PharmaCoNets of Lormetazepam (SPCN: 56.94 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lormetazepamhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Lormetazepamhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Lormetazepamhsa00500Starch and sucrose metabolism1.25E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lormetazepamhsa00730Thiamine metabolism2.32E-032P05186, P24666ALPL, ACP1More
Lormetazepamhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Lormetazepamhsa01523Antifolate resistance1.43E-032Q92820, P04818GGH, TYMSMore
Lormetazepamhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Lormetazepamhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Lormetazepamhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Lormetazepamhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Lormetazepamhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Lormetazepamhsa03030DNA replication5.00E-021P27694RPA1More
Lormetazepamhsa03050Proteasome1.40E-021P55036PSMD4More
Lormetazepamhsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Lormetazepamhsa04064NF-kappa B signaling pathway5.05E-0411P10415, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1More
Lormetazepamhsa04071Sphingolipid signaling pathway8.39E-048P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Lormetazepamhsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Lormetazepamhsa04080Neuroactive ligand-receptor interaction9.01E-0410P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADMMore
Lormetazepamhsa04110Cell cycle1.97E-057P06493, O60566, O75293, P30304, P33981, P42773, P01106CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Lormetazepamhsa04120Ubiquitin mediated proteolysis1.06E-046Q14145, Q13042, Q13191, P62837, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, UBE2D2, HERC1, HUWE1More
Lormetazepamhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Lormetazepamhsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Lormetazepamhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Lormetazepamhsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Lormetazepamhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Lormetazepamhsa04217Necroptosis4.24E-0510P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2DMore
Lormetazepamhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Lormetazepamhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Lormetazepamhsa04340Hedgehog signaling pathway1.05E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Lormetazepamhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Lormetazepamhsa04514Cell adhesion molecules1.22E-022P23229, P30511ITGA6, HLA-FMore
Lormetazepamhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Lormetazepamhsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Lormetazepamhsa04613Neutrophil extracellular trap formation4.72E-0415O60603, P05164, P08246, Q9UM07, P04908, Q93077, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Lormetazepamhsa04621NOD-like receptor signaling pathway5.21E-0312Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P59665, P59666, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA1; DEFA1B, DEFA3, DEFA4More
Lormetazepamhsa04640Hematopoietic cell lineage4.71E-035P21926, P07766, P01730, P06127, P09564CD9, CD3E, CD4, CD5, CD7More
Lormetazepamhsa04650Natural killer cell mediated cytotoxicity3.67E-039P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Lormetazepamhsa04657IL-17 signaling pathway1.35E-039P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Lormetazepamhsa04658Th1 and Th2 cell differentiation4.96E-0710Q04759, P20963, P09693, Q16539, P06239, Q14765, P42226, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, STAT6, GATA3, TBX21, HLA-DOBMore
Lormetazepamhsa04659Th17 cell differentiation6.05E-0510Q04759, Q16539, P06239, P42226, P13765, P14778, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, LCK, STAT6, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247More
Lormetazepamhsa04660T cell receptor signaling pathway3.75E-0411P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3BMore
Lormetazepamhsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Lormetazepamhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Lormetazepamhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Lormetazepamhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Lormetazepamhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Lormetazepamhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Lormetazepamhsa04730Long-term depression5.00E-021Q14344GNA13More
Lormetazepamhsa04810Regulation of actin cytoskeleton2.68E-022P23229, Q14344ITGA6, GNA13More
Lormetazepamhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Lormetazepamhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Lormetazepamhsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Lormetazepamhsa04932Non-alcoholic fatty liver disease6.73E-059P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Lormetazepamhsa04940Type I diabetes mellitus6.87E-042P48023, P01375FASLG, TNFMore
Lormetazepamhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Lormetazepamhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Lormetazepamhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Lormetazepamhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Lormetazepamhsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Lormetazepamhsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Lormetazepamhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Lormetazepamhsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Lormetazepamhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Lormetazepamhsa05143African trypanosomiasis1.51E-032P01375, P48023TNF, FASLGMore
Lormetazepamhsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Lormetazepamhsa05150Staphylococcus aureus infection3.62E-038P21730, P21462, O75015, P13765, Q16581, P59665, P59666, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA1; DEFA1B, DEFA3, DEFA4More
Lormetazepamhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Lormetazepamhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Lormetazepamhsa05163Human cytomegalovirus infection1.49E-036P30511, P62873, Q14344, P61586, P63092, P61769HLA-F, GNB1, GNA13, RHOA, GNAS, B2MMore
Lormetazepamhsa05169Epstein-Barr virus infection5.92E-0312P13765, Q13547, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247More
Lormetazepamhsa05171Coronavirus disease - COVID-193.15E-049P01584, P62753, P25398, Q9UHA3, P36578, P32969, P18077, P62829, O14786IL1B, RPS6, RPS12, RSL24D1, RPL4, RPL9, RPL35A, RPL23, NRP1More
Lormetazepamhsa05202Transcriptional misregulation in cancer9.99E-0516Q12778, Q15532, Q13315, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522FOXO1, SS18, ATM, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Lormetazepamhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Lormetazepamhsa05217Basal cell carcinoma1.43E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Lormetazepamhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Lormetazepamhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.46E-0410P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, Q9HC35, P01730CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Lormetazepamhsa05321Inflammatory bowel disease2.80E-067O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3More
Lormetazepamhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Lormetazepamhsa05330Allograft rejection1.51E-032P48023, P01375FASLG, TNFMore
Lormetazepamhsa05332Graft-versus-host disease3.10E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Lormetazepamhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Lormetazepamhsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore

Community members of Lormetazepam (SDC: 4.81)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)