PharmaCoNets of Levonordefrin (SPCN: 74.36 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Levonordefrinhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Levonordefrinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Levonordefrinhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Levonordefrinhsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Levonordefrinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Levonordefrinhsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Levonordefrinhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Levonordefrinhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Levonordefrinhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Levonordefrinhsa01522Endocrine resistance2.16E-021P04049RAF1More
Levonordefrinhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Levonordefrinhsa03010Ribosome1.53E-058P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3More
Levonordefrinhsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Levonordefrinhsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Levonordefrinhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Levonordefrinhsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Levonordefrinhsa04014Ras signaling pathway3.65E-021P04049RAF1More
Levonordefrinhsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Levonordefrinhsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Levonordefrinhsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Levonordefrinhsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Levonordefrinhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Levonordefrinhsa04071Sphingolipid signaling pathway3.35E-035P04049, P21453, Q9H228, P01375, Q13362RAF1, S1PR1, EDG8, TNF, PPP2R5CMore
Levonordefrinhsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Levonordefrinhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Levonordefrinhsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Levonordefrinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Levonordefrinhsa04140Autophagy - animal2.82E-021P04049RAF1More
Levonordefrinhsa04141Protein processing in endoplasmic reticulum2.82E-048P18848, Q15437, Q15436, Q99941, P11142, P07900, Q9NR31, P14625ATF4, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, SAR1A, HSP90B1More
Levonordefrinhsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Levonordefrinhsa04151PI3K-Akt signaling pathway4.12E-049P62753, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGKMore
Levonordefrinhsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Levonordefrinhsa04210Apoptosis2.16E-021P04049RAF1More
Levonordefrinhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Levonordefrinhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Levonordefrinhsa04218Cellular senescence2.49E-021P04049RAF1More
Levonordefrinhsa04261Adrenergic signaling in cardiomyocytes1.73E-049P07550, P51828, P22694, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Levonordefrinhsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Levonordefrinhsa04360Axon guidance2.49E-021P04049RAF1More
Levonordefrinhsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Levonordefrinhsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Levonordefrinhsa04510Focal adhesion3.48E-021P04049RAF1More
Levonordefrinhsa04540Gap junction1.33E-021P04049RAF1More
Levonordefrinhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Levonordefrinhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Levonordefrinhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Levonordefrinhsa04613Neutrophil extracellular trap formation2.65E-021P04049RAF1More
Levonordefrinhsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Levonordefrinhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Levonordefrinhsa04650Natural killer cell mediated cytotoxicity2.93E-058P01375, P20963, P04049, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Levonordefrinhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Levonordefrinhsa04660T cell receptor signaling pathway1.66E-021P04049RAF1More
Levonordefrinhsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Levonordefrinhsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Levonordefrinhsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Levonordefrinhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Levonordefrinhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Levonordefrinhsa04720Long-term potentiation1.66E-021P04049RAF1More
Levonordefrinhsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Levonordefrinhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Levonordefrinhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Levonordefrinhsa04728Dopaminergic synapse3.20E-036Q99941, P18848, Q13557, Q13362, Q14738, P0DP23CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Levonordefrinhsa04730Long-term depression1.16E-021P04049RAF1More
Levonordefrinhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Levonordefrinhsa04742Taste transduction1.01E-021P30939HTR1FMore
Levonordefrinhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Levonordefrinhsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Levonordefrinhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Levonordefrinhsa04912GnRH signaling pathway3.36E-034P51828, P18848, Q13557, P04049ADCY7, ATF4, CAMK2D, RAF1More
Levonordefrinhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Levonordefrinhsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Levonordefrinhsa04915Estrogen signaling pathway4.99E-046P04049, Q99941, P18848, P51828, P07900, P11142RAF1, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Levonordefrinhsa04916Melanogenesis1.33E-021P04049RAF1More
Levonordefrinhsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Levonordefrinhsa04918Thyroid hormone synthesis1.98E-045P51828, Q99941, P18848, P14625, P02768ADCY7, CREBL1, ATF4, HSP90B1, ALBMore
Levonordefrinhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Levonordefrinhsa04921Oxytocin signaling pathway4.61E-034P0DP23, P04049, Q96RR4, Q13469CALM1, RAF1, CAMKK2, NFATC2More
Levonordefrinhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Levonordefrinhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Levonordefrinhsa04926Relaxin signaling pathway5.73E-047Q99941, P18848, P22694, P14780, P51828, P04049, P30679CREBL1, ATF4, PRKACB, MMP9, ADCY7, RAF1, GNA15More
Levonordefrinhsa04927Cortisol synthesis and secretion2.72E-044Q99941, P18848, P51828, P22694CREBL1, ATF4, ADCY7, PRKACBMore
Levonordefrinhsa04928Parathyroid hormone synthesis, secretion and action3.95E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Levonordefrinhsa04929GnRH secretion4.98E-031P04049RAF1More
Levonordefrinhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Levonordefrinhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Levonordefrinhsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Levonordefrinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Levonordefrinhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Levonordefrinhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Levonordefrinhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Levonordefrinhsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Levonordefrinhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Levonordefrinhsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Levonordefrinhsa05034Alcoholism2.49E-021P04049RAF1More
Levonordefrinhsa05132Salmonella infection4.98E-021P04049RAF1More
Levonordefrinhsa05133Pertussis4.20E-021P0C0L4C4AMore
Levonordefrinhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Levonordefrinhsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Levonordefrinhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Levonordefrinhsa05152Tuberculosis3.98E-021P04049RAF1More
Levonordefrinhsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Levonordefrinhsa05161Hepatitis B5.33E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Levonordefrinhsa05163Human cytomegalovirus infection4.98E-021P04049RAF1More
Levonordefrinhsa05164Influenza A3.65E-021P04049RAF1More
Levonordefrinhsa05167Kaposi sarcoma-associated herpesvirus infection1.06E-024P23458, Q13469, P04049, P0DP23JAK1, NFATC2, RAF1, CALM1More
Levonordefrinhsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Levonordefrinhsa05171Coronavirus disease - COVID-194.36E-058P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37AMore
Levonordefrinhsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Levonordefrinhsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Levonordefrinhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Levonordefrinhsa05210Colorectal cancer1.66E-021P04049RAF1More
Levonordefrinhsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Levonordefrinhsa05212Pancreatic cancer4.13E-033P04049, Q15311, P23458RAF1, RALBP1, JAK1More
Levonordefrinhsa05213Endometrial cancer9.95E-031P04049RAF1More
Levonordefrinhsa05214Glioma9.95E-031P04049RAF1More
Levonordefrinhsa05215Prostate cancer3.72E-033P18848, P14625, P04049ATF4, HSP90B1, RAF1More
Levonordefrinhsa05218Melanoma6.63E-031P04049RAF1More
Levonordefrinhsa05219Bladder cancer4.98E-031P04049RAF1More
Levonordefrinhsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Levonordefrinhsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Levonordefrinhsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Levonordefrinhsa05224Breast cancer1.49E-021P04049RAF1More
Levonordefrinhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Levonordefrinhsa05226Gastric cancer8.29E-031P04049RAF1More
Levonordefrinhsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Levonordefrinhsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Levonordefrinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More
Levonordefrinhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Levonordefrinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Levonordefrinhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Levonordefrinhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Levonordefrin (SDC: 4.26)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)