PharmaCoNets of Lisuride (SPCN: 155.14 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lisuridehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Lisuridehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Lisuridehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Lisuridehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Lisuridehsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Lisuridehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lisuridehsa00520Amino sugar and nucleotide sugar metabolism7.85E-043Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Lisuridehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Lisuridehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Lisuridehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Lisuridehsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Lisuridehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Lisuridehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Lisuridehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Lisuridehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Lisuridehsa01522Endocrine resistance2.16E-021P04049RAF1More
Lisuridehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Lisuridehsa03020RNA polymerase3.03E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Lisuridehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Lisuridehsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Lisuridehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Lisuridehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Lisuridehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Lisuridehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Lisuridehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Lisuridehsa04022cGMP-PKG signaling pathway6.45E-035P04049, P18848, Q8WYR1, P05141, P0DP24RAF1, ATF4, PIK3R5, SLC25A5, CALM2More
Lisuridehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Lisuridehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Lisuridehsa04061Viral protein interaction with cytokine and cytokine receptor1.70E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Lisuridehsa04062Chemokine signaling pathway1.90E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, P04049CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RAF1More
Lisuridehsa04064NF-kappa B signaling pathway2.08E-0618O00463, P14778, P01584, P01375, P19174, Q04759, Q13077, Q16548, P07948, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, TRAF1, BCL2A1, LYN, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Lisuridehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Lisuridehsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Lisuridehsa04071Sphingolipid signaling pathway3.35E-035P04049, P21453, Q9H228, P01375, Q13362RAF1, S1PR1, EDG8, TNF, PPP2R5CMore
Lisuridehsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Lisuridehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Lisuridehsa04114Oocyte meiosis1.35E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Lisuridehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Lisuridehsa04140Autophagy - animal2.82E-021P04049RAF1More
Lisuridehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Lisuridehsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Lisuridehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Lisuridehsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Lisuridehsa04210Apoptosis7.82E-034O75460, O43521, P18848, P04049ERN1, BCL2L11, ATF4, RAF1More
Lisuridehsa04213Longevity regulating pathway - multiple species2.70E-037P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Lisuridehsa04217Necroptosis3.89E-049P01375, P48023, Q14765, P15104, P05141, P01584, P0C0S5, Q99878, Q9H444TNF, FASLG, STAT4, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CHMP4BMore
Lisuridehsa04218Cellular senescence2.49E-021P04049RAF1More
Lisuridehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Lisuridehsa04270Vascular smooth muscle contraction2.27E-037P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Lisuridehsa04360Axon guidance2.49E-021P04049RAF1More
Lisuridehsa04370VEGF signaling pathway9.75E-044P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Lisuridehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Lisuridehsa04380Osteoclast differentiation9.58E-0513Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Lisuridehsa04510Focal adhesion3.48E-021P04049RAF1More
Lisuridehsa04540Gap junction1.33E-021P04049RAF1More
Lisuridehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Lisuridehsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Lisuridehsa04612Antigen processing and presentation9.02E-058P13765, P01730, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Lisuridehsa04613Neutrophil extracellular trap formation1.03E-0318P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Lisuridehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Lisuridehsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Lisuridehsa04625C-type lectin receptor signaling pathway2.21E-0410Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Lisuridehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Lisuridehsa04640Hematopoietic cell lineage6.03E-0615P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1BMore
Lisuridehsa04650Natural killer cell mediated cytotoxicity4.83E-0915P19174, P01375, P78314, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Lisuridehsa04657IL-17 signaling pathway1.06E-049O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Lisuridehsa04658Th1 and Th2 cell differentiation3.66E-1015Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Lisuridehsa04659Th17 cell differentiation1.34E-0815Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Lisuridehsa04660T cell receptor signaling pathway8.29E-0816P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Lisuridehsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Lisuridehsa04664Fc epsilon RI signaling pathway7.50E-034P01375, Q16539, Q9UQC2, P04049TNF, MAPK14, GAB2, RAF1More
Lisuridehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Lisuridehsa04668TNF signaling pathway1.71E-049P01375, O00463, Q16539, P18848, P19875, P01584, P20749, P14780, P20333TNF, TRAF5, MAPK14, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1BMore
Lisuridehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Lisuridehsa04720Long-term potentiation1.06E-024P16298, P51812, Q02750, P04049PPP3CB, RPS6KA3, MAP2K1, RAF1More
Lisuridehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Lisuridehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Lisuridehsa04730Long-term depression1.16E-021P04049RAF1More
Lisuridehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Lisuridehsa04742Taste transduction1.01E-021P30939HTR1FMore
Lisuridehsa04750Inflammatory mediator regulation of TRP channels3.66E-0513P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Lisuridehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Lisuridehsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Lisuridehsa04912GnRH signaling pathway2.74E-027P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694, P04049ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB, RAF1More
Lisuridehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Lisuridehsa04914Progesterone-mediated oocyte maturation5.00E-035Q17RY0, Q9Y6D9, P51812, Q02750, P04049CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Lisuridehsa04915Estrogen signaling pathway1.12E-026P04049, Q08828, P51828, P0DMV8, P0DP23, Q15788RAF1, ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Lisuridehsa04916Melanogenesis1.33E-021P04049RAF1More
Lisuridehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Lisuridehsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Lisuridehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Lisuridehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Lisuridehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Lisuridehsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Lisuridehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Lisuridehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Lisuridehsa04929GnRH secretion4.98E-031P04049RAF1More
Lisuridehsa04932Non-alcoholic fatty liver disease6.81E-0712P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Lisuridehsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Lisuridehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Lisuridehsa04970Salivary secretion2.43E-036P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Lisuridehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Lisuridehsa04976Bile secretion3.14E-035O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Lisuridehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Lisuridehsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Lisuridehsa05016Huntington disease3.74E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Lisuridehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Lisuridehsa05022Pathways of neurodegeneration - multiple diseases6.94E-0413P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2More
Lisuridehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Lisuridehsa05034Alcoholism2.49E-021P04049RAF1More
Lisuridehsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Lisuridehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Lisuridehsa05131Shigellosis2.93E-026Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315RRAGD, UBB, SEPT6, ELMO2, PTK2, ATMMore
Lisuridehsa05132Salmonella infection4.98E-021P04049RAF1More
Lisuridehsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Lisuridehsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Lisuridehsa05140Leishmaniasis2.29E-029P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4More
Lisuridehsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Lisuridehsa05144Malaria1.74E-036P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Lisuridehsa05146Amoebiasis4.49E-0714P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Lisuridehsa05152Tuberculosis3.98E-021P04049RAF1More
Lisuridehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Lisuridehsa05161Hepatitis B1.99E-021P04049RAF1More
Lisuridehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Lisuridehsa05163Human cytomegalovirus infection2.02E-0314P04049, P01375, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, O00463RAF1, TNF, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TRAF5More
Lisuridehsa05164Influenza A3.65E-021P04049RAF1More
Lisuridehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Lisuridehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Lisuridehsa05170Human immunodeficiency virus 1 infection1.21E-026P04049, Q02750, P62879, P16298, Q05397, Q13315RAF1, MAP2K1, GNB2, PPP3CB, PTK2, ATMMore
Lisuridehsa05202Transcriptional misregulation in cancer6.59E-0315P17844, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522DDX5, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Lisuridehsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Lisuridehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Lisuridehsa05210Colorectal cancer1.66E-021P04049RAF1More
Lisuridehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Lisuridehsa05212Pancreatic cancer1.16E-021P04049RAF1More
Lisuridehsa05213Endometrial cancer9.95E-031P04049RAF1More
Lisuridehsa05214Glioma9.95E-031P04049RAF1More
Lisuridehsa05215Prostate cancer1.33E-021P04049RAF1More
Lisuridehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Lisuridehsa05218Melanoma6.63E-031P04049RAF1More
Lisuridehsa05219Bladder cancer4.98E-031P04049RAF1More
Lisuridehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Lisuridehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Lisuridehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Lisuridehsa05224Breast cancer1.49E-021P04049RAF1More
Lisuridehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Lisuridehsa05226Gastric cancer8.29E-031P04049RAF1More
Lisuridehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Lisuridehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Lisuridehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.36E-0513P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, CD4More
Lisuridehsa05321Inflammatory bowel disease7.47E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Lisuridehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Lisuridehsa05332Graft-versus-host disease9.47E-055P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Lisuridehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Lisuridehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Lisuridehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Lisuride (SDC: 7.68)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416Ki0.5
DRD2P14416Ki0.66
DRD2P14416Ki0.8