PharmaCoNets of Linaclotide (SPCN: 21.98 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Linaclotidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Linaclotidehsa00220Arginine biosynthesis1.54E-022P05089, P49448ARG1, GLUD2More
Linaclotidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Linaclotidehsa00910Nitrogen metabolism2.93E-022P22748, P49448CA4, GLUD2More
Linaclotidehsa00983Drug metabolism - other enzymes3.20E-023P04183, P32320, P05164TK1, CDA, MPOMore
Linaclotidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Linaclotidehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Linaclotidehsa04060Cytokine-cytokine receptor interaction5.39E-0310P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Linaclotidehsa04061Viral protein interaction with cytokine and cytokine receptor4.81E-039P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Linaclotidehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Linaclotidehsa04064NF-kappa B signaling pathway3.68E-0412O00463, P14778, P01375, P19174, Q04759, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643TRAF5, IL1R1, TNF, PLCG1, PRKCQ, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Linaclotidehsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Linaclotidehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Linaclotidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Linaclotidehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Linaclotidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Linaclotidehsa04612Antigen processing and presentation9.89E-037P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Linaclotidehsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Linaclotidehsa04640Hematopoietic cell lineage2.01E-0310P14778, P27930, P11215, P25063, P07766, P09693, P01732, P09564, P13765, P01375IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNFMore
Linaclotidehsa04650Natural killer cell mediated cytotoxicity2.22E-0511P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Linaclotidehsa04657IL-17 signaling pathway2.52E-037O00463, Q16539, P09341, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, CXCL1, MMP9, ANAPC5, LCN2, TNFMore
Linaclotidehsa04658Th1 and Th2 cell differentiation1.40E-0612Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Linaclotidehsa04659Th17 cell differentiation1.74E-0512Q04759, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Linaclotidehsa04660T cell receptor signaling pathway2.81E-0512P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Linaclotidehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Linaclotidehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Linaclotidehsa04964Proximal tubule bicarbonate reclamation2.74E-033P22748, P00918, P49448CA4, CA2, GLUD2More
Linaclotidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Linaclotidehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Linaclotidehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Linaclotidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Linaclotidehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Linaclotidehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Linaclotidehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Linaclotidehsa05146Amoebiasis1.01E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Linaclotidehsa05202Transcriptional misregulation in cancer1.84E-0416Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Linaclotidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.13E-038P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQMore
Linaclotidehsa05310Asthma3.20E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Linaclotidehsa05321Inflammatory bowel disease1.25E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Linaclotidehsa05322Systemic lupus erythematosus3.90E-026P08246, P08311, P01375, P13765, Q16778, P12814ELA2, CTSG, TNF, HLA-DOB, HIST2H2BE, ACTN1More
Linaclotidehsa05332Graft-versus-host disease2.55E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Linaclotidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Linaclotide (SDC: 3.54)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)