PharmaCoNets of Lorlatinib (SPCN: 83.54 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lorlatinibhsa00030Pentose phosphate pathway1.94E-032P52209, P37837PGD, TALDO1More
Lorlatinibhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Lorlatinibhsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Lorlatinibhsa00500Starch and sucrose metabolism2.67E-021P35573AGLMore
Lorlatinibhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Lorlatinibhsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Lorlatinibhsa00590Arachidonic acid metabolism2.48E-033P11712, P09917, P09960CYP2C9, ALOX5, LTA4HMore
Lorlatinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Lorlatinibhsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Lorlatinibhsa00630Glyoxylate and dicarboxylate metabolism9.62E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Lorlatinibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Lorlatinibhsa00770Pantothenate and CoA biosynthesis1.94E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Lorlatinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Lorlatinibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Lorlatinibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Lorlatinibhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Lorlatinibhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Lorlatinibhsa01524Platinum drug resistance4.94E-022P78417, P52701GSTO1, MSH6More
Lorlatinibhsa03013RNA transport3.52E-024P52298, O14893, O14602, P78345NCBP2, GEMIN2, EIF1AY, RPP38More
Lorlatinibhsa03022Basal transcription factors3.52E-033O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Lorlatinibhsa03040Spliceosome4.48E-0410Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8More
Lorlatinibhsa03050Proteasome4.83E-021P55036PSMD4More
Lorlatinibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Lorlatinibhsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Lorlatinibhsa04010MAPK signaling pathway4.76E-025Q15283, P21860, Q12933, P01584, O14944RASA2, ERBB3, TRAF2, IL1B, EREGMore
Lorlatinibhsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Lorlatinibhsa04020Calcium signaling pathway1.43E-037Q96DU7, Q08828, P21796, Q13557, P21860, P30679, P23634ITPKC, ADCY1, VDAC1, CAMK2D, ERBB3, GNA15, ATP2B4More
Lorlatinibhsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Lorlatinibhsa04064NF-kappa B signaling pathway2.98E-0412P10415, O00463, Q13546, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341BCL2, TRAF5, RIPK1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1More
Lorlatinibhsa04070Phosphatidylinositol signaling system2.37E-036P19174, P0DP23, P23743, Q86XP1, P27987, Q96DU7PLCG1, CALM1, DGKA, DGKH, ITPKB, ITPKCMore
Lorlatinibhsa04114Oocyte meiosis6.23E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Lorlatinibhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Lorlatinibhsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Lorlatinibhsa04141Protein processing in endoplasmic reticulum1.22E-0411P18848, P30101, Q15437, P60604, Q99941, P11142, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Lorlatinibhsa04145Phagosome1.72E-0413O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Lorlatinibhsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Lorlatinibhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Lorlatinibhsa04217Necroptosis1.93E-024P01568, Q13489, Q13546, Q6FI13IFNA21, BIRC3, RIPK1, H2AC18; H2AC19More
Lorlatinibhsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Lorlatinibhsa04270Vascular smooth muscle contraction2.89E-022P35579, P35318MYH9, ADMMore
Lorlatinibhsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Lorlatinibhsa04370VEGF signaling pathway3.06E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Lorlatinibhsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Lorlatinibhsa04390Hippo signaling pathway5.79E-034P04628, Q9UJU2, O43623, Q13489WNT1, LEF1, SNAI2, BIRC3More
Lorlatinibhsa04520Adherens junction3.91E-022Q13485, O43318SMAD4, MAP3K7More
Lorlatinibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Lorlatinibhsa04540Gap junction2.59E-044Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Lorlatinibhsa04550Signaling pathways regulating pluripotency of stem cells4.73E-023Q13873, Q02750, Q86SE9BMPR2, MAP2K1, PCGF5More
Lorlatinibhsa04612Antigen processing and presentation3.69E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Lorlatinibhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lorlatinibhsa04623Cytosolic DNA-sensing pathway3.04E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Lorlatinibhsa04640Hematopoietic cell lineage4.72E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Lorlatinibhsa04650Natural killer cell mediated cytotoxicity7.47E-0412P16298, P50591, P01375, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Lorlatinibhsa04658Th1 and Th2 cell differentiation4.78E-038Q04759, P20963, P09693, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Lorlatinibhsa04659Th17 cell differentiation8.36E-0414P25963, Q04759, P19174, P06239, P42224, P14784, P13765, Q9HBE5, Q9UL17, P23771, P84022, P08238, P09693, P20963NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL21R, TBX21, GATA3, SMAD3, HSP90AB1, CD3G, CD247More
Lorlatinibhsa04660T cell receptor signaling pathway4.75E-0310P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCKMore
Lorlatinibhsa04664Fc epsilon RI signaling pathway2.60E-046P04141, Q9UQC2, P07948, P19174, P09917, P20292CSF2, GAB2, LYN, PLCG1, ALOX5, ALOX5APMore
Lorlatinibhsa04668TNF signaling pathway1.26E-024Q12933, Q99941, P01584, O95429TRAF2, CREBL1, IL1B, BAG4More
Lorlatinibhsa04713Circadian entrainment2.29E-037P0DP23, Q13557, Q02153, P62873, P63218, P50151, Q08828CALM1, CAMK2D, GUCY1B3, GNB1, GNG5, GNG10, ADCY1More
Lorlatinibhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Lorlatinibhsa04720Long-term potentiation2.85E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Lorlatinibhsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Lorlatinibhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Lorlatinibhsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Lorlatinibhsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Lorlatinibhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Lorlatinibhsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Lorlatinibhsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Lorlatinibhsa04750Inflammatory mediator regulation of TRP channels4.25E-023P01584, Q08828, Q13557IL1B, ADCY1, CAMK2DMore
Lorlatinibhsa04911Insulin secretion3.43E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Lorlatinibhsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Lorlatinibhsa04914Progesterone-mediated oocyte maturation1.00E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Lorlatinibhsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Lorlatinibhsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Lorlatinibhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Lorlatinibhsa04926Relaxin signaling pathway4.13E-035P63218, Q99941, P18848, P51828, P30679GNG5, CREBL1, ATF4, ADCY7, GNA15More
Lorlatinibhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Lorlatinibhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Lorlatinibhsa04932Non-alcoholic fatty liver disease4.44E-024Q12933, P01584, P12074, O15239TRAF2, IL1B, COX6A1, NDUFA1More
Lorlatinibhsa04934Cushing syndrome1.98E-056Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Lorlatinibhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Lorlatinibhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Lorlatinibhsa05010Alzheimer disease1.23E-028Q92542, O15239, P05496, P12074, P01584, Q12933, O15169, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, IL1B, TRAF2, AXIN1, PSMC4More
Lorlatinibhsa05012Parkinson disease2.28E-0312P62987, O15239, P12074, P05496, P60604, P43686, P19174, P0DP23, Q13557, Q71U36, Q13509, P68371UBA52, NDUFA1, COX6A1, ATP5G1, UBE2G2, PSMC4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Lorlatinibhsa05014Amyotrophic lateral sclerosis2.99E-027O15239, P12074, P05496, Q12933, P43686, P37198, P35658NDUFA1, COX6A1, ATP5G1, TRAF2, PSMC4, NUP62, NUP214More
Lorlatinibhsa05017Spinocerebellar ataxia2.16E-022Q8TB72, P21796PUM2, VDAC1More
Lorlatinibhsa05020Prion disease2.99E-027P01584, P46531, O15239, P05496, P12074, P43686, Q99941IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, PSMC4, CREBL1More
Lorlatinibhsa05022Pathways of neurodegeneration - multiple diseases9.10E-039O15239, P12074, P05496, Q12933, O15169, P01584, Q13557, P62987, P43686NDUFA1, COX6A1, ATP5G1, TRAF2, AXIN1, IL1B, CAMK2D, UBA52, PSMC4More
Lorlatinibhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Lorlatinibhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Lorlatinibhsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Lorlatinibhsa05034Alcoholism1.96E-046Q96RR4, Q93077, P62807, O60814, P84243, P68431CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lorlatinibhsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Lorlatinibhsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Lorlatinibhsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Lorlatinibhsa05131Shigellosis1.80E-025Q13546, Q9UDY8, Q12778, Q13315, P10415RIPK1, MALT1, FOXO1, ATM, BCL2More
Lorlatinibhsa05132Salmonella infection4.61E-0512P25963, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, Q13561, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Lorlatinibhsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Lorlatinibhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Lorlatinibhsa05140Leishmaniasis4.71E-0310P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, NCF4More
Lorlatinibhsa05144Malaria1.14E-025P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Lorlatinibhsa05146Amoebiasis1.95E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Lorlatinibhsa05160Hepatitis C3.16E-024P52630, P60033, Q9NZJ5, P49841STAT2, CD81, EIF2AK3, GSK3BMore
Lorlatinibhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Lorlatinibhsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Lorlatinibhsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Lorlatinibhsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Lorlatinibhsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Lorlatinibhsa05200Pathways in cancer1.46E-0419P08238, P42224, P25963, P19174, P43246, P84022, Q13485, P20585, P52701, P30279, P62873, P63218, P50151, Q14344, P78417, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, SMAD4, MSH3, MSH6, CCND2, GNB1, GNG5, GNG10, GNA13, GSTO1, GADD45B, CALM1, IFNA21, IL2RBMore
Lorlatinibhsa05202Transcriptional misregulation in cancer2.35E-0212Q13315, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Lorlatinibhsa05203Viral carcinogenesis2.63E-037Q99941, P18848, P27348, Q15283, P61978, P62807, O60814CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12More
Lorlatinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Lorlatinibhsa05210Colorectal cancer4.94E-022Q13485, P52701SMAD4, MSH6More
Lorlatinibhsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Lorlatinibhsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Lorlatinibhsa05215Prostate cancer3.03E-023P10415, Q12778, Q9NRA1BCL2, FOXO1, PDGFCMore
Lorlatinibhsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Lorlatinibhsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Lorlatinibhsa05321Inflammatory bowel disease1.30E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Lorlatinibhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lorlatinibhsa05332Graft-versus-host disease2.17E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More

Community members of Lorlatinib (SDC: 5.00)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)