PharmaCoNets of Linagliptin (SPCN: 47.79 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Linagliptinhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Linagliptinhsa00500Starch and sucrose metabolism3.88E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Linagliptinhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Linagliptinhsa00730Thiamine metabolism3.79E-022P05186, P24666ALPL, ACP1More
Linagliptinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Linagliptinhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Linagliptinhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Linagliptinhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Linagliptinhsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Linagliptinhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Linagliptinhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Linagliptinhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Linagliptinhsa04012ErbB signaling pathway1.91E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Linagliptinhsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Linagliptinhsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Linagliptinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Linagliptinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Linagliptinhsa04064NF-kappa B signaling pathway1.89E-0314P10415, O00463, P14778, P01375, P19174, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643BCL2, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTBMore
Linagliptinhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Linagliptinhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Linagliptinhsa04071Sphingolipid signaling pathway2.06E-027Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Linagliptinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Linagliptinhsa04080Neuroactive ligand-receptor interaction2.54E-027P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADMMore
Linagliptinhsa04110Cell cycle2.06E-026Q9UBD5, P06493, Q14683, P30304, P33981, P01106ORC3, CDK1, SMC1A, CDC25A, TTK, MYCMore
Linagliptinhsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Linagliptinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Linagliptinhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Linagliptinhsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Linagliptinhsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Linagliptinhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Linagliptinhsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Linagliptinhsa04213Longevity regulating pathway - multiple species1.17E-025P42338, P08069, Q9Y4H2, P11142, Q13547PIK3CB, IGF1R, IRS2, HSPA8, HDAC1More
Linagliptinhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Linagliptinhsa04340Hedgehog signaling pathway1.43E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Linagliptinhsa04510Focal adhesion3.48E-021P08069IGF1RMore
Linagliptinhsa04520Adherens junction8.29E-031P08069IGF1RMore
Linagliptinhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Linagliptinhsa04613Neutrophil extracellular trap formation1.37E-0212O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Linagliptinhsa04621NOD-like receptor signaling pathway2.64E-0210Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4More
Linagliptinhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Linagliptinhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Linagliptinhsa04657IL-17 signaling pathway1.28E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Linagliptinhsa04658Th1 and Th2 cell differentiation4.07E-0614Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Linagliptinhsa04659Th17 cell differentiation2.41E-0413Q04759, Q16539, P19174, P06239, P42226, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Linagliptinhsa04660T cell receptor signaling pathway1.40E-0414P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Linagliptinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Linagliptinhsa04730Long-term depression1.16E-021P08069IGF1RMore
Linagliptinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Linagliptinhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Linagliptinhsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Linagliptinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Linagliptinhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Linagliptinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Linagliptinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Linagliptinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Linagliptinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Linagliptinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Linagliptinhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Linagliptinhsa05150Staphylococcus aureus infection4.37E-026P21730, P21462, O75015, P13765, Q16581, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4More
Linagliptinhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Linagliptinhsa05169Epstein-Barr virus infection4.32E-0211P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247More
Linagliptinhsa05202Transcriptional misregulation in cancer9.73E-0515Q15532, P14780, P27930, Q16548, Q13077, Q15652, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522SS18, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Linagliptinhsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Linagliptinhsa05214Glioma9.95E-031P08069IGF1RMore
Linagliptinhsa05215Prostate cancer1.33E-021P08069IGF1RMore
Linagliptinhsa05217Basal cell carcinoma1.43E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Linagliptinhsa05218Melanoma6.63E-031P08069IGF1RMore
Linagliptinhsa05224Breast cancer1.49E-021P08069IGF1RMore
Linagliptinhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Linagliptinhsa05231Choline metabolism in cancer2.60E-023Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Linagliptinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Linagliptinhsa05321Inflammatory bowel disease7.62E-047O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3More
Linagliptinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Linagliptinhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Linagliptin (SDC: 4.72)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)