PharmaCoNets

PharmaCoNets of Levoleucovorin (S_PCN: 7.07 )

Levoleucovorin regulated-network (S_DN: 4.98)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Levoleucovorin

hsa00190

Oxidative phosphorylation

3.27E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Levoleucovorin

hsa00230

Purine metabolism

4.02E-02

P31350, P21589

RRM2, NT5E

Levoleucovorin

hsa00240

Pyrimidine metabolism

2.54E-04

P31350, P21589, P04818

RRM2, NT5E, TYMS

Levoleucovorin

hsa00280

Valine, leucine and isoleucine degradation

2.75E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Levoleucovorin

hsa00600

Sphingolipid metabolism

4.56E-02

Q9BX95, Q06136, P06280

SGPP1, FVT1, GLA

Levoleucovorin

hsa00670

One carbon pool by folate

3.62E-02

P00374

DHFR

Levoleucovorin

hsa00790

Folate biosynthesis

3.62E-02

P00374

DHFR

Levoleucovorin

hsa01100

Metabolic pathways

1.66E-02

Q9Y234, O14521, P15144, Q99707, P11310, P27707, Q13370, P36959, Q13956, P22748, P55809, P06280, P30043, Q02252, O60701, O14772, O95954, Q9HCC0, P33121, P04406, Q96EB6, O15466, P36551, Q9BX95, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809

LIPT1, SDHD, ANPEP, MTR, ACADM, DCK, PDE3B, GMPR, PDE6H, CA4, OXCT1, GLA, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, MCCC2, ACSL1, GAPDH, SIRT1, ST8SIA5, CPOX, SGPP1, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q99707	MTR	Methionine synthase	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.764
Q99707	MTR	Methionine synthase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.735
Q99707	MTR	Methionine synthase	P15144	ANPEP	Aminopeptidase N	-0.755
Q99707	MTR	Methionine synthase	Q99707	MTR	Methionine synthase	1
Q99707	MTR	Methionine synthase	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.862
Q99707	MTR	Methionine synthase	P27707	DCK	Deoxycytidine kinase	0.88
Q99707	MTR	Methionine synthase	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0.764
Q99707	MTR	Methionine synthase	P36959	GMPR	GMP reductase 1	-0.819
Q99707	MTR	Methionine synthase	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0.869
Q99707	MTR	Methionine synthase	P22748	CA4	Carbonic anhydrase 4	-0.8
Q99707	MTR	Methionine synthase	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	0.777
Q99707	MTR	Methionine synthase	P06280	GLA	Alpha-galactosidase A	-0.755
Q99707	MTR	Methionine synthase	P30043	BLVRB	Flavin reductase	-0.802
Q99707	MTR	Methionine synthase	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	0.782
Q99707	MTR	Methionine synthase	O60701	UGDH	UDP-glucose 6-dehydrogenase	0.791
Q99707	MTR	Methionine synthase	O14772	FPGT	Fucose-1-phosphate guanylyltransferase	0.818
Q99707	MTR	Methionine synthase	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.825
Q99707	MTR	Methionine synthase	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	0.782
Q99707	MTR	Methionine synthase	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.737
Q99707	MTR	Methionine synthase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.819
Q99707	MTR	Methionine synthase	Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	0.702
Q99707	MTR	Methionine synthase	O15466	ST8SIA5	Alpha-2,8-sialyltransferase 8E	-0.754
Q99707	MTR	Methionine synthase	P36551	CPOX	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	0.769
Q99707	MTR	Methionine synthase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.833
Q99707	MTR	Methionine synthase	P09960	LTA4H	Leukotriene A-4 hydrolase	-0.771
Q99707	MTR	Methionine synthase	Q9P2R7	SUCLA2	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0.852
Q99707	MTR	Methionine synthase	Q9UHY7	ENOPH1	Enolase-phosphatase E1	0.803
Q99707	MTR	Methionine synthase	P35573	AGL	Glycogen debranching enzyme	0.718
Q99707	MTR	Methionine synthase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.726
Q99707	MTR	Methionine synthase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.931
Q99707	MTR	Methionine synthase	Q02809	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	-0.735

Levoleucovorin

hsa01523

Antifolate resistance

6.06E-03

Q92820, P04818

GGH, TYMS

Levoleucovorin

hsa03013

RNA transport

2.29E-04

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3

Levoleucovorin

hsa04015

Rap1 signaling pathway

2.26E-02

P25116, Q8TEU7, P08514

F2R, RAPGEF6, ITGA2B

Levoleucovorin

hsa04022

cGMP-PKG signaling pathway

1.05E-02

P24844, Q8WYR1, Q15746

MYL9, PIK3R5, MYLK

Levoleucovorin

hsa04024

cAMP signaling pathway

1.40E-02

P48058, P25116, P24844

GRIA4, F2R, MYL9

Levoleucovorin

hsa04064

NF-kappa B signaling pathway

2.83E-02

P10415, Q13489, O00463, Q13546, Q9UDY8, Q13077, Q16548, P24522

BCL2, BIRC3, TRAF5, RIPK1, MALT1, TRAF1, BCL2A1, GADD45A

Levoleucovorin

hsa04071

Sphingolipid signaling pathway

1.03E-02

P21453, Q9H228, Q16537, Q9BX95, Q16539, P10415

S1PR1, EDG8, PPP2R5E, SGPP1, MAPK14, BCL2

Levoleucovorin

hsa04110

Cell cycle

2.34E-02

P06493, O60566, P33981

CDK1, BUB1B, TTK

Levoleucovorin

hsa04115

p53 signaling pathway

3.34E-02

P31350, P06493

RRM2, CDK1

Levoleucovorin

hsa04145

Phagosome

2.33E-02

O75015, Q15075, Q15080, P14598, Q13509, Q13488, O60603

FCGR3B, EEA1, NCF4, NCF1, TUBB3, TCIRG1, TLR2

Levoleucovorin

hsa04270

Vascular smooth muscle contraction

4.65E-02

Q15746, P24844

MYLK, MYL9

Levoleucovorin

hsa04510

Focal adhesion

3.36E-02

P08514, Q15746, P24844

ITGA2B, MYLK, MYL9

Levoleucovorin

hsa04512

ECM-receptor interaction

2.44E-02

P07359, P08514

GP1BA, ITGA2B

Levoleucovorin

hsa04514

Cell adhesion molecules

4.65E-02

P16109, O00501

SELP, CLDN5

Levoleucovorin

hsa04530

Tight junction

7.42E-04

Q8TEU7, O00501, Q14247, P24844

RAPGEF6, CLDN5, CTTN, MYL9

Levoleucovorin

hsa04610

Complement and coagulation cascades

2.94E-02

P25116, P10909

F2R, CLU

Levoleucovorin

hsa04611

Platelet activation

1.59E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Levoleucovorin

hsa04613

Neutrophil extracellular trap formation

7.45E-03

O60603, P05164, P08246, Q9UM07, Q92769, Q6FI13, Q15080, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, HDAC2, H2AC18; H2AC19, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Levoleucovorin

hsa04668

TNF signaling pathway

4.96E-02

O00463, Q13546, Q13489, Q16539, Q13077, P14780

TRAF5, RIPK1, BIRC3, MAPK14, TRAF1, MMP9

Levoleucovorin

hsa04724

Glutamatergic synapse

2.94E-02

P48058, Q9NSB8

GRIA4, HOMER2

Levoleucovorin

hsa04810

Regulation of actin cytoskeleton

1.38E-03

P24844, Q15746, P08514, P25116

MYL9, MYLK, ITGA2B, F2R

Levoleucovorin

hsa04921

Oxytocin signaling pathway

6.37E-03

Q15746, P24844, Q8WYR1

MYLK, MYL9, PIK3R5

Levoleucovorin

hsa05034

Alcoholism

2.79E-02

P62879, Q9BTM1

GNB2, H2AFJ

Levoleucovorin

hsa05130

Pathogenic Escherichia coli infection

2.51E-02

Q14247, O00501, P25116

CTTN, CLDN5, F2R

Levoleucovorin

hsa05200

Pathways in cancer

4.70E-02

P17301, P20585, P62879

ITGA2, MSH3, GNB2

Levoleucovorin

hsa05202

Transcriptional misregulation in cancer

1.61E-03

Q15532, P41732, P14780, P27930, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q92769, P24522

SS18, TSPAN7, MMP9, IL1R2, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC2, GADD45A

Levoleucovorin

hsa05217

Basal cell carcinoma

2.01E-02

Q13635, P04628, Q9UJU2, P24522

PTCH1, WNT1, LEF1, GADD45A

Community members of Levoleucovorin (S_DC: 1.42)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

TYMS

Thymidylate synthase

Predicted

0.4553

0.2706

0.1893

0.9582

P00374

DHFR

Dihydrofolate reductase

Predicted

0.338

0.1868

0.2263

0.7688

Q99707

MTR

Methionine synthase

Predicted

0.1612

0.0562

0.195

0.3881

P08514

ITGA2B

Integrin alphaNoneIIb

Predicted

0.0782

0.3248

0.779

1.4677

P09958

FURIN

Furin

Predicted

0.1569

0.075

0.2286

PharmaCoNets of Levoleucovorin (SPCN: 7.07 )

Levoleucovorin regulated-network (SDN: 4.98)

Community members of Levoleucovorin (SDC: 1.42)

PharmaCoNets of Levoleucovorin (S_PCN: 7.07 )

Levoleucovorin regulated-network (S_DN: 4.98)

Community members of Levoleucovorin (S_DC: 1.42)