PharmaCoNets of Leuprolide (SPCN: 10.43 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Leuprolidehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Leuprolidehsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Leuprolidehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Leuprolidehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Leuprolidehsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Leuprolidehsa01100Metabolic pathways4.11E-027P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHEMore
Leuprolidehsa01200Carbon metabolism4.06E-025P37837, O14521, P50213, P60891, Q02252TALDO1, SDHD, IDH3A, PRPS1, ALDH6A1More
Leuprolidehsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Leuprolidehsa03013RNA transport4.73E-029P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, TACC3More
Leuprolidehsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Leuprolidehsa03050Proteasome3.05E-021P55036PSMD4More
Leuprolidehsa04080Neuroactive ligand-receptor interaction4.15E-022Q01726, P41968MC1R, MC3RMore
Leuprolidehsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Leuprolidehsa04330Notch signaling pathway7.49E-032Q92542, P49768NCSTN, PSEN1More
Leuprolidehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Leuprolidehsa04613Neutrophil extracellular trap formation9.53E-0313P17252, O60603, P08246, Q9UM07, Q92769, Q6FI13, P14598, Q15080, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, ELA2, PADI4, HDAC2, H2AC18; H2AC19, NCF1, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Leuprolidehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Leuprolidehsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Leuprolidehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Leuprolidehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Leuprolidehsa04912GnRH signaling pathway3.39E-024P17252, Q16539, Q9Y6R4, Q14643PRKCA, MAPK14, MAP3K4, ITPR1More
Leuprolidehsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Leuprolidehsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Leuprolidehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Leuprolidehsa04972Pancreatic secretion3.86E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Leuprolidehsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Leuprolidehsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Leuprolidehsa05222Small cell lung cancer4.26E-026P10826, Q13489, P10415, Q13077, O00463, P24522RARB, BIRC3, BCL2, TRAF1, TRAF5, GADD45AMore
Leuprolidehsa05415Diabetic cardiomyopathy3.19E-027P17252, P14598, Q15080, Q16718, O14521, Q16539, P14780PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9More
Leuprolidehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Leuprolide (SDC: 2.88)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
O60603TLR2TollNonelike receptor 2Predicted10.21260.080511.2673
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)