PharmaCoNets of Lidocaine (SPCN: 68.84 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lidocainehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Lidocainehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Lidocainehsa00250Alanine, aspartate and glutamate metabolism8.48E-032Q96RQ9, P15104IL4I1, GLULMore
Lidocainehsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Lidocainehsa00280Valine, leucine and isoleucine degradation8.40E-056P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Lidocainehsa00310Lysine degradation4.50E-022Q9NVH6, O15047TMLHE, SETD1AMore
Lidocainehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lidocainehsa00630Glyoxylate and dicarboxylate metabolism4.20E-074P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Lidocainehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Lidocainehsa00983Drug metabolism - other enzymes2.07E-033P04183, P32320, P05164TK1, CDA, MPOMore
Lidocainehsa01100Metabolic pathways2.28E-0321Q9UJ14, P30041, P15104, Q96DU7, Q08828, Q02153, P20839, P40926, P08237, Q86XP1, Q96RQ9, Q9UHK6, Q86VZ5, Q9H4F1, Q9BRR6, P05166, P12074, P05496, O15239, O15047, Q9NVH6GGTL3, PRDX6, GLUL, ITPKC, ADCY1, GUCY1B3, IMPDH1, MDH2, PFKM, DGKH, IL4I1, AMACR, SGMS1, ST6GALNAC4, ADPGK, PCCB, COX6A1, ATP5G1, NDUFA1, SETD1A, TMLHEMore
Lidocainehsa01522Endocrine resistance4.07E-045P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Lidocainehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Lidocainehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Lidocainehsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Lidocainehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Lidocainehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Lidocainehsa03040Spliceosome8.73E-048Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, O43447DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, PPIHMore
Lidocainehsa03450Non-homologous end-joining4.48E-031P78527PRKDCMore
Lidocainehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Lidocainehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Lidocainehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Lidocainehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Lidocainehsa04070Phosphatidylinositol signaling system3.21E-035P0DP23, P42338, Q86XP1, P27987, Q96DU7CALM1, PIK3CB, DGKH, ITPKB, ITPKCMore
Lidocainehsa04071Sphingolipid signaling pathway1.70E-035Q9H228, P01375, Q13362, Q9BX95, P10415EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Lidocainehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Lidocainehsa04110Cell cycle1.35E-021P78527PRKDCMore
Lidocainehsa04137Mitophagy - animal3.55E-044Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Lidocainehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Lidocainehsa04146Peroxisome4.38E-034O43933, O96011, P56589, P33121PEX1, PEX11B, PEX3, ACSL1More
Lidocainehsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Lidocainehsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Lidocainehsa04330Notch signaling pathway1.30E-043Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Lidocainehsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Lidocainehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Lidocainehsa04613Neutrophil extracellular trap formation6.84E-0822P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, Q16778, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Lidocainehsa04621NOD-like receptor signaling pathway2.77E-038Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Lidocainehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Lidocainehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Lidocainehsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Lidocainehsa04657IL-17 signaling pathway1.14E-037P07900, O00463, Q16539, P49841, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, MMP9, TNF, IL1BMore
Lidocainehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Lidocainehsa04659Th17 cell differentiation1.89E-0411Q04759, P19174, P06239, P42224, P14784, P14778, P40189, Q9UL17, P08238, P07766, P20963PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL1R1, IL6ST, TBX21, HSP90AB1, CD3E, CD247More
Lidocainehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Lidocainehsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Lidocainehsa04664Fc epsilon RI signaling pathway2.20E-036P01375, Q16539, P42338, Q9UQC2, P07948, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5More
Lidocainehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Lidocainehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Lidocainehsa04713Circadian entrainment9.20E-034Q13557, Q02153, P61952, Q08828CAMK2D, GUCY1B3, GNG11, ADCY1More
Lidocainehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Lidocainehsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Lidocainehsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Lidocainehsa04727GABAergic synapse4.58E-046Q08828, P63218, P50151, P61952, P15104, Q15111ADCY1, GNG5, GNG10, GNG11, GLUL, PLCL1More
Lidocainehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Lidocainehsa04911Insulin secretion3.04E-023Q08828, Q99941, Q13557ADCY1, CREBL1, CAMK2DMore
Lidocainehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Lidocainehsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Lidocainehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Lidocainehsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Lidocainehsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Lidocainehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Lidocainehsa04932Non-alcoholic fatty liver disease9.01E-047P49841, P18848, P01584, P13073, O15239, Q16718, O14521GSK3B, ATF4, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Lidocainehsa04934Cushing syndrome9.20E-034Q99941, Q08828, O15169, Q13557CREBL1, ADCY1, AXIN1, CAMK2DMore
Lidocainehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Lidocainehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Lidocainehsa05010Alzheimer disease2.41E-028P49768, Q92542, O15239, P05496, P12074, Q12933, O15169, P43686PSEN1, NCSTN, NDUFA1, ATP5G1, COX6A1, TRAF2, AXIN1, PSMC4More
Lidocainehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Lidocainehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Lidocainehsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Lidocainehsa05022Pathways of neurodegeneration - multiple diseases2.24E-0520P49841, O15239, Q16718, O14521, P13073, P12074, P05496, P18848, Q12933, Q13561, P05141, Q16539, O15169, P01584, P49768, Q08752, O15020, Q13557, P62987, P43686GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, ATF4, TRAF2, DCTN2, SLC25A5, MAPK14, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CAMK2D, UBA52, PSMC4More
Lidocainehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Lidocainehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Lidocainehsa05131Shigellosis3.32E-039P01375, O00463, Q04759, Q9UDY8, Q9H1Y0, P20810, O43524, P10415, Q96A32TNF, TRAF5, PRKCQ, MALT1, ATG5, CAST, FOXO3, BCL2, MYLPFMore
Lidocainehsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Lidocainehsa05144Malaria9.55E-044O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Lidocainehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Lidocainehsa05150Staphylococcus aureus infection6.42E-058P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Lidocainehsa05152Tuberculosis7.83E-047O75015, P48382, O60603, P01375, P10415, P49913, Q9UDY8FCGR3B, RFX5, TLR2, TNF, BCL2, CAMP, MALT1More
Lidocainehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Lidocainehsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Lidocainehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Lidocainehsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Lidocainehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Lidocainehsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Lidocainehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Lidocainehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Lidocainehsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Lidocainehsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Lidocainehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Lidocainehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Lidocainehsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore
Lidocainehsa05418Fluid shear stress and atherosclerosis1.40E-0411Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Lidocaine (SDC: 4.91)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P02763ORM1AlphaNone1Noneacid glycoprotein 1Reported10.05530.057900.1435
P19652ORM2AlphaNone1Noneacid glycoprotein 2Reported10.09380.057900.1628
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P26358DNMT1DNAPredicted00.34040.28090.26590.998
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)