PharmaCoNets of Lindane (SPCN: 8.72 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lindanehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Lindanehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Lindanehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Lindanehsa03050Proteasome1.40E-021P55036PSMD4More
Lindanehsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Lindanehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Lindanehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Lindanehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Lindanehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Lindanehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Lindanehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Lindanehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Lindanehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Lindanehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Lindanehsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Lindanehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Lindanehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Lindanehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Lindanehsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Lindanehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Lindanehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Lindanehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Lindanehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Lindanehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Lindanehsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Lindanehsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Lindanehsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Lindanehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Lindanehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Lindanehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Lindanehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Lindanehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Lindanehsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Lindanehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Lindanehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Lindanehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Lindanehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Lindanehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Lindanehsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Lindanehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Lindanehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Lindane (SDC: 1.84)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonPredicted00.13940.40970.15791.0469
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)