PharmaCoNets of Loracarbef (SPCN: 9.51 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Loracarbefhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Loracarbefhsa00500Starch and sucrose metabolism8.52E-034O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Loracarbefhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Loracarbefhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Loracarbefhsa00730Thiamine metabolism3.79E-022P05186, P24666ALPL, ACP1More
Loracarbefhsa00920Sulfur metabolism8.89E-031Q16762TSTMore
Loracarbefhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Loracarbefhsa04064NF-kappa B signaling pathway2.69E-029P10415, O00463, P01375, Q04759, Q13077, Q16548, Q8WV28, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Loracarbefhsa04071Sphingolipid signaling pathway2.06E-027Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Loracarbefhsa04080Neuroactive ligand-receptor interaction2.54E-027P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADMMore
Loracarbefhsa04122Sulfur relay system8.89E-031Q16762TSTMore
Loracarbefhsa04340Hedgehog signaling pathway1.43E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Loracarbefhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Loracarbefhsa04610Complement and coagulation cascades1.29E-052P00734, P0C0L4F2, C4AMore
Loracarbefhsa04613Neutrophil extracellular trap formation1.37E-0212O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Loracarbefhsa04614Renin-angiotensin system9.97E-042P50052, P10619AGTR2, CTSAMore
Loracarbefhsa04621NOD-like receptor signaling pathway2.64E-0210Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4More
Loracarbefhsa04657IL-17 signaling pathway1.28E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Loracarbefhsa04658Th1 and Th2 cell differentiation3.21E-039Q04759, P20963, P09693, Q16539, Q14765, P42226, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, STAT6, GATA3, TBX21, HLA-DOBMore
Loracarbefhsa04659Th17 cell differentiation3.18E-028Q04759, Q16539, P42226, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, STAT6, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Loracarbefhsa04660T cell receptor signaling pathway1.07E-029P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3BMore
Loracarbefhsa04924Renin secretion4.38E-021P07550ADRB2More
Loracarbefhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Loracarbefhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Loracarbefhsa05133Pertussis2.64E-032P0DP23, P0C0L4CALM1, C4AMore
Loracarbefhsa05143African trypanosomiasis1.74E-032P69905, P68871HBA2, HBBMore
Loracarbefhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Loracarbefhsa05150Staphylococcus aureus infection4.37E-026P21730, P21462, O75015, P13765, Q16581, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4More
Loracarbefhsa05169Epstein-Barr virus infection4.32E-0211P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247More
Loracarbefhsa05202Transcriptional misregulation in cancer8.07E-0414Q15532, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522SS18, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Loracarbefhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Loracarbefhsa05217Basal cell carcinoma1.43E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Loracarbefhsa05321Inflammatory bowel disease7.62E-047O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3More
Loracarbefhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Loracarbef (SDC: 2.88)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
Q16762TSTThiosulfate sulfurtransferasePredicted00.19330.14580.16810.5563
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)