PharmaCoNets of Levocarnitine (SPCN: 6.10 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Levocarnitinehsa00270Cysteine and methionine metabolism4.56E-023Q99707, P26358, Q9UHY7MTR, DNMT1, ENOPH1More
Levocarnitinehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin3.03E-021O14792HS3ST1More
Levocarnitinehsa00591Linoleic acid metabolism1.65E-021P11712CYP2C9More
Levocarnitinehsa00730Thiamine metabolism4.51E-021Q9Y6K8AK5More
Levocarnitinehsa00830Retinol metabolism3.49E-021P00325ADH1BMore
Levocarnitinehsa00920Sulfur metabolism1.65E-021Q16762TSTMore
Levocarnitinehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Levocarnitinehsa03013RNA transport4.20E-0313O14980, P52298, Q09161, O14893, P37198, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, NUP62, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, TACC3, FXR1More
Levocarnitinehsa03022Basal transcription factors1.91E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Levocarnitinehsa04014Ras signaling pathway4.65E-023Q15311, P0DP23, P17612RALBP1, CALM1, PRKACAMore
Levocarnitinehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Levocarnitinehsa04071Sphingolipid signaling pathway2.96E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Levocarnitinehsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Levocarnitinehsa04114Oocyte meiosis2.15E-023P0DP23, P17612, Q13362CALM1, PRKACA, PPP2R5CMore
Levocarnitinehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Levocarnitinehsa04122Sulfur relay system1.65E-021Q16762TSTMore
Levocarnitinehsa04142Lysosome2.98E-022P10619, P49281CTSA, SLC11A2More
Levocarnitinehsa04144Endocytosis4.07E-035Q9H444, O75351, P42566, Q15438, Q14161CHMP4B, VPS4B, EPS15, PSCD1, GIT2More
Levocarnitinehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Levocarnitinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Levocarnitinehsa04217Necroptosis4.56E-034P23458, Q9NQC7, Q9H444, O75351JAK1, CYLD, CHMP4B, VPS4BMore
Levocarnitinehsa04261Adrenergic signaling in cardiomyocytes2.50E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Levocarnitinehsa04612Antigen processing and presentation3.21E-026P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Levocarnitinehsa04613Neutrophil extracellular trap formation1.23E-035P11215, Q13547, P58876, Q16778, O60814ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Levocarnitinehsa04713Circadian entrainment4.42E-022P0DP23, P17612CALM1, PRKACAMore
Levocarnitinehsa04720Long-term potentiation4.42E-022P0DP23, P17612CALM1, PRKACAMore
Levocarnitinehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Levocarnitinehsa04728Dopaminergic synapse1.55E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Levocarnitinehsa04740Olfactory transduction6.71E-032P0DP23, P17612CALM1, PRKACAMore
Levocarnitinehsa04910Insulin signaling pathway3.62E-022P0DP23, P17612CALM1, PRKACAMore
Levocarnitinehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Levocarnitinehsa04916Melanogenesis2.87E-022P17612, P0DP23PRKACA, CALM1More
Levocarnitinehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Levocarnitinehsa04921Oxytocin signaling pathway1.84E-023P0DP23, P17612, Q96RR4CALM1, PRKACA, CAMKK2More
Levocarnitinehsa04924Renin secretion1.09E-022P17612, P0DP23PRKACA, CALM1More
Levocarnitinehsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Levocarnitinehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Levocarnitinehsa04962Vasopressin-regulated water reabsorption4.51E-021Q9UJW0DCTN4More
Levocarnitinehsa04970Salivary secretion2.20E-022P17612, P0DP23PRKACA, CALM1More
Levocarnitinehsa04971Gastric acid secretion2.87E-022P17612, P0DP23PRKACA, CALM1More
Levocarnitinehsa04976Bile secretion2.20E-022P17612, Q14032PRKACA, BAATMore
Levocarnitinehsa05031Amphetamine addiction2.87E-022P0DP23, P17612CALM1, PRKACAMore
Levocarnitinehsa05034Alcoholism9.58E-057P17612, Q13547, P0DP23, Q96RR4, P58876, Q16778, O60814PRKACA, HDAC1, CALM1, CAMKK2, H2BC5, HIST2H2BE, H2BC12More
Levocarnitinehsa05150Staphylococcus aureus infection8.37E-035P21462, O75015, Q14532, P59665, P59666FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3More
Levocarnitinehsa05202Transcriptional misregulation in cancer1.63E-0315Q15532, Q13315, P14780, P27930, Q15744, Q16548, P11215, O15550, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, UTX, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Levocarnitinehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Levocarnitinehsa05212Pancreatic cancer2.87E-022Q15311, P23458RALBP1, JAK1More
Levocarnitinehsa05321Inflammatory bowel disease2.29E-024P13765, Q14765, P23771, Q9HBE5HLA-DOB, STAT4, GATA3, IL21RMore
Levocarnitinehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Levocarnitinehsa05332Graft-versus-host disease7.89E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More

Community members of Levocarnitine (SDC: 1.07)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P43155CRATCarnitine ONoneacetyltransferaseReported00.06810.019200.0724
Q9UKG9CROTPeroxisomal carnitine ONoneoctanoyltransferaseReported00.13110.01270.10970.2007
P05164MPOMyeloperoxidaseReported10.20350.53680.55021.7255
Q8NFZ4NLGN2NeuroliginNone2Predicted00.5660.06920.16270.5841
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
Q9H2D1SLC25A32Mitochondrial folate transporter/carrierPredicted00.05530.002200.032
Q9BQT8SLC25A21Mitochondrial 2Noneoxodicarboxylate carrierPredicted00.03840.004100.0274
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)