PharmaCoNets of Lipoic-acid (SPCN: 3.30 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lipoic-acidhsa00280Valine, leucine and isoleucine degradation4.31E-023Q9HCC0, Q02252, P11310MCCC2, ALDH6A1, ACADMMore
Lipoic-acidhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Lipoic-acidhsa00520Amino sugar and nucleotide sugar metabolism2.21E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Lipoic-acidhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series9.01E-032P06865, O75752HEXA, B3GALNT1More
Lipoic-acidhsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Lipoic-acidhsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Lipoic-acidhsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Lipoic-acidhsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Lipoic-acidhsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Lipoic-acidhsa04064NF-kappa B signaling pathway3.23E-027P10415, Q12933, Q13546, Q9UDY8, Q13077, P10145, P19784BCL2, TRAF2, RIPK1, MALT1, TRAF1, IL8, CSNK2A2More
Lipoic-acidhsa04071Sphingolipid signaling pathway4.94E-025Q9BX95, P04637, P10415, Q86VZ5, Q12933SGPP1, TP53, BCL2, SGMS1, TRAF2More
Lipoic-acidhsa04114Oocyte meiosis2.19E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Lipoic-acidhsa04370VEGF signaling pathway1.35E-023P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Lipoic-acidhsa04622RIG-I-like receptor signaling pathway1.76E-035P01568, Q9H1Y0, Q13546, Q12933, P10145IFNA21, ATG5, RIPK1, TRAF2, IL8More
Lipoic-acidhsa04914Progesterone-mediated oocyte maturation2.81E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Lipoic-acidhsa05131Shigellosis4.92E-026Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315RRAGD, UBB, SEPT6, ELMO2, PTK2, ATMMore
Lipoic-acidhsa05132Salmonella infection1.96E-0210P10145, P57764, Q12933, Q13546, P10415, O75369, O60603, P51808, Q13561, Q13509IL8, GSDMDC1, TRAF2, RIPK1, BCL2, FLNB, TLR2, DYNLT3, DCTN2, TUBB3More
Lipoic-acidhsa05133Pertussis3.88E-034P05107, P0DP23, P10145, P0C0L4ITGB2, CALM1, IL8, C4AMore
Lipoic-acidhsa05144Malaria3.88E-035P69905, P68871, O60603, P05107, P10145HBA2, HBB, TLR2, ITGB2, IL8More
Lipoic-acidhsa05152Tuberculosis1.86E-028P0DP23, P05107, P48382, P25208, O60603, P10415, P01568, Q9UDY8CALM1, ITGB2, RFX5, NFYB, TLR2, BCL2, IFNA21, MALT1More
Lipoic-acidhsa05170Human immunodeficiency virus 1 infection1.65E-026Q02750, P62879, P16298, Q05397, Q13315, P23528MAP2K1, GNB2, PPP3CB, PTK2, ATM, CFL1More
Lipoic-acidhsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Lipoic-acidhsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More

Community members of Lipoic-acid (SDC: 1.18)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)