PharmaCoNets of Loratadine (SPCN: 159.13 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Desloratadinehsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Desloratadinehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Desloratadinehsa00030Pentose phosphate pathway3.59E-124P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Desloratadinehsa00040Pentose and glucuronate interconversions1.95E-032P15121, O60701AKR1B1, UGDHMore
Desloratadinehsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Desloratadinehsa00052Galactose metabolism1.02E-066P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Desloratadinehsa00071Fatty acid degradation2.23E-035P11310, O75521, P00325, P11766, P33121ACADM, ECI2, ADH1B, ADH5, ACSL1More
Desloratadinehsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Desloratadinehsa00190Oxidative phosphorylation2.11E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Desloratadinehsa00220Arginine biosynthesis2.76E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Desloratadinehsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Desloratadinehsa00250Alanine, aspartate and glutamate metabolism6.84E-053Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Desloratadinehsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Desloratadinehsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Desloratadinehsa00310Lysine degradation2.14E-057Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Desloratadinehsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Desloratadinehsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Desloratadinehsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Desloratadinehsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Desloratadinehsa00500Starch and sucrose metabolism3.27E-084O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Desloratadinehsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Desloratadinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Desloratadinehsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Desloratadinehsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Desloratadinehsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Desloratadinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Desloratadinehsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Desloratadinehsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Desloratadinehsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Desloratadinehsa00590Arachidonic acid metabolism2.97E-021P09917ALOX5More
Desloratadinehsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Desloratadinehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Desloratadinehsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Desloratadinehsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Desloratadinehsa00630Glyoxylate and dicarboxylate metabolism6.65E-094P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Desloratadinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Desloratadinehsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Desloratadinehsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Desloratadinehsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Desloratadinehsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Desloratadinehsa00770Pantothenate and CoA biosynthesis7.20E-043O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Desloratadinehsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Desloratadinehsa00790Folate biosynthesis4.23E-044Q92820, P05186, P15121, P42330GGH, ALPL, AKR1B1, AKR1C3More
Desloratadinehsa00830Retinol metabolism3.48E-055P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Desloratadinehsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Desloratadinehsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Desloratadinehsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Desloratadinehsa00970Aminoacyl-tRNA biosynthesis2.65E-034O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Desloratadinehsa00980Metabolism of xenobiotics by cytochrome P4504.00E-021P09211GSTP1More
Desloratadinehsa00983Drug metabolism - other enzymes9.89E-085P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Desloratadinehsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Desloratadinehsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Desloratadinehsa01200Carbon metabolism7.14E-034P51854, P52209, P37837, P60891TKTL1, PGD, TALDO1, PRPS1More
Desloratadinehsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Desloratadinehsa01230Biosynthesis of amino acids1.52E-056P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Desloratadinehsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Desloratadinehsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Desloratadinehsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Desloratadinehsa01523Antifolate resistance2.16E-054P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Desloratadinehsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Desloratadinehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Desloratadinehsa03010Ribosome1.18E-1320P26373, P62753, P42677, P25398, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62899, P62910, P18077, P61927, Q02878, P36578, P27635, P05386, P62249, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL31, RPL32, RPL35A, RPL37, RPL6, RPL4, RPL10, RPLP1, RPS16, RPS3More
Desloratadinehsa03013RNA transport5.47E-2029P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Desloratadinehsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Desloratadinehsa03020RNA polymerase7.29E-084P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Desloratadinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Desloratadinehsa03040Spliceosome3.42E-1320Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, O75940, P51991, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, SMNDC1, HNRPA3, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Desloratadinehsa03050Proteasome1.21E-021P28074PSMB5More
Desloratadinehsa03060Protein export1.16E-104Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Desloratadinehsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Desloratadinehsa03430Mismatch repair4.38E-021P20585MSH3More
Desloratadinehsa03450Non-homologous end-joining4.32E-021Q9NP87POLMMore
Desloratadinehsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Desloratadinehsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Desloratadinehsa04012ErbB signaling pathway3.54E-0610P21860, Q13153, P16333, Q13191, Q13557, P19174, O14944, P42338, P01106, P04049ERBB3, PAK1, NCK1, CBLB, CAMK2D, PLCG1, EREG, PIK3CB, MYC, RAF1More
Desloratadinehsa04014Ras signaling pathway6.01E-0412P04049, P31751, P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1More
Desloratadinehsa04015Rap1 signaling pathway1.87E-0514P04049, P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P31751, P0DP23, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, AKT2, CALM1, PLCG1More
Desloratadinehsa04020Calcium signaling pathway1.12E-0812Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P0DP24, P0DP23, P05141, P51828, P23634ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Desloratadinehsa04022cGMP-PKG signaling pathway2.03E-0812Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Desloratadinehsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Desloratadinehsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Desloratadinehsa04061Viral protein interaction with cytokine and cytokine receptor1.29E-049Q8NHW4, P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Desloratadinehsa04062Chemokine signaling pathway1.60E-0621P25024, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P14598, P42224, P04049, P25963, Q8WYR1CXCR1, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, NCF1, STAT1, RAF1, NFKBIA, PIK3R5More
Desloratadinehsa04064NF-kappa B signaling pathway5.09E-1623P10415, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Desloratadinehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Desloratadinehsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Desloratadinehsa04070Phosphatidylinositol signaling system5.07E-059P19174, P0DP23, O14986, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7PLCG1, CALM1, PIP5K1B, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKCMore
Desloratadinehsa04071Sphingolipid signaling pathway1.91E-0710P04049, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, Q9UQC2, Q12933, Q02156RAF1, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, GAB2, TRAF2, PRKCEMore
Desloratadinehsa04072Phospholipase D signaling pathway4.96E-058P04049, P31751, Q9UQC2, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, GAB2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Desloratadinehsa04080Neuroactive ligand-receptor interaction1.38E-0512P08311, P28472, P78334, Q15722, P21453, Q9H228, P43657, P21462, P21730, P30939, P07550, P35318CTSG, GABRB3, GABRE, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, HTR1F, ADRB2, ADMMore
Desloratadinehsa04110Cell cycle1.19E-0813Q9UBD5, P30260, P06493, O60566, Q14683, O75293, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Desloratadinehsa04114Oocyte meiosis5.73E-1011Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Desloratadinehsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Desloratadinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Desloratadinehsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Desloratadinehsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Desloratadinehsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Desloratadinehsa04141Protein processing in endoplasmic reticulum2.15E-0714P18848, Q12933, P30101, Q15437, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23B, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Desloratadinehsa04142Lysosome1.11E-0511O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Desloratadinehsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Desloratadinehsa04145Phagosome4.61E-0410O75015, Q15080, P14598, Q13509, P68371, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Desloratadinehsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Desloratadinehsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Desloratadinehsa04151PI3K-Akt signaling pathway7.29E-0933P62753, P42338, P21860, P43657, O43521, P04637, P27348, P20827, P49767, Q13362, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P61952, O15335, P02452, P24821, Q16363, Q13751, P22105, P14784, P23458, P01568, Q99941, P18848, Q96BR1, O00141, Q6ZUJ8, P30281, P56279RPS6, PIK3CB, ERBB3, P2RY5, BCL2L11, TP53, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, GNG11, CHAD, COL1A1, TNC, LAMA4, LAMB3, TNXB, IL2RB, JAK1, IFNA21, CREBL1, ATF4, SGK3, SGK, PIK3AP1, CCND3, TCL1AMore
Desloratadinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Desloratadinehsa04210Apoptosis1.88E-048O76075, Q14790, P01375, P48023, Q9NR28, Q16548, P42575, P04049DFFB, CASP8, TNF, FASLG, DIABLO, BCL2A1, CASP2, RAF1More
Desloratadinehsa04211Longevity regulating pathway2.10E-057P31751, P08069, Q08828, P51828, Q99941, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, CREBL1, ATF4, CAMKK2More
Desloratadinehsa04213Longevity regulating pathway - multiple species1.23E-079P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Desloratadinehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Desloratadinehsa04217Necroptosis2.74E-1020P01375, Q12933, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q13557, Q9H444, O75351, P45880TNF, TRAF2, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, CAMK2D, CHMP4B, VPS4B, VDAC2More
Desloratadinehsa04218Cellular senescence3.45E-0511P01106, P31751, P04049, P30281, O75293, P30304, P06493, P0DP23, P01889, P10321, P12236MYC, AKT2, RAF1, CCND3, GADD45B, CDC25A, CDK1, CALM1, HLA-B, HLA-C, SLC25A6More
Desloratadinehsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Desloratadinehsa04261Adrenergic signaling in cardiomyocytes3.43E-1114P67936, P07550, Q08828, P51828, P22694, P31751, Q99941, P18848, Q13362, Q14738, P0DP24, P0DP23, Q13557, P23634TPM4, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, CAMK2D, ATP2B4More
Desloratadinehsa04270Vascular smooth muscle contraction1.71E-0611P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Desloratadinehsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Desloratadinehsa04330Notch signaling pathway4.48E-054Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Desloratadinehsa04340Hedgehog signaling pathway2.59E-045P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Desloratadinehsa04360Axon guidance1.32E-0412P16298, Q05397, P16333, P20827, O95631, Q13873, P42338, P07332, P04049, P19174, O14639, P24844PPP3CB, PTK2, NCK1, EFNA1, NTN1, BMPR2, PIK3CB, FES, RAF1, PLCG1, ABLIM1, MYL9More
Desloratadinehsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Desloratadinehsa04371Apelin signaling pathway6.36E-0616P62873, P63218, P50151, P61952, Q8WYR1, P31751, P04049, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, RPS6, CALM1, CALM2More
Desloratadinehsa04380Osteoclast differentiation2.23E-0914Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Desloratadinehsa04390Hippo signaling pathway2.24E-067O95835, P84022, Q13485, P04628, Q9UJU2, O43623, Q13489LATS1, SMAD3, SMAD4, WNT1, LEF1, SNAI2, BIRC3More
Desloratadinehsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Desloratadinehsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Desloratadinehsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Desloratadinehsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Desloratadinehsa04540Gap junction8.97E-044Q13509, P68371, P04049, Q9NRA1TUBB3, TUBB2C, RAF1, PDGFCMore
Desloratadinehsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Desloratadinehsa04610Complement and coagulation cascades1.45E-084P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Desloratadinehsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Desloratadinehsa04612Antigen processing and presentation1.34E-1012P13765, P48382, P01730, Q14953, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Desloratadinehsa04613Neutrophil extracellular trap formation8.07E-0728P19174, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q99878, Q93077, P62807, Q16778, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC14, HIST1H2AC, HIST1H2BC, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Desloratadinehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Desloratadinehsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Desloratadinehsa04621NOD-like receptor signaling pathway2.55E-0312P01584, P07900, Q14643, P23458, P45880, P10599, P43490, O00463, P29728, P01375, P09341, P12838IL1B, HSP90AA1, ITPR1, JAK1, VDAC2, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Desloratadinehsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Desloratadinehsa04623Cytosolic DNA-sensing pathway1.82E-105P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Desloratadinehsa04625C-type lectin receptor signaling pathway4.35E-0913Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Desloratadinehsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Desloratadinehsa04640Hematopoietic cell lineage5.04E-1120P13612, P07359, P08514, P21926, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, GP1BA, ITGA2B, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Desloratadinehsa04650Natural killer cell mediated cytotoxicity1.04E-2020P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Desloratadinehsa04657IL-17 signaling pathway6.19E-0915P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, S100A9, IL1BMore
Desloratadinehsa04658Th1 and Th2 cell differentiation1.44E-2918P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, JAK1, RUNX3More
Desloratadinehsa04659Th17 cell differentiation9.55E-2421P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Desloratadinehsa04660T cell receptor signaling pathway1.38E-2019P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Desloratadinehsa04662B cell receptor signaling pathway4.10E-1313P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Desloratadinehsa04664Fc epsilon RI signaling pathway2.22E-079P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Desloratadinehsa04666Fc gamma R-mediated phagocytosis4.61E-034P08637, O75015, P04049, P06396FCGR3A, FCGR3B, RAF1, GSNMore
Desloratadinehsa04668TNF signaling pathway7.83E-0712P01375, Q12933, O00463, Q16539, Q99941, P18848, P19875, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Desloratadinehsa04710Circadian rhythm4.86E-021O15516CLOCKMore
Desloratadinehsa04713Circadian entrainment1.96E-068P0DP23, P0DP24, Q13557, Q02153, P62873, P61952, Q08828, P51828CALM1, CALM2, CAMK2D, GUCY1B3, GNB1, GNG11, ADCY1, ADCY7More
Desloratadinehsa04714Thermogenesis1.49E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Desloratadinehsa04720Long-term potentiation5.72E-1010Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1More
Desloratadinehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Desloratadinehsa04722Neurotrophin signaling pathway1.76E-0610Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, IRAK1, BCL2, CALM1More
Desloratadinehsa04723Retrograde endocannabinoid signaling3.71E-024P62873, P61952, Q08828, O15239GNB1, GNG11, ADCY1, NDUFA1More
Desloratadinehsa04724Glutamatergic synapse2.84E-057O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Desloratadinehsa04725Cholinergic synapse4.51E-0710Q08828, P51828, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2More
Desloratadinehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Desloratadinehsa04727GABAergic synapse6.02E-089Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Desloratadinehsa04728Dopaminergic synapse1.38E-0916P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP24, P0DP23, O15516, P48058GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM2, CALM1, CLOCK, GRIA4More
Desloratadinehsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Desloratadinehsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Desloratadinehsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Desloratadinehsa04744Phototransduction4.99E-073P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Desloratadinehsa04750Inflammatory mediator regulation of TRP channels7.30E-1114P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Desloratadinehsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Desloratadinehsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Desloratadinehsa04911Insulin secretion1.14E-105Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Desloratadinehsa04912GnRH signaling pathway3.61E-0712Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P04049, P45985ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, RAF1, MAP2K4More
Desloratadinehsa04913Ovarian steroidogenesis5.67E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Desloratadinehsa04914Progesterone-mediated oocyte maturation1.58E-086P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Desloratadinehsa04915Estrogen signaling pathway2.16E-1212P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Desloratadinehsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Desloratadinehsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Desloratadinehsa04918Thyroid hormone synthesis2.03E-066Q08828, P51828, Q99941, P18848, P02768, P05543ADCY1, ADCY7, CREBL1, ATF4, ALB, SERPINA7More
Desloratadinehsa04919Thyroid hormone signaling pathway3.02E-0611P49841, P19174, P04049, P42224, P22694, P60709, Q13547, O60244, Q9NVC6, Q9UM47, P01106GSK3B, PLCG1, RAF1, STAT1, PRKACB, ACTB, HDAC1, MED14, MED17, NOTCH3, MYCMore
Desloratadinehsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Desloratadinehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Desloratadinehsa04922Glucagon signaling pathway4.86E-044P14618, P06737, P31751, P0DP23PKM2, PYGL, AKT2, CALM1More
Desloratadinehsa04923Regulation of lipolysis in adipocytes5.39E-064Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Desloratadinehsa04924Renin secretion3.10E-064P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Desloratadinehsa04925Aldosterone synthesis and secretion3.02E-128Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Desloratadinehsa04926Relaxin signaling pathway1.36E-0916P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P22694, P49767, P14780, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, PRKACB, VEGFC, MMP9, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Desloratadinehsa04927Cortisol synthesis and secretion2.43E-085Q99941, P18848, Q08828, P51828, P22694CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Desloratadinehsa04928Parathyroid hormone synthesis, secretion and action3.95E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Desloratadinehsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Desloratadinehsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Desloratadinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Desloratadinehsa04932Non-alcoholic fatty liver disease1.87E-1316P31751, P01375, P49841, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, P19404, O14521AKT2, TNF, GSK3B, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHDMore
Desloratadinehsa04933AGE-RAGE signaling pathway in diabetic complications2.11E-036P84022, Q13485, P10415, P42338, P49767, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1More
Desloratadinehsa04934Cushing syndrome3.40E-116Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Desloratadinehsa04935Growth hormone synthesis, secretion and action4.62E-057Q08828, P51828, P04049, Q99941, P18848, P31751, P45985ADCY1, ADCY7, RAF1, CREBL1, ATF4, AKT2, MAP2K4More
Desloratadinehsa04940Type I diabetes mellitus7.38E-044P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Desloratadinehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Desloratadinehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Desloratadinehsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Desloratadinehsa04970Salivary secretion1.31E-1010P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1, GUCY1B3, CAMPMore
Desloratadinehsa04971Gastric acid secretion1.49E-086Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Desloratadinehsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Desloratadinehsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Desloratadinehsa04975Fat digestion and absorption1.68E-031O14494PLPP1More
Desloratadinehsa04976Bile secretion8.33E-076O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Desloratadinehsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Desloratadinehsa05010Alzheimer disease3.15E-1021P49768, Q92542, O15239, O95298, P19404, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, Q12933, P18848, O15169, P67870, P31751, P05141, P45880, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFC2, NDUFV2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, AXIN1, CSNK2B, AKT2, SLC25A5, VDAC2, PSMB4, PSMC4More
Desloratadinehsa05012Parkinson disease5.92E-0414O15239, O95298, P13073, P12074, P05496, P05141, P12236, O75460, P18848, P28070, P43686, P0DP23, P0DP24, Q13557NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, ERN1, ATF4, PSMB4, PSMC4, CALM1, CALM2, CAMK2DMore
Desloratadinehsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Desloratadinehsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Desloratadinehsa05017Spinocerebellar ataxia1.13E-0410Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P28074, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, PSMB5, SLC25A5, VDAC1More
Desloratadinehsa05020Prion disease5.40E-0821P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, P18848, P05141, P12236, P45880, P28070, P43686, P49841, P67870, Q99941, Q16539IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMB4, PSMC4, GSK3B, CSNK2B, CREBL1, MAPK14More
Desloratadinehsa05022Pathways of neurodegeneration - multiple diseases5.48E-1032P49841, P67870, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P45880, Q16539, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP24, P0DP23, Q13557, P62987, P28070, P43686GSK3B, CSNK2B, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, VDAC2, MAPK14, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM2, CALM1, CAMK2D, UBA52, PSMB4, PSMC4More
Desloratadinehsa05030Cocaine addiction7.19E-043Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Desloratadinehsa05031Amphetamine addiction1.37E-077P0DP24, P0DP23, Q13557, P22694, Q99941, P18848, Q13547CALM2, CALM1, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Desloratadinehsa05032Morphine addiction5.68E-032P78334, P32298GABRE, GRK4More
Desloratadinehsa05033Nicotine addiction4.01E-021P78334GABREMore
Desloratadinehsa05034Alcoholism4.25E-0410Q99941, P18848, Q13547, P0DP24, P62873, P61952, P04049, P0C0S5, P62807, Q16778CREBL1, ATF4, HDAC1, CALM2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2BC, HIST2H2BEMore
Desloratadinehsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Desloratadinehsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Desloratadinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.55E-1010Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSKMore
Desloratadinehsa05130Pathogenic Escherichia coli infection2.77E-039P16333, Q13509, P60709, P25963, P04406, P29350, Q15438, P35579, P55061NCK1, TUBB3, ACTB, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Desloratadinehsa05131Shigellosis2.79E-0514Q12933, Q13546, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q12778, Q13315, P10415, P07737TRAF2, RIPK1, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, ELMO2, PTK2, FOXO1, ATM, BCL2, PFN1More
Desloratadinehsa05132Salmonella infection8.99E-1019P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, Q9BQS8, Q13561, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Desloratadinehsa05133Pertussis1.43E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Desloratadinehsa05134Legionellosis2.58E-089P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Desloratadinehsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Desloratadinehsa05140Leishmaniasis1.88E-0715P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4More
Desloratadinehsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Desloratadinehsa05143African trypanosomiasis1.54E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Desloratadinehsa05144Malaria6.81E-0710P60033, P69905, P68871, O60603, P01375, P05107, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL1B, IL8, KLRK1More
Desloratadinehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Desloratadinehsa05146Amoebiasis4.87E-1614P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Desloratadinehsa05150Staphylococcus aureus infection5.41E-0815P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Desloratadinehsa05152Tuberculosis1.04E-047P04049, P0DP23, P48382, P31751, P10415, Q9UDY8, P51617RAF1, CALM1, RFX5, AKT2, BCL2, MALT1, IRAK1More
Desloratadinehsa05160Hepatitis C1.31E-047Q13546, P01568, P60033, P04049, P49841, P01375, P48023RIPK1, IFNA21, CD81, RAF1, GSK3B, TNF, FASLGMore
Desloratadinehsa05161Hepatitis B1.14E-058P04049, Q99941, P18848, P25963, Q13485, P10415, P27348, P84022RAF1, CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3More
Desloratadinehsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Desloratadinehsa05163Human cytomegalovirus infection1.28E-1024P31751, P04049, P01375, P62873, P50151, P61952, Q14643, P0DP23, P0DP24, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P61769AKT2, RAF1, TNF, GNB1, GNG10, GNG11, ITPR1, CALM1, CALM2, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, B2MMore
Desloratadinehsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Desloratadinehsa05165Human papillomavirus infection2.80E-0410P02452, P24821, Q16363, P30281, Q9UM47, P01568, P01889, P10321, Q99437, P04628COL1A1, TNC, LAMA4, CCND3, NOTCH3, IFNA21, HLA-B, HLA-C, ATP6V0B, WNT1More
Desloratadinehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Desloratadinehsa05167Kaposi sarcoma-associated herpesvirus infection3.64E-048P31751, P42224, P25963, P62873, P19174, P04049, P01106, P0DP23AKT2, STAT1, NFKBIA, GNB1, PLCG1, RAF1, MYC, CALM1More
Desloratadinehsa05168Herpes simplex virus 1 infection4.64E-0317O00463, O60603, P25963, Q05823, Q07955, Q01130, Q16629, Q9Y2A4, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, RNASEL, SFRS1, SFRS2, SFRS7, ZNF443, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Desloratadinehsa05169Epstein-Barr virus infection1.72E-0617P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Desloratadinehsa05170Human immunodeficiency virus 1 infection3.07E-0612P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P51617, Q13315, P10415, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, IRAK1, ATM, BCL2, AP1M2More
Desloratadinehsa05171Coronavirus disease - COVID-193.37E-1119P23396, P62753, P25398, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P46776, P62899, P62910, P18077, P61927, P05386RPS3, RPS6, RPS12, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPLP1More
Desloratadinehsa05200Pathways in cancer2.27E-0734Q13751, P42338, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P43246, P84022, Q13485, P20585, P52701, Q13547, P14923, P30279, P30281, P10415, Q13077, P49767, P14921, P31751, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, Q9UM47, P78417, O75293, P0DP23, P14784, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, MSH2, SMAD3, SMAD4, MSH3, MSH6, HDAC1, JUP, CCND2, CCND3, BCL2, TRAF1, VEGFC, ETS1, AKT2, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, NOTCH3, GSTO1, GADD45B, CALM1, IL2RB, KNG1More
Desloratadinehsa05202Transcriptional misregulation in cancer2.59E-0921Q12778, Q13315, P41732, P17844, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, ATM, TSPAN7, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Desloratadinehsa05203Viral carcinogenesis2.00E-0614Q12933, Q99941, P18848, P30281, P27348, Q13547, P06396, P12814, P01889, P10321, P61978, P06493, P62807, Q16778TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, GSN, ACTN1, HLA-B, HLA-C, HNRPK, CDK1, HIST1H2BC, HIST2H2BEMore
Desloratadinehsa05204Chemical carcinogenesis4.00E-021P09211GSTP1More
Desloratadinehsa05205Proteoglycans in cancer9.53E-0615Q13009, Q12955, O75369, P60709, P04049, P14780, P01106, P01375, P08069, P23588, P19174, Q13635, P22694, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MMP9, MYC, TNF, IGF1R, EIF4B, PLCG1, PTCH1, PRKACB, PTPN6, CD63More
Desloratadinehsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Desloratadinehsa05210Colorectal cancer8.05E-0611Q9UKG1, P84022, Q13485, P43246, P04049, P01106, P10415, P52701, P20585, P37173, O75293APPL1, SMAD3, SMAD4, MSH2, RAF1, MYC, BCL2, MSH6, MSH3, TGFBR2, GADD45BMore
Desloratadinehsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Desloratadinehsa05212Pancreatic cancer1.45E-058P42338, P31751, P04049, Q15311, P23458, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4, GADD45BMore
Desloratadinehsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Desloratadinehsa05214Glioma6.68E-066P08069, P0DP23, P04049, P31751, P19174, O75293IGF1R, CALM1, RAF1, AKT2, PLCG1, GADD45BMore
Desloratadinehsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Desloratadinehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Desloratadinehsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Desloratadinehsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Desloratadinehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Desloratadinehsa05220Chronic myeloid leukemia2.22E-058Q13547, Q13485, P25963, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, NFKBIA, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Desloratadinehsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Desloratadinehsa05222Small cell lung cancer1.36E-034P31751, Q13489, P10415, P25963AKT2, BIRC3, BCL2, NFKBIAMore
Desloratadinehsa05223Non-small cell lung cancer3.89E-055P31751, P10826, P04049, Q9HC35, O75293AKT2, RARB, RAF1, EML4, GADD45BMore
Desloratadinehsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Desloratadinehsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Desloratadinehsa05226Gastric cancer8.56E-055P04049, P31751, P84022, Q13485, P10415RAF1, AKT2, SMAD3, SMAD4, BCL2More
Desloratadinehsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Desloratadinehsa05231Choline metabolism in cancer2.51E-069P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Desloratadinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.20E-1518P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Desloratadinehsa05310Asthma7.64E-083P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Desloratadinehsa05321Inflammatory bowel disease1.01E-158O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Desloratadinehsa05322Systemic lupus erythematosus3.82E-0511P08637, O75015, P08246, P08311, P01375, P10747, P13765, P62807, Q16778, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, HIST1H2BC, HIST2H2BE, SNRPB, ACTN1More
Desloratadinehsa05323Rheumatoid arthritis1.89E-047P01375, Q06643, P13765, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, CD28, CXCL1, CXCL2, TLR2More
Desloratadinehsa05330Allograft rejection2.02E-034P13765, P48023, P10747, P01375HLA-DOB, FASLG, CD28, TNFMore
Desloratadinehsa05332Graft-versus-host disease1.54E-136P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Desloratadinehsa05340Primary immunodeficiency2.12E-066P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Desloratadinehsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Desloratadinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Desloratadinehsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Desloratadinehsa05415Diabetic cardiomyopathy1.68E-048P30405, Q15080, Q16718, O14521, Q16539, P49841, P14780, P37173PPIF, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9, TGFBR2More
Desloratadinehsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More
Loratadinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Loratadinehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Loratadinehsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Loratadinehsa00500Starch and sucrose metabolism6.40E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Loratadinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Loratadinehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Loratadinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Loratadinehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Loratadinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Loratadinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Loratadinehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Loratadinehsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Loratadinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Loratadinehsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Loratadinehsa00970Aminoacyl-tRNA biosynthesis2.24E-033O95363, P14868, Q15046FARS2, DARS, KARSMore
Loratadinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Loratadinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Loratadinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Loratadinehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Loratadinehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Loratadinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Loratadinehsa01522Endocrine resistance2.16E-021P04049RAF1More
Loratadinehsa01523Antifolate resistance2.04E-022P04818, P18054TYMS, ALOX12More
Loratadinehsa03013RNA transport8.18E-059P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P55884, O15371, P20042EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Loratadinehsa03040Spliceosome1.81E-0616O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Loratadinehsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Loratadinehsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Loratadinehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Loratadinehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Loratadinehsa04012ErbB signaling pathway8.14E-034P21860, Q13557, O14944, P04049ERBB3, CAMK2D, EREG, RAF1More
Loratadinehsa04014Ras signaling pathway1.13E-029P04049, P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174RAF1, PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Loratadinehsa04015Rap1 signaling pathway5.88E-0413P04049, P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P17252, P19174RAF1, EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PRKCA, PLCG1More
Loratadinehsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Loratadinehsa04022cGMP-PKG signaling pathway1.40E-025P04049, Q99941, P23634, P51828, P45880RAF1, CREBL1, ATP2B4, ADCY7, VDAC2More
Loratadinehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Loratadinehsa04061Viral protein interaction with cytokine and cytokine receptor4.68E-037P09341, P19875, P25024, P02775, P25025, Q13651, P14784CXCL1, CXCL2, CXCR1, PPBP, CXCR2, IL10RA, IL2RBMore
Loratadinehsa04062Chemokine signaling pathway2.48E-0415P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, P04049, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, RAF1, PIK3R5More
Loratadinehsa04064NF-kappa B signaling pathway8.22E-0515O00463, P14778, P01584, P01375, P19174, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Loratadinehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Loratadinehsa04071Sphingolipid signaling pathway3.92E-034P04049, Q9H228, P01375, Q9UQC2RAF1, EDG8, TNF, GAB2More
Loratadinehsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Loratadinehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Loratadinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Loratadinehsa04140Autophagy - animal2.82E-021P04049RAF1More
Loratadinehsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Loratadinehsa04150mTOR signaling pathway7.74E-034P04049, Q02750, Q9NQL2, P51812RAF1, MAP2K1, RRAGD, RPS6KA3More
Loratadinehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Loratadinehsa04210Apoptosis3.64E-035O76075, P01375, Q9NR28, Q16548, P04049DFFB, TNF, DIABLO, BCL2A1, RAF1More
Loratadinehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Loratadinehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Loratadinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Loratadinehsa04218Cellular senescence2.49E-021P04049RAF1More
Loratadinehsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Loratadinehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Loratadinehsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Loratadinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Loratadinehsa04360Axon guidance1.51E-027P16333, P20827, O95631, P42338, P07332, P04049, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, RAF1, PLCG1More
Loratadinehsa04370VEGF signaling pathway1.79E-044P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Loratadinehsa04371Apelin signaling pathway4.16E-038P63218, P50151, Q8WYR1, P04049, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, RAF1, MEF2D, GNA13, SMAD4, SMAD3More
Loratadinehsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Loratadinehsa04390Hippo signaling pathway2.17E-035P63261, P84022, Q13485, O15105, Q13489ACTG1, SMAD3, SMAD4, SMAD7, BIRC3More
Loratadinehsa04510Focal adhesion3.48E-021P04049RAF1More
Loratadinehsa04530Tight junction3.00E-048Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247, P24844RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9More
Loratadinehsa04540Gap junction1.33E-021P04049RAF1More
Loratadinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Loratadinehsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Loratadinehsa04613Neutrophil extracellular trap formation6.73E-0419P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Loratadinehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Loratadinehsa04625C-type lectin receptor signaling pathway1.88E-0310Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Loratadinehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Loratadinehsa04640Hematopoietic cell lineage2.62E-0314P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1BMore
Loratadinehsa04650Natural killer cell mediated cytotoxicity6.51E-0617P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Loratadinehsa04657IL-17 signaling pathway4.37E-048O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Loratadinehsa04658Th1 and Th2 cell differentiation2.95E-0514Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Loratadinehsa04659Th17 cell differentiation1.12E-0618P25963, Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Loratadinehsa04660T cell receptor signaling pathway2.11E-0515P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Loratadinehsa04662B cell receptor signaling pathway2.42E-036P42338, P60033, P07948, P21854, Q8N149, P04049PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Loratadinehsa04664Fc epsilon RI signaling pathway5.86E-035P42338, P07948, P19174, P04049, P09917PIK3CB, LYN, PLCG1, RAF1, ALOX5More
Loratadinehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Loratadinehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Loratadinehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Loratadinehsa04720Long-term potentiation2.17E-034P16298, P51812, Q02750, P04049PPP3CB, RPS6KA3, MAP2K1, RAF1More
Loratadinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Loratadinehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Loratadinehsa04730Long-term depression1.16E-021P04049RAF1More
Loratadinehsa04750Inflammatory mediator regulation of TRP channels4.09E-0512P14778, P01584, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Loratadinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Loratadinehsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Loratadinehsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Loratadinehsa04912GnRH signaling pathway2.74E-027P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694, P04049ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB, RAF1More
Loratadinehsa04914Progesterone-mediated oocyte maturation5.89E-034Q17RY0, P51812, Q02750, P04049CPEB4, RPS6KA3, MAP2K1, RAF1More
Loratadinehsa04915Estrogen signaling pathway1.26E-025P04049, Q99941, P51828, P07900, P11142RAF1, CREBL1, ADCY7, HSP90AA1, HSPA8More
Loratadinehsa04916Melanogenesis1.33E-021P04049RAF1More
Loratadinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Loratadinehsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Loratadinehsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Loratadinehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Loratadinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Loratadinehsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Loratadinehsa04926Relaxin signaling pathway2.32E-021P04049RAF1More
Loratadinehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Loratadinehsa04929GnRH secretion4.98E-031P04049RAF1More
Loratadinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Loratadinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Loratadinehsa04933AGE-RAGE signaling pathway in diabetic complications2.11E-036P84022, Q13485, P10415, P42338, P49767, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1More
Loratadinehsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Loratadinehsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Loratadinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Loratadinehsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Loratadinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Loratadinehsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Loratadinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Loratadinehsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Loratadinehsa05020Prion disease1.81E-027P01584, P46531, P11142, P05496, P12074, P45880, Q99941IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1More
Loratadinehsa05034Alcoholism2.78E-045P04049, Q93077, P62807, O60814, P68431RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Loratadinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Loratadinehsa05132Salmonella infection6.67E-035P25963, P04049, Q13489, P10415, Q9BQS8NFKBIA, RAF1, BIRC3, BCL2, FYCO1More
Loratadinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Loratadinehsa05140Leishmaniasis1.93E-0310P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4More
Loratadinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Loratadinehsa05144Malaria2.43E-026P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Loratadinehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Loratadinehsa05146Amoebiasis2.17E-0513P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Loratadinehsa05152Tuberculosis3.98E-021P04049RAF1More
Loratadinehsa05160Hepatitis C1.98E-048P60033, O00501, P29728, P04049, P49841, P01375, P48023, P01106CD81, CLDN5, OAS2, RAF1, GSK3B, TNF, FASLG, MYCMore
Loratadinehsa05161Hepatitis B6.38E-045P04049, P25963, Q13485, P10415, P84022RAF1, NFKBIA, SMAD4, BCL2, SMAD3More
Loratadinehsa05163Human cytomegalovirus infection4.00E-028P04049, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463RAF1, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Loratadinehsa05164Influenza A3.65E-021P04049RAF1More
Loratadinehsa05167Kaposi sarcoma-associated herpesvirus infection4.57E-035P62879, P16298, P04049, Q02750, P0CG47GNB2, PPP3CB, RAF1, MAP2K1, UBBMore
Loratadinehsa05170Human immunodeficiency virus 1 infection1.31E-036P04049, Q02750, P62879, P16298, Q05397, P20333RAF1, MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Loratadinehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Loratadinehsa05202Transcriptional misregulation in cancer6.59E-0315P17844, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522DDX5, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Loratadinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Loratadinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Loratadinehsa05205Proteoglycans in cancer1.15E-025Q12955, P04049, Q14247, P17252, P08962ANK3, RAF1, CTTN, PRKCA, CD63More
Loratadinehsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Loratadinehsa05210Colorectal cancer1.68E-034P84022, Q13485, P04049, P10415SMAD3, SMAD4, RAF1, BCL2More
Loratadinehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Loratadinehsa05212Pancreatic cancer9.10E-045P42338, P04049, P84022, Q13485, O75293PIK3CB, RAF1, SMAD3, SMAD4, GADD45BMore
Loratadinehsa05213Endometrial cancer4.26E-033O15169, Q02750, P04049AXIN1, MAP2K1, RAF1More
Loratadinehsa05214Glioma9.95E-031P04049RAF1More
Loratadinehsa05215Prostate cancer1.33E-021P04049RAF1More
Loratadinehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Loratadinehsa05218Melanoma6.63E-031P04049RAF1More
Loratadinehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Loratadinehsa05220Chronic myeloid leukemia1.61E-047Q13547, Q13485, P25963, P84022, P42338, P04049, O75293HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, RAF1, GADD45BMore
Loratadinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Loratadinehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Loratadinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Loratadinehsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Loratadinehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Loratadinehsa05226Gastric cancer2.93E-046P04049, Q02750, O15169, P84022, Q13485, P10415RAF1, MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Loratadinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Loratadinehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Loratadinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer5.38E-0513P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, CD4More
Loratadinehsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Loratadinehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Loratadinehsa05321Inflammatory bowel disease1.21E-027O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Loratadinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Loratadinehsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Loratadinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Loratadinehsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Loratadinehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore
Loratadinehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Loratadine (SDC: 7.22)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)