PharmaCoNets of Levamisole (SPCN: 5.26 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Levamisolehsa00250Alanine, aspartate and glutamate metabolism1.22E-022Q96RQ9, P15104IL4I1, GLULMore
Levamisolehsa00270Cysteine and methionine metabolism3.39E-022Q96RQ9, P40926IL4I1, MDH2More
Levamisolehsa00330Arginine and proline metabolism4.40E-021P17707AMD1More
Levamisolehsa00440Phosphonate and phosphinate metabolism4.40E-021Q9Y6K0CEPT1More
Levamisolehsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Levamisolehsa00561Glycerolipid metabolism1.12E-023Q8NEB5, P14550, Q86XP1PPAPDC1B, AKR1A1, DGKHMore
Levamisolehsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Levamisolehsa00740Riboflavin metabolism4.40E-021Q969G6RFKMore
Levamisolehsa00830Retinol metabolism4.40E-021P00325ADH1BMore
Levamisolehsa00900Terpenoid backbone biosynthesis1.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Levamisolehsa04020Calcium signaling pathway2.41E-025Q96DU7, Q13557, P21860, P26678, P63092ITPKC, CAMK2D, ERBB3, PLN, GNASMore
Levamisolehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Levamisolehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Levamisolehsa04330Notch signaling pathway1.12E-023Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Levamisolehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Levamisolehsa04610Complement and coagulation cascades1.06E-021P0C0L4C4AMore
Levamisolehsa04622RIG-I-like receptor signaling pathway3.39E-022Q12933, P10145TRAF2, IL8More
Levamisolehsa04650Natural killer cell mediated cytotoxicity3.18E-039P16298, P50591, P78314, P06239, O60880, P20963, Q02750, P26718, O75015PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRK1, FCGR3BMore
Levamisolehsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Levamisolehsa04659Th17 cell differentiation7.42E-037Q16539, P06239, P13765, P14778, Q9UL17, P09693, P20963MAPK14, LCK, HLA-DOB, IL1R1, TBX21, CD3G, CD247More
Levamisolehsa04713Circadian entrainment1.75E-024Q13557, Q02153, P61952, P63092CAMK2D, GUCY1B3, GNG11, GNASMore
Levamisolehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Levamisolehsa04728Dopaminergic synapse2.41E-025P63092, P61952, Q99941, Q13557, O15516GNAS, GNG11, CREBL1, CAMK2D, CLOCKMore
Levamisolehsa04911Insulin secretion4.88E-023P63092, Q99941, Q13557GNAS, CREBL1, CAMK2DMore
Levamisolehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Levamisolehsa04934Cushing syndrome1.75E-024Q99941, P63092, O15169, Q13557CREBL1, GNAS, AXIN1, CAMK2DMore
Levamisolehsa05031Amphetamine addiction4.88E-023Q13557, P63092, Q99941CAMK2D, GNAS, CREBL1More
Levamisolehsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Levamisolehsa05150Staphylococcus aureus infection2.01E-022P0C0L4, P20036C4A, HLA-DPA1More
Levamisolehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Levamisolehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Levamisolehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Levamisolehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Levamisolehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Levamisolehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.03E-025P20963, P09693, P06239, O60603, Q16539CD247, CD3G, LCK, TLR2, MAPK14More
Levamisolehsa05322Systemic lupus erythematosus2.92E-022P0C0L4, P20036C4A, HLA-DPA1More

Community members of Levamisole (SDC: 1.78)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P24387CRHBPCorticotropinNonereleasing factorNonebinding proteinPredicted00.51080.024200.3039
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q6PL18ATAD2ATPase family AAA domainNonecontaining protein 2Predicted00.19630.051200.2006
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)