PharmaCoNets of Lithium-citrate (SPCN: 29.06 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lithium-citratehsa00051Fructose and mannose metabolism3.92E-033P15121, P19367, P08237AKR1B1, HK1, PFKMMore
Lithium-citratehsa00052Galactose metabolism3.77E-045P06280, P08237, O43451, P15121, P19367GLA, PFKM, MGAM, AKR1B1, HK1More
Lithium-citratehsa00220Arginine biosynthesis2.33E-022P05089, P49448ARG1, GLUD2More
Lithium-citratehsa00500Starch and sucrose metabolism1.37E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lithium-citratehsa00564Glycerophospholipid metabolism3.56E-023P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Lithium-citratehsa00730Thiamine metabolism1.32E-063Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Lithium-citratehsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Lithium-citratehsa01100Metabolic pathways2.92E-0339Q9NR34, Q9Y234, P35790, P05089, Q16772, P30041, P19367, P48426, P22557, P32320, P20839, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, P15121, P08237, O95861, Q9HCC0, P33121, Q86VZ5, P48651, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P14927MAN1C1, LIPT1, CHKA, ARG1, GSTA3, PRDX6, HK1, PIP4K2A, ALAS2, CDA, IMPDH1, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, AKR1B1, PFKM, BPNT1, MCCC2, ACSL1, SGMS1, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, UQCRBMore
Lithium-citratehsa01240Biosynthesis of cofactors3.71E-036Q969G6, P05186, P22557, Q9Y6K8, Q9Y234, O75911RFK, ALPL, ALAS2, AK5, LIPT1, DHRS3More
Lithium-citratehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Lithium-citratehsa03013RNA transport3.61E-0316P62826, P52298, Q09161, O14893, P61326, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, Q14240, P23588, Q9Y6A5, Q14232RAN, NCBP2, NCBP1, GEMIN2, MAGOH, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, EIF4A2, EIF4B, TACC3, EIF2B1More
Lithium-citratehsa03020RNA polymerase6.21E-044P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Lithium-citratehsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Lithium-citratehsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Lithium-citratehsa04024cAMP signaling pathway3.94E-024Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Lithium-citratehsa04060Cytokine-cytokine receptor interaction8.61E-039P14784, P27930, P14778, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, Q93038IL2RB, IL1R2, IL1R1, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNFRSF25More
Lithium-citratehsa04061Viral protein interaction with cytokine and cytokine receptor2.06E-036Q8NHW4, P25024, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Lithium-citratehsa04062Chemokine signaling pathway4.68E-038P25024, P47992, Q9UBD3, P07948, P42338, P63218, P50151, P49407CXCR1, XCL1, XCL2, LYN, PIK3CB, GNG5, GNG10, ARRB1More
Lithium-citratehsa04064NF-kappa B signaling pathway8.99E-0515P10415, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CYLDMore
Lithium-citratehsa04066HIF-1 signaling pathway2.94E-022Q09472, P46527EP300, CDKN1BMore
Lithium-citratehsa04070Phosphatidylinositol signaling system9.86E-034P0DP23, O14986, Q16760, P48426CALM1, PIP5K1B, DGKD, PIP4K2AMore
Lithium-citratehsa04072Phospholipase D signaling pathway2.40E-036P31751, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Lithium-citratehsa04080Neuroactive ligand-receptor interaction2.66E-039P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2, ADMMore
Lithium-citratehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Lithium-citratehsa04114Oocyte meiosis1.35E-025P0DP23, Q08828, P51828, Q13362, Q14738CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Lithium-citratehsa04140Autophagy - animal1.71E-025P31751, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Lithium-citratehsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Lithium-citratehsa04213Longevity regulating pathway - multiple species4.54E-023P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Lithium-citratehsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Lithium-citratehsa04340Hedgehog signaling pathway1.50E-024P17612, P22694, Q13635, P10415PRKACA, PRKACB, PTCH1, BCL2More
Lithium-citratehsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Lithium-citratehsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Lithium-citratehsa04610Complement and coagulation cascades3.19E-021P0C0L4C4AMore
Lithium-citratehsa04612Antigen processing and presentation4.02E-028P13765, P48382, P26715, P26717, Q13241, P01732, P10966, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, CD8B, TNFMore
Lithium-citratehsa04613Neutrophil extracellular trap formation5.71E-0313O60603, P05164, P08246, Q9UM07, Q92769, Q6FI13, P12236, Q15080, P08311, O75015, P21730, P21462, O43315TLR2, MPO, ELA2, PADI4, HDAC2, H2AC18; H2AC19, SLC25A6, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9More
Lithium-citratehsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Lithium-citratehsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Lithium-citratehsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Lithium-citratehsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Lithium-citratehsa04640Hematopoietic cell lineage3.13E-0410P08514, P14778, P27930, P25063, P07766, P01732, P01730, P06127, P09564, P13765ITGA2B, IL1R1, IL1R2, CD24, CD3E, CD8A, CD4, CD5, CD7, HLA-DOBMore
Lithium-citratehsa04657IL-17 signaling pathway1.88E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Lithium-citratehsa04658Th1 and Th2 cell differentiation3.72E-047Q04759, P07766, P20963, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, LCK, TBX21, IL2RB, RUNX3More
Lithium-citratehsa04659Th17 cell differentiation2.67E-0511Q04759, Q16539, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P07766, P20963PRKCQ, MAPK14, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, CD3E, CD247More
Lithium-citratehsa04660T cell receptor signaling pathway9.76E-0514P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P07766, P20963, P09693, P01732, P10966, Q13191, P06239TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CD8B, CBLB, LCKMore
Lithium-citratehsa04662B cell receptor signaling pathway4.02E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Lithium-citratehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Lithium-citratehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Lithium-citratehsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Lithium-citratehsa04720Long-term potentiation4.54E-023P0DP23, P18848, Q08828CALM1, ATF4, ADCY1More
Lithium-citratehsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Lithium-citratehsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Lithium-citratehsa04750Inflammatory mediator regulation of TRP channels4.76E-048P14778, P01584, Q08828, P51828, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PIK3CB, PRKCH, PRKCQ, CALM1More
Lithium-citratehsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Lithium-citratehsa04912GnRH signaling pathway1.39E-024Q08828, P51828, P18848, P0DP23ADCY1, ADCY7, ATF4, CALM1More
Lithium-citratehsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Lithium-citratehsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Lithium-citratehsa04923Regulation of lipolysis in adipocytes5.15E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Lithium-citratehsa04924Renin secretion1.50E-024P17612, P22694, P07550, Q14643PRKACA, PRKACB, ADRB2, ITPR1More
Lithium-citratehsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Lithium-citratehsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Lithium-citratehsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Lithium-citratehsa04932Non-alcoholic fatty liver disease1.04E-025P31751, P18848, O75460, P01584, O95298AKT2, ATF4, ERN1, IL1B, NDUFC2More
Lithium-citratehsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Lithium-citratehsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Lithium-citratehsa04970Salivary secretion1.59E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Lithium-citratehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Lithium-citratehsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Lithium-citratehsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Lithium-citratehsa05014Amyotrophic lateral sclerosis1.41E-024P12074, Q13148, P09651, P49790COX6A1, TARDBP, HNRNPA1, NUP153More
Lithium-citratehsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Lithium-citratehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Lithium-citratehsa05022Pathways of neurodegeneration - multiple diseases1.67E-029O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4More
Lithium-citratehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Lithium-citratehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Lithium-citratehsa05143African trypanosomiasis3.19E-022P69905, P68871HBA2, HBBMore
Lithium-citratehsa05146Amoebiasis6.53E-0511P09341, P14778, P27930, P01375, O60603, P42338, P05089, P17612, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ARG1, PRKACA, PRKACB, ACTN1, CTSGMore
Lithium-citratehsa05163Human cytomegalovirus infection4.02E-0617P31751, P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Lithium-citratehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Lithium-citratehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Lithium-citratehsa05202Transcriptional misregulation in cancer1.11E-0212P41732, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, Q92769, P24522TSPAN7, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC2, GADD45AMore
Lithium-citratehsa05212Pancreatic cancer2.40E-023P31751, Q15311, P23458AKT2, RALBP1, JAK1More
Lithium-citratehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Lithium-citratehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Lithium-citratehsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Lithium-citratehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.97E-0310P42338, O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4More
Lithium-citratehsa05321Inflammatory bowel disease1.40E-026O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Lithium-citratehsa05322Systemic lupus erythematosus4.70E-028O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Lithium-citratehsa05332Graft-versus-host disease3.26E-025P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Lithium-citratehsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore
Lithium-citratehsa05418Fluid shear stress and atherosclerosis1.26E-048Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Lithium-citrate (SDC: 2.31)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)