PharmaCoNets

PharmaCoNets of Levosimendan (S_PCN: 11.36 )

Levosimendan regulated-network (S_DN: 15.36)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Levosimendan

hsa00071

Fatty acid degradation

2.52E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Levosimendan

hsa00190

Oxidative phosphorylation

1.07E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Levosimendan

hsa00500

Starch and sucrose metabolism

1.07E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Levosimendan

hsa00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

4.77E-02

Q7LGA3

HS2ST1

Levosimendan

hsa00630

Glyoxylate and dicarboxylate metabolism

4.12E-03

P40925, P15104

MDH1, GLUL

Levosimendan

hsa00730

Thiamine metabolism

8.96E-04

Q9Y6K8, P05186, P24666

AK5, ALPL, ACP1

Levosimendan

hsa00760

Nicotinate and nicotinamide metabolism

3.52E-02

P21589

NT5E

Levosimendan

hsa00770

Pantothenate and CoA biosynthesis

2.27E-02

O95498, O95497

VNN2, VNN1

Levosimendan

hsa00970

Aminoacyl-tRNA biosynthesis

2.77E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Levosimendan

hsa01100

Metabolic pathways

3.52E-02

P05089, O95455, P21953, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q9UNP4, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737

ARG1, TGDS, BCKDHB, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, ST3GAL5, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P05089	ARG1	Arginase-1	0.807
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	O95455	TGDS	dTDP-D-glucose 4,6-dehydratase	-0.716
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P21953	BCKDHB	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	-0.709
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P32320	CDA	Cytidine deaminase	0.714
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P11766	ADH5	Alcohol dehydrogenase class-3	-0.857
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P06280	GLA	Alpha-galactosidase A	0.706
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.919
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.779
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	O43451	MGAM	Maltase-glucoamylase	0.925
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.883
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.715
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.71
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.74
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	Q08477	CYP4F3	Cytochrome P450 4F3	0.793
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P15907	ST6GAL1	Beta-galactoside alpha-2,6-sialyltransferase 1	-0.722
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.726
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P37837	TALDO1	Transaldolase	0.843
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P32321	DCTD	Deoxycytidylate deaminase	-0.737
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.899
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.709
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.899
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P46976	GYG1	Glycogenin-1	0.866
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P06737	PYGL	Glycogen phosphorylase, liver form	0.783

Levosimendan

hsa01524

Platinum drug resistance

4.45E-02

P10415, Q13489, P78417, P43246

BCL2, BIRC3, GSTO1, MSH2

Levosimendan

hsa02010

ABC transporters

4.89E-02

Q99758

ABCA3

Levosimendan

hsa03040

Spliceosome

6.64E-08

Q14562, O43143, O60508, P17844, P08579, O75940, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O43447

DHX8, DHX15, CDC40, DDX5, SNRPB2, SMNDC1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, PPIH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.853
P0DP25	CALM3	Calmodulin-3	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP24	CALM2	Calmodulin-2	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP23	CALM1	Calmodulin-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.818
P0DP25	CALM3	Calmodulin-3	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP24	CALM2	Calmodulin-2	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP23	CALM1	Calmodulin-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP25	CALM3	Calmodulin-3	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP23	CALM1	Calmodulin-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.734
P0DP25	CALM3	Calmodulin-3	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P0DP24	CALM2	Calmodulin-2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P0DP23	CALM1	Calmodulin-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.786
P0DP24	CALM2	Calmodulin-2	Q15365	PCBP1	Poly(rC)-binding protein 1	0.75
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.73
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.776
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.758
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.87
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP25	CALM3	Calmodulin-3	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP23	CALM1	Calmodulin-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP25	CALM3	Calmodulin-3	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P0DP24	CALM2	Calmodulin-2	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P0DP23	CALM1	Calmodulin-1	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748

Levosimendan

hsa04014

Ras signaling pathway

1.72E-04

P31751, P20827, Q9NRA1, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P19174

AKT2, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P20827	EFNA1	Ephrin-A1	0.783
P0DP25	CALM3	Calmodulin-3	P20827	EFNA1	Ephrin-A1	-0.795
P0DP23	CALM1	Calmodulin-1	P20827	EFNA1	Ephrin-A1	-0.795
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9NRA1	PDGFC	Platelet-derived growth factor C	0.766
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49767	VEGFC	Vascular endothelial growth factor C	0.761
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP25	CALM3	Calmodulin-3	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
P0DP23	CALM1	Calmodulin-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	Q15311	RALBP1	RalA-binding protein 1	0.858
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.833
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744

Levosimendan

hsa04015

Rap1 signaling pathway

8.16E-04

P20827, Q9NRA1, P49767, Q13009, Q08828, P51828, P31751, P0DP23, P17252, P19174

EFNA1, PDGFC, VEGFC, TIAM1, ADCY1, ADCY7, AKT2, CALM1, PRKCA, PLCG1

Levosimendan

hsa04020

Calcium signaling pathway

7.32E-08

P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P20020, P23634, Q9NRA1, P49767

ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP25	CALM3	Calmodulin-3	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP24	CALM2	Calmodulin-2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP23	CALM1	Calmodulin-1	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP24	CALM2	Calmodulin-2	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP23	CALM1	Calmodulin-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P20020	ATP2B1	Plasma membrane calcium-transporting ATPase 1	0.763
P0DP25	CALM3	Calmodulin-3	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP24	CALM2	Calmodulin-2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP23	CALM1	Calmodulin-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9NRA1	PDGFC	Platelet-derived growth factor C	0.766
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49767	VEGFC	Vascular endothelial growth factor C	0.761
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84

Levosimendan

hsa04024

cAMP signaling pathway

3.01E-03

Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009

ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1

Levosimendan

hsa04060

Cytokine-cytokine receptor interaction

4.71E-02

P78552, O75509

IL13RA1, TNFRSF21

Levosimendan

hsa04062

Chemokine signaling pathway

2.04E-02

P51684, Q8NHW4, P19174, P62873, Q08828, P51828, Q13009, P14598, P42224, P31751

CCR6, CCL4L2, PLCG1, GNB1, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2

Levosimendan

hsa04064

NF-kappa B signaling pathway

2.28E-04

P10415, Q13489, P51617, P01584, P29965, P19174, O75293, Q8NHW4, Q9NQC7

BCL2, BIRC3, IRAK1, IL1B, CD40LG, PLCG1, GADD45B, CCL4L2, CYLD

Levosimendan

hsa04070

Phosphatidylinositol signaling system

7.22E-05

P19174, P0DP23, P23743, P48426, P27987, P17252

PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCA

Levosimendan

hsa04071

Sphingolipid signaling pathway

3.36E-02

P17252, Q13510, Q13362, P10415, Q9UQC2, P01042

PRKCA, ASAH1, PPP2R5C, BCL2, GAB2, KNG1

Levosimendan

hsa04072

Phospholipase D signaling pathway

2.44E-03

P31751, Q92529, P19174, P17252, Q14344, Q15438, Q08828, P51828, P23743, P00734

AKT2, SHC3, PLCG1, PRKCA, GNA13, PSCD1, ADCY1, ADCY7, DGKA, F2

Levosimendan

hsa04140

Autophagy - animal

2.58E-02

P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9

AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8

Levosimendan

hsa04144

Endocytosis

8.99E-03

P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7

HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6

Levosimendan

hsa04145

Phagosome

1.22E-02

P60709, P63261, Q15080, P14598, Q13509, P68371, Q13488

ACTB, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1

Levosimendan

hsa04150

mTOR signaling pathway

2.23E-02

P42338, Q13322, P49841

PIK3CB, GRB10, GSK3B

Levosimendan

hsa04151

PI3K-Akt signaling pathway

4.68E-03

O43521, P27348, P20827, P49767, Q13362, P08238, P62873, P16144, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8

BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, GNB1, ITGB4, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1

Levosimendan

hsa04210

Apoptosis

6.18E-03

P07384, P60709, P63261

CAPN1, ACTB, ACTG1

Levosimendan

hsa04217

Necroptosis

1.82E-09

P01568, P23458, Q13489, Q9NQC7, P42224, P08238, P01584, P0C0S5, Q6FI13, Q93077, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351, Q08752

IFNA21, JAK1, BIRC3, CYLD, STAT1, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, HIST1H2AC, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.778
P0DP23	CALM1	Calmodulin-1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.883
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	P0C0S5	H2AFZ	Histone H2A.Z	0.749
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.75
P0DP25	CALM3	Calmodulin-3	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP24	CALM2	Calmodulin-2	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP23	CALM1	Calmodulin-1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q93077	HIST1H2AC	Histone H2A type 1-C	0.715
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP24	CALM2	Calmodulin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.713
P0DP23	CALM1	Calmodulin-1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.73
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.881
P0DP25	CALM3	Calmodulin-3	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP24	CALM2	Calmodulin-2	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP23	CALM1	Calmodulin-1	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP24	CALM2	Calmodulin-2	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.763
P0DP23	CALM1	Calmodulin-1	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.713
P0DP23	CALM1	Calmodulin-1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.784
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.728

Levosimendan

hsa04261

Adrenergic signaling in cardiomyocytes

4.43E-06

P09493, Q08828, P51828, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634

TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4

Levosimendan

hsa04360

Axon guidance

7.54E-05

P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P19174

CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, PLCG1

Levosimendan

hsa04371

Apelin signaling pathway

3.08E-02

P62873, P31751, Q08828, P51828, Q13370, Q13485, P0DP23

GNB1, AKT2, ADCY1, ADCY7, PDE3B, SMAD4, CALM1

Levosimendan

hsa04380

Osteoclast differentiation

6.79E-03

Q9NQC7, Q9UQC2, P23458, P42224, P06239, P42338, P01584, P14778, Q15080, P14598, Q8N149

CYLD, GAB2, JAK1, STAT1, LCK, PIK3CB, IL1B, IL1R1, NCF4, NCF1, LILRA2

Levosimendan

hsa04390

Hippo signaling pathway

2.80E-02

P60709, P63261

ACTB, ACTG1

Levosimendan

hsa04510

Focal adhesion

3.76E-02

P16144, O75369, Q15942, P17252, Q13489, P10415, P49767

ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFC

Levosimendan

hsa04520

Adherens junction

1.58E-02

P60709, P63261

ACTB, ACTG1

Levosimendan

hsa04530

Tight junction

3.88E-03

P60709, P63261, P60660

ACTB, ACTG1, MYL6

Levosimendan

hsa04540

Gap junction

2.22E-03

P17252, Q13509, P68371, Q08828, P51828, Q9NRA1

PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7, PDGFC

Levosimendan

hsa04611

Platelet activation

2.61E-02

P60709, P63261

ACTB, ACTG1

Levosimendan

hsa04620

Toll-like receptor signaling pathway

1.33E-02

P51617, P01568, P31751, P42224, Q8NHW4

IRAK1, IFNA21, AKT2, STAT1, CCL4L2

Levosimendan

hsa04621

NOD-like receptor signaling pathway

1.89E-03

P01584, P08238, Q16539, P23458, P42224, P01568, Q9H3M7, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838

IL1B, HSP90AB1, MAPK14, JAK1, STAT1, IFNA21, TXNIP, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4

Levosimendan

hsa04623

Cytosolic DNA-sensing pathway

3.53E-03

P01568, P25963, Q8NHW4

IFNA21, NFKBIA, CCL4L2

Levosimendan

hsa04630

JAK-STAT signaling pathway

1.16E-02

P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568

AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21

Levosimendan

hsa04657

IL-17 signaling pathway

8.67E-04

P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, P04141, P01375, P06702

NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, CSF2, TNF, S100A9

Levosimendan

hsa04659

Th17 cell differentiation

4.12E-02

P06239, P14784, P14778, P07766

LCK, IL2RB, IL1R1, CD3E

Levosimendan

hsa04660

T cell receptor signaling pathway

3.80E-02

P04141, P25963, P10747, P19174, P16333, P29350

CSF2, NFKBIA, CD28, PLCG1, NCK1, PTPN6

Levosimendan

hsa04662

B cell receptor signaling pathway

7.09E-04

P25963, P49841, P42338, P20023, P21854, Q8N149

NFKBIA, GSK3B, PIK3CB, CR2, CD72, LILRA2

Levosimendan

hsa04666

Fc gamma R-mediated phagocytosis

2.78E-02

P08575, P19174, P23528, Q9UQC2, P14598, P17252

PTPRC, PLCG1, CFL1, GAB2, NCF1, PRKCA

Levosimendan

hsa04670

Leukocyte transendothelial migration

4.07E-02

P60709, P63261

ACTB, ACTG1

Levosimendan

hsa04713

Circadian entrainment

5.73E-06

O15399, P0DP23, Q13557, P17252, P62873, Q08828, P51828, O15055

GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, ADCY1, ADCY7, PER2

Levosimendan

hsa04714

Thermogenesis

3.64E-04

P15336, P60709, P63261, P36542

ATF2, ACTB, ACTG1, ATP5C1

Levosimendan

hsa04720

Long-term potentiation

3.26E-03

P17252, Q13557, P0DP23, P18848, O15399, Q08828

PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1

Levosimendan

hsa04724

Glutamatergic synapse

4.08E-02

O15399, Q08828, P51828, P17252, P62873

GRIN2D, ADCY1, ADCY7, PRKCA, GNB1

Levosimendan

hsa04725

Cholinergic synapse

4.42E-04

Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415

ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2

Levosimendan

hsa04727

GABAergic synapse

4.08E-02

Q08828, P51828, P62873, P46459, P17252

ADCY1, ADCY7, GNB1, NSF, PRKCA

Levosimendan

hsa04730

Long-term depression

3.52E-02

Q14344

GNA13

Levosimendan

hsa04740

Olfactory transduction

2.61E-02

P62873, Q13557, P0DP23

GNB1, CAMK2D, CALM1

Levosimendan

hsa04744

Phototransduction

2.17E-07

P62873, P0DP23

GNB1, CALM1

Levosimendan

hsa04750

Inflammatory mediator regulation of TRP channels

5.09E-06

P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P17252, P24723, P0DP23, P01042

IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCA, PRKCH, CALM1, KNG1

Levosimendan

hsa04911

Insulin secretion

3.47E-02

Q08828, P17252, P18848, Q13557

ADCY1, PRKCA, ATF4, CAMK2D

Levosimendan

hsa04912

GnRH signaling pathway

2.85E-02

P17252, Q08828, P18848, Q13557, P0DP23

PRKCA, ADCY1, ATF4, CAMK2D, CALM1

Levosimendan

hsa04914

Progesterone-mediated oocyte maturation

3.26E-02

Q08828, P51828, P31751, Q13370, Q9UJX4, P08238

ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1

Levosimendan

hsa04915

Estrogen signaling pathway

3.28E-03

P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415

ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2

Levosimendan

hsa04919

Thyroid hormone signaling pathway

3.20E-02

P60709, P63261

ACTB, ACTG1

Levosimendan

hsa04921

Oxytocin signaling pathway

1.77E-03

P60660, P60709, P63261

MYL6, ACTB, ACTG1

Levosimendan

hsa04923

Regulation of lipolysis in adipocytes

2.12E-02

Q08828, P51828, Q13370, P31751

ADCY1, ADCY7, PDE3B, AKT2

Levosimendan

hsa04925

Aldosterone synthesis and secretion

6.45E-04

P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634

ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4

Levosimendan

hsa04929

GnRH secretion

3.63E-02

P42338, P49407

PIK3CB, ARRB1

Levosimendan

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.13E-07

Q13485, P01584, P42224, P10415, P31751, Q12778, P49767, P17252, P19174

SMAD4, IL1B, STAT1, BCL2, AKT2, FOXO1, VEGFC, PRKCA, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP25	CALM3	Calmodulin-3	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP23	CALM1	Calmodulin-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q12778	FOXO1	Forkhead box protein O1	0.753
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49767	VEGFC	Vascular endothelial growth factor C	0.761
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744

Levosimendan

hsa04935

Growth hormone synthesis, secretion and action

3.93E-02

P19174, Q08828, P51828, P17252, P31751, P42224

PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1

Levosimendan

hsa04960

Aldosterone-regulated sodium reabsorption

4.38E-02

P48048

KCNJ1

Levosimendan

hsa04970

Salivary secretion

1.35E-03

Q08828, P51828, P23634, P17252, P0DP23

ADCY1, ADCY7, ATP2B4, PRKCA, CALM1

Levosimendan

hsa04971

Gastric acid secretion

1.02E-02

P60709, P63261

ACTB, ACTG1

Levosimendan

hsa04972

Pancreatic secretion

1.92E-03

P23634, P17252, Q08828, P51828, P62491

ATP2B4, PRKCA, ADCY1, ADCY7, RAB11A

Levosimendan

hsa04973

Carbohydrate digestion and absorption

4.12E-03

O43451, P42338

MGAM, PIK3CB

Levosimendan

hsa05012

Parkinson disease

3.12E-02

Q16718, O14521, P19174, P0DP23, Q13509, P68371

NDUFA5, SDHD, PLCG1, CALM1, TUBB3, TUBB2C

Levosimendan

hsa05014

Amyotrophic lateral sclerosis

2.98E-02

P36542, P60709, P63261

ATP5C1, ACTB, ACTG1

Levosimendan

hsa05017

Spinocerebellar ataxia

1.75E-02

P17252, O75460, Q8TB72, O15399, P31751, P28070, O00232

PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMD12

Levosimendan

hsa05022

Pathways of neurodegeneration - multiple diseases

2.29E-02

Q13509, P68371, Q16718, O14521, Q13561, P19174, P17252, Q08752, P0DP23

TUBB3, TUBB2C, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, PPID, CALM1

Levosimendan

hsa05031

Amphetamine addiction

2.85E-02

O15399, P0DP23, Q13557, P18848, P17252

GRIN2D, CALM1, CAMK2D, ATF4, PRKCA

Levosimendan

hsa05032

Morphine addiction

4.08E-02

Q08828, P51828, P62873, Q13370, P17252

ADCY1, ADCY7, GNB1, PDE3B, PRKCA

Levosimendan

hsa05100

Bacterial invasion of epithelial cells

1.02E-02

P60709, P63261

ACTB, ACTG1

Levosimendan

hsa05110

Vibrio cholerae infection

6.20E-04

Q13488, P17252, P19174, P60709, P63261

TCIRG1, PRKCA, PLCG1, ACTB, ACTG1

Levosimendan

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.27E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Levosimendan

hsa05131

Shigellosis

1.91E-02

P60709, P63261, P07384

ACTB, ACTG1, CAPN1

Levosimendan

hsa05132

Salmonella infection

2.92E-05

P51617, P01584, P25963, P08238, Q96RF0, Q13489, P10415, P04406, P08575, O75369, Q13561, Q13509, P68371, P49754, Q9NP90

IRAK1, IL1B, NFKBIA, HSP90AB1, SNAG1, BIRC3, BCL2, GAPDH, PTPRC, FLNB, DCTN2, TUBB3, TUBB2C, VPS41, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	Q96RF0	SNAG1	Sorting nexin-18	0.703
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.76
P0DP24	CALM2	Calmodulin-2	P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	0.716
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75369	FLNB	Filamin-B	-0.715
P0DP25	CALM3	Calmodulin-3	O75369	FLNB	Filamin-B	0.874
P0DP24	CALM2	Calmodulin-2	O75369	FLNB	Filamin-B	0.874
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13561	DCTN2	Dynactin subunit 2	-0.744
P0DP25	CALM3	Calmodulin-3	Q13561	DCTN2	Dynactin subunit 2	0.739
P0DP24	CALM2	Calmodulin-2	Q13561	DCTN2	Dynactin subunit 2	0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13509	TUBB3	Tubulin beta-3 chain	-0.808
P0DP25	CALM3	Calmodulin-3	Q13509	TUBB3	Tubulin beta-3 chain	0.892
P0DP24	CALM2	Calmodulin-2	Q13509	TUBB3	Tubulin beta-3 chain	0.892
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P68371	TUBB2C	Tubulin beta-4B chain	-0.721
P0DP25	CALM3	Calmodulin-3	P68371	TUBB2C	Tubulin beta-4B chain	0.742
P0DP24	CALM2	Calmodulin-2	P68371	TUBB2C	Tubulin beta-4B chain	0.742
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	-0.718
P0DP25	CALM3	Calmodulin-3	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.791

Levosimendan

hsa05133

Pertussis

3.94E-04

P0DP23, P01584, P23528, P09871, P51617

CALM1, IL1B, CFL1, C1S, IRAK1

Levosimendan

hsa05135

Yersinia infection

3.88E-03

P60709, P63261, Q16513

ACTB, ACTG1, PKN2

Levosimendan

hsa05140

Leishmaniasis

1.16E-03

P13612, O75015, P14598, P42224, P25963, P01375, P29350, P49006, Q16539, Q15080

ITGA4, FCGR3B, NCF1, STAT1, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4

Levosimendan

hsa05143

African trypanosomiasis

3.87E-02

P01584, P17252, P01042

IL1B, PRKCA, KNG1

Levosimendan

hsa05145

Toxoplasmosis

5.28E-05

P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651

IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RA

Levosimendan

hsa05146

Amoebiasis

4.20E-02

P09341, P14778, P27930, P01375, P05089

CXCL1, IL1R1, IL1R2, TNF, ARG1

Levosimendan

hsa05161

Hepatitis B

1.31E-04

P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617

PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1

Levosimendan

hsa05162

Measles

1.74E-04

P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415

IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2

Levosimendan

hsa05163

Human cytomegalovirus infection

3.30E-04

P31751, P01375, P62873, P50151, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, P18848, O00463, P61769, P01568

AKT2, TNF, GNB1, GNG10, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TRAF5, B2M, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P01375	TNF	Tumor necrosis factor	0.701
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.742
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.82
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.701
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	P25025	CXCR2	C-X-C chemokine receptor type 2	0.928
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.868
P0DP24	CALM2	Calmodulin-2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
Q99712	KCNJ15	ATP-sensitive inward rectifier potassium channel 15	O00463	TRAF5	TNF receptor-associated factor 5	-0.769
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852

Levosimendan

hsa05164

Influenza A

7.10E-03

P48551, P60709, P63261

IFNAR2, ACTB, ACTG1

Levosimendan

hsa05167

Kaposi sarcoma-associated herpesvirus infection

5.71E-03

P01568, P42224, P25963, P40189, P62873, P19174, P04141, P0DP23

IFNA21, STAT1, NFKBIA, IL6ST, GNB1, PLCG1, CSF2, CALM1

Levosimendan

hsa05168

Herpes simplex virus 1 infection

5.39E-07

P25963, P01568, P01584, Q9UBU9, Q9GZY0, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, P52738, O75820, Q9UDV6, P10415, Q14232

NFKBIA, IFNA21, IL1B, NXF1, NXF2; NXF2B, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF140, ZNF189, ZNF212, BCL2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.772
P0DP23	CALM1	Calmodulin-1	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.743
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.704
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.776
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.758
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.87
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13398	ZNF211	Zinc finger protein 211	-0.759
P0DP25	CALM3	Calmodulin-3	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP24	CALM2	Calmodulin-2	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP23	CALM1	Calmodulin-1	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP23	CALM1	Calmodulin-1	Q6P280	ZNF529	Zinc finger protein 529	0.767
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q03923	ZNF85	Zinc finger protein 85	0.79
P0DP25	CALM3	Calmodulin-3	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP24	CALM2	Calmodulin-2	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP23	CALM1	Calmodulin-1	Q03923	ZNF85	Zinc finger protein 85	-0.818
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P52738	ZNF140	Zinc finger protein 140	0.717
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75820	ZNF189	Zinc finger protein 189	0.715
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9UDV6	ZNF212	Zinc finger protein 212	-0.808
P0DP25	CALM3	Calmodulin-3	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP24	CALM2	Calmodulin-2	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP23	CALM1	Calmodulin-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.797

Levosimendan

hsa05170

Human immunodeficiency virus 1 infection

4.12E-05

P31751, P62873, P0DP23, P61073, P17252, P61769, P01568, P51617, P19174, P23528, P10415, Q9Y6Q5

AKT2, GNB1, CALM1, CXCR4, PRKCA, B2M, IFNA21, IRAK1, PLCG1, CFL1, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP25	CALM3	Calmodulin-3	P23528	CFL1	Cofilin-1	-0.832
P0DP24	CALM2	Calmodulin-2	P23528	CFL1	Cofilin-1	-0.832
P0DP23	CALM1	Calmodulin-1	P23528	CFL1	Cofilin-1	-0.832
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP24	CALM2	Calmodulin-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP23	CALM1	Calmodulin-1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742

Levosimendan

hsa05171

Coronavirus disease - COVID-19

1.36E-02

P25963, P42224, P01568, P40189, P04141, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCA

Levosimendan

hsa05200

Pathways in cancer

3.38E-10

P23458, P08238, P42224, P25963, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, Q12778, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P40189, P16871, P00734, P01042

JAK1, HSP90AB1, STAT1, NFKBIA, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, FOXO1, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL6ST, IL7R, F2, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	Q15311	RALBP1	RalA-binding protein 1	0.858
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P43246	MSH2	DNA mismatch repair protein Msh2	-0.768
P0DP25	CALM3	Calmodulin-3	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP24	CALM2	Calmodulin-2	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP23	CALM1	Calmodulin-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP25	CALM3	Calmodulin-3	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP23	CALM1	Calmodulin-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P14923	JUP	Junction plakoglobin	0.735
P0DP25	CALM3	Calmodulin-3	P14923	JUP	Junction plakoglobin	-0.852
P0DP24	CALM2	Calmodulin-2	P14923	JUP	Junction plakoglobin	-0.852
P0DP23	CALM1	Calmodulin-1	P14923	JUP	Junction plakoglobin	-0.852
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49767	VEGFC	Vascular endothelial growth factor C	0.761
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q12778	FOXO1	Forkhead box protein O1	0.753
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.833
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP25	CALM3	Calmodulin-3	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP24	CALM2	Calmodulin-2	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP23	CALM1	Calmodulin-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.713
P0DP25	CALM3	Calmodulin-3	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP23	CALM1	Calmodulin-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	Q15788	NCOA1	Nuclear receptor coactivator 1	0.731
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP24	CALM2	Calmodulin-2	O43521	BCL2L11	Bcl-2-like protein 11	0.75
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP24	CALM2	Calmodulin-2	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP23	CALM1	Calmodulin-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P40189	IL6ST	Interleukin-6 receptor subunit beta	-0.746
P0DP23	CALM1	Calmodulin-1	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.718
P0DP23	CALM1	Calmodulin-1	P00734	F2	Prothrombin	-0.738
P0DP25	CALM3	Calmodulin-3	P01042	KNG1	Kininogen-1	-0.71
P0DP24	CALM2	Calmodulin-2	P01042	KNG1	Kininogen-1	-0.71
P0DP23	CALM1	Calmodulin-1	P01042	KNG1	Kininogen-1	-0.71