PharmaCoNets of Levorphanol (SPCN: 203.15 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Levorphanolhsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Levorphanolhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Levorphanolhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Levorphanolhsa00190Oxidative phosphorylation2.22E-054Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Levorphanolhsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Levorphanolhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Levorphanolhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Levorphanolhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Levorphanolhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Levorphanolhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Levorphanolhsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Levorphanolhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Levorphanolhsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Levorphanolhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Levorphanolhsa00970Aminoacyl-tRNA biosynthesis3.94E-064O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Levorphanolhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Levorphanolhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Levorphanolhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Levorphanolhsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Levorphanolhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Levorphanolhsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Levorphanolhsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Levorphanolhsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Levorphanolhsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Levorphanolhsa03008Ribosome biogenesis in eukaryotes1.31E-047Q9NYH9, O14980, O60832, P78345, Q9BVP2, O15381, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NVL, NXF2; NXF2BMore
Levorphanolhsa03010Ribosome1.03E-022P46777, P50914RPL5, RPL14More
Levorphanolhsa03013RNA transport8.71E-1117O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1More
Levorphanolhsa03020RNA polymerase5.06E-032P24928, P62487POLR2A, POLR2GMore
Levorphanolhsa03022Basal transcription factors2.97E-033P20226, O00268, Q15544TBP, TAF4, TAF11More
Levorphanolhsa03040Spliceosome5.79E-037Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19More
Levorphanolhsa03050Proteasome1.21E-021P28074PSMB5More
Levorphanolhsa03430Mismatch repair4.38E-021P20585MSH3More
Levorphanolhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Levorphanolhsa04010MAPK signaling pathway1.23E-033P08069, Q9H2K8, Q12933IGF1R, TAOK3, TRAF2More
Levorphanolhsa04012ErbB signaling pathway3.31E-021Q13153PAK1More
Levorphanolhsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Levorphanolhsa04015Rap1 signaling pathway3.62E-049P20827, P49767, P08069, P06213, P63261, P25116, O00522, P0DP23, P17252EFNA1, VEGFC, IGF1R, INSR, ACTG1, F2R, KRIT1, CALM1, PRKCAMore
Levorphanolhsa04020Calcium signaling pathway1.16E-037Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Levorphanolhsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Levorphanolhsa04024cAMP signaling pathway7.32E-036P0DP23, P23634, Q16566, O15399, P25116, Q13153CALM1, ATP2B4, CAMK4, GRIN2D, F2R, PAK1More
Levorphanolhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Levorphanolhsa04062Chemokine signaling pathway2.43E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Levorphanolhsa04064NF-kappa B signaling pathway3.88E-0417P10415, Q13489, P51617, Q13546, P14778, P29965, P19174, Q04759, Q9UDY8, Q13077, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643BCL2, BIRC3, IRAK1, RIPK1, IL1R1, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Levorphanolhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Levorphanolhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Levorphanolhsa04070Phosphatidylinositol signaling system3.54E-035P0DP23, Q14643, P23743, O14732, P17252CALM1, ITPR1, DGKA, IMPA2, PRKCAMore
Levorphanolhsa04071Sphingolipid signaling pathway2.48E-0611P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415, Q12933, Q02156PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, TRAF2, PRKCEMore
Levorphanolhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Levorphanolhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Levorphanolhsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Levorphanolhsa04114Oocyte meiosis3.19E-035P51812, Q02750, P16298, Q17RY0, P08069RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Levorphanolhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Levorphanolhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Levorphanolhsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Levorphanolhsa04142Lysosome3.31E-023P43234, Q9UBR2, P34059CTSO, CTSZ, GALNSMore
Levorphanolhsa04145Phagosome9.66E-059P63261, Q15080, P14598, Q13509, P68371, Q13488, O60603, P27824, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, CANX, HLA-DOBMore
Levorphanolhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Levorphanolhsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Levorphanolhsa04151PI3K-Akt signaling pathway1.65E-0316P62753, P25116, O43521, P27348, P49767, Q13362, Q8WYR1, P62873, P16144, O60603, P01568, P18848, P10415, P17252, O00141, Q6ZUJ8RPS6, F2R, BCL2L11, YWHAQ, VEGFC, PPP2R5C, PIK3R5, GNB1, ITGB4, TLR2, IFNA21, ATF4, BCL2, PRKCA, SGK, PIK3AP1More
Levorphanolhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Levorphanolhsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Levorphanolhsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Levorphanolhsa04213Longevity regulating pathway - multiple species1.14E-035P42338, P08069, Q9Y4H2, P11142, Q13547PIK3CB, IGF1R, IRS2, HSPA8, HDAC1More
Levorphanolhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Levorphanolhsa04217Necroptosis1.53E-0516P01375, P01568, P48023, Q13489, P42224, Q14765, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, PPIDMore
Levorphanolhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Levorphanolhsa04261Adrenergic signaling in cardiomyocytes2.45E-0410P09493, P07550, P22694, P18848, Q13362, Q16537, P0DP23, P17252, P10415, P20020TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Levorphanolhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Levorphanolhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Levorphanolhsa04390Hippo signaling pathway9.73E-046P63261, P84022, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD3, SMAD4, LEF1, SNAI2, BIRC3More
Levorphanolhsa04392Hippo signaling pathway - multiple species1.51E-021Q13153PAK1More
Levorphanolhsa04510Focal adhesion9.88E-037Q15942, P17252, Q13489, P10415, P08069, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, IGF1R, VEGFC, ACTG1More
Levorphanolhsa04520Adherens junction2.26E-035Q13485, Q9UJU2, O43623, P08069, P63261SMAD4, LEF1, SNAI2, IGF1R, ACTG1More
Levorphanolhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Levorphanolhsa04540Gap junction1.53E-034P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Levorphanolhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Levorphanolhsa04610Complement and coagulation cascades1.29E-052P00734, P0C0L4F2, C4AMore
Levorphanolhsa04612Antigen processing and presentation9.45E-059P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Levorphanolhsa04613Neutrophil extracellular trap formation5.01E-0720P17252, P11215, O60603, P08246, Q13547, Q92769, P04908, Q6FI13, Q93077, P58876, P62807, P33778, Q16778, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, ELA2, HDAC1, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Levorphanolhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Levorphanolhsa04622RIG-I-like receptor signaling pathway2.47E-021Q12933TRAF2More
Levorphanolhsa04625C-type lectin receptor signaling pathway3.31E-021Q13153PAK1More
Levorphanolhsa04630JAK-STAT signaling pathway1.44E-024P01106, Q09472, P48551, P16871MYC, EP300, IFNAR2, IL7RMore
Levorphanolhsa04640Hematopoietic cell lineage9.75E-0513P21926, P14778, P27930, P11215, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P16871CD9, IL1R1, IL1R2, ITGAM, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, IL7RMore
Levorphanolhsa04650Natural killer cell mediated cytotoxicity1.47E-1118P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13153, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Levorphanolhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Levorphanolhsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Levorphanolhsa04659Th17 cell differentiation1.43E-0411P25963, Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P07766, P20963NFKBIA, PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, CD3E, CD247More
Levorphanolhsa04660T cell receptor signaling pathway1.93E-0615P01375, Q04759, P42338, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Levorphanolhsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Levorphanolhsa04668TNF signaling pathway2.67E-036P01375, P18848, P19875, P01584, P14780, P20333TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1BMore
Levorphanolhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Levorphanolhsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Levorphanolhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Levorphanolhsa04720Long-term potentiation2.69E-068P17252, Q16566, P16298, P0DP23, P51812, O15399, Q02750, Q14643PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1, ITPR1More
Levorphanolhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Levorphanolhsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Levorphanolhsa04725Cholinergic synapse1.88E-024Q14643, P17252, P62873, P10415ITPR1, PRKCA, GNB1, BCL2More
Levorphanolhsa04728Dopaminergic synapse2.76E-0311Q14643, P17252, P14416, P62873, P63218, P50151, P49841, Q16539, P49407, Q13362, P0DP23ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, CALM1More
Levorphanolhsa04730Long-term depression1.16E-021P08069IGF1RMore
Levorphanolhsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Levorphanolhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Levorphanolhsa04912GnRH signaling pathway3.85E-033P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Levorphanolhsa04913Ovarian steroidogenesis5.67E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Levorphanolhsa04914Progesterone-mediated oocyte maturation5.89E-034P08069, Q17RY0, P51812, Q02750IGF1R, CPEB4, RPS6KA3, MAP2K1More
Levorphanolhsa04916Melanogenesis3.55E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Levorphanolhsa04919Thyroid hormone signaling pathway4.44E-023P60709, Q09472, P01106ACTB, EP300, MYCMore
Levorphanolhsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Levorphanolhsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Levorphanolhsa04923Regulation of lipolysis in adipocytes4.24E-034P07550, P06213, P42338, Q9Y4H2ADRB2, INSR, PIK3CB, IRS2More
Levorphanolhsa04924Renin secretion7.38E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Levorphanolhsa04925Aldosterone synthesis and secretion2.90E-046Q14643, P0DP23, P17252, Q16566, P20020, P23634ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4More
Levorphanolhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Levorphanolhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Levorphanolhsa04930Type II diabetes mellitus1.28E-032P06213, Q02156INSR, PRKCEMore
Levorphanolhsa04932Non-alcoholic fatty liver disease1.52E-0510P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHDMore
Levorphanolhsa04933AGE-RAGE signaling pathway in diabetic complications6.24E-057P84022, Q13485, P42224, P10415, Q12778, P49767, P17252SMAD3, SMAD4, STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Levorphanolhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Levorphanolhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Levorphanolhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Levorphanolhsa04966Collecting duct acid secretion1.13E-044Q13488, P02730, P00918, Q9Y666TCIRG1, SLC4A1, CA2, SLC12A7More
Levorphanolhsa04970Salivary secretion4.63E-058P07550, P22694, Q14643, P20020, P23634, P17252, P0DP23, P49913ADRB2, PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1, CAMPMore
Levorphanolhsa04971Gastric acid secretion4.76E-023P17252, P63261, P0DP23PRKCA, ACTG1, CALM1More
Levorphanolhsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Levorphanolhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Levorphanolhsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Levorphanolhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Levorphanolhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Levorphanolhsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Levorphanolhsa05010Alzheimer disease5.01E-0313Q16718, O14521, P13073, Q14643, O75460, P0DP23, P0DP24, P01584, P18848, Q13509, P68371, P05141, Q08752NDUFA5, SDHD, COX4I1, ITPR1, ERN1, CALM1, CALM2, IL1B, ATF4, TUBB3, TUBB2C, SLC25A5, PPIDMore
Levorphanolhsa05012Parkinson disease4.51E-0311Q16718, O14521, P13073, P05141, O75460, P18848, Q14643, P0DP23, P0DP24, Q13509, P68371NDUFA5, SDHD, COX4I1, SLC25A5, ERN1, ATF4, ITPR1, CALM1, CALM2, TUBB3, TUBB2CMore
Levorphanolhsa05014Amyotrophic lateral sclerosis3.61E-0317O15399, P01375, P10415, Q16718, O14521, P36542, Q13509, P68371, P09651, Q53GS7, Q7Z3B4, P35658, P43243, P63261, Q09161, Q16629, Q9GZY0GRIN2D, TNF, BCL2, NDUFA5, SDHD, ATP5C1, TUBB3, TUBB2C, HNRNPA1, GLE1, NUP54, NUP214, MATR3, ACTG1, NCBP1, SFRS7, NXF2; NXF2BMore
Levorphanolhsa05016Huntington disease4.87E-025P13073, P24928, P62487, P05141, O75460COX4I1, POLR2A, POLR2G, SLC25A5, ERN1More
Levorphanolhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Levorphanolhsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Levorphanolhsa05022Pathways of neurodegeneration - multiple diseases2.05E-0519Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P17252, P20333, Q16539, P01584, Q08752, P0DP23, P0DP24ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, IL1B, PPID, CALM1, CALM2More
Levorphanolhsa05031Amphetamine addiction1.61E-037O15399, P0DP23, Q16566, P22694, P18848, P17252, Q13547GRIN2D, CALM1, CAMK4, PRKACB, ATF4, PRKCA, HDAC1More
Levorphanolhsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Levorphanolhsa05120Epithelial cell signaling in Helicobacter pylori infection3.15E-058Q16539, Q13153, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, PAK1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Levorphanolhsa05131Shigellosis3.33E-0310Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Levorphanolhsa05132Salmonella infection7.94E-0714P51617, P25963, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, NFKBIA, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Levorphanolhsa05133Pertussis1.79E-044P0DP23, P23528, P09871, P0C0L4CALM1, CFL1, C1S, C4AMore
Levorphanolhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Levorphanolhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Levorphanolhsa05140Leishmaniasis1.06E-048P14598, P42224, P13765, O60603, P29350, P49006, P51617, Q15080NCF1, STAT1, HLA-DOB, TLR2, PTPN6, MARCKSL1, IRAK1, NCF4More
Levorphanolhsa05143African trypanosomiasis1.11E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Levorphanolhsa05144Malaria1.30E-057P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Levorphanolhsa05145Toxoplasmosis1.02E-037P25963, P10415, Q13489, P42224, P13765, O60603, P29965NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Levorphanolhsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Levorphanolhsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Levorphanolhsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Levorphanolhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Levorphanolhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Levorphanolhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Levorphanolhsa05164Influenza A8.62E-034Q09472, P48551, P29728, P60709EP300, IFNAR2, OAS2, ACTBMore
Levorphanolhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Levorphanolhsa05167Kaposi sarcoma-associated herpesvirus infection3.04E-0310P01568, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1More
Levorphanolhsa05168Herpes simplex virus 1 infection1.94E-029Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2More
Levorphanolhsa05169Epstein-Barr virus infection1.47E-0312P20023, P01106, Q92769, P04637, Q13546, P10415, P24522, P48551, O60603, P29728, P51617, P09693CR2, MYC, HDAC2, TP53, RIPK1, BCL2, GADD45A, IFNAR2, TLR2, OAS2, IRAK1, CD3GMore
Levorphanolhsa05170Human immunodeficiency virus 1 infection2.10E-0617Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q13546, Q14643, P01568, P51617, O60603, Q13315, P09693, P10415, Q9Y6Q5, P20333MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, ITPR1, IFNA21, IRAK1, TLR2, ATM, CD3G, BCL2, AP1M2, TNFRSF1BMore
Levorphanolhsa05171Coronavirus disease - COVID-191.93E-024P48551, P29728, P46777, P50914IFNAR2, OAS2, RPL5, RPL14More
Levorphanolhsa05200Pathways in cancer2.66E-0315P42224, Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P78417, P0DP23, P01568STAT1, LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GSTO1, CALM1, IFNA21More
Levorphanolhsa05202Transcriptional misregulation in cancer8.55E-045P27930, P11215, P08069, Q13547, P12980IL1R2, ITGAM, IGF1R, HDAC1, LYL1More
Levorphanolhsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Levorphanolhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Levorphanolhsa05205Proteoglycans in cancer1.09E-026P14780, P01375, P08069, P23588, Q13635, P22694MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACBMore
Levorphanolhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Levorphanolhsa05211Renal cell carcinoma3.42E-033Q09472, Q99814, Q13153EP300, EPAS1, PAK1More
Levorphanolhsa05212Pancreatic cancer4.21E-033P37173, P84022, Q13485TGFBR2, SMAD3, SMAD4More
Levorphanolhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Levorphanolhsa05214Glioma1.39E-046P08069, P0DP23, Q16566, P17252, P04637, P24522IGF1R, CALM1, CAMK4, PRKCA, TP53, GADD45AMore
Levorphanolhsa05215Prostate cancer1.33E-021P08069IGF1RMore
Levorphanolhsa05216Thyroid cancer1.58E-035P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Levorphanolhsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Levorphanolhsa05218Melanoma6.63E-031P08069IGF1RMore
Levorphanolhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Levorphanolhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Levorphanolhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Levorphanolhsa05224Breast cancer1.49E-021P08069IGF1RMore
Levorphanolhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Levorphanolhsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Levorphanolhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.99E-048P42338, P19174, P07766, P20963, P06239, Q04759, Q9HC35, P01730PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ, EML4, CD4More
Levorphanolhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Levorphanolhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Levorphanolhsa05322Systemic lupus erythematosus2.33E-0712P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Levorphanolhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Levorphanolhsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Levorphanolhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Levorphanolhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Levorphanolhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Levorphanolhsa05415Diabetic cardiomyopathy1.58E-037P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3BMore
Levorphanolhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Levorphanolhsa05418Fluid shear stress and atherosclerosis2.49E-0311Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Levorphanol (SDC: 7.80)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07101THTyrosine 3NonemonooxygenasePredicted00.04320.08880.49370.6929
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P11511CYP19A1AromatasePredicted00.815610.15882.5666
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)