PharmaCoNets of Levothyroxine (SPCN: 11.59 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Levothyroxinehsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Levothyroxinehsa00440Phosphonate and phosphinate metabolism2.16E-021Q9Y6K0CEPT1More
Levothyroxinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Levothyroxinehsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Levothyroxinehsa00564Glycerophospholipid metabolism2.52E-023P48651, Q9Y6K0, Q86XP1PTDSS1, CEPT1, DGKHMore
Levothyroxinehsa00565Ether lipid metabolism4.27E-021Q9Y6K0CEPT1More
Levothyroxinehsa00740Riboflavin metabolism2.16E-021Q969G6RFKMore
Levothyroxinehsa00785Lipoic acid metabolism4.27E-021Q9Y234LIPT1More
Levothyroxinehsa00983Drug metabolism - other enzymes3.10E-022P20839, Q16772IMPDH1, GSTA3More
Levothyroxinehsa01100Metabolic pathways2.79E-0214Q9Y234, Q16772, Q02153, P20839, O94777, Q9Y6K0, Q86XP1, Q9UHK6, Q86VZ5, P48651, Q969G6, P14927, Q06055, Q9NVH6LIPT1, GSTA3, GUCY1B3, IMPDH1, DPM2, CEPT1, DGKH, AMACR, SGMS1, PTDSS1, RFK, UQCRB, ATP5G2, TMLHEMore
Levothyroxinehsa01240Biosynthesis of cofactors1.75E-022Q969G6, Q9Y234RFK, LIPT1More
Levothyroxinehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Levothyroxinehsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Levothyroxinehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Levothyroxinehsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Levothyroxinehsa03420Nucleotide excision repair4.91E-022P07992, P54727ERCC1, RAD23BMore
Levothyroxinehsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Levothyroxinehsa04020Calcium signaling pathway5.81E-047Q96DU7, Q13557, P21860, P05141, P12236, P26678, P63092ITPKC, CAMK2D, ERBB3, SLC25A5, SLC25A6, PLN, GNASMore
Levothyroxinehsa04022cGMP-PKG signaling pathway2.71E-049P24844, P61586, P26678, Q99941, P18848, Q8WYR1, P05141, P12236, Q15746MYL9, RHOA, PLN, CREBL1, ATF4, PIK3R5, SLC25A5, SLC25A6, MYLKMore
Levothyroxinehsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Levothyroxinehsa04151PI3K-Akt signaling pathway1.36E-029P21860, P27348, O14944, P07900, Q15831, P22105, Q99941, P18848, O95988ERBB3, YWHAQ, EREG, HSP90AA1, STK11, TNXB, CREBL1, ATF4, TCL1BMore
Levothyroxinehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Levothyroxinehsa04261Adrenergic signaling in cardiomyocytes3.12E-025P63092, Q99941, P18848, P26678, Q13557GNAS, CREBL1, ATF4, PLN, CAMK2DMore
Levothyroxinehsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Levothyroxinehsa04330Notch signaling pathway4.91E-022P49768, P78504PSEN1, JAG1More
Levothyroxinehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Levothyroxinehsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Levothyroxinehsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Levothyroxinehsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Levothyroxinehsa04520Adherens junction4.91E-022P07947, P19784YES1, CSNK2A2More
Levothyroxinehsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Levothyroxinehsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Levothyroxinehsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Levothyroxinehsa04622RIG-I-like receptor signaling pathway1.63E-022Q12933, P10145TRAF2, IL8More
Levothyroxinehsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Levothyroxinehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Levothyroxinehsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Levothyroxinehsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Levothyroxinehsa04911Insulin secretion4.47E-034P63092, Q99941, P18848, Q13557GNAS, CREBL1, ATF4, CAMK2DMore
Levothyroxinehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Levothyroxinehsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Levothyroxinehsa04925Aldosterone synthesis and secretion1.68E-024Q99941, P18848, P63092, Q13557CREBL1, ATF4, GNAS, CAMK2DMore
Levothyroxinehsa04927Cortisol synthesis and secretion2.40E-023Q99941, P18848, P63092CREBL1, ATF4, GNASMore
Levothyroxinehsa04928Parathyroid hormone synthesis, secretion and action2.33E-024P63092, P61586, Q99941, P18848GNAS, RHOA, CREBL1, ATF4More
Levothyroxinehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Levothyroxinehsa04934Cushing syndrome1.37E-035Q99941, P18848, P63092, O15169, Q13557CREBL1, ATF4, GNAS, AXIN1, CAMK2DMore
Levothyroxinehsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Levothyroxinehsa05010Alzheimer disease1.36E-029Q92542, O15239, P05496, P18848, O15169, P05141, P12236, P43686, P62195NCSTN, NDUFA1, ATP5G1, ATF4, AXIN1, SLC25A5, SLC25A6, PSMC4, PSMC5More
Levothyroxinehsa05012Parkinson disease2.88E-039O15239, P05496, P05141, P12236, P63092, P18848, P43686, P62195, Q13557NDUFA1, ATP5G1, SLC25A5, SLC25A6, GNAS, ATF4, PSMC4, PSMC5, CAMK2DMore
Levothyroxinehsa05014Amyotrophic lateral sclerosis3.92E-028P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214More
Levothyroxinehsa05020Prion disease1.15E-029P46531, O15239, P05496, P18848, P05141, P12236, P43686, P62195, Q99941NOTCH1, NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, CREBL1More
Levothyroxinehsa05022Pathways of neurodegeneration - multiple diseases1.57E-0210O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5More
Levothyroxinehsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Levothyroxinehsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Levothyroxinehsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Levothyroxinehsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Levothyroxinehsa05144Malaria1.17E-023P68871, P05107, P10145HBB, ITGB2, IL8More
Levothyroxinehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Levothyroxinehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Levothyroxinehsa05203Viral carcinogenesis7.09E-036Q99941, P18848, P27348, Q15283, P61586, P61978CREBL1, ATF4, YWHAQ, RASA2, RHOA, HNRPKMore
Levothyroxinehsa05206MicroRNAs in cancer1.54E-026P21860, P61978, P46531, P63279, P22105, P61586ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RHOAMore
Levothyroxinehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Levothyroxinehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Levothyroxinehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Levothyroxinehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Levothyroxinehsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Levothyroxinehsa05415Diabetic cardiomyopathy1.92E-026P05141, P12236, O15239, P05496, Q13557, P26678SLC25A5, SLC25A6, NDUFA1, ATP5G1, CAMK2D, PLNMore

Community members of Levothyroxine (SDC: 1.55)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P40926MDH2Malate dehydrogenase, mitochondrialPredicted00.47210.16110.24740.8055
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P05107ITGB2Integrin betaNone2Predicted10.19860.0080.94341.0587
P26012ITGB8Integrin betaNone8Predicted00.12270.02490.5130.6241
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)