PharmaCoNets of Lopinavir (SPCN: 56.69 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lopinavirhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Lopinavirhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Lopinavirhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Lopinavirhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Lopinavirhsa00190Oxidative phosphorylation3.56E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Lopinavirhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Lopinavirhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Lopinavirhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Lopinavirhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Lopinavirhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Lopinavirhsa00750Vitamin B6 metabolism3.56E-021O00764PDXKMore
Lopinavirhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Lopinavirhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Lopinavirhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Lopinavirhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Lopinavirhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Lopinavirhsa012102-Oxocarboxylic acid metabolism3.56E-021P50213IDH3AMore
Lopinavirhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Lopinavirhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Lopinavirhsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Lopinavirhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Lopinavirhsa03008Ribosome biogenesis in eukaryotes1.37E-034O14980, O60832, P78345, Q9BVP2XPO1, DKC1, RPP38, GNL3More
Lopinavirhsa03013RNA transport2.48E-0513O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3More
Lopinavirhsa03050Proteasome4.83E-021P55036PSMD4More
Lopinavirhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Lopinavirhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Lopinavirhsa04064NF-kappa B signaling pathway6.48E-0416P10415, Q13489, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, P24522, P09341, P19875, Q06643BCL2, BIRC3, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, GADD45A, CXCL1, CXCL2, LTBMore
Lopinavirhsa04071Sphingolipid signaling pathway4.69E-048P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Lopinavirhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Lopinavirhsa04080Neuroactive ligand-receptor interaction1.30E-0210P08311, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1, C3AR1More
Lopinavirhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Lopinavirhsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Lopinavirhsa04145Phagosome6.05E-0510O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Lopinavirhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Lopinavirhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Lopinavirhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Lopinavirhsa04360Axon guidance1.66E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Lopinavirhsa04390Hippo signaling pathway2.30E-023P63261, P04628, O43623ACTG1, WNT1, SNAI2More
Lopinavirhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Lopinavirhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Lopinavirhsa04550Signaling pathways regulating pluripotency of stem cells1.96E-023P04628, P40189, P14653WNT1, IL6ST, HOXB1More
Lopinavirhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Lopinavirhsa04613Neutrophil extracellular trap formation4.18E-0418P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1More
Lopinavirhsa04630JAK-STAT signaling pathway4.43E-023P48551, P40189, Q06124IFNAR2, IL6ST, PTPN11More
Lopinavirhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Lopinavirhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Lopinavirhsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Lopinavirhsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Lopinavirhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Lopinavirhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Lopinavirhsa04666Fc gamma R-mediated phagocytosis1.86E-036O75015, P23528, P06396, O14494, P14598, P17252FCGR3B, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Lopinavirhsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Lopinavirhsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Lopinavirhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Lopinavirhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Lopinavirhsa04916Melanogenesis5.28E-036P0DP23, Q9UJU2, P17252, P49841, Q01726, P04628CALM1, LEF1, PRKCA, GSK3B, MC1R, WNT1More
Lopinavirhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Lopinavirhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Lopinavirhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Lopinavirhsa04940Type I diabetes mellitus4.18E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Lopinavirhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Lopinavirhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Lopinavirhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Lopinavirhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Lopinavirhsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q06055, O15020ATP5G2, SPTBN2More
Lopinavirhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lopinavirhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Lopinavirhsa05132Salmonella infection2.93E-0210P51617, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Lopinavirhsa05133Pertussis4.20E-021P0C0L4C4AMore
Lopinavirhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Lopinavirhsa05140Leishmaniasis8.87E-037O75015, P14598, P13765, O60603, P01375, P51617, Q15080FCGR3B, NCF1, HLA-DOB, TLR2, TNF, IRAK1, NCF4More
Lopinavirhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Lopinavirhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Lopinavirhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Lopinavirhsa05150Staphylococcus aureus infection1.65E-026P21730, P21462, O75015, P13765, Q16581, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMPMore
Lopinavirhsa05152Tuberculosis1.53E-0412Q13488, P0DP23, O75015, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, P51617TCIRG1, CALM1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1More
Lopinavirhsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Lopinavirhsa05202Transcriptional misregulation in cancer2.62E-0312Q12778, Q15532, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Lopinavirhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Lopinavirhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Lopinavirhsa05205Proteoglycans in cancer1.09E-0210Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Lopinavirhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Lopinavirhsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Lopinavirhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Lopinavirhsa05321Inflammatory bowel disease1.14E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Lopinavirhsa05322Systemic lupus erythematosus1.24E-0413O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Lopinavirhsa05332Graft-versus-host disease2.17E-024P13765, P10747, P01375, P26715HLA-DOB, CD28, TNF, KLRC1More
Lopinavirhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Lopinavirhsa05416Viral myocarditis2.30E-022P10747, P63261CD28, ACTG1More

Community members of Lopinavir (SDC: 5.20)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P07384CAPN1CalpainNone1 catalytic subunitPredicted00.0230.14890.60380.9131
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)