PharmaCoNets

PharmaCoNets of Levallorphan (S_PCN: 176.58 )

Levallorphan regulated-network (S_DN: 22.41)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Levallorphan

hsa00030

Pentose phosphate pathway

1.08E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Levallorphan

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Levallorphan

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Levallorphan

hsa00190

Oxidative phosphorylation

1.03E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Levallorphan

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Levallorphan

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Levallorphan

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Levallorphan

hsa00500

Starch and sucrose metabolism

9.22E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Levallorphan

hsa00565

Ether lipid metabolism

3.00E-03

Q8N661

TMEM86B

Levallorphan

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Levallorphan

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Levallorphan

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Levallorphan

hsa00730

Thiamine metabolism

4.66E-02

P05186, P24666

ALPL, ACP1

Levallorphan

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Levallorphan

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Levallorphan

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Levallorphan

hsa00970

Aminoacyl-tRNA biosynthesis

3.94E-06

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Levallorphan

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Levallorphan

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Levallorphan

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Levallorphan

hsa01230

Biosynthesis of amino acids

2.22E-03

P51854, P60891, Q99707, P37837

TKTL1, PRPS1, MTR, TALDO1

Levallorphan

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Levallorphan

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Levallorphan

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Levallorphan

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Levallorphan

hsa03008

Ribosome biogenesis in eukaryotes

2.03E-03

Q9NYH9, O14980, O60832, P78345, Q9BVP2

UTP6, XPO1, DKC1, RPP38, GNL3

Levallorphan

hsa03010

Ribosome

1.03E-02

P46777, P50914

RPL5, RPL14

Levallorphan

hsa03013

RNA transport

1.40E-08

O14980, P52298, Q09161, O14893, P61326, P38919, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, P78345, Q14240, P23588, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713

Levallorphan

hsa03020

RNA polymerase

4.40E-02

P24928, P62487

POLR2A, POLR2G

Levallorphan

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Levallorphan

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Levallorphan

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Levallorphan

hsa04010

MAPK signaling pathway

1.23E-03

P08069, Q9H2K8, Q12933

IGF1R, TAOK3, TRAF2

Levallorphan

hsa04014

Ras signaling pathway

3.65E-02

P08069

IGF1R

Levallorphan

hsa04015

Rap1 signaling pathway

5.18E-04

P08069, P06213, O00522

IGF1R, INSR, KRIT1

Levallorphan

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Levallorphan

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Levallorphan

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.70E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Levallorphan

hsa04062

Chemokine signaling pathway

6.08E-06

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Levallorphan

hsa04064

NF-kappa B signaling pathway

1.13E-05

P10415, Q13489, P51617, O00463, Q13546, P14778, P29965, P19174, Q04759, Q9UDY8, Q13077, P07948, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P51684	CCR6	C-C chemokine receptor type 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.869
P51684	CCR6	C-C chemokine receptor type 6	Q13077	TRAF1	TNF receptor-associated factor 1	0.768
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Levallorphan

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Levallorphan

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Levallorphan

hsa04070

Phosphatidylinositol signaling system

3.54E-03

P0DP23, Q14643, P23743, O14732, P17252

CALM1, ITPR1, DGKA, IMPA2, PRKCA

Levallorphan

hsa04071

Sphingolipid signaling pathway

2.48E-06

P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415, Q12933, Q02156

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, TRAF2, PRKCE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P21462	FPR1	fMet-Leu-Phe receptor	P17252	PRKCA	Protein kinase C alpha type	-0.731
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P21462	FPR1	fMet-Leu-Phe receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.716
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P21462	FPR1	fMet-Leu-Phe receptor	P01375	TNF	Tumor necrosis factor	0.77
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P21462	FPR1	fMet-Leu-Phe receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.878
P51684	CCR6	C-C chemokine receptor type 6	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.819
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P21462	FPR1	fMet-Leu-Phe receptor	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.932
P51684	CCR6	C-C chemokine receptor type 6	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.876
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P21462	FPR1	fMet-Leu-Phe receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.855
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
Q02156	PRKCE	Protein kinase C epsilon type	Q12933	TRAF2	TNF receptor-associated factor 2	-0.78
Q02156	PRKCE	Protein kinase C epsilon type	Q02156	PRKCE	Protein kinase C epsilon type	1

Levallorphan

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Levallorphan

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Levallorphan

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Levallorphan

hsa04114

Oocyte meiosis

2.99E-02

P08069

IGF1R

Levallorphan

hsa04120

Ubiquitin mediated proteolysis

2.51E-03

Q14145, Q13042, P62837, Q15751, O95071, P0CG47

KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB

Levallorphan

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Levallorphan

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Levallorphan

hsa04140

Autophagy - animal

2.82E-02

P08069

IGF1R

Levallorphan

hsa04142

Lysosome

3.31E-02

P43234, Q9UBR2, P34059

CTSO, CTSZ, GALNS

Levallorphan

hsa04144

Endocytosis

4.10E-02

O75351, P62491, Q14161

VPS4B, RAB11A, GIT2

Levallorphan

hsa04145

Phagosome

1.59E-03

Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB

Levallorphan

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Levallorphan

hsa04151

PI3K-Akt signaling pathway

1.65E-03

P62753, P25116, O43521, P27348, P49767, Q13362, Q8WYR1, P62873, P16144, O60603, P01568, P18848, P10415, P17252, O00141, Q6ZUJ8

RPS6, F2R, BCL2L11, YWHAQ, VEGFC, PPP2R5C, PIK3R5, GNB1, ITGB4, TLR2, IFNA21, ATF4, BCL2, PRKCA, SGK, PIK3AP1

Levallorphan

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Levallorphan

hsa04210

Apoptosis

3.63E-02

O75460, O43521, P18848

ERN1, BCL2L11, ATF4

Levallorphan

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Levallorphan

hsa04213

Longevity regulating pathway - multiple species

1.14E-03

P42338, P08069, Q9Y4H2, P11142, Q13547

PIK3CB, IGF1R, IRS2, HSPA8, HDAC1

Levallorphan

hsa04217

Necroptosis

1.79E-07

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P61073	CXCR4	C-X-C chemokine receptor type 4	P15104	GLUL	Glutamine synthetase	0.754
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P61073	CXCR4	C-X-C chemokine receptor type 4	P0C0S5	H2AFZ	Histone H2A.Z	0.732
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P61073	CXCR4	C-X-C chemokine receptor type 4	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.731
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Levallorphan

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Levallorphan

hsa04261

Adrenergic signaling in cardiomyocytes

2.45E-04

P09493, P07550, P22694, P18848, Q13362, Q16537, P0DP23, P17252, P10415, P20020

TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1

Levallorphan

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Levallorphan

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Levallorphan

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Levallorphan

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Levallorphan

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Levallorphan

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Levallorphan

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Levallorphan

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Levallorphan

hsa04612

Antigen processing and presentation

5.80E-06

P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Levallorphan

hsa04613

Neutrophil extracellular trap formation

5.01E-07

P17252, P11215, O60603, P08246, Q13547, Q92769, P04908, Q6FI13, Q93077, P58876, P62807, P33778, Q16778, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539

PRKCA, ITGAM, TLR2, ELA2, HDAC1, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Levallorphan

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Levallorphan

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Levallorphan

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Levallorphan

hsa04630

JAK-STAT signaling pathway

1.44E-02

P01106, Q09472, P48551, P16871

MYC, EP300, IFNAR2, IL7R

Levallorphan

hsa04640

Hematopoietic cell lineage

9.84E-08

P13612, P21926, P14778, P27930, P11215, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P16871, P13765

ITGA4, CD9, IL1R1, IL1R2, ITGAM, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, IL7R, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P07101	TH	Tyrosine 3-monooxygenase	P20023	CR2	Complement receptor type 2	0.827
P07101	TH	Tyrosine 3-monooxygenase	P11836	MS4A1	B-lymphocyte antigen CD20	0.759
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P07101	TH	Tyrosine 3-monooxygenase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.738
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P07101	TH	Tyrosine 3-monooxygenase	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.921
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777

Levallorphan

hsa04650

Natural killer cell mediated cytotoxicity

3.13E-11

P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Levallorphan

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

Levallorphan

hsa04658

Th1 and Th2 cell differentiation

2.82E-10

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Levallorphan

hsa04659

Th17 cell differentiation

2.90E-08

Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Levallorphan

hsa04660

T cell receptor signaling pathway

1.05E-07

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Levallorphan

hsa04666

Fc gamma R-mediated phagocytosis

2.22E-02

P49006, P06396, P14598, P17252

MARCKSL1, GSN, NCF1, PRKCA

Levallorphan

hsa04668

TNF signaling pathway

2.67E-03

P01375, P18848, P19875, P01584, P14780, P20333

TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1B

Levallorphan

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Levallorphan

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Levallorphan

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Levallorphan

hsa04720

Long-term potentiation

3.85E-03

P17252, P0DP23, Q14643

PRKCA, CALM1, ITPR1

Levallorphan

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Levallorphan

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Levallorphan

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Levallorphan

hsa04725

Cholinergic synapse

1.88E-02

Q14643, P17252, P62873, P10415

ITPR1, PRKCA, GNB1, BCL2

Levallorphan

hsa04728

Dopaminergic synapse

2.76E-03

Q14643, P17252, P14416, P62873, P63218, P50151, P49841, Q16539, P49407, Q13362, P0DP23

ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, CALM1

Levallorphan

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Levallorphan

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Levallorphan

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Levallorphan

hsa04912

GnRH signaling pathway

3.85E-03

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Levallorphan

hsa04913

Ovarian steroidogenesis

5.67E-04

P42330, P22694, P06213, P08069

AKR1C3, PRKACB, INSR, IGF1R

Levallorphan

hsa04914

Progesterone-mediated oocyte maturation

2.16E-02

P08069

IGF1R

Levallorphan

hsa04919

Thyroid hormone signaling pathway

4.44E-02

P60709, Q09472, P01106

ACTB, EP300, MYC

Levallorphan

hsa04922

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Levallorphan

hsa04923

Regulation of lipolysis in adipocytes

4.24E-03

P07550, P06213, P42338, Q9Y4H2

ADRB2, INSR, PIK3CB, IRS2

Levallorphan

hsa04924

Renin secretion

7.38E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Levallorphan

hsa04925

Aldosterone synthesis and secretion

1.54E-02

Q14643, P0DP23, P17252, P20020

ITPR1, CALM1, PRKCA, ATP2B1

Levallorphan

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Levallorphan

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Levallorphan

hsa04930

Type II diabetes mellitus

1.28E-03

P06213, Q02156

INSR, PRKCE

Levallorphan

hsa04932

Non-alcoholic fatty liver disease

1.52E-05

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHD

Levallorphan

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.27E-02

P42224, P10415, Q12778, P49767, P17252

STAT1, BCL2, FOXO1, VEGFC, PRKCA

Levallorphan

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Levallorphan

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Levallorphan

hsa04962

Vasopressin-regulated water reabsorption

1.80E-02

P62491, P46459

RAB11A, NSF

Levallorphan

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Levallorphan

hsa04966

Collecting duct acid secretion

1.13E-04

Q13488, P02730, P00918, Q9Y666

TCIRG1, SLC4A1, CA2, SLC12A7

Levallorphan

hsa04970

Salivary secretion

4.79E-04

P07550, P22694, Q14643, P20020, P17252, P0DP23, P49913

ADRB2, PRKACB, ITPR1, ATP2B1, PRKCA, CALM1, CAMP

Levallorphan

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Levallorphan

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Levallorphan

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Levallorphan

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Levallorphan

hsa05010

Alzheimer disease

5.01E-03

Q16718, O14521, P13073, Q14643, O75460, P0DP23, P0DP24, P01584, P18848, Q13509, P68371, P05141, Q08752

NDUFA5, SDHD, COX4I1, ITPR1, ERN1, CALM1, CALM2, IL1B, ATF4, TUBB3, TUBB2C, SLC25A5, PPID

Levallorphan

hsa05012

Parkinson disease

4.51E-03

Q16718, O14521, P13073, P05141, O75460, P18848, Q14643, P0DP23, P0DP24, Q13509, P68371

NDUFA5, SDHD, COX4I1, SLC25A5, ERN1, ATF4, ITPR1, CALM1, CALM2, TUBB3, TUBB2C

Levallorphan

hsa05016

Huntington disease

4.87E-02

P13073, P24928, P62487, P05141, O75460

COX4I1, POLR2A, POLR2G, SLC25A5, ERN1

Levallorphan

hsa05020

Prion disease

1.31E-03

Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14

Levallorphan

hsa05022

Pathways of neurodegeneration - multiple diseases

2.05E-05

Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P17252, P20333, Q16539, P01584, Q08752, P0DP23, P0DP24

ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, IL1B, PPID, CALM1, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759

Levallorphan

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Levallorphan

hsa05034

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Levallorphan

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.62E-04

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Levallorphan

hsa05131

Shigellosis

3.33E-03

Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Levallorphan

hsa05132

Salmonella infection

4.24E-05

P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371

IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C

Levallorphan

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Levallorphan

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Levallorphan

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Levallorphan

hsa05140

Leishmaniasis

5.36E-06

P14598, P42224, P13765, O60603, P25963, P29350, P49006, P51617, Q15080

NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, IRAK1, NCF4

Levallorphan

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Levallorphan

hsa05144

Malaria

1.30E-05

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Levallorphan

hsa05145

Toxoplasmosis

1.11E-02

P10415, Q13489, P42224, P13765, O60603, P29965

BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Levallorphan

hsa05146

Amoebiasis

7.67E-07

P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Levallorphan

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Levallorphan

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Levallorphan

hsa05163

Human cytomegalovirus infection

1.72E-02

P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463

TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5

Levallorphan

hsa05164

Influenza A

8.62E-03

Q09472, P48551, P29728, P60709

EP300, IFNAR2, OAS2, ACTB

Levallorphan

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Levallorphan

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.73E-02

P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2

IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1

Levallorphan

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Levallorphan

hsa05169

Epstein-Barr virus infection

2.78E-05

P20023, P13765, P01106, Q13547, Q92769, P04637, Q13546, O00463, P10415, P07948, Q13761, P24522, P48551, O60603, P29728, P51617, P07766, P09693, P20963

CR2, HLA-DOB, MYC, HDAC1, HDAC2, TP53, RIPK1, TRAF5, BCL2, LYN, RUNX3, GADD45A, IFNAR2, TLR2, OAS2, IRAK1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07101	TH	Tyrosine 3-monooxygenase	P20023	CR2	Complement receptor type 2	0.827
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P07101	TH	Tyrosine 3-monooxygenase	P01106	MYC	Myc proto-oncogene protein	0.872
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P07101	TH	Tyrosine 3-monooxygenase	P48551	IFNAR2	Interferon alpha/beta receptor 2	0.814
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P07101	TH	Tyrosine 3-monooxygenase	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.754
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07101	TH	Tyrosine 3-monooxygenase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.738
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927

Levallorphan

hsa05170

Human immunodeficiency virus 1 infection

1.03E-04

P62873, P0DP23, P17252, Q13546, Q14643, P01568, P51617, O60603, Q13315, P09693, P10415, Q9Y6Q5

GNB1, CALM1, PRKCA, RIPK1, ITPR1, IFNA21, IRAK1, TLR2, ATM, CD3G, BCL2, AP1M2

Levallorphan

hsa05171

Coronavirus disease - COVID-19

1.93E-02

P48551, P29728, P46777, P50914

IFNAR2, OAS2, RPL5, RPL14

Levallorphan

hsa05200

Pathways in cancer

4.99E-02

P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568

STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21

Levallorphan

hsa05202

Transcriptional misregulation in cancer

8.55E-04

P27930, P11215, P08069, Q13547, P12980

IL1R2, ITGAM, IGF1R, HDAC1, LYL1

Levallorphan

hsa05203

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Levallorphan

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Levallorphan

hsa05205

Proteoglycans in cancer

1.09E-02

P14780, P01375, P08069, P23588, Q13635, P22694

MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACB

Levallorphan

hsa05211

Renal cell carcinoma

1.67E-02

Q09472, Q99814

EP300, EPAS1

Levallorphan

hsa05212

Pancreatic cancer

3.40E-02

P37173

TGFBR2

Levallorphan

hsa05214

Glioma

1.40E-03

P08069, P0DP23, P17252, P04637, P24522

IGF1R, CALM1, PRKCA, TP53, GADD45A

Levallorphan

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Levallorphan

hsa05216

Thyroid cancer

1.58E-03

P01106, Q9UJU2, P04637, P24522, O75293

MYC, LEF1, TP53, GADD45A, GADD45B

Levallorphan

hsa05217

Basal cell carcinoma

4.42E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Levallorphan

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Levallorphan

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Levallorphan

hsa05224

Breast cancer

1.49E-02

P08069

IGF1R

Levallorphan

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Levallorphan

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

9.97E-06

P42338, P19174, P07766, P20963, P09693, P06239, Q04759, Q9HC35, P01730

PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, EML4, CD4

Levallorphan

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Levallorphan

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Levallorphan

hsa05322

Systemic lupus erythematosus

2.33E-07

P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Levallorphan

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Levallorphan

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Levallorphan

hsa05332

Graft-versus-host disease

9.47E-05

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Levallorphan

hsa05340

Primary immunodeficiency

1.31E-04

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Levallorphan

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Levallorphan

hsa05415

Diabetic cardiomyopathy

5.60E-05

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Levallorphan

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Levallorphan

hsa05418

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Levallorphan (S_DC: 7.88)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P07101

Tyrosine 3Nonemonooxygenase

Predicted

0.0432

0.0888

0.4937

0.6929

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P06213

INSR

Insulin receptor

Predicted

0.2794

0.7813

0.7209

2.4232

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

Q9GZT9

EGLN1

Egl nine homolog 1

Predicted

0.5804

0.6061

0.2556

1.7581

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

PharmaCoNets of Levallorphan (SPCN: 176.58 )

Levallorphan regulated-network (SDN: 22.41)

Community members of Levallorphan (SDC: 7.88)

PharmaCoNets of Levallorphan (S_PCN: 176.58 )

Levallorphan regulated-network (S_DN: 22.41)

Community members of Levallorphan (S_DC: 7.88)