsa05222

Small cell lung cancer

1.94E-02

P10415, Q13077, P04637, P24522

BCL2, TRAF1, TP53, GADD45A

Losartan

hsa05224

Breast cancer

5.34E-03

Q9UJU2, P49841, Q92837, P04637, P24522

LEF1, GSK3B, FRAT1, TP53, GADD45A

Losartan

hsa05226

Gastric cancer

8.86E-03

Q9UJU2, P04637, P24522, P14923, P10415

LEF1, TP53, GADD45A, JUP, BCL2

Losartan

hsa05230

Central carbon metabolism in cancer

4.04E-02

P07195, P04637

LDHB, TP53

Losartan

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.22E-04

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, CD4

Losartan

hsa05321

Inflammatory bowel disease

1.19E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B

Losartan

hsa05322

Systemic lupus erythematosus

1.49E-05

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Losartan

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Losartan

hsa05332

Graft-versus-host disease

1.27E-04

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Losartan

hsa05415

Diabetic cardiomyopathy

4.23E-02

P30405, P37173

PPIF, TGFBR2

Losartan

hsa05418

Fluid shear stress and atherosclerosis

2.06E-04

Q16539, P78417, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, Q92974

MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2

Community members of Losartan (S_DC: 6.84)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

O14684

PTGES

Prostaglandin E synthase

Predicted

0.4531

0.6358

0.1565

1.6547

Q9GZT9

EGLN1

Egl nine homolog 1

Predicted

0.5804

0.6061

0.2556

1.7581

Q13153

PAK1

Serine/threonineNoneprotein kinase PAK 1

Predicted

0.4647

0.3471

0.7819

1.7084

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P37173

TGFBR2

TGFNonebeta receptor typeNone2

Predicted

0.2867

0.379

0.8742

1.7755

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

P14625

HSP90B1

Endoplasmin

Predicted

0.2336

0.1497

0.5384

0.9546

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

O15151

MDM4

Protein Mdm4

Predicted

0.1014

0.0898

0.2489

0.4791

P11766

ADH5

Alcohol dehydrogenase classNone3

Predicted

0.265

0.1397

0.2146

0.6265

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P46091

GPR1

ChemerinNonelike receptor 2

Predicted

0.2476

0.1372

0.3982

P32248

CCR7

CNoneC chemokine receptor type 7

Predicted

0.1391

0.0461

0.3304

0.4922

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P43657

P2RY5

Lysophosphatidic acid receptor 6

Predicted

0.7539

0.0448

0.3708

0.8373

P32302

CXCR5

CNoneXNoneC chemokine receptor type 5

Predicted

0.2455

0.0459

0.3304

0.545

Q99527

GPER1

GNoneprotein coupled estrogen receptor 1

Predicted

0.0249

0.1294

0.2138

0.485

PharmaCoNets of Losartan (SPCN: 164.51 )

Losartan regulated-network (SDN: 24.05)

Community members of Losartan (SDC: 6.84)

PharmaCoNets of Losartan (S_PCN: 164.51 )

Losartan regulated-network (S_DN: 24.05)

Community members of Losartan (S_DC: 6.84)