PharmaCoNets of Lisinopril (SPCN: 19.34 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lisinoprilhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Lisinoprilhsa00190Oxidative phosphorylation2.05E-044Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Lisinoprilhsa00500Starch and sucrose metabolism2.87E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lisinoprilhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Lisinoprilhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Lisinoprilhsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Lisinoprilhsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Lisinoprilhsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Lisinoprilhsa04060Cytokine-cytokine receptor interaction3.95E-0211P27930, P08476, Q13651, P25024, P25025, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL10RA, CXCR1, CXCR2, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Lisinoprilhsa04061Viral protein interaction with cytokine and cytokine receptor1.31E-027P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNFMore
Lisinoprilhsa04071Sphingolipid signaling pathway1.94E-026Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Lisinoprilhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Lisinoprilhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Lisinoprilhsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Lisinoprilhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Lisinoprilhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Lisinoprilhsa04612Antigen processing and presentation1.81E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Lisinoprilhsa04640Hematopoietic cell lineage2.20E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Lisinoprilhsa04650Natural killer cell mediated cytotoxicity4.63E-039P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Lisinoprilhsa04657IL-17 signaling pathway3.52E-026O00463, Q16539, P09341, P14780, P80188, P01375TRAF5, MAPK14, CXCL1, MMP9, LCN2, TNFMore
Lisinoprilhsa04658Th1 and Th2 cell differentiation4.23E-0510Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Lisinoprilhsa04659Th17 cell differentiation1.22E-0311P25963, Q04759, Q16539, P06239, P13765, Q9UL17, P23771, P84022, Q13485, P09693, P20963NFKBIA, PRKCQ, MAPK14, LCK, HLA-DOB, TBX21, GATA3, SMAD3, SMAD4, CD3G, CD247More
Lisinoprilhsa04660T cell receptor signaling pathway1.60E-0310P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14More
Lisinoprilhsa04668TNF signaling pathway1.81E-027P01375, O00463, Q16539, P18848, P09341, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL1, BCL3, MMP9More
Lisinoprilhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Lisinoprilhsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Lisinoprilhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Lisinoprilhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Lisinoprilhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Lisinoprilhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Lisinoprilhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Lisinoprilhsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Lisinoprilhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Lisinoprilhsa05144Malaria4.23E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Lisinoprilhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Lisinoprilhsa05146Amoebiasis9.15E-037P09341, P27930, P01375, P05089, P22694, P12814, P08311CXCL1, IL1R2, TNF, ARG1, PRKACB, ACTN1, CTSGMore
Lisinoprilhsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Lisinoprilhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Lisinoprilhsa05202Transcriptional misregulation in cancer1.95E-0212P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Lisinoprilhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Lisinoprilhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Lisinoprilhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Lisinoprilhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Lisinoprilhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Lisinoprilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.52E-026O95267, P20963, P09693, P06239, Q04759, Q16539RASGRP1, CD247, CD3G, LCK, PRKCQ, MAPK14More
Lisinoprilhsa05310Asthma1.29E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Lisinoprilhsa05321Inflammatory bowel disease8.46E-046O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Lisinoprilhsa05322Systemic lupus erythematosus4.08E-027O75015, P08246, P08311, P01375, P13765, Q16778, P12814FCGR3B, ELA2, CTSG, TNF, HLA-DOB, HIST2H2BE, ACTN1More
Lisinoprilhsa05332Graft-versus-host disease5.27E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More

Community members of Lisinopril (SDC: 2.78)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P05089ARG1ArginaseNone1Predicted10.46310.01790.29750.5648
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)